Gene APG1 (Bakers Yeast)

APG1

Species: Bakers Yeast
Alias: APG1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
APG1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 302 Kinase domain by global Sugen HMM Fasta, JSON
APG1.AA Protein Refseq_NP 897 Required for autophagy; Apg1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of APG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase APG1.AA ULK 24-325 32 8.9e-121 407.55 In-house 1-324 (324) Show / Hide 
Range on Protein: 24-325
Range on HMM: 1-324/324
Sequence Identity: 32% (113 aa)

YTAEKEIGKGSFA-TVYRGH-LTSD-KSQHVAIKEVSRAKLKNKKLL-------ENLEIEIAILKKIK---HPH--IVGLIDCERTSTD--FYLIMEYCA
|   ...|||||. .||.|    .. . |.||.| ... |...||..       ..|. || |.||.|   ||.  || |.|. .||..  .|.||||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

LGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPI
 |||  ..|..|.|.| . .             ... |    ......|.....|.|...| .||||||||.|.. . ... |||   .   | ..  ..
GGDLEQYIKKNKKLPE-T-E-------------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK---K---V-HP-NGV

LKIADFGFARFLPNTSLAETLC----------GSPLYMAPEILNYQ----KYN-AKADLWSVGTVVFEMCCGTPPFRASNHLELF----KKIK-------
|||||||||... | ......|          |.||||||.||. |    .|. .|.|.||.|.. .||  | .||...   ...    | |.       
LKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQI

-RANDVITFPSYC---NIEPELKELICSLLTFDPAQRIGFEEFFANKVV
   |  | ||...   .| ||.|.||  .|..|. .|| .||.|.....
YIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase APG1.AA ULK 24-325 31 3.2e-115 389.07 In-house 1-329 (329) Show / Hide 
Range on Protein: 24-325
Range on HMM: 1-329/329
Sequence Identity: 31% (111 aa)

YTAEKEIGKGSFATVYRGHLTSDK---SQHVAIKEVSRAKLKNKKLLEN-------LEIEIAILKKIK--------HPHIVGLIDCERTSTD--FYLIME
|   ...|||||..||.|    .|    . ||.| ... |...|. . .       |. || |.||.|        ||.|| |.|. .||..  .|.|||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYN
||  |||  ..|..|.|.|.. .             ... |    ......|.....|.|...| .|||||||| |.. . ... |||   .   | .. 
YCNGGDLEQYIKKNKKLPEDT-E-------------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK---K---V-HP-

LPILKIADFGFARFLPNT------SLAET----LCGSPLYMAPEILNYQ----KYN-AKADLWSVGTVVFEMCCGTPPFRASNHLELFKKIKRANDVITF
 ..|||||||||... |        .. .    |||.||||||.||. |    .|. .|.|.||.|.. .||  | |||.|.   .....|.. .  ...
NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPP

PSY-------CN---------IEPELKELICSLLTFDPAQRIGFEEFFANKVV
|..        .         | ||.|.||  .|..|. .|| .||.|.....
PWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase APG1.AA S_TKc 24-325 29 2.5e-81 277.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-325
Range on HMM: 1-231/231
Sequence Identity: 29% (94 aa)

YTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCERTSTDFYLIMEYCAL--GDLTFLLKRRKE--
|.  ..||||.|..||... ..   ..||||...          |... ||.|||| .||.|| |.|. .. ...|..||||    |||  ..|.|.   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFA
    . | |                        . .|..|...||... |.. .|||.||.|.||..                        .||.|||.|
LRFPFPE-H------------------------ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------------------HIKICDFGLA

RFLPNTSLAETLCGSPLYMAPEILNYQKYNA-KADLWSVGTVVFEMCCGTPPFRASNHLELFKKIKRANDVITFPSYCNIEPELKELICSLLTFDPAQRI
|.|       |.||.| |||||.|   .|.  |.| ||.| ...||.|| |||.  .. ..||||.               ||.|..|. .|..||..|.
RQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRP

GFEEFFA-------NKVV
.  | ..          .
TA-EALQDEWDIKCHPWF
Kinase APG1.AA AGC 24-318 20 9.4e-77 197.12 In-house 1-388 (395) Show / Hide 
Range on Protein: 24-318
Range on HMM: 1-388/395
Sequence Identity: 20% (92 aa)

YTAEKEIGKGSFATVYRGHLTS-----DKSQHVAIKEVSRAK---LKNKKLLENLEIE------------IAILKKIK----------HPHIVG-LIDCE
.   | |||||| .||     .     |  .  |.| .. ..   .|.|. .|.  .|              ||.|..          || ||  |  . 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RTSTD--FYLIMEYCA--------LGD-LTFLLKR-RKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLS------YLQQ-------LASALKFLRS-K
 . .    |..|||.          |.  .|| .. |                          . . ....      |. .       ...|| .| | .
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGR--------------------------R-KEGRFDEERARFYAAEMQKICGCIVLALEYLHSHM

NLVHRD-IKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFARFLP----------------------------------------------
. .||| .|| |.||                          .|..|||..  ..                                              
GIIHRDYLKPENILLDED---------------------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQED

-----NTSLAETLCG--SPLYMAPEILNYQKYNAKADLWS--VGTVVFEMCCGTPPFRASN----------HLELFKKIKRA----NDVITFPSY-----
     .. .. |.||  .| |||||||    |.  .| ||  .| . .|| .| |||.. |          . |.|.||.      |. ..||..     
DTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQF

---CNIEPELKELICSLLTFDPAQRIG----------FEE
    .. ||.| ||  ||. ||..|.|          .||
PEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEE
Kinase APG1.AA Pkinase 24-325 26 5.8e-76 263.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-325
Range on HMM: 1-293/293
Sequence Identity: 26% (88 aa)

YTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLE-IEIAILKKIKHPHIVGLIDCERTSTDFYLIMEYCALG----DLTFLLKRRK
|. .. ||.|||..||..|  ..    ||.|.... . | .|. ...   ||.|.|...||.|| |.|. ..... |..||||  |    ||  ....  
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

ELMENHPLLRTVFEKYPPPSENHNGL--HRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLS-TPLIGYHDSKSFHELGFVGIYNLPILKIADFGFA
                    ..|...      . .|. |....|... |.. .|||.||.|.|.. .. |.                   ..||.|||.|
--------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------------CVKICDFGLA

RF--LPNTSLAETLCGSPLYMAPEILN-YQKYNAKADLWSVGTVVFEMCCGTPPFRAS------NHLELFKKIKRANDVITFPSYCNIE-----------
..  . | | . |.||.| |||||... .|.|  |.| ||.| ...||.|| |||. .      ........|...     .|  |.|            
KQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHW

------PELKELICSLLTFDPAQRIGFEEFFANKVV
      .|.|..|...|..||..|...|. .  . .
TFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase APG1.AA CAMK 29-318 21 5e-74 237.74 In-house 1-418 (425) Show / Hide 
Range on Protein: 29-318
Range on HMM: 1-418/425
Sequence Identity: 21% (98 aa)

EIGKGSFATVYRGHLTSDKS-----------QHVAIKEVSRAKLKN-------------------------KKLLENLEIEIAILKK-------IKHPHI
..|.|||..|...  ....            |.|||| ... |||.                          | ..|.. ||.|.||       ..||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGLIDCER------------TSTD--------FYLIM---EYCALG----D-LTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLH-------RAF--
. |..               | ..        .|..|   |||  |    | . .. .....  |.                             . |  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF---------------------DQFDIVERGRFTE

--VLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTP------LIGYHDSKSFHELGFVGIYNLPI-LKIADFGFARFLPN-------------------
  .  | .|..||.... |.| ||||.|| |.||..       . . ||  .|         .    .||.|||||....                    
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPV-E-HDE-IF-D-------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW

-----TSLAETLCGSPLYMA-PEILNY--------------QKYNAKADLWSVGTVVFEMCCGTPPFRAS-------------NHLELFKKIKRAN-DVI
     . . .| ||.| ||| ||.||.              . |. |.| ||.| . . | ||.|||...             |  |||.||.... | .
TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFP

TFP--------------------SYCNIEPELKELICSLLTFDPAQRIGFEE
 ..                    .  .. .| | ||...|. || .|.  |.
PPYFSPISCNYGPEWWDDISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQ
Kinase APG1.AA CAMKL 24-318 25 1.4e-67 214.66 In-house 1-290 (297) Show / Hide 
Range on Protein: 24-318
Range on HMM: 1-290/297
Sequence Identity: 25% (84 aa)

YTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLK-NKKLLEN-----------LEIEIAILKKIK---HPHIVGLIDCERTSTD------FYLIM
|. .|..|||||..|  .. ..   ..|||| . . |.. . . . |           .. ||.|.|...   ||.|. | ..  |..       .||.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCALGD---LTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPL-IGYHDSKSFHELGF
|||  |.   . .. |...                         ..      | .|. ||.... |.. ||||||| |.||.                  
EYCSGGEMDLFDYIVKHGHRR---------------------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-------------

VGIYNLPILKIADFGFARF-----LPNTSLAETLCGSPLYMAPEILNY--QKYN-AKADLWSVGTVVFEMCCGTPPFRAS--------NHLELFKKIKRA
        .||.||||. .      ..  . .| |||| ||||||..   ..|.  |.| || | . . | ||. ||..         |. .|..||.. 
-------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMC-

NDVITFPSYCNIEPELKELICSLLTFDPAQRIGFEE
 .   .| .. .  ... || ..|. .| .|.  ..
-G-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQ
Kinase APG1.AA Ciliate-E2 24-325 21 1.5e-67 230.69 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-325
Range on HMM: 1-365/365
Sequence Identity: 21% (91 aa)

YTAEKEIGKGSFATVYRGHLTSD----------------------KSQHVAIKEVSRAKLKNKKLLENLEIEIA----------ILKKIKHPHIVGLIDC
|   | ||.|.|..||..   ..                      |.. .|.| ..  .....|  ...  ||           ||....||.|. ...|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

ER--TSTDFYLIMEYCALGDLTFLLK-----RRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLAS---------------ALKFLRSKN-L
    . . .||.||||  |||  ..|     | .|.                 .   . .    .. . .|...               ||..| |||  
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE----------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNI

VHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFAR----------------FLPNTS-----------------LAETLCGSPLYMA
.||||||.|.|.                          .||.|||...                 ... .                 .. |.||.| |||
IHRDIKPENILF--------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMA

PEILNYQK---------YNAKADLWSVGTVVFEMCCGTPPFRASNHLELFKKIKRANDVITFP--------------SYCNIEPELKELICS----LLTF
|||||..|         |. |.|.||.| . .||..| |||        ...||  .  . .|              |. ....| | ||      .|  
PEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQK

DPAQRIG-FEEFFANKVV
|| .||. .|. . ..  
DPEKRITGWEQILNHPWF
Kinase APG1.AA NEK 24-325 27 2.6e-64 219.99 In-house 1-286 (286) Show / Hide 
Range on Protein: 24-325
Range on HMM: 1-286/286
Sequence Identity: 27% (91 aa)

YTAEKEIGKGSFATVYRGHLTSDKSQ----HVAIKEVSRAKLKNKKLLENLE-IEIAILKKIKHPHIVGLIDC--ERTSTDFYLIMEYCA-LGDLTFL--
|.  |.||.||| .||.   .||...     ...|...  .  . |  .|.   |. |||..|||.||. .|.  |. .  .. .||||   |||  .  
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-LKRRK----ELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSK-----NLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYN
 .|..|     . |.                         .. ...|...|||.. ..     . .||||||||. |.   ..|                
SIKKQKQKGKYFEEE------------------------QIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY----------------

LPILKIADFGFARFLPNT-SLAET-LCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCG--TPPFRAS--NHLELFKKIKRANDVITFPSYCNI--E
 ...|| ||| .. | .| ..| | . | | ||.||... ..|| |.| ||.| |..|||.    .||.|.  |...|..||..    ...|        
-HNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG---PQYPPIPSHRMY

-PELKELICSLLTFDPAQRIGFEEFFANKVV
 ..|..|| ..|. || ||   .. ...  .
SQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase APG1.AA Ciliate-E2-Unclassified 24-325 23 6.3e-57 195.44 In-house 1-352 (352) Show / Hide 
Range on Protein: 24-325
Range on HMM: 1-352/352
Sequence Identity: 23% (90 aa)

YTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLEN--------LEIEIA--------------ILKKIKHPHIVGLIDCERTSTDFYLI
|.  | ||.|.|..||.    ..| |  |.|. . .. ...|. .|        .|...               ||. ..||.|| ...|...   .|..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCALGDLTFLLKRRKE-----------LMENHPLLRTVFE---KYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKN-LVHRDIKPQNLLLSTPLIG
||||  ||| . .| ||            ..... .         .                . |. |. ..|..| .||  .||||||.|.|..     
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA----------------KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-

YHDSKSFHELGFVGIYNLPILKIADFGFARFLPN----------------TSLAETLCGSPLYM----APEILNYQKYN----AKADLWSVGTVVFEMCC
                |.  .||.|||..... .                  .. | ||.| ||    |||.|  |.|.     |.| ||.| . .||. 
----------------NY-YIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

GTPPFRASNHLE----------------LFKKIKRANDVITFPSY----CNIEPELK----ELICSLLTFDPAQRIGFEEFFANKVV
|..|| . |  .                |...||  |  .   .     ... || |    .|....|  .| .||.||. .     
GYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase APG1.AA STE 24-313 20 3.5e-56 192.96 In-house 1-345 (359) Show / Hide 
Range on Protein: 24-313
Range on HMM: 1-345/359
Sequence Identity: 20% (77 aa)

YTAEKEIGKGSFATVYRGHLTS-----DKSQH---------VAIKEVS----RA----------KLKNKKLLENLEIEIAILKKIK--HPHIVGLIDCER
..  ..||||.| |||..         .. .          .|||...    ..          . ||.. ..... || |.|| .  ||.||  ..|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS-------TDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASA-LKFLRSKNLVHRDIKPQNLLLSTPLI
         .. ...|||.. | |. ..|....  ..... |          .    .    .  ...|.  . |..| |.. .||||||.| ||     
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ---------H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----

GYHDSKSFHELGFVGIYNLPILKIADFGFARFLPN---------------TSL--AETLCGSPLYMAPEILNY------QKYNAKADLWSVGTVVFEMCC
                      |..|||..  | .               |.     |..|.| .||||...       ..|..|.| ||.| .. ||..
---------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT

GTPPFRA-SNHLELFKKIKRA-------------NDVITFPS-----------------YCNIEPELKELICSLLTFDPAQR
| ||.   ...  .| ...               ..  ..|.                   .  ||.|. |   |. || .|
GKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKR
Kinase APG1.AA MARK 208-318 40 6.8e-32 101.67 In-house 146-255 (262) Show / Hide 
Range on Protein: 208-318
Range on HMM: 146-255/262
Sequence Identity: 40% (46 aa)

KIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYN-AKADLWSVGTVVFEMCCGTPPFRASN--HLELFKKIKRANDVITFPSYCNIEPELKELICS
||.||||..  |. .. .| ||.| ||||||.....|.  |.| || | | . | ||. ||....    ||.||| | .    .. .|.. .|.. ||..
KIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGK----YDIPCHVSKECRNLIQR

LLTFDPAQRIGFEE
|||..| .|.  ||
LLTVNPEERPTIEE
Kinase APG1.AA Pkinase_Tyr 24-267 26 1.1e-28 97.74 Pfam 1-216 (270) Show / Hide 
Range on Protein: 24-267
Range on HMM: 1-216/270
Sequence Identity: 26% (68 aa)

YTAEKEIGKGSFATVYRGHLT---SDKSQHVAIKEVSRAKLKNKK-LLENLEIEIAILKKI-KHPHIVGLIDCER-TSTD--FYLIMEYCALGDLTFLLK
 |  |..|.|.| .||.|...   ... ..||.| . . .   .  ..| .  |..|.|.. .||.|| |. .    .     |..|||...|||   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFA
...                    |. . |     |.. .| |... .| |||..|||.   | |..                     |. . ||.||| |
KHR--------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--------------------NN-VVKICDFGLA

RFLPNTSLA-ETLCGSPL---YMAPEILNYQKYNAKADLWSVGTVVFEMCC-GTPP-F
| . |..    .  |..|    |||| .|| |.. | | || | . .|..  |  | .
RDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase APG1.AA TyrKc 24-324 21 3.6e-21 77.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-324
Range on HMM: 1-280/280
Sequence Identity: 21% (72 aa)

YTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKI--KHPHIVGLIDCERTS-------TDFYLIMEYCALGDLTFLL
 | .|..| | | .||.|...    . ||.| .   .      .| .  |. |..|.  .||.|| |. . ...          ...|||...|||   |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGF
.....                        |  .  ||.  | |.   .| |||..|||.   | |.. ..                     . ||.||| 
RKHRPK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------------TVKISDFGL

ARFLPNT-------SLAET----LCG--SPL-YMAPEILNYQKYNAKADLWSVGTVVFEMC-CGTPPFRA-----SNHLELFKKIKRANDVITFPSYC--
.|.. .        .   .     .    |.  |||| .|| |.. | | || | . .|..  | .|         .  |.....|. .     |...  
SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPM

---NIEPELKELICSLLTFDPAQRIGFEEFFANKV
      .|. ... .   .||..|  |.|    . 
SFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase APG1.AA MARK 24-110 37 3.5e-19 59.51 In-house 1-89 (262) Show / Hide 
Range on Protein: 24-110
Range on HMM: 1-89/262
Sequence Identity: 37% (34 aa)

YTAEKEIGKGSFATVYRG-HLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCER--TSTD-FYLIMEYCALGDL
|   |.||.||.|.|. . |. ..  ..|||| . . ||   . ..|.. ||.|.||..||.|. | .     |..  .||||||.  |.|
YKMLKTIGHGSYAKVKLACHKHTG--RKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGEL
Kinase APG1.AA MARK 154-180 55 5.5e-07 19.07 In-house 111-137 (262) Show / Hide 
Range on Protein: 154-180
Range on HMM: 111-137/262
Sequence Identity: 55% (15 aa)

QQLASALKFLRSKNLVHRDIKPQNLLL
.|. ||.... ||| |||||||.|.|.
RQIVSAVNYCHSKNIVHRDIKPENILI
DUF3543 APG1.AA DUF3543 582-894 29 1.5e-78 272.07 Pfam 1-275 (275) Show / Hide 
Range on Protein: 582-894
Range on HMM: 1-275/275
Sequence Identity: 29% (103 aa)

PETLKLDNTNIVSILESLAAKAFVVYSYAEVKFSQIVPLSTTLKGMANFENRRSMDSNAIAEEQDSDDAEEEDETLKKYKEDCLSTKTFGKGRTLS----
  ... ..| .|..||..|.....||. ||||..|..||                                             |. |.| |...     
QTSMDDEHTRTVQKLEECATRSDCVYGFAEVKYKQLIPLMP-------------------------------------------SVSTYGLGDANVQGRD

--------ATSQLSATFNKLPRSEMILLCNEAIVLYMKALSILSKSMQVTSNWWYE-------------SQEKSC-SLRVNVLVQWLREKFNECLEKADF
         |.... |             .||.|||.|||| |.|||...| |||              | . .  |.|.| .|||.||.|||||||..|
DSMHQDDGLTPDAIVTW----------KSEEALVLYVKALSLLAKSMDIASAWWYRKNRGEDFNMTRDSSNQLCPTSNRINQVVQWIRERFNECLEKCEF

LRLKI---NDLRFKHASEVAENQTLEEKGSS-------EEPVYLEKLLYDRALEISKMAAHMELKGENLYNCELAYATSLWMLETSLDDDDFTNAYGDYP
.|||.   . .  . .. ...|   |  .|.        ..|. |||.||||||.|..||  ||.||.| .||.||.|..||||  |..|.         
VRLKLQEAQKRLPEDHPSHPKNHSNESSSSGSSNDVVVSSGVTAEKLMYDRALEMSRTAAINELFGEDLPGCEIAYHTAIWMLEALLENDED--------

FKTNIHLKSNDVEDKEKYHSVLDENDRIIIRKYIDSIANRLKILRQKMN
             . .  ...||..|.....|||.|| .||..||.|| 
-------------EDKDENDGLDDEDKQMVEKYIVSIRKRLSVLRKKMY