Gene MEC1 (Bakers Yeast)
MEC1
Sequence
Protein domains of MEC1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| UME | MEC1.AA | UME | 872-979 | 40 | 7.4e-54 | 186.15 | SMART | 1-115 (115) | Show / Hide |
Range on Protein: 872-979 Range on HMM: 1-115/115 Sequence Identity: 40% (47 aa) FQKKLQDNILGIFQVFSSDIHDVEGRTTYYEKLRVINGISFLIIYAPKKSIISALAQ---ISICLQTGLGLKEVRYEAFRCWHLLVRHLND---EE-LST |...|||..|||.|.|....||..|...||||.|....|.|.| |. .|.|.|...| |..||||.|. .|.|....||||....|||. |. ... FADFLQDHFLGIMQWFNMIMHDSHGKKPYYEKKRALRSIEFMIKYMMGKHISSFRPQIIQIMACLQTALEIPELRHHCCRCWHCFIKHLNEVSCEHYIGP VIDSLIAFILQKWSE .|| ..|.||..|.. LIDQIFAIILPYWPT |
|||||||||
| UME | MEC1.AA | UME | 872-979 | 40 | 1.1e-53 | 183.43 | Pfam | 1-112 (112) | Show / Hide |
Range on Protein: 872-979 Range on HMM: 1-112/112 Sequence Identity: 40% (45 aa) FQKKLQDNILGIFQVFSSDIHDVEGRTTYYEKLRVINGISFLIIYAPKKSIISALAQISICLQTGLGLK--EVRYEAFRCWHLLVRHLND--EELSTVID ....|||..|||...||...||..||..|.||.|.|..|...| |. .|.|.||..||..|||..|... |.||..|||||.....|.. |.|...|| MADFLQDHFLGIITRFSMVMHDFQGRQPYFEKKRCIRSIEEMIKYMCGKHISSARPQIMACLQSALEIPEEELRYHCFRCWHVFIQTLDEVPEHLGPLID SLIAFILQKWSE .....|...| QTFVIIIPYWDT |
|||||||||
| Kinase | MEC1.AA | PI3Kc | 1059-1350 | 29 | 4.8e-110 | 372.82 | SMART | 1-333 (336) | Show / Hide |
Range on Protein: 1059-1350 Range on HMM: 1-333/336 Sequence Identity: 29% (97 aa) GIMCKK-EDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLK------------------------ ....|. .| |||. ||. .|. ...||...|.|.| ...|..... ..||..|.|||..||..|...... | AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM --IKYSLKSLHDRWQHTAVDGKLEFYMEQVD-KFPPILYQWFLENFPDP-INWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDC ............||.. . .|........ ..||.||.||.|.|||| ..|..||....||.|.. ||..|||.||||..||.||..||...|.||.. MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH LFEKGKRLPVP-----EIVPFRLTPNLLDALG----IIGTEGTFKKSSEVTLALMRKNEVALMNVIETIMYDRNMDHSIQK--ALKVLRNKIRGIDPQDG .|..|...|.. | ||||||...... | . | .| |.. . .. .|||. ..||..|. .|| .|.. . ..|.||...| .. | IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE LVLSVAGQT-ETLIQEATSEDNLSKMYIGWLPF ... . || .|.. |.. | ....|| . . EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNW |
|||||||||
| Kinase | MEC1.AA | PI3_PI4_kinase | 1057-1299 | 26 | 3.7e-96 | 330.57 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1057-1299 Range on HMM: 1-300/300 Sequence Identity: 26% (80 aa) IYGIMCK-KEDVR--QDNQYMQFA-----------------------TTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYE .|....| ..| | ||.. ||. ..|. ...|| ..|.|......|..... ..||..|.|||..|.. |..|... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV SLKIKY-------SLKSLHDRWQHTAVDGKLEFYMEQVDKFPPILYQWFLENFPDP-INWFNARNTYARSYAVMAMVGHILGLGDRHCENILL--DIQTG ..|.|. ..|. |.|. .... ...|.|.. ...|.|||||....||. .|..||....||.|.|..|..|||.||||..||.. | || KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG KVLHVDFDCLFE--KGKRLPVPEIVPFRLTP------NLLDAL------GIIGTEGTFKKSSEVTLALMRKNEVALMNVI-------ETIMYDRNMDHSI .. |.||.. |. |.|....|| ||||.|. .. .|. . .| .|.|... .......|.. ...||.. |. ..| .... HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
|||||||||
| Kinase | MEC1.AA | PIKK | 1029-1289 | 38 | 2.6e-82 | 279.78 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1029-1289 Range on HMM: 1-290/290 Sequence Identity: 38% (113 aa) IIR-FGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILS .|| . . | ...||| . | |.|| .| .|| .|| ||| ||. | .| || ...|| | | ||| . ||..| |.| |||. |. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK TKYESLKIKYSLK-------------------------SLHDRWQHTAVDGKLEFYMEQVDK-FPPILYQWFLENFPDPINWFNARNTYARSYAVMAMVG .. .|.. . . . || . . |.| .||... .|... ||.. |||| |. .| |.|||||| ||| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG HILGLGDRHCENILLDIQTGKVLHVDFDCLFE-KGKRLPVPEIVPFRLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEVALMNVIETI |||||||| |||..| |||...|.|| |.|| ...||||||.||||||.|. .|.|..|.|| | .. |... .||.. ||.| |. YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
|||||||||
| Kinase | MEC1.AA | ATR | 1027-1289 | 37 | 9.1e-80 | 271.31 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 1027-1289 Range on HMM: 1-267/267 Sequence Identity: 37% (101 aa) VSIIRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSIL | | ....||.|||.. . |||| .| .||| |.|.|.| . |.| ..|.. || .|.| . . |.|. | ..|.|.| | | .|||.|| AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL STKYESLKIKYSLKSLHDRWQH--TAVDGKLEFY-MEQVDKFPPILYQWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKV .. |.. . |. . . |. . . . ||| .||. |||| .|. .|. | |||||..||| |.|||||| .|||.| .| . DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGEC LHVDFDCLFEKGKRLPVPEIVPFRLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEVALMNVIETI |||. |.| .|... |||||||||| |. ..| ..|.| |.. ||.. .||.. .| |... VHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
|||||||||
| Kinase | MEC1.AA | ATM | 1146-1292 | 42 | 1.2e-43 | 137.11 | In-house | 97-243 (304) | Show / Hide |
Range on Protein: 1146-1292 Range on HMM: 97-243/304 Sequence Identity: 42% (62 aa) QHTAVDGKLEFYMEQVDKFPPILYQWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVPF | . . | | .|. | |. . .| | || || | | || | ..|| |||||||| |||. | . |.| ||.|| || || ||| QKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF RLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEVALMNVIETIMYD ||| . | .|| | || |.. | |. || |. ..| ..|| RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYD |
|||||||||
| Kinase | MEC1.AA | FRAP | 1182-1299 | 41 | 1.6e-32 | 114.41 | In-house | 133-251 (251) | Show / Hide |
Range on Protein: 1182-1299 Range on HMM: 133-251/251 Sequence Identity: 41% (49 aa) WFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDF-DCLFEKGKRLPVPEIVPFRLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEV ||. | | || |.| |.| |||||||| ||.|. .|||..|.|| || .| || .||||| | |. . | ||... .|. . .| . WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE ALMNVIETIMYDRNMDHSI .| |.| || . . SVMAVLEAFVYDPLFYWRL |
|||||||||
| Kinase | MEC1.AA | SMG1 | 1179-1241 | 57 | 5.2e-26 | 83.05 | In-house | 180-242 (242) | Show / Hide |
Range on Protein: 1179-1241 Range on HMM: 180-242/242 Sequence Identity: 57% (36 aa) PINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPE | |. |||| |||.||| |.|||||| .|.|.|. || | |.|. ||||| | ||| PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
|||||||||
| Kinase | MEC1.AA | FATC | 1319-1351 | 57 | 8.3e-19 | 63.29 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 1319-1351 Range on HMM: 1-33/33 Sequence Identity: 57% (19 aa) LVLSVAGQTETLIQEATSEDNLSKMYIGWLPFW . ||| .| . ||||||...||..||||| |.| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
|||||||||
| Kinase | MEC1.AA | DNAPK | 1186-1248 | 42 | 9.8e-16 | 53.58 | In-house | 187-250 (301) | Show / Hide |
Range on Protein: 1186-1248 Range on HMM: 187-250/301 Sequence Identity: 42% (27 aa) RNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFE-KGKRLPVPEIVPFRLT | ..|.||| . ||| |||| .| . .| . .|| | . ||||| ||||| REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLT |
|||||||||
| Kinase | MEC1.AA | FRAP | 1058-1136 | 28 | 1.6e-07 | 23.83 | In-house | 2-81 (251) | Show / Hide |
Range on Protein: 1058-1136 Range on HMM: 2-81/251 Sequence Identity: 28% (23 aa) YGIMCK-KEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLKIKY | . | .||.||| || . || . ..|. | | ||.. | . |.. |.. ||. .. . .|.| YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRY |
|||||||||
| Kinase | MEC1.AA | DNAPK | 1027-1125 | 31 | 1.1e-05 | 16.39 | In-house | 2-101 (301) | Show / Hide |
Range on Protein: 1027-1125 Range on HMM: 2-101/301 Sequence Identity: 31% (31 aa) VSIIRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSIL | | | | ||..|| . | | | . | || ||| | | . | . | | |.. . | .| | | |.|. || VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL |
|||||||||
| Kinase | MEC1.AA | ATM | 1059-1113 | 32 | 0.000703 | 7.83 | In-house | 2-56 (304) | Show / Hide |
Range on Protein: 1059-1113 Range on HMM: 2-56/304 Sequence Identity: 32% (18 aa) GIMCKKEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILE .. ..|.||| | || . ||| | | | | | |.|| QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLE |
|||||||||
| Kinase | MEC1.AA | SMG1 | 1037-1076 | 39 | 0.001106 | 7.9 | In-house | 2-42 (242) | Show / Hide |
Range on Protein: 1037-1076 Range on HMM: 2-42/242 Sequence Identity: 39% (16 aa) KVFSSLKKPKQLNIIGSDGNIYGIMCKK-EDVRQDNQYMQF . |||.| .|||| | . | ||. | ||| TILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQF |
|||||||||