Gene AlphaK3 (Human)

AlphaK3

Species: Human
Alias: ALPK1, FLJ22670, 8430410J10Rik, LAK, AlphaK3, KIAA1527
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4q25,

Classification

Group: Atypical
Family: Alpha
Subfamily: Alpha-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
AlphaK3.AA Protein Sugen Kinome 1907 None Fasta, JSON
AlphaK3.NA RNA Sugen Kinome 10936 None Fasta, JSON
AlphaK3.kin_dom Protein Kinase Domain None 64 None Fasta, JSON

Protein domain

Protein domains of AlphaK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set AlphaK3.AA I-set 279-371 32 8.3e-22 76.52 Pfam 1-92 (92) Show / Hide 
Range on Protein: 279-371
Range on HMM: 1-92/92
Sequence Identity: 32% (31 aa)

PLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLP--KYEITHQG-NRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEV
| |....|.  |.| ...||.| |||.|.|.|.|.||. .|      .  .. .|  | ...||  ...  .|. .|   |.|| | ..|.  |.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 AlphaK3.AA IGc2 291-361 28 3.7e-14 54.28 SMART 1-56 (56) Show / Hide 
Range on Protein: 291-361
Range on HMM: 1-56/56
Sequence Identity: 28% (20 aa)

SEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKG
 |. .|..||..||.|.|...||| ...|.              .. ||.. . ..||. .|. .|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG AlphaK3.AA IG 285-372 17 2.5e-08 34.9 SMART 1-58 (58) Show / Hide 
Range on Protein: 285-372
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

LKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDA---AIYQASAQNSKGIVSC--SGVLEVG
 .  .|.| ..|..|| |.     ...||                         |.. . ..||.   ..|.  |.  .| ...  .  |.| 
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 AlphaK3.AA IGc2 1489-1555 23 0.001051 10.41 SMART 1-56 (56) Show / Hide 
Range on Protein: 1489-1555
Range on HMM: 1-56/56
Sequence Identity: 23% (16 aa)

DASGSLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHG
   .|. | |   .   |   .| |   |.          .   | |  ..| | |.|.|.  |..|
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG AlphaK3.AA IG 1483-1566 14 0.024189 11.29 SMART 1-58 (58) Show / Hide 
Range on Protein: 1483-1566
Range on HMM: 1-58/58
Sequence Identity: 14% (13 aa)

RVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDC---GVYRCTIHNEHGSAST--DFCLSPE
   .   . ....| | .        ..|                     | | ...| |    |.|.|. .  ||...    . |. .
PP-VTVKEGETVTLTC-VS------QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set AlphaK3.AA I-set 1544-1561 33 0.282522 6.84 Pfam 71-88 (92) Show / Hide 
Range on Protein: 1544-1561
Range on HMM: 71-88/92
Sequence Identity: 33% (6 aa)

GVYRCTIHNEHGSASTDF
|.|.|.  |. |.|....
GKYTCVATNSFGEAECTA
Alpha_kinase AlphaK3.AA Alpha_kinase 1622-1819 19 4.2e-57 196.95 SMART 1-255 (255) Show / Hide 
Range on Protein: 1622-1819
Range on HMM: 1-255/255
Sequence Identity: 19% (50 aa)

LRKASQAKVIYGL--EPIFESG--RTCII--------------KVSSLLVFGPSSETSL-VGRNYD----VTIQGCKIQNMSREYCKIFAAEARAAPGFG
  | ... ... .  .  |. |  |.|.               ..  . .|.......  . |...    .... .. |.|.......| .||. .....
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-HNPCP

EVPEIIPLYLIYRP-------ANNIPY-----------------ATLEEDLGKPLESYCSREWGCAEAPTASGS-----SEAMQKCQTFQHWLYQWTNGS
.....||.|....|        .||||                 ...|. ..   . |...  |.. .......     .|....||.|.|| |.|.|..
KKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNN-GWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQ

FLVTDLAGV----DW--KMTDVQIATKLR-GYQGLKESCFPALLDRFASSHQCNAYC
.||.|. ||    ..  ..||.||.|. . ||.. .  . .. ...|...||||..|
MLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase AlphaK3.AA Alpha-Unclassified 1748-1819 48 5.1e-49 157.92 In-house 135-215 (215) Show / Hide 
Range on Protein: 1748-1819
Range on HMM: 135-215/215
Sequence Identity: 48% (39 aa)

SSEAMQKCQTFQHWLYQWTNGSFLVTDLAG-VD------WKMTDVQIATKLRGYQGLKESCFPALLDRFASSH--QCNAYC
..|| |.|.|.|||.|||||....|.||.| ||      |||||.||.|....|||.|..|.....|.....|  |||.||
EYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQRYQGFKTNCGMRFIDYWFNNHHVQCNHYC
Kinase AlphaK3.AA Alpha 1748-1819 37 2.2e-45 127.0 In-house 137-215 (215) Show / Hide 
Range on Protein: 1748-1819
Range on HMM: 137-215/215
Sequence Identity: 37% (30 aa)

SSEAMQKCQTFQHWLYQWTNGSFLVTDLA-GVD-WKMTDVQIAT---KLRGYQGLKESCFPALLDRFASSH--QCNAYC
..|. |..|.|.|| .|..||...|.||. ||. ||.||.||..   . .|.......|... ..||...|  |||.||
DNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGMFRFFYTHHVQCNHYC
Alpha_kinase AlphaK3.AA Alpha_kinase 1674-1819 19 9.6e-23 79.9 Pfam 54-225 (225) Show / Hide 
Range on Protein: 1674-1819
Range on HMM: 54-225/225
Sequence Identity: 19% (34 aa)

CKIQNMSREYCKIFAAEARAAPGFGEVPEIIPLYLIYRPANNIP-----------------YATLEEDLGK-PLESYCSR-EW-GCAEAPTASG-SSEAM
||.|.........| .... .  ..  .|.......|.. .. .                 |...|  .     . |..   | .      .   .... 
CKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHNKPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVY-----DNMDRNDPWN

QKCQTFQHWLYQWTNGSFLVTDLAGVD--W---KMTDVQIATKLRGY---Q--GLKESCFPALLDRFAS-SHQCNAYC
|..|.|.|. |...|| ..|.|. ||.      . || || || . |   .  | .. . .   ..| . .|.|| .|
QYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYEMDFDEG-MGNLGQEGIEKFFQNQHKCNHIC
Kinase AlphaK3.AA VWL 1756-1824 33 8.3e-08 19.45 In-house 137-206 (206) Show / Hide 
Range on Protein: 1756-1824
Range on HMM: 137-206/206
Sequence Identity: 33% (24 aa)

QTFQHWLYQWTNGSFLVTDLAGVD-WKMTDVQIATKLR-GYQGLKESCFPALLDRFASSHQCNAYCELLGL
| | |  .| . |  .. || |..    || || .. .    |      . .| || ..||||.||  | |
QAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGML-RFFMTHQCNKYCQKLQL
Kinase AlphaK3.AA Alpha-Unclassified 1699-1725 32 4.4e-07 18.96 In-house 87-114 (215) Show / Hide 
Range on Protein: 1699-1725
Range on HMM: 87-114/215
Sequence Identity: 32% (9 aa)

EVPEIIPLYLIYRPANNIP-YATLEEDL
....|.|  || |. .||. ....|. |
QIFYIPPIFLIHREDKNIKGCISVEPYL
Kinase AlphaK3.AA ChaK 1758-1784 51 0.000716 11.44 In-house 154-180 (219) Show / Hide 
Range on Protein: 1758-1784
Range on HMM: 154-180/219
Sequence Identity: 51% (14 aa)

FQHWLYQWTNGSFLVTDLAGVDWKMTD
| || | .| |  || || ||   .||
FSHWTYEYTRGELLVLDLQGVGENLTD
Kinase AlphaK3.AA Alpha 1699-1723 24 0.039425 1.69 In-house 91-115 (215) Show / Hide 
Range on Protein: 1699-1723
Range on HMM: 91-115/215
Sequence Identity: 24% (6 aa)

EVPEIIPLYLIYRPANNIPYATLEE
.......  ||... .||.|...|.
QFVHCYIYELIHCHNHNIKYYSVEN