Gene KIC1 (Bakers Yeast)

KIC1

Species: Bakers Yeast
Alias: KIC1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: YSK

Sequence

Name Sequence Type Origin Length Description Download
KIC1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 254 Kinase domain by global Sugen HMM Fasta, JSON
KIC1.AA Protein Refseq_NP 1080 Kinase that interacts with Cdc31p; N-rich kinase 1; Kic1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of KIC1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KIC1.AA YSK 23-276 58 1.1e-218 665.58 In-house 1-257 (257) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-257/257
Sequence Identity: 58% (150 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP---GKIDEK
|...|.||||.||.||||....|.||.|||...|....||.||.|.|||||...... .||.|||||||||.||||||.|.|||...|..|   |..|||
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSP-YITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEK

YIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEG-VYYDTKVDIWSLGITTYEIATGNP
||..|.||.|..|...|....|||||||||||....|.|||||||||.|...|...|.|..|||||||||||... .|||.|.||||||||.||.|.|.|
YIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEP

PYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI
||||....|.|.||.|..||.||.||||...|||...||..||..|.||..|||.|||
PYCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase KIC1.AA STE20 23-276 43 1.8e-138 466.3 In-house 1-288 (288) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-288/288
Sequence Identity: 43% (125 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRV----YAIKVLNLDSDS---DEVEDVQREIQFLASLKQISNITRYYGSYLKD----TSLWIIMEHCAGGSLRSLL
.. .|.||.| .|.|||.|...||..    .|||..||....   ||.||.| ||.... .|   ||..||||||||    ..|||.||.|.||||. ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

R-----PG-----KIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQ----TSL-RRQTMAGTPYWMAPEVIMEG--
.      .     ...|..| .|.||.| .|. .|. ..|||||||.|.|.| .|.|||.||||.||...    |   .|.|. |||||||||||..   
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--VYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLII--KSKPPRLED---RSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI
    ||.|.||||||||. | |.|.|||.|. ..||| .|.  . .||.|.|   ...|.....|...||. ||..| .|..||| .||
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase KIC1.AA STE 23-276 32 1.7e-122 413.27 In-house 1-359 (359) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-359/359
Sequence Identity: 32% (117 aa)

FKRTEVIGRGKFGVVYKGYNVK---------------TGRVYAIKVLNLDSDS----------------DEVEDVQREIQFLASLKQ-ISNITRYYGSYL
... |.||.| ||.|||..|.|               ||...|||..||....                .|......||...  ...   || .|||.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------TSLWIIMEHCAGGSLRSLLR-------P--------GKIDEKYIGVIMRELLVA-LKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAA
|.       ..|||.||...||||.....       |        ....|. |..| |..| . |. .|. ..||||||.||.|.     ||||||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QVNQ---------------TSL-RRQTMAGTPYWMAPEVIMEG-----VYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKS-----------
|...               |.  .|.|..||| |||||||. .       ||||.||||||.|  | |||.||..|   .||| .|...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KPPRLED------------------RSYSTSLKEFIALCLDEDPKERLSADDLLK--SKFI
    .||.|.|                  ...| ..|.||..||. ||..| .|..|||   .||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase KIC1.AA S_TKc 23-276 30 2.5e-97 330.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAG--GSLRSLLRPGK-----
..  ..||.| ||.|||....||||..|||...        |...|||| | .  .  || ..|...   ..|...||.| |  |.|.....  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDT-KVDIWSLGITTYE
  ..|  .  .|.... ||. .|. ..||||.| .|.|...  ..|.||||.|.|.        |. |||..|||||.     |.. |.|.||.|.. ||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

IATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLK-------SKFI
 ..| ||..  .  . ...|             | ..|.||  ||. ||..|..| ..|.         ..
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KIC1.AA MST 23-276 40 8.3e-91 288.87 In-house 1-254 (254) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-254/254
Sequence Identity: 40% (106 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYL--KDTSLWIIMEHCAGGSLRSLLRPGKI--DE
|   | .|.| .|.|||  . .|| ..|||... ..|    ..   || ..   |   .| .|||||.  |.. .||.||.|..||.  . .  ..   |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNED---LQEIIKEISIMQQCKS-KYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNE

KYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNP
  | .| .  |  |.  |.   |||||||.| |. .||. || ||||..|   |   |.|  |||||||||||.| . ||.|.||||||||  | | |.|
QQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQE-IKYDCKADIWSLGITAIEMAEGMP

PYCDVEALRAMQLIIKSKPPRLED-RSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI
|| |. . ||| .|... || . |   .|. .  |.. ||  .| .| .| .||.  ||
PYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase KIC1.AA Pkinase 23-276 30 1.3e-89 308.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQR---EIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGG----SLRSLLR---
... ..||.| ||.|||.....||...|.|............   |   ||| ...| .  || |.|...  .......||.| ||    .| ....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

PGKI--DEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNV----KLCDFGVAAQV-NQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS
 |..  .|. .  .|...| .|. .|. ..||||.| .|.|| |.|..    |.||||.|.|. .  .   .| .|||..||||||..| ||..|||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGITTYEIATGNPPYCDV----EALRAMQLIIKSKP-PRLEDRSYS---------------------TSLKEFIALCLDEDPKERLSADDLLKSKFI
.|.. || ..|.||...     . .. ||.| . .. |  .|....                      ..|.||  ||. |||.|..|...|.....
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KIC1.AA PAKA 23-276 41 3.1e-85 289.49 In-house 1-260 (260) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-260/260
Sequence Identity: 41% (108 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRV--YAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK-----
.|..| || |  | ||...|.||.     |||..|.. . .  | .  ||  . . |.  || .|. ||| |  ||..||  .||.|  ..         
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQ-PKKELIINEILVMKECKH-KNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCN

-IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIA
 .||. |. . || | .|. ||. ..||||||  |.|.  .|.||. ||| .|| .|  ..|.|| |||||||||||  .  || ||||||||| . |..
YMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVI-RRKQYDEKVDIWSLGIMAIEMI

TGNPPYCDVEALRAMQLIIKS-KPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI
 | ||| .   |||| || .  ||....  . | ....| ..||. |...| ||..||.  |.
EGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase KIC1.AA STE11 23-276 35 5.3e-84 285.39 In-house 1-303 (303) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-303/303
Sequence Identity: 35% (109 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDS-------DEVED------VQREIQFLASLKQISNITRYYGSYL---KDTSLWIIMEHCAGGS
... |.||.| ||.|||..||.||...|.|   .. ..       .|...       | ||. .  |.   || ||||. |   .. .. |.||.|.|||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNH-KNIVRYYGCCLHDNQNDHVNIFMEYCPGGS

LRSLLR-P-GK--IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGN-VKLCDFGVAAQVNQTSLRRQT----------MAGTPY-------
|.|.||   |.   ||. | .  . .| .|.  |. ..||||||.||.|.  .|| .|| ||| | ....  .. ..          | ||||       
LSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTP

-WMAPEVIMEGVY--YDTKVDIWSLGITTYEIATGNPPYCDVEA--LRAMQLIIKS-K--PPRLEDRS----YSTSLKEFIALCLDEDPKERLSADDLLK
 |||||||...    |..|.|||||| | .| |||.||. . ..    ||  |... |  ||  |. |     |  ...|. .|.  |||.| .|..||.
MWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQ

SKFI
 .||
HPFI
Kinase KIC1.AA MSN 23-276 42 4.5e-82 270.77 In-house 1-265 (265) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-265/265
Sequence Identity: 42% (114 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLK------DTSLWIIMEHCAGGSLRSLLRPGK-
|.  ||.| | .| ||||  ||||.. ||||...    || |... || .|       ||  ||| ..|      |  ||..|| |. ||.  |..  | 
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE--DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKG

--IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIM----EGVYYDTKVDIWSLGIT
  . | .|  | ||.|  |  .|.. |||||||  |||.|.. .||| ||||.||...|  || |  |||||||||||         || . |.||.|||
QSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGIT

TYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI
  |.| |.|| ||.. .||. || .  ||.|  . .|   ..|.  ||  . ..| .....||  ||
AIEMAEGQPPLCDMHPMRALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase KIC1.AA KHS 23-276 38 1.1e-74 250.56 In-house 1-258 (258) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-258/258
Sequence Identity: 38% (100 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLR-PGKIDEKYI
.     .| | .| |||  ..... . |.||. .. . |... .|.||  .   .   ||  |.||||.   |||.||.| ||||  . .  |.. |  |
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPG-DDFAVIQQEIMMMKDCRHP-NIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQI

GVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEV--IMEGVYYDTKVDIWSLGITTYEIATGNPP
  . || | .|. .|    .||||| ||.|.|..|.||| ||||.||. .|  .|.   ||||||||||  .     |.   |||..|||  |.|   ||
AYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPP

YCDVEALRAMQLIIKS--KPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADDLLKSKFI
  |.  .||. |. ||  .||.|.|.. .| .  .|. ..|  .|| | .|. ||. .|.
MFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase KIC1.AA SLK 23-276 37 8.8e-71 237.99 In-house 1-259 (259) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-259/259
Sequence Identity: 37% (97 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLL--RPGKIDEKY
..    .| | || |||  .  .... | |....... .|.||   ||. |...|   || . |..|  |  ||...|.|.|| . ...      . |. 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDE-EELEDYMVEIDILSECK-HPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQ

IGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVY----YDTKVDIWSLGITTYEIATG
| .. .... ||. .|...|||||.|| |.|.| .|.|.| ||||.|.  .|  .| |  ||||||||||.|   .    || |.||||||||  |.| .
IQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQM

NPPYCDVEALRAMQLIIKSKPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADDLLKSKFI
 ||. ... .| .  | || ||.||  | .| . |.|.  ||. ||. | ....|.. ...
EPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase KIC1.AA STE11-Unclassified 23-276 32 9e-69 234.79 In-house 1-308 (308) Show / Hide 
Range on Protein: 23-276
Range on HMM: 1-308/308
Sequence Identity: 32% (99 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDS---DEVEDV-----QREIQFLASLKQISNITRYYGSY--LKDTSLWIIMEHCAGGSLRSLLR
..  |.||.| || |||. |..|| ..|.| ..   ..    .....     | |.. | .|    || .|||     . ... |.|| ..|||..|.|.
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNH-KNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLN

P-GKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAA---------------------QVNQTS----LRRQTMAGTPY--
  |. ||. | .  ...|  |.  |. ..||||||.||.||  .|..|| ||| |                      .  |..      ...| ||||  
KYGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-WMAPEVIME--GVYYDTKVDIWSLGITTYEIATGNPPYCDVEA--LRAMQL-IIKSK--PPRLEDRS---------YSTSLKEFIALCLDEDPKERLSA
 |||||||       ...|.|||||| | .| ||| .|. . ..  . .. . |..|.  |. .|. |          |. .|.|. .|.  |||.|..|
FWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

DDLLKSKFI
. ||. .||
NQLLQHPFI
Kinase KIC1.AA TyrKc 23-275 24 1.6e-27 98.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-275
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASL-KQISNITRYYGSYLKD-------TSLWIIMEHCAGGSLRSLLRPG
 .  ...|.| ||.||||      .  |.|.|. |.    .||  ||.. . .| ..  || | ||  ...         |.|.||....|.|.. ||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

K--IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQT--------SLRR----QTMA-GTPYWMAPEVIMEGVYYDT
.  .  |    ..         .|. |.||||. | |.|..... || .||| .  .             |     .. .     |||||.|..|..  |
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-T

KVDIWSLGITTYEIAT-GNPPYCD-----VEALRAMQLIIKSKPPRLEDRSY---------STSLKEFIALCLDEDPKERLSADDLLKSKF
| |.|| |.. .|| | | .|| .     ... ...... . .  |..   .         .. . . .  | .|||..| .  .. ...|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase KIC1.AA Pkinase_Tyr 139-234 38 4.1e-21 72.12 Pfam 131-231 (270) Show / Hide 
Range on Protein: 139-234
Range on HMM: 131-231/270
Sequence Identity: 38% (39 aa)

NVIHRDIKAANVLITNEGNVKLCDFGVAAQV-NQTSL-RRQTMAGTPY-WMAPEVIMEGVYYDTKVDIWSLGITTYEIAT-GNPP-YCDVEALRAMQLI-
| ||||. | |.|.|... || |||| |  . |     | .. .  |  |||||.|..|. . || |.|| |.. .|| | |  | | ..   . ...| 
NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIY

IK
 .
ED
Kinase KIC1.AA Pkinase_Tyr 23-112 29 2.9e-17 59.07 Pfam 1-99 (270) Show / Hide 
Range on Protein: 23-112
Range on HMM: 1-99/270
Sequence Identity: 29% (29 aa)

FKRTEVIGRGKFGVVYKGYNV----KTGRVYAIKVLNLDSDSDE--VEDVQREIQFLASLKQISNITRYYGSYL-KDTS--LWIIMEHCAGGSLRSLLR
 .  ...|.| ||.||||.      .|.   |.|.|. ......   ||  ||.. . .| .  || |.||  . .. .  ..|.||....|.|.. ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR