Gene AlphaK2 (Human)
AlphaK2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AlphaK2.kin_dom | Protein Kinase Domain | None | 119 | None | Fasta, JSON |
| AlphaK2.AA | Protein | Sugen Kinome | 2170 | None | Fasta, JSON |
| AlphaK2.NA | RNA | Sugen Kinome | 7308 | None | Fasta, JSON |
Protein domains of AlphaK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| I-set | AlphaK2.AA | I-set | 12-104 | 25 | 1.8e-16 | 58.44 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 12-104 Range on HMM: 1-92/92 Sequence Identity: 25% (25 aa) LCFLSTLLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISN---YEFFENQ-YIHVLHLSCCTKNDAAVYQISAKNSFGMICCSASVEV .|. .. ...| | ..| . | ..|.|.|.|.|.|.|| . . . . ... ... | | ... |. .| . |.|||| |.|...| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP-----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
|||||||||
| IG | AlphaK2.AA | IG | 18-105 | 13 | 4.2e-07 | 30.83 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 18-105 Range on HMM: 1-58/58 Sequence Identity: 13% (13 aa) LLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISNYEFFENQYIHVLHLSCCTKNDA---AVYQISAKNSFGMICC--SASVEVE . | | ....|.| .| ...|| |.. ...|. ..|. |. |.. . .. ..|. PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
|||||||||
| IGc2 | AlphaK2.AA | IGc2 | 24-94 | 25 | 2e-06 | 28.66 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 24-94 Range on HMM: 1-56/56 Sequence Identity: 25% (18 aa) PEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISNYEFFENQYIHVLHLSCCTKNDAAVYQISAKNSFG | ...|.|. .| | |...||| || .. . |... |..|. .|. .| |. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| IG | AlphaK2.AA | IG | 1793-1876 | 16 | 7.2e-05 | 23.42 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1793-1876 Range on HMM: 1-58/58 Sequence Identity: 16% (15 aa) QAEMFPEHSGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQ---GLYYCCIKNSYGKVTA--EFNLTAE . . ..|.|.| .. .| |. . | ...| |. | ||| . .|.... ...|| . PP-VTVKEGETVTLTC-VS------QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
|||||||||
| IGc2 | AlphaK2.AA | IGc2 | 1799-1865 | 23 | 0.000172 | 17.94 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1799-1865 Range on HMM: 1-56/56 Sequence Identity: 23% (16 aa) EHSGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQGLYYCCIKNSYG . ..| | | |. .| .| |.| ..... . . | ..| | |.| | |. | HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG |
|||||||||
| I-set | AlphaK2.AA | I-set | 1821-1875 | 27 | 0.003878 | 13.16 | Pfam | 34-92 (92) | Show / Hide |
Range on Protein: 1821-1875 Range on HMM: 34-92/92 Sequence Identity: 27% (16 aa) WTKDSKSIAQ----VQRSAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTA |.|| . ... .| .. .. | .. | .. | | | | | .||.|.......|| WFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
|||||||||
| Kinase | AlphaK2.AA | Alpha-Unclassified | 2007-2125 | 51 | 4.8e-85 | 277.29 | In-house | 87-215 (215) | Show / Hide |
Range on Protein: 2007-2125 Range on HMM: 87-215/215 Sequence Identity: 51% (67 aa) EVPEIIPIFLIHRPENNIP-YATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQG-VG------MKLTDVGIATLAK ....|.|||||||...||. ...||..|||||||||...||||||...|.||.|.|||.|||.||.|..|..|.|.|| |. .|.||..|.|... QIFYIPPIFLIHREDKNIKGCISVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQ GYKGFKGNCSMTFIDQFKALH--QCNKYC .|.|||.||.|.|||.....| |||.|| RYQGFKTNCGMRFIDYWFNNHHVQCNHYC |
|||||||||
| Alpha_kinase | AlphaK2.AA | Alpha_kinase | 1906-2125 | 24 | 4.3e-84 | 286.59 | SMART | 1-255 (255) | Show / Hide |
Range on Protein: 1906-2125 Range on HMM: 1-255/255 Sequence Identity: 24% (64 aa) HDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYK----LAAQECYVQNTARYYAKIYAAEAQP ..... ... .| .|...|..| .|.... ... |..|..|. ||.|... .. .| ...|... |..... .|......|... .||| DNKWTCQETCVKI-KEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTW----DEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ- LEGFGEVPEIIPIFLIHRP-------ENNIPY-----------------ATVEEELIGEFVKYSIRDGKEINFLRRES------EAGQKCCTFQHWVYQK ..........||....|.| ..|||| ...|... ||||||. ..|..... |... |....|..|.|| |.. HNPCPKKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEW TSGCLLVTDMQGV----GM--KLTDVGIATLAK-GYKGFKGNCSMTFIDQFKALHQCNKYC .....||.|.||| |. ..||..|.| . ||.. .||. .. |..| ..||||..| SNHQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC |
|||||||||
| Kinase | AlphaK2.AA | Alpha | 2007-2125 | 37 | 6.1e-76 | 215.53 | In-house | 91-215 (215) | Show / Hide |
Range on Protein: 2007-2125 Range on HMM: 91-215/215 Sequence Identity: 37% (47 aa) EVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQ-GVG-MKLTDVGIAT---LAKGYK .........|||....||.|..||....||..||....|... ||....|..|....|.||..|...|.|.|.|.| ||| .||||..|.. |..|.| QFVHCYIYELIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVD-FLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMK GFKGNCSMTFIDQFKALH--QCNKYC ...|||.......|.. | |||.|| FGDGNCGYEGMFRFFYTHHVQCNHYC |
|||||||||
| Alpha_kinase | AlphaK2.AA | Alpha_kinase | 1925-2125 | 22 | 2.5e-63 | 220.44 | Pfam | 1-225 (225) | Show / Hide |
Range on Protein: 1925-2125 Range on HMM: 1-225/225 Sequence Identity: 22% (52 aa) FGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNA----IAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRP |..| .|..|| ... .|...... ||.|... .... |. . ... |.|..|.......... ...| . .. .|.......... FAQGAMRWCFRMFDTW--DPNWRNNQNCVAKWYKKIKNYNQKQ------SIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYEL ENNIP-----------------YATVEEELIG-EFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVG--M---KLTDVGIATLA |.. . |...| . | |||||. .|. . .|.....|....|.|. |... |...|.|.|||| . .||| | | EDHNKPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD KGY---K--GFKGNCSMTFIDQFKA-LHQCNKYC . | . | .||.. |..| . |.||..| GNYEMDFDEG-MGNLGQEGIEKFFQNQHKCNHIC |
|||||||||
| Kinase | AlphaK2.AA | ChaK | 2028-2125 | 36 | 1.9e-09 | 33.64 | In-house | 121-219 (219) | Show / Hide |
Range on Protein: 2028-2125 Range on HMM: 121-219/219 Sequence Identity: 36% (39 aa) TVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTF---------IDQFKAL |.|. . ||| || | || | | || | | | ||| |.|||| ||| . . | | | | | |.| TIEKCMTGEFRKYNNNNGDEIIPTNTLEEI---MLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEE-----KQSCDMVFGPANLGEDAIRNFRAK HQCNKYC | || | HHCNSCC |
|||||||||
| Kinase | AlphaK2.AA | VWL | 2119-2130 | 75 | 1.3e-05 | 12.76 | In-house | 195-206 (206) | Show / Hide |
Range on Protein: 2119-2130 Range on HMM: 195-206/206 Sequence Identity: 75% (9 aa) HQCNKYCKMLGL |||||||. | | HQCNKYCQKLQL |
|||||||||
| Kinase | AlphaK2.AA | VWL | 2064-2090 | 35 | 0.009615 | 4.11 | In-house | 139-166 (206) | Show / Hide |
Range on Protein: 2064-2090 Range on HMM: 139-166/206 Sequence Identity: 35% (10 aa) FQHWVYQKTSGCLLVTDMQGVG-MKLTD | | .| . | ... |.||.. ||| FSHFTWQYSQGYCMIVDLQGNEDGMLTD |
|||||||||