Gene HAL5 (Bakers Yeast)

HAL5

Species: Bakers Yeast
Alias: HAL5
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: HAL

Sequence

Name Sequence Type Origin Length Description Download
HAL5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 335 Kinase domain by global Sugen HMM Fasta, JSON
HAL5.AA Protein Refseq_NP 855 `Protein kinase homolog, mutant is salt and pH sensitive; Hal5p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of HAL5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HAL5.AA HAL 503-837 38 7.89999999999e-209 700.04 In-house 1-363 (363) Show / Hide 
Range on Protein: 503-837
Range on HMM: 1-363/363
Sequence Identity: 38% (150 aa)

GKSIGVVGAGAYGVVKICARCKTAKDVLPYSTYSNGKKLFFAVKELK--PKPGDQIDKFCTRLTSEFIIGHSLSHPHFEANAMIAGNVSRTTPPKHVFNA
||...|.|.||||.||||.||...|||.||.||....| .|||||..  .|......|.|...||||.|||.|.|.||.|          ..|||||...
GKCNKVLGWGAYGEVKICQRCRNKKDVPPYDTYHYRDKKVFAVKEFRKPMKYNESPEKYCKKCTSEFCIGHTLHHHHFNA----------KKPPKHVVHI

PNILKILDLMEYS---NSFVEVMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQ
|||...||....|   ....||||.|..|||.....||.       |.|||..      ....|..|..|..|||..||.||||.||||.||||||....
PNICETLDIFYDSYTTDKWCEVMEYCPYGDLFAMVMRNG-------GKSRLKG------WRKMHYMEICCCFKQLCHGVKYMHDMGIAHRDLKPENCVMT

PNGLLKICDFGTSSVFQTA---WEKHVHFQSGAMGSEPYVAPEEFIRDA----------EYDPRLVDCWSCGIVYCTMVMGQYLWKIAIPEKDSLFKSFL
|.|..|.||||.|..|...   |||.||...|..||.||.|||....|.          |||||.||||||||.||.|.|....|||...|.||......
PDGICKLCDFGISDWFHYPPHDWEKNVHMCHGIVGSDPYLAPEVMYFDEKKHYDEKFQQEYDPRCVDCWSCGIIYCCMIMKRFPWKIPCKEDDSFRMFCY

S--------------EIKDDGQFYLFEE-------------------LRHVSSELNRLRKIALYRTFQVDPTKRITIEQLLQSSWM
.              |....|... |||                   ..|....|.. ......|.....|.||||........||
HYDCFIFHHNVTRTQEFPEKGCYHPFEEMEPENTPNNVQGKNNVNMGPHHIRHFLPHHCRHIMWRMLDWEPAKRITMDDIFNDPWM
Kinase HAL5.AA S_TKc 503-837 21 5.1e-47 163.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 503-837
Range on HMM: 1-231/231
Sequence Identity: 21% (74 aa)

GKSIGVVGAGAYGVVKICARCKTAKDVLPYSTYSNGKKLFFAVKELKPKPGDQIDKFCTRLTSEFIIGHSLSHPHFEANAMIAGNVSRTTPPKHVFNAPN
 . . ..| ||.|.|. |   |               .  .|.|..|                           |..    |  .           . ||
YEILRKIGKGAFGKVYKCRHKK--------------TGRIVAIKIIK--------------------------EHIRREIQILKK-----------HHPN

ILKILDLMEYSNSFVEVMEFCAS--GDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQPNG
| |..| ..  ...  |||.|    |||.... ...                 .| ..|... .| ..|.|......|.|.||| |.||||||||.    
IVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR----------------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--

LLKICDFGTSSVFQTAWEKHVHFQSGAMGSEPYVAPEEFIRDAEYDPRLVDCWSCGIVYCTMVMGQYLWKIAIPEKDSLFKSFLSEIKDDGQFYLFEELR
 .|||||| . ..           .   |.  |.||| .     |... .| ||||..   |. |. ..     . . .||  .                
HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------

HVSSELNRLRKIALYRTFQVDPTKRITIEQLLQ-------SSWM
       .  |  . . .|.||.||.|. ..||         |.
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HAL5.AA Pkinase 601-837 25 8.4e-46 163.03 Pfam 60-293 (293) Show / Hide 
Range on Protein: 601-837
Range on HMM: 60-293/293
Sequence Identity: 25% (66 aa)

PNILKILDLMEYSNSFVEVMEFCASG----DLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPL--HPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENI
|||....| .|....   |||.|  |    ||......                     .. ..   . |. ..|.|.| |..|.|..|| |.|||||||
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI

LFQPNGLL----KICDFGTSSVFQTAWEKHVHFQSGAMGSEPYVAPEEFIRDAEYDPRLVDCWSCGIVYCTMVMGQYLWKIA----IPEKDSLFKSFLSE
|.  || .    |||||| . .|.   . . .  ..  |. .|.|||  ||...|... || ||||..   |. |. ... .      ... ...  .. 
LIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGP

IKDDGQFYLFEEL----------RHVSSELNRLRKIALYRTFQVDPTKRITIEQLLQSSWM
. .   ... ..           . .  ....  |  ... ...||.||.|.||.||. |.
PLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HAL5.AA CAMK 601-758 19 3.3e-36 113.64 In-house 98-323 (425) Show / Hide 
Range on Protein: 601-758
Range on HMM: 98-323/425
Sequence Identity: 19% (47 aa)

PNILKILDLMEYSNS-------------------FVEVM---EFCASG----DLYSLLTRN------NISNESNNGSSRLIQTVKEGSGSP--------L
|||.|... .| ..                    .. ||   |.|  |    ||.. ....      ..                              .
PNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFD---------------------QFDIVERGRF

HPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQPN-----------------GLLKICDFGTSSVFQTAWEKH-------------------VHFQ
.  ||  ...|.. .|.|.|.|.|.|.||||||||.. |                 . .||.||| . .|.   . .                    .  
TEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKM

SGAMGSEPYVA-PEEFIRD------------AEYDPRLVDCWSCGIV
.   |. .|.| || . .              .|... .|.||||..
KTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase HAL5.AA Ciliate-E2 601-837 20 6.4e-35 117.29 In-house 92-365 (365) Show / Hide 
Range on Protein: 601-837
Range on HMM: 92-365/365
Sequence Identity: 20% (65 aa)

PNILKILDLME--YSNSFVEVMEFCASGDLYSLLT-----RNNISNESNNGSSRLIQTVKEGSGSPLHPLEADC--FMKQLLN---------------GV
|||.|. .  .    |..  |||.|  |||....      ||.. .                .   . . |  .  .|||.|.               ..
PNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE----------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILAL

QYMHDHG-IAHCDLKPENILFQPNGLLKICDFGTSS------------VFQTAWEKHV---HFQSGAM-------------GSEPYVAPEEFIRDAEY--
.|.|  . | | |.|||||||     .||.|||.|             . .  .       . ..| |             |. .|.||| . .  ..  
EYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ

-----DPRLVDCWSCGIVYCTMVMGQYLWKIAIPEKDSLFKSFLSEIKDDGQFYLFEEL---------------RHVSSE-LNRLRK--IALYRTFQVDP
         .| ||.|..   |..|.. .                ... .... ....                 ..| |  . ..|      | .|.||
QKQKGYDYKCDIWSLGVILYEMLFGKPPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK---RMLQKDP

TKRIT-IEQLLQSSWM
 |||| .||.|.  |.
EKRITGWEQILNHPWF
Kinase HAL5.AA CAMKL 601-770 29 4.8e-33 102.7 In-house 75-237 (297) Show / Hide 
Range on Protein: 601-770
Range on HMM: 75-237/297
Sequence Identity: 29% (55 aa)

PNILKILDLMEYSNS------FVEVMEFCASGD--LYSLL---TRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDL
||| |... .| ..       .. ||| | .|.  |.  .    . .                      .... ||  . .|.. .|.|.|.|||.| |.
PNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRR---------------------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDI

KPENILFQPNG--LLKICDFGTSSVFQT--AWEKHVHFQSGAMGSEPYVAPEEFIR-DAEYDPRLVDCWSCGIVYCTMVMGQYLWK
||||||.  ||   .||.||| |  ..    ..   .. .   || || ||| | .   .|| . ||.||||..  .|| |.. ..
KPENILLDENGNNNIKIIDFGFSNMYRPCIFGP--GQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFD
Kinase HAL5.AA AMPK 619-758 34 2.9e-26 75.01 In-house 78-189 (254) Show / Hide 
Range on Protein: 619-758
Range on HMM: 78-189/254
Sequence Identity: 34% (48 aa)

VMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQPNGLLKICDFGTSSVFQTAWE
|||. . |.|..  ...                        |   ||  |..| ..|| |.|.|.|.| ||||||.|.  |  .|| ||| | . . . |
VMEYVSGGELFDYIVKH----------------------GRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG-E

KHVHFQSGAMGSEPYVAPEEFIRDAEYDPRLVDCWSCGIV
    | . | ||  | || | |    |  . || ||||..
----FLKTACGSPCYAAP-EMISGKLYCGPEVDIWSCGVI
Kinase HAL5.AA Ciliate-E2-Unclassified 598-837 21 4.1e-25 84.06 In-house 78-352 (352) Show / Hide 
Range on Protein: 598-837
Range on HMM: 78-352/352
Sequence Identity: 21% (63 aa)

FNAPNILKILDLMEYSNSFVEVMEFCASGDLYSLLT-RNN---ISNESNNGSSRLIQTVKEGSGS----------PLHPLEAD-----CFMKQLLNGVQY
.. |.|.| ..  .  . .  |||.|  |||   .. |..   .                   |            .   .|       ...|.|.| .|
HPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQK-------------------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEY

MHDHG-IAHCDLKPENILFQPNG---LLKICDFGTSSVFQTA--------------WEKHVHFQSGAMGSEP-YVAPEEFIRDAEYDP--RLVDCWSCGI
.|  . | | |.|||||||. ||    .||.||| |.  |.               .... . ..|  .  | | ||| . .   ...    .|.||.|.
LHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGV

VYCTMVMGQYLWK---IAIPEKDSL-------FKSFLSEIKDDGQFYLFEELRHVSSELNRLRKIALY----RTFQVDPTKRITIEQLLQSSWM
.   |..|.|  .     . ....        .| ....||.  ...  .. . ..  ..   |  .     . ....| ||||.||.|.  |.
ILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase HAL5.AA Ciliate-E2a 601-710 33 1.3e-24 69.35 In-house 59-156 (275) Show / Hide 
Range on Protein: 601-710
Range on HMM: 59-156/275
Sequence Identity: 33% (40 aa)

PNILKILDLMEYSNSFVEVMEFCASGDLYSLLTRNN-ISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLL-NGVQYMHDHGIAHCDLKPENILFQ-
|||.|. .  |  |..  |||.| .|.||. .  .  .  |                       |.  .|.|||  |..|||  .| | |||||||||  
PNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE---------------------IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKN

--PNG----LLKICDFGTS
  .|.     .|| |||..
CSKNSIQNSDIKIIDFGLA
Kinase HAL5.AA ULK 601-708 34 6e-21 69.94 In-house 78-187 (329) Show / Hide 
Range on Protein: 601-708
Range on HMM: 78-187/329
Sequence Identity: 34% (42 aa)

PNILKILDLMEYS--NSFVEVMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQP
||| | .|  | |  | .  .||.|  ||| ... .|. ..|.               .  |   ||  |.||.||| ...|.|.| |.|.||.|||   
PNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDT-E-----------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHN

N------------GLLKICDFG
.            | |||.|||
GQPKTDSKKVHPNGVLKIADFG
Kinase HAL5.AA ULK 601-708 33 3.4e-20 68.38 In-house 73-183 (324) Show / Hide 
Range on Protein: 601-708
Range on HMM: 73-183/324
Sequence Identity: 33% (41 aa)

PN--ILKILDLMEYS--NSFVEVMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILF
||  | | .|  | |  | .  .||.|  ||| ... .|. ..|                .  |   ||  |.||..|| ...|.|.| |.|.||.||| 
PNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-T-E-----------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI

QPN------------GLLKICDFG
  .            | |||.|||
HNGQPKTDSKKVHPNGVLKIADFG
Kinase HAL5.AA CHK1 664-713 38 6e-17 56.12 In-house 106-162 (276) Show / Hide 
Range on Protein: 664-713
Range on HMM: 106-162/276
Sequence Identity: 38% (22 aa)

EADCFMKQLLNGVQYMHDHG-IAHCDLKPENILFQPNG------LLKICDFGTSSVF
|| .. |||..|. | |..| ..| |.||||.|   ..       ||| ||| ....
EAHRYFKQLISGLKYIHCCGGVTHRDIKPENLLLDKHDSNDMPDNLKIADFGLATWY
Kinase HAL5.AA Ciliate-E2a 819-837 47 3e-08 20.43 In-house 257-275 (275) Show / Hide 
Range on Protein: 819-837
Range on HMM: 257-275/275
Sequence Identity: 47% (9 aa)

QVDPTKRITIEQLLQSSWM
..|| ||||..|.|.. |.
EKDPKKRITAQQALNHPWF
Kinase HAL5.AA CAMKL 819-837 52 4.9e-08 21.58 In-house 279-297 (297) Show / Hide 
Range on Protein: 819-837
Range on HMM: 279-297/297
Sequence Identity: 52% (10 aa)

QVDPTKRITIEQLLQSSWM
||.|.||.||.|...  ||
QVNPEKRPTIHQIMNHPWM
Kinase HAL5.AA CAMK 819-837 68 4.9e-08 21.24 In-house 407-425 (425) Show / Hide 
Range on Protein: 819-837
Range on HMM: 407-425/425
Sequence Identity: 68% (13 aa)

QVDPTKRITIEQLLQSSWM
||||.||.|||| |.  ||
QVDPEKRMTIEQCLNHPWM
Kinase HAL5.AA TyrKc 503-762 14 2e-06 -117.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 503-762
Range on HMM: 1-280/280
Sequence Identity: 14% (52 aa)

GKSIGVVGAGAYGVVKICARCKTAKDVLPYSTYSNGKKLFFAVKELKPKPGDQIDKFCTRLTSEFIIGHSLSHPHFEANAMIAGNVSRTTPPKHVF--NA
 . . . | ||.|.|   .. |                .  ||| ||.               .|.          ||. |            . .  . 
ITLGKKLGEGAFGEVYK-GTWK----------------IQVAVKMLKEDA-----------REDFMR---------EARIM------------CKLGGHH

PNILKILDLMEYS-------NSFVEVMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPEN
|||....     .            |||... ||| . | ..                        | . .   |. |  .| .| |.... | ||   |
PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN

ILFQPNGLLKICDFG-----TSS--------VFQTAWEKHVH------------FQSG-------------------AMGSEPY-------VAPEEFIRD
.|   |.  ||.|||     ..         .  .. .|. .            .. |                     | .||       . ..| |..
CLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY

AEYD-----PRL-----------------VDCWSC--------GIVYCTM
 .       |                    .||            ..  .
VKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HAL5.AA ULK 814-837 29 5e-06 17.31 In-house 301-324 (324) Show / Hide 
Range on Protein: 814-837
Range on HMM: 301-324/324
Sequence Identity: 29% (7 aa)

LYRTFQVDPTKRITIEQLLQSSWM
..| .|.|...||..|....  |.
IRRMLQYDEKDRISWEEIFNHPWF
Kinase HAL5.AA ULK 814-837 33 5e-06 17.23 In-house 306-329 (329) Show / Hide 
Range on Protein: 814-837
Range on HMM: 306-329/329
Sequence Identity: 33% (8 aa)

LYRTFQVDPTKRITIEQLLQSSWM
..| .|.|...||..|.|..  |.
IRRMLQYDEKDRISWEELFNHPWF
Kinase HAL5.AA AMPK 819-837 52 6e-06 13.67 In-house 236-254 (254) Show / Hide 
Range on Protein: 819-837
Range on HMM: 236-254/254
Sequence Identity: 52% (10 aa)

QVDPTKRITIEQLLQSSWM
||||.|||||... ...| 
QVDPMKRITIHDIRNHPWF
Kinase HAL5.AA CHK1 819-837 42 9.2e-05 12.96 In-house 258-276 (276) Show / Hide 
Range on Protein: 819-837
Range on HMM: 258-276/276
Sequence Identity: 42% (8 aa)

QVDPTKRITIEQLLQSSWM
...|.||.||||. .. | 
CENPNKRATIEQIEKDPWY
Kinase HAL5.AA CHK1 729-772 38 0.000107 12.73 In-house 177-219 (276) Show / Hide 
Range on Protein: 729-772
Range on HMM: 177-219/276
Sequence Identity: 38% (17 aa)

GSEPYVAPEEFIRDAEYDPRLVDCWSCGIVYCTMVMGQYLWKIA
|. ||.||| . . ..|    || ||||.|  .|  |.  |. .
GTPPYMAPEVCTG-KQYRGPPVDIWSCGVVLMAMLTGELPWDQP
Kinase HAL5.AA Pkinase 503-577 20 0.001123 14.08 Pfam 1-61 (293) Show / Hide 
Range on Protein: 503-577
Range on HMM: 1-61/293
Sequence Identity: 20% (16 aa)

GKSIGVVGAGAYGVVKICARCKTAKDVLPYSTYSNGKKLFFAVKELKPKPGDQIDKFCTRLTS--EFIIGHSLSHPH
 . ....|.|..|.|..| . .| |               .|||..| .  .. .... ...   |  | ..|.||.
YHIGRKIGSGSFGCVYKCHHKGTGK--------------IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPN
Kinase HAL5.AA CAMK 508-520 46 0.021943 2.69 In-house 1-13 (425) Show / Hide 
Range on Protein: 508-520
Range on HMM: 1-13/425
Sequence Identity: 46% (6 aa)

VVGAGAYGVVKIC
. | |..|.|| |
TLGRGSFGKVKLC