Gene zyg-8 (Nematode worm)

zyg-8

Species: Nematode worm
Alias: Y79H2A.11, CE31133, zyg-8, Y75B8A.a, aSWK052, Y75B8A.aandY79H2A.g
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: III:14.4279, WormBase Physical Map location: III: 12057100-12067358

Classification

Group: CAMK
Family: DCAMKL

Sequence

Name Sequence Type Origin Length Description Download
zyg-8.AA Protein Genbank 802 None Fasta, JSON
zyg-8.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 238 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of zyg-8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DCX zyg-8.AA DCX 206-298 46 2.2e-48 167.97 SMART 1-96 (96) Show / Hide 
Range on Protein: 206-298
Range on HMM: 1-96/96
Sequence Identity: 46% (45 aa)

HLLKAKRLRFYRNGDQYFKGIQYALQSDR-VKSMQPLMEDLMKTVICDSTALPHGIRHIFTIDGAQRITSVDQFEDG-GGYVCSSTD-AFKPVDYS
|. |.||..||||||..|||......... .||...|..|...|....   .|||.|||.|.||..|.||.|.|||| ..|||..|. .||||||.
HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD
DCX zyg-8.AA DCX 228-293 36 1e-12 47.64 Pfam 1-68 (68) Show / Hide 
Range on Protein: 228-293
Range on HMM: 1-68/68
Sequence Identity: 36% (25 aa)

YALQSDRVKSMQPLMEDLMKTVICDSTALPHG-IRHIFTIDGAQRITSVDQ-FEDGGGYVCS-STDAFK
... ..|.|..  |..|. . .  |   ||.| .|.|.| ||  |.|| |. ..||| |||. .  .||
MVVNRRRFKTFDALLDDITE-SLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK
DCX zyg-8.AA DCX 335-423 30 1.5e-41 145.23 SMART 1-96 (96) Show / Hide 
Range on Protein: 335-423
Range on HMM: 1-96/96
Sequence Identity: 30% (29 aa)

DFVFPRIIKVIRNGVKPRRISRHLLNKKT-ARSFDQVLRDLTF---VVKLDSG-AIRKLFTLSG-RPVLSLQDFFRDDDVFVAYGGN-EKMAADDL
....|..|...|||.......|...|.|. ..|||..|.|.|.   .||.|.. ..|...|..| ..| ||..|...||..|....| . . .|..
HHWKPKRICFYRNGDPFFKGVRLVINRKWQFKSFDHLLQDVTQTKLHVKMDCPHGVRHIYTTDGRHRVTSLDEFEDGDDFYVCCCTNEKFKPVDYD
DCX zyg-8.AA DCX 357-418 30 9.5e-23 82.83 Pfam 1-68 (68) Show / Hide 
Range on Protein: 357-418
Range on HMM: 1-68/68
Sequence Identity: 30% (21 aa)

HLLNKKTARSFDQVLRDLTF----VVKLDSGAIRKLFTLSG-RPVLSLQDFFRDDDVFVAY-GGNEKM
 ..|......||..| |.|     .|.|..||.||..|..| ..| ||..|. |....|.. | .. .
MVVNRRRFKTFDALLDDITESLHDKVQLPFGAVRKIYTPDGGHRVTSLDEFLQDGGCYVCCCGNERFK
Kinase zyg-8.AA DCAMKL 482-743 49 3.4e-186 584.84 In-house 1-279 (279) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-279/279
Sequence Identity: 49% (138 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKV-----------------IARENVIGKEHLIEMELAILQKIDHTFIVQLYDHWFVDDSYYLSLELIEMG
.|..|.|||||.|||.|.......|...|||.                 |......||||.|..|..|.|||.|..|.|||.||.....|||..|....|
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGG

DLFEHLRIVRRVPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGELGVKLADFGLAAEMPKDFGVLSTICGTPTYVAPEVLNKTGYGCKV
|||..........||||..|||||..||.|.||..|||||.|.||||..|.|.||...||.|||||.....|||.|.|.||||||||||.|..|||||||
DLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILMETGYGCKV

DIWAAGVILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAGELLNDEWM
||||||||||..|.|||||.|.|.....||..||.|.|.||.|.||..| |.. ||  .   ||  ||.|.. .   | 
DIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV
Kinase zyg-8.AA CAMK 487-743 21 2.2e-106 343.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 487-743
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

LIGDGNTAVVYEVIDK-TNNDDR----------KAMKVIARENVIG---------------------------KEHLIEMELAILQK-------IDHTFI
 .| |. ..|...|.| |... |           |.|.| .. . .                           ... .. |..|..|       .||  |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDHWFV-------------------DDSYYLSL---ELIEMG----DLFEHLRIV---------------RRVPERDAVRMMTCLGQALEYIHELGI
..||...                     |. .|. .   |... |    |||....                 .|..||.| |..  . .|..|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDVKLENLLIVKDEFGEL------------G-VKLADFGLAAEMPKDFG-----------------------VLSTICGTPTYVA-PEVLNK------
|||| |.||.|..... ..             . .|..|||.|...... .                        ..| |||| |.| |||||.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------TGYGCKVDIWAAGVILYAILVGFPPFQSSDG-----------SEQDLFSAIMSGEFSFPSPSWDDVS-------WS-------------VRH
        ..|| |.|.|..|||||. |.|.|||.....           ....||  ||.|...||.| ....|       |.             ...
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIMCLIHTDPFHRYSAGELLNDEWM
|| ..  .|| .|... . ||..||
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase zyg-8.AA CAMK1 482-743 35 3.3e-97 283.12 In-house 1-276 (276) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-276/276
Sequence Identity: 35% (100 aa)

FQLVRLIGDGNTAVVYEVIDKTN--NDDRKAMKVIA-RENVIGKE----HLIEMELAILQK---IDHTFIVQLYDHWFVDDSYYLSLELIEMGDLFEHLR
...   || |  ..||....| .  |..  |.|.|  .... .|.     ..|.|..|..|   ||| .|...|..   |. .|| .||.  |.||.  |
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD--R

IVRRVP--ERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGELGVK--LADFGLAAEMPKDFGVLSTICGTPTYVAPEVLNK---TGYGCKV
|| .    |.||.. |  . .|.||.|..|||||| | |||| .  ...   .|  .|||||.     | ....| |||| |||||||.    ..|. ..
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSK-IKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKAC

DIWAAGVILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWS-VRHLIMCLIHTDPFHRYSAGELLNDEWM
|.| .|||.| .|.|.|||..... .. ||. |...|. |||| ||..| . . ..| ...  ||  ||.. . ||. | 
DMWSIGVITYILLCGYPPFYDENV-DNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase zyg-8.AA S_TKc 482-743 32 1.6e-84 288.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKEHLIEMELAILQKIDHTFIVQLYDHWFVDDSYYLSLELIEM--GDLFEHLRIVRR----
....|.|| |  ..|| ...|   . . |.|.|           |. |..||.| .| .||.|||..   |..|. .|...   ||||....  .|    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGELGVKLADFGLAAEMPKDFGVLSTICGTPTYVAPEVLNKTGYGC-KVDIWAAGVI
   || .| ..|  . .||||.|..||.|||.| ||.|. .       .|..|||||...       .|.|||| |.|||||   |||. |.|.|. |.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAGELLN-------DEWM
||  |.| |||.     .| .|  |.              | .....|. . . || .|..| |.|.       ..|.
LYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase zyg-8.AA Pkinase 482-743 29 2.7e-76 264.57 Pfam 1-293 (293) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKEH-----LIEMELAILQKIDHTFIVQLYDHWFVDDSYYLSLELIEMG----DLFEHLR-
....| || |. ..||. ..| ... . |.|.| ...   ...     |  .|..|.....| .||.||| .  .|..|. .|. |.|    |||.... 
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-IVRRV--PERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIV-KDEFGELGVKLADFGLAAEM-PKDFGVLSTICGTPTYVAPEVLN-KTGYGCKVD
   ...  .|... ..|. . ..|||.|. ||.|||.|.||.||. ... ..  ||..|||||. .     . ..|.|||| |.||||..  ..|| |||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWAAGVILYAILVGFPPFQSS----DGSEQDLFSAIMSGEFSFPSPSWDDVS-----------------WSVRHLIMCLIHTDPFHRYSAGELLNDEWM
.|..|.|||  | | |||...    . ... ..  ||.....|..| |...|                  . ...| .... ||  |..| ..|...|.
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase zyg-8.AA RAD53 482-743 30 3e-75 223.47 In-house 1-305 (305) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-305/305
Sequence Identity: 30% (94 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIAR-------ENVIGKEHLIEMELAILQKIDHTFIVQLYDHWFV-DDSYYLSLELIEMGDLFEHLRIV
. ... .| || ..|.....|..   . |.| |          ..|.|.  .. |. ||.|. |  |...||  .. ...||. |||.. |.||.  .||
YYMSKELGSGNFGTVKLAYEKKTC-QKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFN--KIV

---RR---VPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGE--------------LGVKLADFGLAAEMPKDFGVLSTICGTPTYVAPE
   |.   . | .. .    .  |. |.|..||.||| | || |.  ....               . .|..||||.  . ..  .. | ||||.|||||
SNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEG-SFMKTMCGTPQYVAPE

VLNK---------------TGYGCKVDIWAAGVILYAILVGFPPFQSSDG---SEQDLFSAIMS-GEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSA
|. .               .||. |||.| .|.||| .| |.|||  ...   .. .||  | . | ..||.|.||..| ....||  ..  || .||..
VITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTI

GELLNDEWM
 |.||  ||
DEALNHPWM
Kinase zyg-8.AA CAMK-Unique 482-743 25 2.6e-74 244.67 In-house 1-363 (363) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-363/363
Sequence Identity: 25% (94 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVI-GKEHL------------------IEMELAILQKIDHTFIVQLYDHW----FVDDS-----
  ..|.||.||  .|||..|...  . .|.|..  . .   | ..                   . |..|... ||  |..||| |    |.|.      
YKMHRIIGHGNFGHVYECMDRETG-KKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYD-WNNPIFCDRKYPLCD

-----------YYLSLELIEMGDLFEHLRI--------------------VRRVPE--RDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFG--
           .|. .|... ||||. .                       ..  |  .|. . |.|| .|..| |...||||| ||||... . .    
LIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

----------ELGVKLADFGLAAEMP--KDFGVLSTICGTPTYVAP--------------EVLNKTGYGCKV----DIWAAGVILYAILVGFPPFQSSDG
           . .||.||||...    |   ...|.|||| |.||              ||.|  .|....    |||. |||.|  |.| ||| ... 
HHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECE

SE------QDLFSAIMSGEF-SFPSPSWDD---VSWSVRHLIMCLIHTDPFHRYSAGELLNDEWM
          .|..|..|.. .|... |..   .| .   .. |.  .|| || || |||  .| 
DRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase zyg-8.AA CAMKL 482-743 26 5e-70 222.63 In-house 1-297 (297) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-297/297
Sequence Identity: 26% (80 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKEHLIEM--------------ELAILQKID---HTFIVQLYDHWFVDDS------YYLSL
..... .| |. ..|   ... ..  . |.|.| ..    ...   .              | .|.....   |  |..||...  ..       .|| .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELIEMGD--LFEHLRIV----RRVPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDE-FGELGVKLADFGLAAEMPK----DFGVLSTICGTP
|... |.  ||....      .| ||..| |. . .  |..|.|..|||||| |.||.|. ..       .|..|||..... .    .   |.| ||.|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

TYVAPEVLNK--T-GYGCKVDIWAAGVILYAILVGFPPFQSSDG------SEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAGELL
 | |||....  .  .| |||||..||||||...|  ||   .           |.  ||.| . .|   | .|| ..|.||  .  ..| .|... ...
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

NDEWM
|..||
NHPWM
Kinase zyg-8.AA Ciliate-E2a 482-743 29 8.4e-70 204.65 In-house 1-275 (275) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-275/275
Sequence Identity: 29% (82 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIG-KEHLIEMELAILQKIDHTFIVQLYDHWFVDDSYYLSLELIEMGDLFEHLRIVRRVPER-
. ....|| || ..|| .  | ..... ..|.| . .... ... ...|..|....||  | .||. .  ...||| .|..| |.|.. ..   |  |  
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-DAVRMMTCLG-QALEYIHELGIVHRDVKLENLLIV-KDEFGE--LGVKLADFGLAAEMPKDFG-VLSTICGTPTYVA------PEVLNKTGYGCKVDIW
 .. ..|  |  |.|.|.| ..|.||| |.||.|.  ..  .   . .|..|||||   .|| . .. ..|||| |||      .|||... |..|.|.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

AAGVILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPS-WDDVSWSVRHLIMCLIHTDPFHRYSAGELLNDEWM
 .|||.|  |.| |||.  .  ... .  .   ...| .|  | ..| .  .|.  .   || .|..| ..||. |.
SCGVIFYILLCGKPPFKGKT--YNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase zyg-8.AA CDPK 482-743 32 2.9e-66 202.32 In-house 1-271 (271) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-271/271
Sequence Identity: 32% (89 aa)

FQLVRLIGDGNTAVVYEVIDK-TNNDDRKAMKVIARENVIGKEH-LI-EMELAILQKIDHTFIVQLYDHWFVDDSYYLSLE--LIEMGDLFEHLRIVRRV
... . .| |.  .|. |..|  .|. | |||.|.  .|. ||   .  .|..|| ..||  |...| .   .. ||. .|  . . |.||.     .. 
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

PERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGE---LGVKLADFGLAAEMPKD----FGVLSTICGTPTYVAPEVLNKTGYGCKVDIWAA
.|..|   |. . .|. |.|. .|||||.| ||.|  ... .      .|. |.|.. . ...      ..|..||||.|.|||||.|  |  |.||| .
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC

GVILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAGELLNDEWM
||||| .|.| |||     ..|. . ... |..||  | ||..| . . ||  .. .||  |.|| . |.. |.
GVILYILLCGYPPFYGK--NDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase zyg-8.AA Ciliate-E2 482-743 23 9.4e-66 224.68 In-house 1-365 (365) Show / Hide 
Range on Protein: 482-743
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDR----------------------KAMKVI---ARENVIGKEHLIE---------MELAILQKIDHTFIVQLYDH
. ....|| || ..||.. .. .. .                       .|||..     |..  ..|..          .|. ||....| .|...|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WF--VDDSYYLSLELIEMGDLFEHLRIVR-----------RVPERDAVRMMTCLGQ---------------ALEYIHELG-IVHRDVKLENLLIVKDEFG
.    |...|| .|... ||||..... .           .  |. . ..|. . |               ||||.|. . |.||| |.||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

ELGVKLADFGLAA----------------EMPKDFG----------------VLSTICGTPTYVAPEVLN---------KTGYGCKVDIWAAGVILYAIL
   .|..||||.                 ...  ..                .  |||||| |.|||.||         ..||. |.|||..|||||  |
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

VGFPPFQSSDGSEQDLFSAIMSGEFSFPSP--------------SWDDVSWSVRHLIMC----LIHTDPFHRYS-AGELLNDEWM
 | |||          .  |. ....||.|              ||...| .. .||      ..  ||  |.. . ..|| .|.
FGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase zyg-8.AA RSK 510-743 31 2.2e-61 210.25 In-house 28-278 (278) Show / Hide 
Range on Protein: 510-743
Range on HMM: 28-278/278
Sequence Identity: 31% (79 aa)

AMKVIARENVIGKE--HLIEM-ELAILQKID-HTFIVQLYDHWFVDDSYYLSLELIEMGDLFEHLRIVRR---VPERDAVRMMTCLGQALEYIHELGIVH
||||. .  .. ..      | |  ||. .  | |||.|..    ..  || .|... |.||.||.  ..     |..|   |  .  |.|..|..||.|
AMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIH

RDVKLENLLIVKDEFGELGVKLADFGLAAEMPKD-FGVLSTICGTPTYVAPEVLN----KTGYGCKVDIWAAGVILYAILVGFPPFQSSDGS--EQDLFS
|| |.|| |   .. .|  .|| |||.. ... |  . . | |.|  |.|||.|.    . |..  .|.|  ||..|  |.|.||||. ...   .... 
RDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMK

AIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYS-----AGELLNDEWM
 |..|.||...| |. .|   ..||  . | ||  |..     | |.....|.
RIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase zyg-8.AA TyrKc 482-742 20 4.1e-12 -26.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 482-742
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKEHLIEMELAILQKI--DHTFIVQLYDHWFVD-------DSYYLSLELIEMGDLFEHLRI
 .| . .| |.  .||. . |       | |..  .     .  .  |. |. |.  .|  ||.||     .       . ... .|. . ||| ..|| 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VRR-VPERDAVRMMTCLGQALEYIHELGIVHRDVKLENLLIVKDEFGELGVKLADFGLAAEMPKD---------FGVLSTICGTP----TYVAPEVLNKT
 |. .. .| . ...   .  ||.|. ...|||    | |. ..      || .||||. .   |           . .. .|         |||..|. 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYGCKVDIWAAGVILYAIL-VGFPPFQS---SDGSEQDLFSAIMSGEFSFPSPS-WDD-----VSWSVRHLIMCLIHTDPFHRYSAGELLNDEW
 .  | |.|. || .. |.  | .|       . | |...  ...|.   . |.          .  .  .. .  | ||  | .  |.  ...
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase zyg-8.AA Pkinase_Tyr 510-630 25 1e-05 20.08 Pfam 32-158 (270) Show / Hide 
Range on Protein: 510-630
Range on HMM: 32-158/270
Sequence Identity: 25% (33 aa)

AMKVIARENVIGKE---HLIEMELAILQKI-DHTFIVQLYDHWF-VDDS--YYLSLELIEMGDLFEHLRI----VRRVPERDAVRMMTCLGQALEYIHEL
| |.. .|.   ..        |..|. .. .|  ||.||      ...  .|. .|. . ||| ..||      ....  | . | .   ...|| .. 
AVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK

GIVHRDVKLENLLIVKDEFGELGVKLADFGLA
...|||.   | |. .    .. || .|||||
NCIHRDLAARNCLVTE----NNVVKICDFGLA