Gene CHK1 (Bakers Yeast)

CHK1

Species: Bakers Yeast
Alias: CHK1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CHK1

Sequence

Name Sequence Type Origin Length Description Download
CHK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
CHK1.AA Protein Refseq_NP 527 checkpoint kinase 1; homolog of the S. pombe and mammalian Chk1 checkpoint kinases; Chk1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of CHK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CHK1.AA CHK1 15-281 44 6.9e-174 583.98 In-house 1-276 (276) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-276/276
Sequence Identity: 44% (124 aa)

VVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKCS---KHPNVLRLIDCNVSKEYMWIILEMADGGDLFDKIEPDV
.....|.|.|||..||....|..|....|.|.||.....||...|.||.||...|...|   ||.||.|........|......|.|||||||||||||.
YEVVQTLGEGAFGQVKLCENQRNPEEAVAMKEIHIKGQHKMCFMDNDIRKEYCIQKMLSKIGKHENVIRMMGMRMDPEFYYLFMEYADGGDLFDKIEPDC

GVDSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNG------NLKLADFGLASQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYADRTDI
|..||.|..||.||.|...|.|...||.||||||||.||||..      |||.||||||...||.||..|......|.||||||||... ..|.....||
GMPSDEAHRYFKQLISGLKYIHCCGGVTHRDIKPENLLLDKHDSNDMPDNLKIADFGLATWYRRHDGEERMLDKRCGTPPYMAPEVCTG-KQYRGPPVDI

WSIGILLFVLLTGQTPWELPS-LENEDFVFFIENDGNLNWGPWSKIEFTHLNLLRKILQPDPNKRVTLKALKLHPWV
||.|..|...|||..||. || ...........|.....|.|||||......||||||...||||.|..... .||.
WSCGVVLMAMLTGELPWDQPSHMDCQEYCWWMDNKHWMHWCPWSKIDCRAICLLRKILCENPNKRATIEQIEKDPWY
Kinase CHK1.AA CAMKL 15-281 30 1.4e-111 357.39 In-house 1-297 (297) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-297/297
Sequence Identity: 30% (91 aa)

VVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKD-----------ITKEVVLQSKCS--KHPNVLRLIDCNVSKEY------MWIIL
  .|.| |.|.|. || |. .. . .  |.|.|.   ...   ..|            |..|. .... .  ||||. .| ..   .|.      .....
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EMADGGD--LFDKI--EPDVG--VDSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNG--NLKLADFGLASQFRRK-DGTLRVSMDQRGSPPY
| ..||.  |||.|  .....   . . |..||.|.|||.||.|  . ..||||||||||||.||  |.|..|||.. ..|.. .|. .  . . |||||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPEVLYS-EEGYYADRTDIWSIGILLFVLLTGQTPWELPSLE-----NEDFVFFIENDGNLNWGPWSKIEFTHLNLLRKILQPDPNKRVTLKALKLHPW
||||.. . .. |..  .||||.|..|.....|. |.. ....     |    . ... |  .. .|...     .|.||.||..|.|| |.. .. |||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

V
.
M
Kinase CHK1.AA CAMK 20-281 21 2.4e-84 271.56 In-house 1-425 (425) Show / Hide 
Range on Protein: 20-281
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

TVGQGAFACVKNAHLQMDPS-----------IILAVKFIHVPTCKK------------------------MGLSDKDITKEVVLQSKCSK------HPNV
| |.|.|. || .    ..               |.|.|     |.                         . . | . .|. . .|...      |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLIDCNVS-------------------KEYMWIIL---EMADGG----DLFDKI--EPD-------------VGVDSDVAQFYFQQLVSAINYLHVECG
..|..   .                   ...|....   |...||    ||||.|   ..               .. . |..||.|..||..|.|    
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

VAHRDIKPENILLDKN-----------------GNLKLADFGLASQFRR---------KDGTLRVSMD-------------QRGSPPYMA-PEVLYSE--
..|||.||||||||.|                 .|.|..|||.| .|..         ..|   . ..             . |.|.||| |||| ..  
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------EGYYADRTDIWSIGILLFVLLTGQTPWELPSLEN---------EDFVFFIEND-GNLNWGP--------------WSKIEFT--------
          . ||   .|.||.|..|...|.|  |.. .. ..         .|   |     |. .. |              |..|           
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

HLNLLRKILQPDPNKRVTLKALKLHPWV
  .|.||.||.||.|| |..  . |||.
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CHK1.AA S_TKc 15-281 29 1.8e-79 271.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-231/231
Sequence Identity: 29% (83 aa)

VVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKCSKHPNVLRLIDCNVSKEYMWIILEMADG--GDLFDKIEPDVG
  .....|.|||..|. ..       | |.| |.           ..| .|. . .|  .|||. .|.|. .. .......|..||  ||||| |.   .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------VDSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNGNLKLADFGLASQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYAD-RTDI
       .  .|.||..|...|..|.|   |. |||.||||||||.  ..|..||||| |.          . . |.| |||||||      |   . |.
HGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----GYGKCKCDW

WSIGILLFVLLTGQTPWELPSLENEDFVFFIENDGNLNWGPWSKIEFTHLNLLRKILQPDPNKRVTLKALKL-------HPWV
||.|..|. .|.|..|..     ... .| .                  ....||.|| ||.|| |   .         |||.
WSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CHK1.AA Pkinase 15-281 27 4e-71 247.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

VVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDIT-KEVVLQSKCSKHPNVLRLIDCNVSKEYMWIILEMADGG----DLFDKIE-
 ..| ..|.|.|.||. .| . ..  | ||| | ..  .|..    ..   |. .  .. .|||..||.|.  .| ......| ..||    |||| |. 
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-PDVGV--DSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNGNL----KLADFGLASQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYAD
  . ..  . ....||. |......|.|  .|. |||.||||||.|.||..    |..||||| ||.      .  ..  |.|.||||||.  .  ||  
WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYGP

RTDIWSIGILLFVLLTGQTPWELP----SLENEDFVFFIENDGNLNWGPWSKIE-------------------FTHLNLLRKILQPDPNKRVTLKALKLH
. |.||.|..|. .|.|..|.       .  .......   .. | .  . ...                    . . .....|..||.|| | . .. |
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PWV
||.
PWF
Kinase CHK1.AA AGC 70-281 22 6.4e-60 152.58 In-house 75-395 (395) Show / Hide 
Range on Protein: 70-281
Range on HMM: 75-395/395
Sequence Identity: 22% (74 aa)

SKCSK---------HPNVLR-LIDCNVSKEY--MWIILE-MA--------DGG-DLFDKIE---PDVGVDSDVAQFYFQQ-------LVSAINYLHVECG
.||..         ||.. . |  .  .|..    ...| |          || .||  .         | ..|.||. .       .|.|. ||| . |
EKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMG

VAHRD-IKPENILLDKNGNLKLADFGLASQFRRKDGT----------------------------LRVSMDQR-------------------G--SPPYM
. ||| .||||||||..|..||.||||. .......                             ..  ....                   |  .| ||
IIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYM

APEVLYSEEGYYADRTDIWS--IGILLFVLLTGQTPWELPSLE-------NEDFVFFIENDGN--LNWG------------PWSKIEFTHLNLLRKILQP
|||.|      |    |.||   |.|.. .|||..|    . .       |.. .|    .|.  .||.            .....     .|..| |..
APEIL------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCK

DPNKRVT----------LKALKLHPWV
||.|| .           . .| ||| 
DPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase CHK1.AA Ciliate-E2-Unclassified 16-281 23 4.9e-52 178.78 In-house 2-352 (352) Show / Hide 
Range on Protein: 16-281
Range on HMM: 2-352/352
Sequence Identity: 23% (83 aa)

VLGDTVGQGAFACVKNA-HLQ---------MDPSIILAVKFI----------HVPTCKKMGLSDKDITKEVVLQS--KCSKHPNVLRLIDCNVSKEYMWI
 .. . |||.|..|. . | .         |  ..| ..| |          .   .||.  ... .  .  .|   . ..||.......|  .|... |
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKY--NKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ILEMADGGDLFDKIEP-----------------DVGVDSDVAQ-----FYFQQLVSAINYLHVECGVAHRDIKPENILLDKNG---NLKLADFGLAS---
..| ..||||.. |.                  .  ..   |.     ||| |......||| . .. ||||||||||.|.||   ..|..|||...   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QFRRKDGTL----------RVSMDQRGSPPYM----APEVLYSEEGYYA--DRTDIWSIGILLFVLLTGQTPWELPSLEN---------------EDFVF
|.. .| |             . .. |.| ||    ||||| ... .       |||| |..|. .|.|. | . .. |                . .  
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

FIENDGNLNWGPW----SKIEFTHLNLLR----KILQPDPNKRVTLKALKLHPWV
..... . .. ||     .. ..  ....    |.|. .|||| |.. .. ||| 
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CHK1.AA Ciliate-E2 15-281 18 6.7e-51 172.96 In-house 1-365 (365) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-365/365
Sequence Identity: 18% (73 aa)

VVLGDTVGQGAFACVKNA-HLQMDP---SIILAVKFIHVPT------------CKKMGLSDKDITKEVVLQSKCSK----------------HPNVLRLI
  .    |||.|..|. . . . .     .|   . . ...             | |  ... ..| .  . .. .                |||.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DCNV--SKEYMWIILEMADGGDLFDKIE------------PDVGVDSDVAQFYFQQLVS---------------AINYLHVECGVAHRDIKPENILLDKN
.|    ..... ...| ..|||||| |.                 .   ......|...               |..||| .  . ||||||||||.   
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

GNLKLADFGLASQF------RRKDGTLRVSMDQRG------------------------SPPYMAPEVLYSEEGY-------YADRTDIWSIGILLFVLL
  .|..||||. ..      |.. . ..  . . .                        .|.|||||.| ... .       |    ||||.|..|. .|
--IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGQTPWELPSLENEDFVFFIEN-DGNLNWG----------------PWSKIEFTHLNLLRK----ILQPDPNKRVT-LKALKLHPWV
.|..|.            .... .....                   | |..    .|..|    .|| ||.|| |  . .. ||| 
FGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CHK1.AA ULK 15-281 23 1e-44 154.0 In-house 1-329 (329) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-329/329
Sequence Identity: 23% (79 aa)

VVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKD-----------ITKEVVLQSKCS-------KHPNVLRLIDCNVSK--EYMWII
 .| .  |.|.|. |  .  . .     ... . .    |  .. |            ...|. .. |         .|||. .|.|.  ..   . .||
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

LEMADGGDLFDKIEPDVGVDSDV----------AQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKN------------GNLKLADFGLASQFRRKDG
.|  .||||.. |. . .   |.          |. .|.|....  .|| . .. ||||||.|||....            | ||.||||.|   .  | 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA---KHVDN

T---LRVSMDQR------GSPPYMAPEVLYSE--EGYYADR-TDIWSIGILLFVLLTGQTP---WELPSLENEDFVFFIEN---------DGNLNWG---
     .. | .       |.| ||||..| ..  .  | |  .||||.|.... .|.|..|   |   .. .      |.|         . .|..    
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

PWSKIEFTHLNLLRKILQPDPNKRVTLKALKLHPWV
.  .|     .|.|. || |...| .   |  |||.
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CHK1.AA ULK 15-281 23 4e-44 152.91 In-house 1-324 (324) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-324/324
Sequence Identity: 23% (75 aa)

VVLGDTVGQGAFA-CVKNAHLQMDP--SIILAVKFIHVPTCKKMGLSD------KDITKEVVLQSKCS--KHPN--VLRLIDCNVSK--EYMWIILEMAD
 .| .  |.|.|.  |  .  . .     . |.| |     .|  . .      . . .|. .. |    ||||  . .|.|.  ..   . .||.|  .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLFDKIEPDVG---------VDSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNGN------------LKLADFGLASQFRR--KDGTLRV
||||.. |. . .            . |. .|.|....  .|| . .. ||||||.|||. ..              ||.||||.| ..    .. ... 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SMD----QRGSPPYMAPEVLYSE--EGYYADR-TDIWSIGILLFVLLTGQTP---WELPSLE--NEDFVF------FIENDGNLNWG---PWSKIEFTHL
..      .|.| ||||..| ..  .  | |  .||||.|.... .|.|..|   |   ...  ... .       ..... ....    .  ||     
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

NLLRKILQPDPNKRVTLKALKLHPWV
.|.|. || |...| .   .  |||.
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase CHK1.AA MARK 121-223 41 4.7e-40 128.74 In-house 109-207 (262) Show / Hide 
Range on Protein: 121-223
Range on HMM: 109-207/262
Sequence Identity: 41% (44 aa)

YFQQLVSAINYLHVECGVAHRDIKPENILLDKNG--NLKLADFGLASQF--RRKDGTLRVSMDQRGSPPYMAPEVLYSEEGYYADRTDIWSIGILLFVLL
.|.|.|||.||.|    ..||||||||||.|.||  | |..|||.. ..   .|           |.|||||||.. . . |..  .|||| |..|....
IFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK------LNTFCGTPPYMAPEIF-LKKPYDGPKVDIWSLGVVLYFMV

TGQTPWE
.|. |..
CGYFPFD
Kinase CHK1.AA STE 15-222 23 1.3e-39 137.62 In-house 1-268 (359) Show / Hide 
Range on Protein: 15-222
Range on HMM: 1-268/359
Sequence Identity: 23% (66 aa)

VVLGDTVGQGAFACVKNAHLQMDP--------------SIILAVKFIHVPTCKKMGLS--------------DKDITKEVVLQSKCSK-HPNVLRLIDCN
  . . .|.|||  |  |    ..                | |.| ... .|...  .               ..| ||. . .||.. |||. . ..| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

VSK-------EYMWIILEMADGGDLFDKIE---PDVGVDS-----------DVAQFYFQQLVSA-INYLHVECGVAHRDIKPENILLDKNGNLKLADFGL
. .       .. ||..|  ||| | | |.      . ..           ..  .. .|.. .  .|||    . |||||| ||||      ||.|||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGV

ASQFRRK--DG----------TLR-VSMDQRGSPPYMAPEVLYSEE----GYYADRTDIWSIGILLFVLLTGQTPW
..|.  .  ..          |    .    |.| .|||||.  ..    . |  . ||||.|...  ..||. ||
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase CHK1.AA TyrKc 15-281 20 8.8e-14 0.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-281
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

VVLGDTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKC-SKHPNVLRLIDCNVSK-------EYMWIILEMADGGDLFDK
..||.. | |||  |  ...     |  ||| ..  .        .|. .|  . .|   .|||..||. . ...       | ..|..| ...||| | 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

I-EPDVGVDSDVAQFYFQQLVSAINYLHVECGVAHRDIKPENILLDKNGNLKLADFGLASQFRRKDGTLR-------VSMDQRG--SPP------YMAPE
. ..   .  .    .  |  .  .||| . .. |||.   |.|...|.  | .||||.     .|..            ....  .         ||||
LRKHRPKLCMKDLLSFCWQIACGMEYLH-SKNCIHRDLAARNCLVGENHTVKISDFGLS-----RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLYSEEGYYADRTDIWSIGILLFVLLT-GQTPWELP---SLENEDFVFFIENDGNLNWGPWS--------KIEFTHLNLLRKILQPDPNKRVTLKALKLH
..   .| .   .|.|| |.... ..| ||.|.. .    ..|.. . .... |.    | .          .  .  . ..  . ||..| | ...  |
CI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--H

PWV
   
ECF
Kinase CHK1.AA Pkinase_Tyr 147-240 28 6e-09 30.94 Pfam 141-233 (270) Show / Hide 
Range on Protein: 147-240
Range on HMM: 141-233/270
Sequence Identity: 28% (28 aa)

NILLDKNGNLKLADFGLASQFRRKDGTL-RVSMDQRGSPPYMAPEVLYSEEGYYADRTDIWSIGILLFVLLT-GQTPWELPSLENEDFVFFI-ENDG
|.|...|.  | .|||||     .|..  |.. . .   . ||||..   .  .   .|.|| |.|.. ..| |..| . | . ||... .| |. .
NCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQP-TYPGMSNEEVYEYIYEDGY
Kinase CHK1.AA MARK 256-281 34 1.4e-07 21.0 In-house 237-262 (262) Show / Hide 
Range on Protein: 256-281
Range on HMM: 237-262/262
Sequence Identity: 34% (9 aa)

NLLRKILQPDPNKRVTLKALKLHPWV
||....|...|..| |.. .  |||.
NLIQRLLTVNPEERPTIEEIMKHPWM
Kinase CHK1.AA STE 256-281 42 0.000192 11.74 In-house 332-359 (359) Show / Hide 
Range on Protein: 256-281
Range on HMM: 332-359/359
Sequence Identity: 42% (12 aa)

NLLRKILQPDPNKRVTLKALKL--HPWV
. ..| || ||||| | . |    ||..
DFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CHK1.AA Pkinase_Tyr 15-103 24 0.006775 10.43 Pfam 1-94 (270) Show / Hide 
Range on Protein: 15-103
Range on HMM: 1-94/270
Sequence Identity: 24% (24 aa)

VVLGDTVGQGAFACVKNAHLQ---MDPSIILAVKFIHVPTCKKMGLS--DKDITKEVVLQSKCSKHPNVLRLIDCNV-SKEY--MWIILEMADGGDL
...| . |.|||  |. ...     .. |  ||| .     . |      .|  .|. . ..  .|||..||. . .  .|   ..|..| . .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL