Gene STE7 (Bakers Yeast)

STE7

Species: Bakers Yeast
Alias: STE7
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
STE7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON
STE7.AA Protein Refseq_NP 515 `Serine/threonine/tyrosine protein kinase of the pheromone pathway, homologous to MAP kinase kinase family; Ste7p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of STE7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase STE7.AA STE7-Unclassified 191-466 44 1.2e-172 579.88 In-house 1-301 (301) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-301/301
Sequence Identity: 44% (136 aa)

LVQLGKIGAGNSGTVVKALHVP------DSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILS
|..|...|.|..|||||.||..      |.||.|.|.||...|......|..|||.......||..|...|||||.......|.|.|||.||||||....
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSI--ADTFVGTSTYMSPERIQGN---
.||....||..  ...|..|....||||.|..||..|.....||||||||.|.|.|||||.|.|||||...|.|..  |.|.||...|||||||||.   
IYKKMYERGPI--RGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPH

--VYSIKGDVWSLGLMIIELVTGEFPLG------GHNDTPD----GILDLLQRIVNEPSPRLPKDR---IYSKEMTDFVNRCCIKNERERSSIHELLH-H
  .||.|.|.|||||.|.|..||..|..      ..|....    ....||..|||.|.||||.|.   |.|||..||...||.|..|||..||.||. |
RPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEH

DLI
..|
PWI
Kinase STE7.AA STE7 191-466 40 3e-152 512.11 In-house 1-288 (288) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-288/288
Sequence Identity: 40% (121 aa)

LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFV
|...|..|.||.|.| |..|.|..|| | |.|....|.... .|...|| .... .....|..||||.|... .. | | ||| |.|.|||.....|...
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDC-IWICMEYMDGGCLDKFYKRVKKVY

QRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSI--ADTFVGTSTYMSPERIQG--NVYSIKGD
 || .  ||....|  . |||. |..||..|....||||||.||||.|.||.||.||||||....|..|.  | ||||...||.||||.|  . |... |
-RG-I--KKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSD

VWSLGLMI-IELVTGEFPLG----------GHNDTPD---GILDLLQRIVNE-PSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLH-HDLI
|||||... ||..||..|..           .|....   .|...|. |||| |.||||   ..|.|..||||.|..|...|| ..|.|.. |. |
VWSLGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase STE7.AA STE 191-466 28 5.7e-100 338.42 In-house 1-359 (359) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-359/359
Sequence Identity: 28% (105 aa)

LVQLGKIGAGNSGTVVKALHV------PDSKI---------VAKKTIPVEQNNS---------------TIINQLVRELSIVKNVKP-HENIITFYGAYY
.  ..||| |..|||.||...      .  ..         .| | ...|..|.               ....|. .|..| |. .. |.||...||.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

N----QHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSK-KTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSK
.    .. ..|. | ||| | ||||.|.  ..   .. . ... ...|.|  |..|.. .| || ..  . .||||||||.|.|.     .|||||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLINSIA--------------D----TFVGTSTYMSPERIQG------NVYSIKGDVWSLGLMIIELVTGEFPLGGHNDT------PDGI-----LDLLQ
.|..|.|              .    |||||  .|.||.||.      . |..| |.||||..|||..||. |.   ...      |...     ...| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

RIVNEPSPRLPKD-----------------RIYSKEMTDFVNRCCIKNERERSSIHELLH--HDLI
 |||.|.|.|| .                 . .|.|. ||.|.|..|. ..| . ..||.  |  |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase STE7.AA Pkinase 191-466 29 5.4e-94 323.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVR--ELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCG----SLDKILS
.. ..|||.|..|.| |. |. ..|||| |.|... ..|    ...|  |..| |..  |.||...|.....   ...| . ||| ..|    .|  ..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYIS

VYKRFVQRGTVSSKKTWF--NELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQI----KLCDFGVSK---KLINSIADTFVGTSTYMSPER
.           .....|   | .. ...| .| ||...... .|||||.||.|.||...|.|    |.||||..|      || ..||.||. ||.|| 
T-----------WRHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

IQ-GNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYS---------------------KEMTDFVNRCCIKNERE
|. |. |. | |.||.|....|...|..|  ||. ..|. .| .|.|..  .|.|. |. ..                     .|. ||...|. |.  .
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RSSIHELLHHDLI
| .....|.|. .
RPTAEQILQHPWF
Kinase STE7.AA S_TKc 191-466 27 4.7e-71 243.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDC--GSLDKILSVYKR
   | ||| |  |.| |. |. . .||| | |.         ... ||..| |.   |.||...|.....    ... . ||| |   |.| ...  ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR

FVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVYSI-KGDV
   |        .|.| .. ...| ....|... .. .|||||.||.|.|...  .||.||||....|     .||.||  ||.|| .    |.  | |.
HGLR-------FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLH-------HDLI
||.| ...|...|. |          .  ....|.             |.|. ||...|. |. ..| .. |.|.       |  .
WSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase STE7.AA MEK5 191-466 39 9.6e-65 221.4 In-house 1-254 (254) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-254/254
Sequence Identity: 39% (109 aa)

LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFV
.     .| || ||| || |||  ||.| | | ..     .  |.. || |.        || ||||..   . | | |  |. | ||||    .|..  
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDI-TLELQKQIMSELEILYKCD-SPYIIGFYGAFF---VENRISICTEFMDGGSLD----MYRCIP

QRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVYSIKGDVWSL
             |  . ...  .  ||  |. . ||.|||.||||.|.| .||||||||||| .|.|||. |..||  || |||| |. | |  |||||
-------------EHILGRMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSL

GLMIIELVTGEFPLGGHNDTP--DGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLI
|....|. || ||    .        . ||| ||.| .|||| |. .|.   .|.|.|  |  ..|   ..|. |  |
GIFFMEMATGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDK-FSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase STE7.AA STE20 191-466 33 9.4e-64 218.11 In-house 1-288 (288) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-288/288
Sequence Identity: 33% (102 aa)

LVQLGKIGAGNSGTVVKALHVPDSKI----VAKKTIPVEQNNS--TIINQLVRELSIVKNVKPHENIITFYGAYYNQHIN-NEIIILMEYSDCGSLDKIL
   | ||| |..|.| || |.|  ..    || | ...|. .     .. .. | || |. | |.||...||.|.  . . .|. |.||| . |||  |.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

S---VYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLIN----SIA---DTFVGTSTYMSP
.   . ..  . |      . .||  |. | ..|| |||.| .. .|||||||  |.|....|..||.||||. .|..    ...   .|||||  .|.|
KHCMKCGKNHK-G------HPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAP

ERIQG-----NVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIV--NEPSPRLPK--DRIYSKEMTDFVNRCCIKNERERSSIHELLHHD
| ||.     . |  | |.|||| ..||...|| |.  ..  |   .  . .|   ..|.|.| .   . .|.|  |||..|  |.  .| .  .||.| 
EVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPY--FDMHP---MRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHP

LI
 |
FI
Kinase STE7.AA MEK1 191-404 43 3.4e-62 211.23 In-house 1-196 (297) Show / Hide 
Range on Protein: 191-404
Range on HMM: 1-196/297
Sequence Identity: 43% (93 aa)

LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVK-PHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRF
. ..| .|.|| | |.|. | .   |.|.| | .|   . | ||..||| .. .   |.  |. ||||.|.   ..|| | ||| | |||| .|   .| 
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPA-IRNQIIRELQVLHECNSPY--IVGFYGAFYS---DGEISICMEYMDGGSLDQVLKKAGRI

VQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVYSIKGDVWS
              |  . |..  || ||  |  ..||.|||.||||.|.||.| ||||||||| .|| |.|  ||||  ||||||.||  |... |.||
P-------------EKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWS

LGLMIIELVTGEFPL
.|| ..|.. | .|.
MGLSLVEMAIGRYPI
Kinase STE7.AA MEK4 298-466 36 2.8e-59 192.06 In-house 101-275 (275) Show / Hide 
Range on Protein: 298-466
Range on HMM: 101-275/275
Sequence Identity: 36% (65 aa)

KKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTF-VGTSTYMSPERIQG--NV--YSIKGDVWSLGL
.|.  .|  . .|.. . . |..| .. ||||||.||||.|.. .| .||||||..  | .||| |  .|   || ||||.   |   | |. |||||| 
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

MIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRI---YSKEMTDFVNRCCIKNERERSSIHELLHHDLI
 ..|. ||.||  . || .  ..| .. .|.  .|.| .|     ||..| .|.| | .|....| .  .|. .. .
TMYEVATGKFPYRKWNDAS--VFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase STE7.AA MEK3 307-466 42 3.1e-56 189.76 In-house 104-264 (264) Show / Hide 
Range on Protein: 307-466
Range on HMM: 104-264/264
Sequence Identity: 42% (70 aa)

ISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTF-VGTSTYMSPERI--QGNV--YSIKGDVWSLGLMIIELVTGE
..|||  .  .| ..  | |.||||.|||||||| .||.|.||||.|  |..|.| |   |   || ||||  ..|   |..| ||||||  .||. .| 
LGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMAIGR

FPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLI
.|     .      . |. .| ||.|.||... .| .. ||.|.|  ||  || |  ||. |  .
YPYDNWHT----PFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase STE7.AA ULK 191-466 25 3.2e-53 183.13 In-house 1-324 (324) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-324/324
Sequence Identity: 25% (85 aa)

LVQLGKIGAGNSG-TVVKALHVPD---SKIVAKKTIP---VEQNNST-----IINQLVRELSIVKNVK--PHEN--IITFYGAYYNQHINNEIIILMEYS
 .   ..| |  | .| |. .. .    ..|| | |.     ....      ....| .| .|.|  |   |.|  |. .|  .....  | | | ||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH-NNIYIIMEYC

DCGSLDKILSVYKR----FVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSK------------GQIKLCDFGVSKKLIN
..| |....  .|.             .|  ..|  . .. .  .||. .|. . .||||||||.| ||. .            |..|..||| .|.. |
NGGDLEQYIKKNKKLPETE--------EKKRLSEQEAIQFFKQICNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

-----SIADTFV------GTSTYMSPERIQGN-----VYSIKGDVWSLGLMIIELVTGEFP--LGGHNDTPDGILDLLQR------IVNEPSPRLP---K
      .  |.|      ||  ||.|. .||.      |..| |.|||| .. |...|. |      ||. ..| .|..       ...    . |   |
NNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPK

DRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLI
| . |.|. |.  |. ...|..| |..|...| ..
DPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase STE7.AA ULK 191-466 25 1.7e-52 180.74 In-house 1-329 (329) Show / Hide 
Range on Protein: 191-466
Range on HMM: 1-329/329
Sequence Identity: 25% (87 aa)

LVQLGKIGAGNSGTVVKALHVPD----SKIVAKKTIP-----VEQNNST---IINQLVRELSIVKNVK-------PHENIITFYGAYYNQHINNEIIILM
 .   ..| |  |.| |. .. .     ..|| | |.      ..|...   ....| .|  | |  |        |.||. .|  .....  | | | |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-NNIYIIM

EYSDCGSLDKILSVYKR-----FVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSK------------GQIKLCDFGVSK
|| . | |..... .|.              .|  ..|  . .. .  |||. .|. . .||||||||.|.||. .            |..|..||| .|
EYCNGGDLEQYIKKNKKLPEDTE--------EKKRLSEQEAIQFFKQILNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

KLINS-----IADTFV------GTSTYMSPERIQGN-----VYSIKGDVWSLGLMIIELVTGEFP--LGGHNDTPDGILDLLQRI-------VNEPSPRL
.. |.     .. |.|      ||  ||.|. .||.      |. | |.|||| .. |...|. |      ||. . |.  | ..       ..   .. 
HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQF

P---KDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLI
|   .| . |.|. |.  |. ...|..| |..||..| ..
PKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase STE7.AA Pkinase_Tyr 191-406 25 5e-20 68.45 Pfam 1-218 (270) Show / Hide 
Range on Protein: 191-406
Range on HMM: 1-218/270
Sequence Identity: 25% (59 aa)

LVQLGKIGAGNSGTVVKALHV----PDSKIVAKKTIPVEQNNSTI--INQLVRELSIVKNVKPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILS
.. . |.|.|. |.|.|.        .   || |..  |.  .    .  . ||..| |.   |.||. .||. . |   |.|.| |||  .|.|.. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTST-------YMSPERIQ
  .         . |  ..  .. .... . .|...| .. ..||||.   |.|.......| |||| .. .  .     . ...        |.|| |.
KHR---------EDKQPLTMKDLLQMCWQIAKGMEYLESK-NCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECIN

GNVYSIKGDVWSLGLMIIELVT-GEFP-LGG
 .....| |||| |  . |..| || |   |
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG
Kinase STE7.AA TyrKc 191-465 19 2.4e-17 57.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-465
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNV-KPHENIITFYGAYYNQHIN----NEIIILMEYSDCGSLDKILSV
.. . |.| |. |.|.|.        || |..  .      .  . ||..| ... . |.||. .||.   |  |      . |.||| . |.|.. |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKL-----------INSI----ADTFVGTSTY
...             ..  .  .... . .| ..| .. ..||||.   |.|.......| .||| |...             .        ..     
HRPK------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLGGH---NDTPDGILDLLQRIVNEPSPRLPKDRI------YSKEMTDFVNRCCIKNERERSSIHELL
|.|| |. .....| |||| | .. |. |   .       .  .    ...... .   .. |..         ..|| .   .|.  .  .| .  |. 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

HHDL
|...
HECF
Kinase STE7.AA MEK1 414-466 47 1.5e-14 45.68 In-house 246-297 (297) Show / Hide 
Range on Protein: 414-466
Range on HMM: 246-297/297
Sequence Identity: 47% (25 aa)

ILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHDLI
| ..|. ||||| |.||. |..|.|. |||. | |||  ||  . .|. |  |
IFEMLDYIVNEPPPKLPH-RVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase STE7.AA MEK4 191-260 32 2.6e-10 29.69 In-house 1-75 (275) Show / Hide 
Range on Protein: 191-260
Range on HMM: 1-75/275
Sequence Identity: 32% (24 aa)

LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNN-----STIINQLVRELSIVKNVKPHENIITFYGAYYN
|  ||.||.|. ||| | .| .  ||.| | | .  .           .| .|.  |.  .   .|. |||| ..
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFK