Gene CDC5 (Bakers Yeast)

CDC5

Species: Bakers Yeast
Alias: CDC5
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
CDC5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 256 Kinase domain by global Sugen HMM Fasta, JSON
CDC5.AA Protein Refseq_NP 705 `CDC5 is dispensable for premeiotic DNA synthesis and recombination, but required for tripartite synaptonemal complexes, haploidization, and spores; Cdc5p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of CDC5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC5.AA PLK-Unclassified 82-337 57 1.6e-192 645.88 In-house 1-264 (264) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-264/264
Sequence Identity: 57% (151 aa)

YHRGHFLGEGGFARCFQIKDDSG-EIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRR-------
||||||||.||||.|.|.|.... .|.|||...|.|......|.||.|||.||||..|.|||.|..||||..|||||||.||||.|||..|||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYA
|.|||.||...|.||..|.||.|..|.|||||||||||...|...||.|||||..|.|..|.|.||||||||||||.|.|||.|||.|||.||.|..||.
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWF
||||||||...||...|..|||...|||....|||..|.||..||...|..||....||.....
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase CDC5.AA PLK 82-337 54 5.6e-182 597.27 In-house 1-258 (258) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-258/258
Sequence Identity: 54% (140 aa)

YHRGHFLGEGGFARCFQIKDDSG-EIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRR-KVLTEP
|.||||||.||||.|....|..  ...|.| | |........|.|. .||.||....|||||.|...|||..||||.||.|.|.|||...||| |.||||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKP
|||....||. ..||.|..|.|||||||||.|...|...||||||||. | .. |||.|.||||||||||||.|...|||.|||.||||...|.||||||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWF
||...||...|.|||....|||...|||||.| ||...|. .| |||....|... .|
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase CDC5.AA PLK1 82-337 49 1.6e-112 371.22 In-house 1-253 (253) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-253/253
Sequence Identity: 49% (127 aa)

YHRGHFLGEGGFARCFQIKD-DSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPE
|..|.|||.||||.|. |.| |  |.||.| |.|. .  .. | |.  |||||....|..||.| . |||..||||.||.|   ||||| |||| .||||
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

VRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPP
 |... ||  ...|.|  ..|||||||||.|.. . ..||||||||  . .. ||| |.||||||||||||  |  ||||||||||.| ..| ||.|.||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKK--GHSFEVDIWSIGCIMYILLFGQPP

FQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWF
| .. ..  | |||  ... |.   ||   . ||| .|  || .||   ...   .|
FETKCLKETYSRIKKNEYRIPSH--ISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase CDC5.AA Pkinase 82-337 32 1.8e-109 374.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

YHRGHFLGEGGFARCFQIKDDSGEI-FAAKTVAKASIKSEKTRKKLL-SEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNG----SLMELLK--RR
||.|  .|.|.|..... .. . .. .| |.. | ..||.| . ... |||||.|...|||||...|.|||....|. .| |..|    .|.....  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KVL--TEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNL----KIGDFGLAAVL-ANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWS
...  .| |..|. .||. ...|.||...||||||. ||..|.|...    ||.|||||...    ..  .|.||||.|.||||.. ...... .||.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWS

LGVMLYALLIGKPPFQAR------DVNTIYERIKCRDFSFPRDKPIS-------------------DEGKILIRDILSLDPIERPSLTEIMDYVWF
.|..|| .| |.|||. .      | . ...||......|......|                   .|.| .|...| .|| .||. ..|.   ||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CDC5.AA PLK2 82-337 44 2.5e-103 333.65 In-house 1-257 (257) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-257/257
Sequence Identity: 44% (116 aa)

YHRGHFLGEGGFARCFQIKD-DSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPN----GSLMELLKRRKVL
| ||  || ||||||. . | |.. ..|.| | .  .   . | | . || .|    |..||||   |||  |.||||| |       |.   .| |..|
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLI
||||||..  ||   ..| |....||||||||| |   |  .||||||||| |  | ... |.||||||||||||     |||.| |||.||   | .|.
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLN--RQGHSCESDIWALGCIMYTMLC

GKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWF
| ||| . .    | .|.   . .|     |   . || ..|| || .|||| .|..   |
GRPPFETANLKETYRCIRHNHYHMPTH--LSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase CDC5.AA S_TKc 82-337 33 1.1e-100 341.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

YHRGHFLGEGGFARCFQIKDDS-GEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPN--GSLMELLKRRKV---
|. .  .|.|.|..... .. . |.|.| | .           .....||||.|.  |||||...|.|.| ...|. .| |..  |.|....|.|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSF-EVDIWSLGVML
   ..| ..||.. ||| |..|.||...||||||  ||..|.  ..||.|||||..|       .|.||||.|.|||||     |... ..|.||.|..|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCIL

YALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMD-------YVWF
| .| |.|||.  ........|.            |.|.| .|| .|  || .||.  |..          ||
YEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC5.AA AGC 82-337 21 6.7e-100 258.36 In-house 1-395 (395) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-395/395
Sequence Identity: 21% (85 aa)

YHRGHFLGEGGFARCFQIKD-------DSGEIFAAKTVAKAS---IKSEKTRKKLLSE------------IQIHKSMS----------HPNIVQ-FIDCF
..    .|.|.| .... ..       |.|...| | . |.    || ... .. ..|             .| . ..          ||.||.    .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDDSN--VYILLEICP---------NG-SLMELLK---RRKVLTEPEVRFFTTQ-------ICGAIKYMHS-RRVIHRD-LKLGNIFFDSNYNLKIGDFG
.|...  .|...| .|          |  |.  |.   ......|...||.. .       |. |. |.|| . .|||| ||. || .|.. ..|. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAAVLANES--------------------------------------------------ERKYTICG--TPNYIAPEVLMGKHSGHSFEVDIWS--LGVM
|. .. |.                                                   .| .|.||  ||.|.|||.|      .....|.||  ||..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

LYALLIGKPPFQAR----------DVNTIYERIK------CRDFSFPRD--------KPISDEGKILIRDILSLDPIERPS----------LTEIMDYVW
.| .|.|.|||..           . . ....|.        .  ||..        . .|.| | ||.  |  || .|.             ||..  |
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase CDC5.AA CAMK 87-337 22 5.4e-96 309.79 In-house 1-425 (425) Show / Hide 
Range on Protein: 87-337
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

FLGEGGFARCFQIKD-DSG------------EIFAAKTVAKASIKS-------------------------EKTRKKLLSEIQIHKS-------MSHPNI
 ||.|.|.  .  ..  ..            . .|.| . |  .|.                         .|.||....||.|.|.       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQFIDCFED-------------------DSNVYILL---EICPNG----SLMELLKRR---------------KVLTEPEVRFFTTQICGAIKYMHSRRV
..... .||                   |...|. .   | |..|     | . ....               . .|| |.|..  ||| |..|.||. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNIFFDSN-----------------YNLKIGDFGLAAVLAN-----------------------ESERKYTICGTPNYIA-PEVLMGK-----
.|||||. || .|.|                 .|.|| |||.|...                         | .  .| |||| |.| |||| ||     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------HSGHSFEVDIWSLGVMLYALLIGKPPFQAR-------------DVNTIYERIKCRDFSFPR--------------DKPISDE--------GKI
       . ......|.||.||.||..| |.|||..              . . ..|.|.  ...||               .. ||||         | 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRDILSLDPIERPSLTEIMDYVWF
||| .|  || .|........  |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CDC5.AA CAMKL 82-337 29 6.5e-88 280.63 In-house 1-297 (297) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-297/297
Sequence Identity: 29% (88 aa)

YHRGHFLGEGGFARCFQIKD-DS-GEIFAAKTVAKASIK-SEKTRKK-----------LLSEIQIHKSMS---HPNIVQFIDCFEDDSN------VYILL
|  |  ||.|.|.     ..    ||  | | . |  |.  ....|.           .  ||||.|...   ||||... ...|....      .|. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EICPNGS--LMELLKRR----KVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNY--NLKIGDFGLAAV---L-ANESERKYTICGTPNYI
| |..|.  |.. ....    . ..|.| |.. .||. |..|.||....|||.|. || .|.|   |.|| |||...       .. .   | ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLMG-KHSGHSFEVDIWSLGVMLYALLIGKPPFQAR--------DVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWF
|||.. | . . . ..|||||.||.|||.. |. || .         .. . |..|.|  . .|  . .| . . ||| .|  .| .||.. .||   |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CDC5.AA ULK 82-337 30 4.6e-77 262.32 In-house 1-329 (329) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-329/329
Sequence Identity: 30% (99 aa)

YHRGHFLGEGGFARCFQI--KDDS---GEIFAAKTVAKASIKSEK-------TRKKLLSEIQIHKSMS--------HPNIVQFIDCFEDD--SNVYILLE
|.  | ||.| |.. ..   |..    .|..|.| . | ... ..         . | .||.| | .         |||||...|.||..   |.|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

ICPNGSLMELLKRRKV----------LTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYN------------LKIGDFGLAAVLANE-----
 |. | |....|..|           |.|.|.. |  ||. . |..|....||||.|. ||  . .              |||.|||.| .. |.     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

SERKYT----ICGTPNYIAPEVLMGK--HSGHS-FEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRD---------------FSFP---RDKPIS
 .  ..    .|||| | ||..|.|.  .  .. ...||||||...| .| |||||.|   |. |..|. .                . ||    |..||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DEGKILIRDILSLDPIERPSLTEIMDYVWF
.| | |||  |  |. .| | .|. .  ||
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CDC5.AA ULK 82-337 31 9.5e-77 261.28 In-house 1-324 (324) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-324/324
Sequence Identity: 31% (101 aa)

YHRGHFLGEGGFA-RCFQI--KDDS--GEIFAAKTVAKASIKSEKTR-------KKLLSEIQIHKSMS---HPN--IVQFIDCFEDD--SNVYILLEICP
|   | ||.| |.   ..   |..   ....|.| . | ...  | .       ..| .|||| | .    |||  ||...|.||..   |.|| .| |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGSLMELLKRRKV---------LTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYN------------LKIGDFGLAAVLANES---ERKYT
 | | ...|..|          |.|.|.. |  ||| . |..|.. .||||.|. ||    .              |||.|||.| .. |..      .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IC------GTPNYIAPEVLMGK--HSGHS-FEVDIWSLGVMLYALLIGKPPFQARDVNTIYER--------------IKCRDFSFP---RDKPISDEGKI
..      ||| | ||..|.|.  .  .. ...||||||...| .| ||.||...  |. |..              || . . ||    |..||.| | 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIRDILSLDPIERPSLTEIMDYVWF
|||  |  |. .| | .|| .  ||
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase CDC5.AA Ciliate-E2 82-337 26 1.1e-75 257.69 In-house 1-365 (365) Show / Hide 
Range on Protein: 82-337
Range on HMM: 1-365/365
Sequence Identity: 26% (101 aa)

YHRGHFLGEGGFA---RCFQIKD---------------------DSGEIFAAKTVAKASIKSEKTRKKLLSEIQ----------IHKSMSHPNIVQFIDC
|     .|.|.|.   .| ..|.                     . . |.| |.. |  |.. |  .... ||.          | ....||||.....|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DDSNVYILLEICPNGSLMELLKRR-----------KVLTEPEVRFFTTQICG---------------AIKYMHSRR-VIHRDLKLGNIFFDSNYNL
|.  ||.|.|. .| |  |.|....| .           | .|| |......||.                |..|.||.  .||||.|. ||.|     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGLAAVLANE-------SERK------------------------YTICGTPNYIAPEVLMGKH-------SGHSFEVDIWSLGVMLYALLIGKPP
|| ||||.  . ..       ...|                        .||||||.| |||.|.||         |.....|||||||.|| .| ||||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQARDVNTIYERIKCRDFSFPRD----------------KPISDEGKILIRD----ILSLDPIERPS-LTEIMDYVWF
|        .. ||  ...||                  | .|.|.| ||.     .|  || .|..   .|..  ||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CDC5.AA Pkinase_Tyr 119-294 27 1.5e-20 70.18 Pfam 41-230 (270) Show / Hide 
Range on Protein: 119-294
Range on HMM: 41-230/270
Sequence Identity: 27% (52 aa)

SEKT--RKKLLSEIQIHKSM-SHPNIVQFIDCFE-DDSN--VYILLEICPNGSLMELLKR----RKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLG
...   |.....|..| |.. .|||||... .   ..    .|| .| .|.|.| . |..    .. || ..   . .||. .  | .|.. |||||   
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAAR

NIFFDSNYNLKIGDFGLAAVL-ANESE-RKYTICGTP-NYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLI-GKPP-FQARDVNTIYERI-K
|.  ..|   ||.|||||  .   .   || . .  |    |||... .    . . |.|| || .. ..  |. | ..  . . .||.| .
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE
Kinase CDC5.AA TyrKc 82-335 22 7.9e-20 73.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 82-335
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSM--SHPNIVQFIDCFEDD-------SNVYILLEICPNGSLMELLKR
 . |. |||| | . .. . .  .  | |.. . .      |. ...|..| ..   .|||||... .  ..         ..|..| .|.|.| . |..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKV-LTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANE-----SERKYTI----CGTP----NYIAPEVLMGKHSGH
..  |. ..   | .||.    | ||...|||||   |.  ..|.  ||.||||.  . ..     |.  |.     .|         |||..  ...  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

SFEVDIWSLGVMLYALL-IGKPPFQA-----RDVNTIYERIKCRDFSFPRDKP-------ISDEGKILIRDILSLDPIERPSLTEIMDYV
... |.|| ||... ..  |..|         .   ..|..| ..   . . .        .||   ....    || .||. .|| .. 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
POLO_box CDC5.AA POLO_box 520-587 27 3.5e-21 81.51 Pfam 1-74 (74) Show / Hide 
Range on Protein: 520-587
Range on HMM: 1-74/74
Sequence Identity: 27% (21 aa)

YSNKHGFSYQLSTEDIGVL-FNNGTTVLRLADAE-EFWYISYDDREGWVASHYLLSE------KPRELSRHLEVVD
|..|.|. ||||.....|. || .| .. ..... ...||.. | . |. ..| ||.       | .| ..|....
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDH-D-PNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box CDC5.AA POLO_box 619-692 37 9.5e-27 99.98 Pfam 1-74 (74) Show / Hide 
Range on Protein: 619-692
Range on HMM: 1-74/74
Sequence Identity: 37% (29 aa)

TRYKPFVMFELSDGTFQFN-FKDHHKMAISDGGK-LVTYIS--PSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIK
.|.| ..|..||.||.|.| |.||.|.... ..| .||||.  |. ...|||| ..|..|    .. . ...|||..|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHG----CYPEDLQKKLTYLK