Gene TPK2 (Bakers Yeast)

TPK2

Species: Bakers Yeast
Alias: TPK2
External Links: Saccharomyces Genome Database Link
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
TPK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
TPK2.AA Protein Refseq_NP 380 Involved in nutrient control of cell growth and division; Tpk2p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of TPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TPK2.AA PKA 70-324 61 1.4e-199 669.28 In-house 1-263 (263) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-263/263
Sequence Identity: 61% (162 aa)

FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIR-MWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNP
|.|..||||||||||.|.|. |.|.|||.|.||||..|..|||||...|...|....|||... |..||||.|...|||.|..|||.|| ||||.||.||
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

VAKFYAA-EVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVITTK-PYNKSVDWWSLGVLIYEMLAGYTPFY
.|||||| ...|||||||..|||||||||||||.|.|||||||||||||.|...||||||||.|.|||.|..| ...||||||.||.|||||||||.|||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY

DT--TPMKTYEKILQGKVVYPPYFHPDV---VDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
|.  .||..||||..||. .|..|..|.    ||..||...|||.|.||...|..||| |.||
DHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase TPK2.AA AGC 70-324 33 4e-191 499.69 In-house 1-395 (395) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-395/395
Sequence Identity: 33% (134 aa)

FQIMRTLGTGSFGRVHLVRSVH------NGRYYAIKVLKKQQ-VVKMK--QVEHTNDE------------RRMLKLVE----------HPFLIR-MWGTF
|.. ...|.||||.|.||| ..      .|.|||.|||||.  .|..|  .||||. |            |..|...           |||... .. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDARN--IFMVMDYIE---------GG-ELFSLLR---KSQRFPNPVAKFYAAE-------VILALEYLHA-HNIIYRD-LKPENILLDRNGHIKITDFG
|| ..  ...||.|..         || |||. |.   |..||. ..|.|||||       ..|||||||  ..||.|| |||||||||..||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKEVQT-----------------------------------------------------VTWTLCG--TPDYIAPEVITTKPYNKSVDWWS--LGVLIY
..||. .                                                      |||.||  ||.|.|||..    |.|..||||  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAGYTPFYDTT----------PMKTYEKIL------QGKVVYP----------PYFHPDVVDLLSKLITADLTRRIGNLQS-----GSRDIKAHPWF
|||.||.|||. .          ||....||.      . || .|          ..| |. .||..||.. | ..|.|....     |  .||.||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase TPK2.AA Akt 70-324 44 1.9e-129 416.01 In-house 1-264 (264) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-264/264
Sequence Identity: 44% (117 aa)

FQIMRTLGTGSFGRVHLVRSVHNGRYY-AIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNP
|.. . || ||||.| ||.   ....| |.|||||.. ....|||||  ||..|. . |||.. .   ||.. ....||||. |||||..|.. .||. .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

VAKFYAAEVILALEYLHAHNIIYRD-LKPENILLDRNGHIKITDFGFAK-E-VQT--VTWTLCGTPDYIAPEVITTKPYNKSVDWWS-LGVLIYEMLAGY
 |.||.||.|||.|.|| .|||||| |||||||.|..|||..|||| .| . ..   .| |.|||| |.|||..  . . |.||||. ||...|||. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFYDTTPMKTYEKILQGKVVYP--PYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
 |||.    . ..||....| .|  ... |.  ||.|.| . | ..| |.  .. ..||.||||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase TPK2.AA SGK 70-324 39 5.8e-126 391.15 In-house 1-283 (283) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-283/283
Sequence Identity: 39% (112 aa)

FQIMRTLGTGSFGRVHLVRSVHN------------------GRYYAIKVLKKQQVV-------KMKQVEHTNDER-RMLKLVEHPFLIRMWGTFQDARNI
|... ..| ||||.| .|. .                    .  ||.|||.||...       | |.. |.  ||   ||.. |||..     || .   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAK---EVQTVTWTLCGTPDYIAPEVITTK
..||||..|||.|. |.. ..|| ..|.|||||...||||||  .||||||||||||||  ||...|||| .|   . .. | | |||| | ||||.  .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

PYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
|. ..||||.|| . |||. |  |||.      |..|. ..   ||.. .|  ||.  | . | . | |    ....|| ||.|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase TPK2.AA AktR 70-324 45 3.5e-118 398.93 In-house 1-268 (268) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-268/268
Sequence Identity: 45% (121 aa)

FQIMRTLGTGSFGRVHLVRSV-HNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLK-LVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPN
|.. . || | ||.| ||.    |...||.|..||.  .. .| .||  ||  .. .. |||....  .||. ...| .|.|..|||||. |.|...| .
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PVAKFYAAEVILALEYLHAH-NIIYRDLKPENILLDRNGHIKITDFGFAK-----EVQTVTWTLCGTPDYIAPEVITT-KPYNKSVDWWSLGVLIYEMLA
 .|.||.|...||||||| | ||||||||||||||| .||.|||||| .|     .   .. ..|||| |.|||.||  |..|||||||..|..||||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GYTPFYD--TTPMKTYEKILQ-GKVVYPPYFHPDVVDLLS-KLITADLTRRIGNLQSGSRDIKAHPWF
|..|||.  .. |  ..|| |  |. ||.|| .   ||.  ||   . . |.|   .|  .|| ||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase TPK2.AA S_TKc 70-324 39 1.5e-112 381.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-231/231
Sequence Identity: 39% (105 aa)

FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEG--GELFSLLRKSQR---
..|.|..| |.||.|...| .. ||..|||..|          ||.  |...||   ||..... ..|||  ...|||.|..|  |.||....| .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPDYIAPEVITTKPYNK-SVDWWSLGVLIYEMLA
   ||  .|.||......||||.| |.||.|||||||||||.  ||||.|||.|...     |.||||.|.||||.   .|.| ..||||.|...||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GYTPFYDTTPMKTYEKILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGS--RDIKAHPWF
||.||.  .......||.           |.. |...|. . | ..|..  .     .|||.||||
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TPK2.AA RSK 73-324 39 4.8e-108 365.24 In-house 1-278 (278) Show / Hide 
Range on Protein: 73-324
Range on HMM: 1-278/278
Sequence Identity: 39% (109 aa)

MRTLGTGSFGRVHLVRSV---HNGRYYAIKVLKKQQVVKMKQ-VEHTNDERRMLKLVE-HPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQR---
.. ||.|..| | |.| .    .|..|| |||||  .|. .  ..||  ||. |.... |||...   .||.   ....|.|..|||||  |.| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDR---NGHIKITDFGFAKE-VQT---VTWTLCGTPDYIAPEVIT---TKP-YNKSVDWWSLGV
|    |.||.||..||.|.|| . ||.|||||||||.|    .||||.|||||.|. .      | | |.| .|.|||...    .  ..|..|||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMLAGYTPFYD---TTPMKTYEKILQGK--VVYP--PYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
|.||||.|..||.     .. .. ..|..||  .  |  .|  ..  ||..|. . |  .|.|   ..  .||.||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase TPK2.AA PKC 70-324 43 6.5e-107 347.6 In-house 1-262 (262) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-262/262
Sequence Identity: 43% (113 aa)

FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKL-VEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNP
|. .. || |||| | |...  . .|||||||||  ...   || |  |.| | |  .||||  .  .||   ..| || |..|| |     ...||. .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

VAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKE---VQTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPF
.|.|||||.|.|| .|| ..||||||| .|.|||. |||||.||| .||     . | | ||||||||||..  ..|.||||||..||| |||.||  ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YDTTPMKTYEKILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSG---SRDIKAHPWF
   .     . |.. ...|| ... . |...... | . ..|.|  ...   ..||..|| |
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase TPK2.AA PKG 70-324 42 4.3e-98 332.2 In-house 1-260 (260) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-260/260
Sequence Identity: 42% (111 aa)

FQIMRTLGTGSFGRVHLVRSVHNG-RYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNP
..|  ||| | |||| ||.. |   | .|.|..||...|. .| ||   |.. .   . .| .|.. || | . ..| |    |||| . ||. ..| ..
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

VAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTV--TWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFY
 ..||.| |. |..|||..|||||||||||..||..| .|. |||||| ...   ||| |||| |.|||.|  |    |||.|.||.|..| | | .|| 
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS

DTTPMKTYEKILQG--KVVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
 . |||||  ||.|  ..  |       ...  ||     | |.|....|  ||| | ||
GSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase TPK2.AA p70 70-324 37 1.2e-95 324.11 In-house 1-299 (299) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-299/299
Sequence Identity: 37% (113 aa)

FQIMRTLGTGSFGRVHLVRSVH---NGRYYAIKVLKKQQVVK-MKQVEHTN-------------------------DERRMLKLVEHPFLIRMWGTFQDA
|. .. || | .| | .|| |    .|..|| |||.| ..|   |  .||                          .||  |  |.|||..     ||. 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

RNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEV---QTV----------TWTLCG
   . . .|. ||||| .| .   ..  .|.||..|.|.|||.|| | ||||||||||..|.  ||.. ||||  ||     .|          |.|.||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQGK--VVYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
|. | |||... . .|. |||||||.|.| || |  ||   .. || .|||.||  .  |||  ..  ||. ||.  . | |.|   .   ||..||.|
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase TPK2.AA Pkinase 70-324 32 3.1e-94 324.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTN-DERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGG----ELFSLLR--KS
..| |..| ||||.| . . . .|. .|.|..||.   . |...|..  | ...| . ||. .|....|.| ..| |||.| |||    .||....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QRF--PNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHI----KITDFGFA----KEVQTVTWTLCGTPDYIAPEVIT-TKPYNKSVDWWSL
 .|  .  ..|||. ... .|||.|...||.|||||||||.|.||||    ||.|||.|       .. ..|.||||.|.|||||   ..| ..||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLIYEMLAGYTPFYDT------TPMKTYEKILQGKVVYPPYFH---------------------PDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
|...|||| |..||..       ..|. ...|..... .. .                       ..  |....... | ..|..      ..|. ||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase TPK2.AA RSK 70-324 36 9.4e-94 317.77 In-house 1-271 (271) Show / Hide 
Range on Protein: 70-324
Range on HMM: 1-271/271
Sequence Identity: 36% (100 aa)

FQIMRTLGTGSFGRVHLVRSV---HNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFP
. . . .|.|||. | ... .    ....||.|..|| ...   .   .  || .|  . ||| ..    |||.....|.||  .||.||  | |   |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

NPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRN----GHIKITDFGFAKEVQT---VTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEML
   .|||.||. ||.|||| . |..|||||||||.|      |||||.||||||..      . | |.|  |.||||.  . . ...||||.||| ||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

AGYTPFYDTTPMKTYEKILQGKVVY-------PPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWF
.|.|||. ..   . ..|.  |..        . .  .   |||... . | ..| |.   |  .|| ||||
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase TPK2.AA Pkinase_Tyr 70-286 24 6.6e-18 61.27 Pfam 1-238 (270) Show / Hide 
Range on Protein: 70-286
Range on HMM: 1-238/270
Sequence Identity: 24% (63 aa)

FQIMRTLGTGSFGRVHLVRSVHNGRYY----------AIKVLKKQQVVKMK--QVEHTNDERRMLKLV-EHPFLIRMWGTFQ-DARN--IFMVMDYIEGG
 .....|| |.||.|..      |...          |.|.| |..  .    . .  . | ...|    || ..|. |    . .   |..|| | ..|
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

ELFSLLRK----SQRFPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEV-----Q-TVT--------WTLCGTPDYIAPE
 | . |||     |... .    .....  ..|||...|.| |||   |.|...|...||.||| |. .       ...        |.        |||
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM--------APE

VITTKPYNKSVDWWSLGVLIYEMLA-GYTP-FYDTTPMKTYEKI-LQGKVVYPP
.| .. ..   | || |||..|..  | .| ... ..   ||.|  .|    .|
CINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCP
Kinase TPK2.AA TyrKc 70-308 20 5.4e-16 35.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 70-308
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLV--EHPFLIRMWGTFQDA-------RNIFMVMDYIEGGELFSLLR
 .  ..|| | ||.|.. .     .  |.|.||.     ..   .   | |... .  .|| ..|. |   .          ...|| | ..| | . ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMR---EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSQR-FPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTV-------TWTLC----GTPD-----YIAPEVITTKPYN
|... ....    ..  .    |||| .|.| |||   |.|...|...||.||| ....                   |. .       |||.| .. ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSVDWWSLGVLIYEMLA-GYTPFYD-----TTPMKTYEKILQGKVVY-PPY--------FHPDVVDLLSKLITA---------DLTRRI
   | || ||...|..  | .| ..      ..   .|.. ||.    ||.         .... .. ..   .         .. ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TPK2.AA S_TK_X 325-380 23 3.3e-10 41.14 SMART 1-79 (79) Show / Hide 
Range on Protein: 325-380
Range on HMM: 1-79/79
Sequence Identity: 23% (19 aa)

SEVVWERLLA--KDIETPYEPPITS---GIGDTSLFD-QYPEEQLDYGIQGDDP-------------------YAEYFQDF
... |..|..  | || |. |.|..   . .||| ||  ..||. .   . |||                   ..... .|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF