Gene TPK1 (Bakers Yeast)

TPK1

Species: Bakers Yeast
Alias: TPK1
External Links: Saccharomyces Genome Database Link
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
TPK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
TPK1.AA Protein Refseq_NP 397 putative catalytic subunit of cAMP-dependent protein kinase; Tpk1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of TPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TPK1.AA PKA 87-341 61 2e-198 665.46 In-house 1-263 (263) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-263/263
Sequence Identity: 61% (161 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIR-MWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNP
|.|..||||||||||.|.|..|.|.|||||.|||. .||||||||...|. .|. ..||||.. |..||||.....|.|.|..|||.|| ||||.||.||
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

VAKFYAA-EVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTK-PYNKSIDWWSFGILIYEMLAGYTPFY
.|||||| ...||||||||..||||||||||||.|||||||||||||||.| |.|.||||||.|.|||....| ...||.|||..|||||||||||.|||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY

DS--NTMKTYEKILNAELRFPPFFNEDV---KDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF
|.  ..|..||||.|....||..|. |.   |||...|...||..|.||..||..|.|||.||
DHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase TPK1.AA AGC 87-341 34 4.6e-190 496.88 In-house 1-395 (395) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-395/395
Sequence Identity: 34% (136 aa)

FQILRTLGTGSFGRVHLIRSRH------NGRYYAMKVLKKEI-VVRLK--QVEHTNDE------------RLMLSIVT----------HPFIIR-MWGTF
|..|...|.||||.|.| | ..      .|.|||||||||.  .|..|  .||||. |            | .|. .           ||||.. .. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDAQQ--IFMIMDYIE---------GG-ELFSLLR---KSQRFPNPVAKFYAAE-------VCLALEYLHS-KDIIYRD-LKPENILLDKNGHIKITDFG
|| .   ....|.|..         || |||. |.   |..||. ..|.|||||       ..|||||||| ..||.|| |||||||||..||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKYVP-----------------------------------------------------DVTYTLCG--TPDYIAPEVVSTKPYNKSIDWWS--FGILIY
..| ..                                                     | |.|.||  ||.|.|||..    |.|. ||||  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAGYTPFYDSN----------TMKTYEKIL------NAELRFP----------PFFNEDVKDLLSRLITRDLSQRLGNLQN-----GTEDVKNHPWF
|||.||.|||. |           |....||.      | ...||          ..| .. |||...|...| ..|||...|     |.|..||||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase TPK1.AA Akt 87-341 45 4.2e-130 418.13 In-house 1-264 (264) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-264/264
Sequence Identity: 45% (120 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYY-AMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNP
|..|. || ||||.| | .   ....| |||||||.  .  .|||||  || .|  . ||||. .   ||... ....|||. |||||..|.. .||. .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

VAKFYAAEVCLALEYLHSKDIIYRD-LKPENILLDKNGHIKITDFGFAK-Y-VPD--VTYTLCGTPDYIAPEVVSTKPYNKSIDWWS-FGILIYEMLAGY
 |.||.||. ||.|.||||.||||| |||||||.||.|||..|||| .|   . |  .|.|.|||| |.|||. . . . |. |||. .|...|||. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFYDSNTMKTYEKILNAELRFP--PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF
 |||. .  . ..||.|....||  ...  . |||.|.| ..| ..|||.  |.....|.||||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase TPK1.AA SGK 87-341 40 4.1e-129 401.05 In-house 1-283 (283) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-283/283
Sequence Identity: 40% (115 aa)

FQILRTLGTGSFGRVHLIRSRHN------------------GRYYAMKVLKKEIVV-------RLKQVEHTNDER-LMLSIVTHPFIIRMWGTFQDAQQI
|..| ..| ||||.| . .                      .  ||||||.|. ..       . |.. |.  ||   |. . ||||.     || ..  
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK---YVPDVTYTLCGTPDYIAPEVVSTK
.. |||..|||.|. |.. ..|| ..|.|||||. .|||||||.|||||||||||||||  ||...|||| .|      | | | |||| | ||||   .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF
|. .. |||. |.. |||. |  |||. |.   |..|.| .|..||..  | .||.  | ..| ..|||   .. ...||||.|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase TPK1.AA AktR 87-341 44 6.7e-128 431.2 In-house 1-268 (268) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-268/268
Sequence Identity: 44% (120 aa)

FQILRTLGTGSFGRVHLIRSR-HNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLS-IVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPN
|.... || | ||.| | . .  |...||||..||.  ....| .||  ||  .  .. ||||...  .||.  ..| ||.|..|||||. |.|...| .
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PVAKFYAAEVCLALEYLHSK-DIIYRDLKPENILLDKNGHIKITDFGFAK--YV---PDVTYTLCGTPDYIAPEVVST-KPYNKSIDWWSFGILIYEMLA
 .|.||.|...|||||||.. .||||||||||||||..||.|||||| .|   .    ...|..|||| |.|||..   |..|||.|||.|||.||||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GYTPFYDSNTMKTYEKILNAE-LRFPPF--FNEDVKDLLS-RLITRDLSQRLGNLQNGTEDVKNHPWF
|..|||..|.   ..||.. . ..||.   | .  |||.  .|  ..  .|||   ||.|..|.||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase TPK1.AA RSK 90-341 41 4.4e-114 385.32 In-house 1-278 (278) Show / Hide 
Range on Protein: 90-341
Range on HMM: 1-278/278
Sequence Identity: 41% (116 aa)

LRTLGTGSFGRVHLIRSR---HNGRYYAMKVLKK-EIVVRLKQVEHTNDERLMLSIVT-HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQR---
|. ||.|..| | | |      .|..|||||||| .||.| | ..||  ||  |. .. ||||..   .||. . ...||.|..|||||  |.| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDK---NGHIKITDFGFAKY-VPD---VTYTLCGTPDYIAPEVVS---TKP-YNKSIDWWSFGI
|    |.||.||. ||.|.||...||.|||||||||.|    .||||.|||||.|. ..|    |.| |.| .|.|||..     .  ..|. ||||.|.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMLAGYTPFYD---SNTMKTYEKILNAE--LRFP--PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF
|.||||.|..||.    .|  .. ..|....  |..|  ..  .. |||.... .|| ..|||   ...|..|.||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase TPK1.AA S_TKc 87-341 38 2.6e-111 377.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-231/231
Sequence Identity: 38% (103 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEG--GELFSLLRKSQR---
..|||..| |.||.|.. | .. ||..|.|..|          ||.  |. .|.   ||.|... ..||| . ..|.|.|..|  |.||....| .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNK-SIDWWSFGILIYEMLA
   ||  .|.||....|.||||.||. ||.|||||||||||.  ||||.|||.|. .    .|.||||.|.||||.   .|.| ..||||.|...||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGT--EDVKNHPWF
||.||.  . .....||.           ...||..... ..| ..|..  .  .  .|.|.||||
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TPK1.AA Aur 144-341 41 8.3e-109 288.16 In-house 58-257 (257) Show / Hide 
Range on Protein: 144-341
Range on HMM: 58-257/257
Sequence Identity: 41% (85 aa)

HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKS--QRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLD-KNGHIKITDFGFAKYVPDVTY
|| |..| | |.|.| |. |..| .||||...|.|.  .||. . | .| ...|.||.|.|||.|| ||.|||||||| .|| ||| ||| . . |.  .
HPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPN--N

----TLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYD-SNTMKTYEKIL-NAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTED
    |.||| ||..||.|. .......| |..|.|.||.. |. ||.  .|...||..|. . ...||... ...||| |..  .| .||. .|    ..
NRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRM-TL----DQ

VKNHPWF
..||||.
IMNHPWI
Kinase TPK1.AA RSK 87-341 40 1.1e-101 344.11 In-house 1-271 (271) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-271/271
Sequence Identity: 40% (109 aa)

FQILRTLGTGSFG---RVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFP
. ... .|.|||.    .. .. . ....||||..||  ..   .   .  || .|. . ||||..    |||.....||||  .||.||  | |   |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

NPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKN----GHIKITDFGFAKYVPD---VTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEML
   .|||.||. ||.|||||..|..|||||||||.|      |||||.|||||| . |    ..| |.|  |.||||.. . . .. ||||||.| ||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

AGYTPFYDSNTMKTYEKILNAELRF-------PPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF
.|.|||.  .   . ..|... |         . |  .  ||||... .||  .|||.  ||.|..|.||||
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase TPK1.AA PKC 87-341 40 3.7e-101 328.66 In-house 1-262 (262) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-262/262
Sequence Identity: 40% (106 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT-HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNP
|. |. || |||| | | ... . .|||.|||||....    || |  |.  |.  . |||   .  .||    .| .| |..|| |     ...||. .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

VAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK---YVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPF
.|.|||||...|| .||.|.||||||| .|.|||. |||||.||| .|   .  | | | ||||||||||... ..|.||.|||.||.| |||.||  ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNG---TEDVKNHPWF
   .     . |.. . ..|  . .. ..... . |.. ..|||  . .   ..|.. || |
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase TPK1.AA p70 87-341 36 1.5e-97 330.41 In-house 1-299 (299) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-299/299
Sequence Identity: 36% (109 aa)

FQILRTLGTGSFGRVHLIRSRH---NGRYYAMKVLKK-EIVVRLKQVEHTN-------------------------DERLMLSIVTHPFIIRMWGTFQDA
|. |. || | .| | ..|      .|..||||||.| .||   |  .||                          .||  |. | ||||.     ||. 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

QQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV---PDV----------TYTLCG
   . | .|. ||||| .| .   ..  .|.||..|. .|||.||...||||||||||..|.. ||.. ||||  |.      |          |.|.||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAE--LRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF
|. | |||... . .|. .|||| |.|.| || |  ||  .|  || .||| .   |. ||   .. .||. .|. |. .||.|   .  .|.. ||.|
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase TPK1.AA Pkinase 87-341 33 2e-94 324.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 87-341
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTN--DERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGG----ELFSLLR--K
..|.|..| ||||.| . . . .|. .|.|..||.     |...|..    ..|...  ||.|.|....|.| . | |.|.| |||    .||....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SQRF--PNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHI----KITDFGFAK---YVPDVTYTLCGTPDYIAPEVVS-TKPYNKSIDWWSF
. .|  .  ..|||. ... .|||.||. ||.|||||||||.|.||||    ||.|||.||   | .....|.||||.|.||||.   ..| ...|.||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILIYEMLAGYTPFYDS------NTMKTYEKILNAELRFPPFFN---------------------EDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF
|...|||| |..||...      . |. ...|. ..|.|. .                       |. ||........| ..|..      |....||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase TPK1.AA Aur 87-121 42 1.9e-16 39.42 In-house 1-35 (257) Show / Hide 
Range on Protein: 87-121
Range on HMM: 1-35/257
Sequence Identity: 42% (15 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKE
|.| . || |.||.|.|.| .. .  .|.||..||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKE
Kinase TPK1.AA TyrKc 87-325 19 2.9e-16 40.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 87-325
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV--THPFIIRMWGTFQDA-------QQIFMIMDYIEGGELFSLLR
 . ...|| | ||.|.. . .   .  | |.||..    ..   .   |  ... .   || |.|. |   .        ......| | ..| | . ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMR---EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSQR-FPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDV-------TYTLC----GTPD-----YIAPEVVSTKPYN
|... ....    ..  ..   |||||| .| |||   |.|...|...||.||| .... |         |       |. .       |||.  .. ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSIDWWSFGILIYEMLA-GYTPFYD-----SNTMKTYEKILNAELRFPPFF---------NEDVKDLLSRLITR---------DLSQRL
   | ||||....|..  | .| ..      .    .|.. . . . .|            ... .. ..   .         .. ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TPK1.AA S_TK_X 342-397 22 8.6e-15 56.38 SMART 1-79 (79) Show / Hide 
Range on Protein: 342-397
Range on HMM: 1-79/79
Sequence Identity: 22% (18 aa)

KEVVWEKLLS--RNIETPYEPPIQQ---GQGDTSQFD-KYPEEDINYGVQGE-----------------DPYADLFRDF
... |.||..  ..|| |. |.|..   ...|||.|| ...||.. . .. .                 ||..... .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase TPK1.AA Pkinase_Tyr 87-241 26 4.3e-14 48.35 Pfam 1-169 (270) Show / Hide 
Range on Protein: 87-241
Range on HMM: 1-169/270
Sequence Identity: 26% (47 aa)

FQILRTLGTGSFGRVHLIRSRHNGRYY----------AMKVLKKEIVVRLK--QVEHTNDERLMLSIV-THPFIIRMWGTFQ-DAQQ--IFMIMDYIEGG
 .....|| |.||.|..      |...          | |.| ||        . .  . |  ...    || |.|. |    . ..  |...| | ..|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

ELFSLLRK----SQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV-PDVTY-T
 | . |||     |... .    ...... ..|||.|| .| |||   |.|...|...||.||| |... .| .| .
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYR
Kinase TPK1.AA Pkinase_Tyr 266-294 35 0.013463 9.42 Pfam 198-228 (270) Show / Hide 
Range on Protein: 266-294
Range on HMM: 198-228/270
Sequence Identity: 35% (11 aa)

WSFGILIYEMLA-GYTP-FYDSNTMKTYEKI
||||.|..|..  | .| ...      ||.|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI