Gene PAK1 (Bakers Yeast)

PAK1

Species: Bakers Yeast
Alias: PAK1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: CAMKK
Subfamily: ELM

Sequence

Name Sequence Type Origin Length Description Download
PAK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 316 Kinase domain by global Sugen HMM Fasta, JSON
PAK1.AA Protein Refseq_NP 1142 high copy suppressor of temperature sensitive cdc17 (DNA polymerase alpha) mutations; Pak1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of PAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PAK1.AA ELM 133-448 64 9.20000000001e-257 859.28 In-house 1-346 (346) Show / Hide 
Range on Protein: 133-448
Range on HMM: 1-346/346
Sequence Identity: 64% (223 aa)

YEIIKELGHGQHGKVKLARDILSKQLVAIKIVDR---------HEKKQRKFFTFIKSSKISENDKIKREIAIM-------------KKCHHKHVVQLIEV
||||.||||||||.||.||||...|||||||..|         |||..|.|.|..|..||.||..|..|..||             |.|||||||||||.
YEIIVELGHGQHGYVKKARDITTGQLVAIKIINRKPWNAQQYSHEKRMRQFQTWKKQGKITENMRINQEMRIMNIEKCRWEIFAASKRCHHKHVVQLIEC

LDDLKSRKIYLVLEYCSRGEVKWCPPDCMESDAKGPSLLSFQE-----TREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDG-TVKISDFGVSLAASS
|||..||||.||||.||||||||||.||||.||..||.|.||.     ||.|||..|.|||||||||.|||||||.|||||..| |||||||||......
LDDPFSRKIWLVLEWCSRGEVKWCPDDCMEIDAQWPSILIFQCSVSTFTRKILRDMVKGLEYLHYQGCIHRDIKPSNLLISENGKTVKISDFGVCMFTPQ

TNSSDSS--ESLDELELAKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFK
|||....  ||....||.|.||||||||||||..|.....||||||||||..|.|||||||..|||||||||||||||...|..||.||.|||||||..|
TNSFNDQNFESCFQRELNKIVGTPAFFAPEMCHTENEYRDYNLTKENLFRFVCCSFMIDIWSLGVTLYCLLFGMLPFFGNNEFELFHKIINDPLKFPIYK

EIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
|...|||||..|.||||||||||.|||||.|||||.|..||||||.
EMLNNKVSKITCMEEYEMAKDLLKKLLEKDPQKRMKIQDIKKHPFM
Kinase PAK1.AA CAMKK 133-448 37 1.1e-195 627.16 In-house 1-396 (396) Show / Hide 
Range on Protein: 133-448
Range on HMM: 1-396/396
Sequence Identity: 37% (151 aa)

YEIIKELGHGQHGKVKLARDILS-KQLVAIKIVDR---HEKKQRKFFTFIKSSKISEN-------------DKIKREIAIMKKCHHKHVVQLIEVLDDLK
||..||.|.||.||||||..    ....||||...   ..|...|.... ...|...|             | ...||||||||.|...|.|.||.|| .
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

SRKIYLV-LEYCSRGEVKWCPPDCMESDAKG-----------------PSLLSFQE---------------------TREILRGVVLGLEYLH-YQG---
..|||.| .|||.||...|.|..... ....                 .|..|.|.                     .....|....|||||| ||.   
NDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACS

----------------IIHRDIKPANLLISGDG---TVKISDFGVSLAASSTNSSDSS-ESLDELELAKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFR
                |||||||| |.||. .|   .|||.|||||.  .......|. ||....||.||.|||||.|||.|  |. ...||..| ..||
YIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYK-YRFR

GSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFE---KIVNDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
... ....||||.||||||..||..||.......|..   ||.|||.|||..||...| || ..|.|..|..|||....|||||.||.|||.||.||.|
FIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNN-VS-IYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase PAK1.AA S_TKc 133-448 25 2.5e-85 290.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 133-448
Range on HMM: 1-231/231
Sequence Identity: 25% (84 aa)

YEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSR--GE
|||....|.|  |||...|.. ....|||||..                     ..|.|||.|.|| ||...|.|..| .|    ..|.|.|||.   |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGD

VKWCPPDCMESDAKGP--SLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVSLAASSTNSSDSSESLDELELAKTVGTPAF
..    | ...  ...  . ..  ..| ... ....|||.| .||||||.||.|.|..   ..||.|||..                       .||| .
LF----DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------TTFCGTPWY

FAPEMCLGEDAFTRYNLTKENLFRGSCISF-MIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLLK
 |||..                      ..  .|.|..|..|| .| |  ||    . ..|.||.                          . |||.. |
MAPEVL--------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------------SPEAKDFIRK

LLEKNPQKRMTIPAIKK-------HPFV
.|.|.|.||.|.  . .       ||..
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK1.AA CAMK 138-448 22 3.1e-74 238.4 In-house 1-425 (425) Show / Hide 
Range on Protein: 138-448
Range on HMM: 1-425/425
Sequence Identity: 22% (100 aa)

ELGHGQHGKVKLARDILSK------------QLVAIKIVDRHEKKQR----------KFFTFIKSSKIS----ENDKIKREIAIMKKCH-------HKHV
.||.|. |||||.......            | |||||.|.   |            ....  |...        ....|||.||||..       |...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLIEVLDDLK-----------------SRKIYLVL---EYCSRGEV------------------KWCPPDCMESDAKGPSL--------LSFQETREIL
..|.|| .| .                  ...|.|.   |||| ||                                            .. .|.| . 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFD---------------QFDIVERGRFTEREARRYF

RGVVLGLEYLHYQGIIHRDIKPANLLISGD-----------------GTVKISDFGVS--LAASSTNS----SDSSESLDEL---------ELAKTVGTP
| .. ...|.| ..|.|||.|| |.|.. .                 ...||.||| .  .  .. |      .. | . .           .   .|||
RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTP

AFFA-PEMCLG--EDAFTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFE-------------LKLFEKIVNDPLKFP--TFKEIQSNK
.. | ||. .|   .... .  |   .     ... .|.|..|| || .| | .|| .| .              .||||| .    ||   |..|  | 
EYMAAPEVLNGKGHCNMQ-N-AT---DEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN-

VSKVSCEEEYEM-------------AKDLLLKLLEKNPQKRMTIPAIKKHPFV
.      .|.               .|||. |.|...|.|||||  ...||..
Y-----GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PAK1.AA Pkinase 133-448 24 1.5e-66 232.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 133-448
Range on HMM: 1-293/293
Sequence Identity: 24% (85 aa)

YEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRG---
|.|.. .| |  |.|...... . ..||.||......|  |  | ..           .||.|||...|...|.|...  |  ...||.|.|||  |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYV

-EVK----WCPPDCMESDAKGPSL-LSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTV----KISDFGVSLAASSTNSSDSSESLDELEL
 . .               .. .. .| .| . ... .. ||||.| .||||||.||.|.||. .|..    ||.|||..  ..      ... .. .  
MDLFDYIST---------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTF--

AKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSD------FELKLFEKIVNDPLKFPTFKEIQSN------
   .||| . ||| ..                 |. ..  .|.|..|..||..|.| .|| ..       .......|   ||.|. ....         
---CGTPWYMAPEVIR----------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH

--KVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
  .  ..   .  | .||.. ..|.|.|.|| |.. |..||..
WHF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK1.AA Ciliate-E2 133-448 22 8.7e-62 210.87 In-house 1-365 (365) Show / Hide 
Range on Protein: 133-448
Range on HMM: 1-365/365
Sequence Identity: 22% (92 aa)

YEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEK-------KQRKFFTFIKSSKISENDKIKREIAIMKKCH----------------HKHVVQLIE
|..|| .| |..|.|....... ....|||| | . .       |. ...  .|. | ..   ||.|| ||.. .                |.......|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESD-AKGPSL------LSFQETREILRGVVL---------------GLEYLHYQG-IIHRDIKPANLLIS
.  . .  .||||.|||. |. .    |....   | ..       .. .| ..| . ..                .||||| .. |||||||| |.|. 
CFQEKDDNNIYLVMEYCQGGDLF----DYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-

GDGTVKISDFGVS---------------------------------LAASSTNSSDSSESLDELELAKTVGTPAFFAPEMCLGED---AFTRYNLTKENL
    .||.||| |                                 .             . .     ..||| . |||.  |..               
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQ------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQ-----------

FRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNKVSKV-----SCEEEYEMAKDLLLK----LLEKNPQKRMT-IP
  .   ....|||..||.||..||| .||        ...| . ...|| .. .   .   .     | ..  . .|||. |    .|.|.|.||.| . 
QKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE

AIKKHPFV
 |..||. 
QILNHPWF
Kinase PAK1.AA CAMKL 133-337 30 2.9e-58 184.47 In-house 1-210 (297) Show / Hide 
Range on Protein: 133-337
Range on HMM: 1-210/297
Sequence Identity: 30% (73 aa)

YEIIKELGHGQHGKVKLARDILS-KQLVAIKIVDRHEKK-----------QRKFFTFIKSSKISENDKIKREIAIMKKCH---HKHVVQLIEVLDDLKS-
|.|.|.||.|  ||||||..|.  .. |||||.|.  ..           | .          |   .|.|||.|||. .   |.....| ||... .  
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH---------ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHD

---RKIYLVLEYCSRGE---VKWC---PPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDG--TVKISDFGVS-----L
    |||||.|||| ||     .    .             ..  |.| . | .| ...|.| .||.|||||| |.|.. .|  ..||.||| |      
IETKKIYLVMEYCSGGEMDLFDYIVKHGHRR--------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC

AASSTNSSDSSESLD--ELELAKTVGTPAFFAPEMCLG--E
              .  .  |    |.|.. |||...|  .
-------------IFGPGQKLKTFCGSPPYMAPEIFQGNNK
Kinase PAK1.AA Ciliate-E2-Unclassified 133-448 24 1.4e-57 197.61 In-house 1-352 (352) Show / Hide 
Range on Protein: 133-448
Range on HMM: 1-352/352
Sequence Identity: 24% (95 aa)

YEIIKELGHGQHGKVKLARDILSKQLV-----AIKIVDRH-EKKQRKFFTFIKSSKISENDK------IKREIA-IMKKCHHKHVVQLIEVLDDLKSRKI
|.||| .|.|..|||......  | ..     ..|| ...  ....|   .. . |. .| |      ....   |.. . | ..| ....  | .  .|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ--NI

YLVLEYCSRGEVKWCPPDCMESDAK----GP---------SLLSFQETR-----EILRGVVLGLEYLHYQG-IIHRDIKPANLLISGDG---TVKISDFG
|.|.|||  |. .    .....  |    |            .. |...      ... ...||||||... |||||||| |.|.. .|    .||.|||
YIVMEYCEGGDLW----QYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG

VSLAASSTNSSDSSE------SLDELELAKTVGTPAFF----APEMCLG-EDA---FTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFS-D
 |    . | .|  .       ... ..  ..||| .     |||.  | .     .                 ...|||..|| ||..||| .||.. .
ISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----------------YKCDIWSLGVILYEMLFGYYPFYDNN

FEL---------------KLFEKIVNDPLKFPTFKE----IQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
 |                 |...| . ...|| |..     ....  |  ..       ||| |.|.||| ||.|.. |..||. 
CEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN-------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase PAK1.AA AGC 256-448 25 5.4e-52 131.61 In-house 154-395 (395) Show / Hide 
Range on Protein: 256-448
Range on HMM: 154-395/395
Sequence Identity: 25% (68 aa)

E---ILRG-VVLGLEYLHY-QGIIHRD-IKPANLLISGDGTVKISDFGVSLAASSTNSSDSSESL-----------------------------------
|   |  | .||.|||||  .|||||| .|| |.|.  || .|..||| .    . .. ..  |                                    
EMQKI-CGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQE

-----DELELAKT-VG--TPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMIDIWA--VGVTLYCLLFGMLPFFSD----------FELKLFEKIV--
     .. ....| .|  || . |||.                       ..  |.|.  .|. .| .|.|  ||..|           . ..|.||   
DDTTRKKRDRTWTFCGPCTPEYMAPEIL---------------------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNG

----NDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMT----------IPAIKKHPFV
    |...|||  .. |. .....| |     ||||. |||.|.| || .          .  ||.||. 
RYFINWKVKFPFPEDPQFPEDRWFSPE-----AKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PAK1.AA Meta 133-299 40 5.6e-45 127.81 In-house 1-170 (287) Show / Hide 
Range on Protein: 133-299
Range on HMM: 1-170/287
Sequence Identity: 40% (74 aa)

YEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKS-----SKISEN---------DKIKREIAIMKKCHHKHVVQLIEVLDDLKSRK
|    |.| |  |.||||     ... |.|| .   ||  | . |..      .|  .          |.. .||||.||  |  || |.|||||     
YRLMEEIGKGSYGVVKLAYNEEDHHHYAMKILSK--KKLLKQYGFMRRPPPRGNKPNQGGCIQPRNPLDRVYQEIAILKKLDHPNVVKLVEVLDDPNEDY

IYLVLEYCSRGEVKWCPPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVS
.|.| ||  .|.|   | |           || .  . ..| .|.|||||||| |||||||| |||.. || ||| |||||
LYMVFEYVEKGPVMEVPCDNP---------LSEDQAWSYFRDIVCGLEYLHYQKIIHRDIKPSNLLLNDDGHVKIADFGVS
Kinase PAK1.AA Meta 361-448 41 1.8e-33 93.96 In-house 211-287 (287) Show / Hide 
Range on Protein: 361-448
Range on HMM: 211-287/287
Sequence Identity: 41% (37 aa)

DIWAVGVTLYCLLFGMLPFFS--DFELKLFEKIVNDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
|.|| ||||||..||  || .  .. . |..||.|.|..||   || |. .            ||. ...|.|||..| .|| || || |
DVWAMGVTLYCFVFGQCPFIDKTNYIMCLHDKIKNHPVMFPEQPEI-SEDL------------KDCIKRMLDKNPEHRIMIPEIKTHPWV
Kinase PAK1.AA CAMKK-Unclassified 133-231 35 5.5e-24 74.76 In-house 1-109 (392) Show / Hide 
Range on Protein: 133-231
Range on HMM: 1-109/392
Sequence Identity: 35% (39 aa)

YEIIKELGHGQHGKVKLARDILS-----KQLVAIKIVDRHEKKQRKFFTFIK--SSKIS-ENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYL--V
||....||.|. |||||| .        ..  |||.  .  .|..||.  .   ..|.  . . .. |||||||  |  .. | || ||    |||.  |
YEFLDKLGRGSFGKVKLATRRYTTDDGVQKQFAIKVFKKQKLKKKKFIYNDNAFTMKMKNRLHLVQQEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQV

LEYCSRGEV
.|||..| .
MEYCQMGQI
Kinase PAK1.AA CAMKK-Unclassified 361-448 33 1.8e-23 73.09 In-house 315-392 (392) Show / Hide 
Range on Protein: 361-448
Range on HMM: 315-392/392
Sequence Identity: 33% (30 aa)

DIWAVGVTLYCLLFGMLPFFSDFELKLFE-KIVNDPLKFPT-FKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
|||. |||.||. .. |||...   .||. .| .. ..||  ..   |            . .|||. |...||| || || .. .||..
DIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCS------------HEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase PAK1.AA CAMK1 133-230 25 1.3e-22 62.46 In-house 1-94 (276) Show / Hide 
Range on Protein: 133-230
Range on HMM: 1-94/276
Sequence Identity: 25% (28 aa)

YEIIKELGHGQHGKVKLARDILS---KQLVAIKIVDRHEKKQRKFFTFIKS-SKISEN---DKIKREIAIMKKC---HHKHVVQLIEVLDDLKSRKIYLV
||..||.| |  ..|.|. .. .   .. .|||. |             |.  | ...   .....||.||||.   .| ......|. ..   ...|||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK------------KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYES--DNHFYLV

LEYCSRGE
.|... ||
MELVTGGE
Kinase PAK1.AA CAMK1 252-333 32 8.7e-20 54.14 In-house 108-184 (276) Show / Hide 
Range on Protein: 252-333
Range on HMM: 108-184/276
Sequence Identity: 32% (29 aa)

QETREILRGVVLGLEYLHYQGIIHRDIKPANLL---ISGDGTVK--ISDFGVSLAASST-NSSDSSESLDELELAKTVGTPAFFAPEM
.. |.| . ..  .||.|..|| |||.|| |||   .. | ..|  |.||| |   ..  |            . . .||| . |||.
KDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN-----------LMKTACGTPGYVAPEV
Kinase PAK1.AA CAMKK-Unclassified 249-334 26 9.5e-20 60.73 In-house 175-277 (392) Show / Hide 
Range on Protein: 249-334
Range on HMM: 175-277/392
Sequence Identity: 26% (30 aa)

LSFQETREILRGVVLGLEYLHYQG---------------------IIHRDIKPANLLISGDGT-----VKISDFGVSLAASSTNSSDSSESLDELE-LAK
.. |  ... |.. .|| |.| ..                     |||||||| |.||. ...     .||.|||.|.  ..          .. . |  
MHEQYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEH----------EQQKKLKN

TVGTPAFFAPEMC
. ||..| ||| .
NAGTYCFMAPEFW
Kinase PAK1.AA CAMK1 360-448 31 2.5e-19 52.8 In-house 197-276 (276) Show / Hide 
Range on Protein: 360-448
Range on HMM: 197-276/276
Sequence Identity: 31% (29 aa)

IDIWAVGVTLYCLLFGMLPFFSDF-ELKLFEKIVNDPLKFPTF--KEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
.|.| .|| .| ||.|  ||...  . .||||| . .. ||..   .| .              |||.. ..||..|.|| |.  . .||..
CDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQE------------AKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase PAK1.AA AGC 133-227 19 7.9e-17 38.58 In-house 1-116 (395) Show / Hide 
Range on Protein: 133-227
Range on HMM: 1-116/395
Sequence Identity: 19% (24 aa)

YEIIKELGHGQHGKVKLARDI------LSKQLVAIKIVDRHEKKQRKFFTFIKSSKIS--ENDKIKRE------------IAIMKKCH----------HK
.|..| .| |  ||| |.|.        .... |.|...  .          |  ..   . .....|              |..||.          | 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKH----------KIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHP

HVVQ-LIEVLDDLKSRKIYLVLEYCS
 .|. |     | . ...|.|.||..
FIVKILHYSFQDKDHTYLYFVMEYMP
Kinase PAK1.AA TyrKc 133-448 21 1.7e-13 -4.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 133-448
Range on HMM: 1-280/280
Sequence Identity: 21% (71 aa)

YEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKC--HHKHVVQLIEVLDDLKS-------RKIYLVL
 . .|.||.|. |.| ... .   . ||.| .  .                     . ||. ||.|   ||...|.|. |   ...         ...|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------------REDFMREARIMCKLGGHHPNIVRLYGVC--TQQGRNFMYIEPLMIVM

EYCSRGEVKWCPPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVSLAASST-NSSDSSESLDELE--LA
||.. |  |    |   .  .    |. ..  ..   .  | |||| ...||||.   | |.. ..|||||||| | .  .  ..  |..  .  |   .
EYMPHGDLK----DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

KTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLL-FGMLPFFSD----FELKLFEKIVNDPLKFPTFKE---IQSNKVSKV
||.      |||              ... |     ..  |.|. ||... .. .|. |   .     . .   . | .    |  ..   . .     |
KTMLPIRWMAPECI------------NYGKF-----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-----V

SCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFV
 | .  || . . ..  . .| .| |  .|  | . 
CCPD--EMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase PAK1.AA CAMKL 421-448 46 1.6e-10 29.66 In-house 270-297 (297) Show / Hide 
Range on Protein: 421-448
Range on HMM: 270-297/297
Sequence Identity: 46% (13 aa)

AKDLLLKLLEKNPQKRMTIPAIKKHPFV
..||. |.|..|| ||.||  |..||..
CRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PAK1.AA Pkinase_Tyr 133-229 25 1.9e-09 32.59 Pfam 1-92 (270) Show / Hide 
Range on Protein: 133-229
Range on HMM: 1-92/270
Sequence Identity: 25% (27 aa)

YEIIKELGHGQHGKVKLARDI----LSKQLVAIKIVDRHEKKQRKFFTFIKSSKISE--NDKIKREIAIMKKC-HHKHVVQLIEVLDDLKSR-KIYLVLE
 ...|.||.|. |.|....        |. ||.|.. .             ..  ..   ..  ||..|||.  ||...|.|. |  | .   .||.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K------------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVME

YCSRG
|.  |
YMPHG
Kinase PAK1.AA Pkinase_Tyr 264-299 44 4.7e-07 24.52 Pfam 123-158 (270) Show / Hide 
Range on Protein: 264-299
Range on HMM: 123-158/270
Sequence Identity: 44% (16 aa)

GLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVS
|.|||. ...||||.   | |.. ...|||.||| .
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase PAK1.AA CAMKL 360-404 30 3e-06 15.99 In-house 217-267 (297) Show / Hide 
Range on Protein: 360-404
Range on HMM: 217-267/297
Sequence Identity: 30% (16 aa)

IDIWAVGVTLYCLLFGMLPFFSD--------FELKLFEKIVNDPLKFPTFKEI
.|||. ||.|| ...| |||  |           .|..||  .  ..| ....
VDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHV
Kinase PAK1.AA Meta 322-337 68 0.000107 9.41 In-house 185-200 (287) Show / Hide 
Range on Protein: 322-337
Range on HMM: 185-200/287
Sequence Identity: 68% (11 aa)

TVGTPAFFAPEMCLGE
|.||||| ||| |. |
TAGTPAFMAPEACSEE