Gene ANPa (Human)

ANPa

Species: Human
Alias: ANPa, GUCY2A, NPR1, ANPRA, NPRA, GUC2A
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1q12,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
ANPa.kin_dom Protein Kinase Domain Sugen Kinome 276 None Fasta, JSON
ANPa.AA Protein Sugen Kinome 1061 None Fasta, JSON
ANPa.NA RNA Sugen Kinome 4201 None Fasta, JSON

Protein domain

Protein domains of ANPa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor ANPa.AA ANF_receptor 54-416 24 2.7e-80 277.87 Pfam 1-364 (364) Show / Hide 
Range on Protein: 54-416
Range on HMM: 1-364/364
Sequence Identity: 24% (96 aa)

RVGPAVELALAQVKARPD-LLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHN-PAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGV--K
...||...|. ...|.|. |||| |.. .   ...    |||  ...||.|..|  . .....||.| |...||.|...||..|....|... ..    |
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY----CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAK

DEYALTTRAGPSYAKL-GDFVAALHRR-LGWERQALMLYAYRPG--DEEHCFFLVEGLFMRVRDR----LNI-TVDHLEFAEDDLSHYTRLLRT-MPRKG
..|  ..| .||.... |......... .|| . | ..|    .  ... |.| .|.... .|..    ... .|.  .  .|| . | . ..  .  |.
NRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVA-VIYDDDDYYYWRGGCYF-MEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKA

RVIYICSSPDAF----RTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYE
|||..|..|| .    | .|. | |.|.....||..  |... |. ..        |...|  .  .|.|...  ..|.. | .||. ||....|     
RVIVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W------WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK----

QFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGE---------NITQRMWN-RSFQGVTGYLKIDSSGDRETDFSLWDMDPE
      .| ..|.. | ..|. .|| .|. ..|  .. ...|          .....||| ..|.|||| ...|..|.| .|...|.|.. 
------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase ANPa.AA RGC 560-803 43 1.3e-142 480.07 In-house 1-300 (300) Show / Hide 
Range on Protein: 560-803
Range on HMM: 1-300/300
Sequence Identity: 43% (131 aa)

KGNLVAVKRVNRK----RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPP------NICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLF
.|..|..|..|..    ....||... |||.||..|...|..|.|.|.|||      |.||..|||.||||||||||..| .||||.||. .|||||| .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNGAICSHGNLKSSNCVVDGRFVLKITDYGL-----ESFR--------------DLDPEQGHTVYAKKLWTAPELLR-MASPPVRG--------SQAGD
||.  | .||||||.|||||.|.|.||||.||     ..|.              ...... |. |.| ||||||.|| ...|. .|        .|.||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIALRSG-----VFHVE--GLDLSPKEIIERVTR----GEQPPFRPSLALQ------SHLEELGLLMQRCWAEDPQERPP-FQQIRLTLRK
|||||||..||..|.|     .|. .  ...|||.||||.| .    |.|.|||||.  .       . ..|  ||..|||||| |||. |.|||..|..
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase ANPa.AA RGC 560-803 43 1.3e-142 480.07 In-house 1-300 (300) Show / Hide 
Range on Protein: 560-803
Range on HMM: 1-300/300
Sequence Identity: 43% (131 aa)

KGNLVAVKRVNRK----RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPP------NICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLF
.|..|..|..|..    ....||... |||.||..|...|..|.|.|.|||      |.||..|||.||||||||||..| .||||.||. .|||||| .
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHNGAICSHGNLKSSNCVVDGRFVLKITDYGL-----ESFR--------------DLDPEQGHTVYAKKLWTAPELLR-MASPPVRG--------SQAGD
||.  | .||||||.|||||.|.|.||||.||     ..|.              ...... |. |.| ||||||.|| ...|. .|        .|.||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYSFGIILQEIALRSG-----VFHVE--GLDLSPKEIIERVTR----GEQPPFRPSLALQ------SHLEELGLLMQRCWAEDPQERPP-FQQIRLTLRK
|||||||..||..|.|     .|. .  ...|||.||||.| .    |.|.|||||.  .       . ..|  ||..|||||| |||. |.|||..|..
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase ANPa.AA TKL 557-801 22 6.5e-49 168.82 In-house 12-364 (364) Show / Hide 
Range on Protein: 557-801
Range on HMM: 12-364/364
Sequence Identity: 22% (81 aa)

AYYKG----------NLVAVKRVNRKRIELT---------------------------RKVLFELKHMRDVQNEHLTRFVGACTDPPN------------
....|          . ||||. ...   ..                            .  .|...|.  . ... .|.|.|..||.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHN--------GAICSHGNLKSSNCVVDGRFV--------------LKITDYGLESF
 .|| .||||.||| ..|        |  | ..  || .|| .||.         .|  | .|||.|. ||  .               .||.|.||  |
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPII-HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

RDLDPEQGHTVYA-------------------KKLWTAPELLRMASP---PV---------RGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSP-----
 . . .. .| ..                    . | |||.||.. .    |           |.. |||||||.| ||. |  ... .. .        
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPF

KEIIERVTRGEQPPFRPSLAL--------QSHLEELGLLMQRCWAEDPQERPPFQQIRLTL
.|... |    ..| .|.  .         . ....  |||.||..||..|| ||.|  .|
EEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ANPa.AA TK 559-801 15 3.2e-31 101.32 In-house 19-486 (486) Show / Hide 
Range on Protein: 559-801
Range on HMM: 19-486/486
Sequence Identity: 15% (74 aa)

YKG-------------------------------NLVAVKRVNRK-RIELTRKVL----------------FELKHMRD--VQNEHLTRFVGACTDP---
|||                                 |||| .  .   . ... .                 |.| |.    . ... |..|.||..   
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

---------PNICILTEYCPRGS----LQDILENESIT--------------------------------------------------------------
         . ..|..||.| |.    |.| | . . .                                                              
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------LDWMFRYSLTNDIVKGMLFLHNGAI-----CSHGNLKSSNCVVDGRFV-----------LKITDYGLE------SFRDLDPEQGHTV
             |.   .     .| .|| .||   .     . |..|   || |. . |            ||.|.||         ||.....  ..
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYR

-------------------------YAKKL---WTAPELLRMASP-----PVRGSQAGDVYSFGIILQEIALRS-GVFHVEGL-------DLSPKEIIER
                            ||   |.||| |.   .       . . . ||.|||. . ||  .  . .. .         . ...|..|.
KSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEY

VTRGEQPPFR---------PSLA--LQSHL-------------EELGLLMQRCWAEDPQERPPFQQIRLTL
..|| .. .|           ..   . .              ||. .|||.||..||..|| |.|..  |
LRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ANPa.AA DRK 598-735 41 4.2e-31 102.59 In-house 62-198 (258) Show / Hide 
Range on Protein: 598-735
Range on HMM: 62-198/258
Sequence Identity: 41% (59 aa)

FVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGA-ICSHGNLKSSNCVVDGRFVLKITDYGLES-FRD-LDPEQGHT
| |.|. || ||| .|| |||||  || .||| .||  . ..  |. ||| .||.   |  |  ||| |  ||  .  |. |.||   |.  ..     |
FMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT

VYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALR
      ||||| ||      |     |||||.|.| |.. |
MCGTPCWTAPEVLRNQ----RYTEKADVYSFAIVLWECVTR
Kinase ANPa.AA TKL-Unique 595-733 36 2.9e-30 104.01 In-house 58-222 (290) Show / Hide 
Range on Protein: 595-733
Range on HMM: 58-222/290
Sequence Identity: 36% (61 aa)

LTRFVGACT----DPPNICILTEYCPRGSLQDILE---------NESITLDWMFRYSLTNDIVKGMLFLHNGA--ICSHGNLKSSNCVVDGR-----FVL
.....|.|.    .||| || .||||.||| | |          |....|..  |... .||..|| .||.    |  |..|||||  || .     .  
IVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPII-HRDLKSSNFLVDNNSNIAEWNI

KITDYGLESFRDLD---PEQGH------TVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIA
|| | ||  |.. .   .  .|      |. .  .| |||.|||       |.  |||||||.| |||
KICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIA
Kinase ANPa.AA RIPK 564-801 24 5.5e-26 85.52 In-house 21-290 (290) Show / Hide 
Range on Protein: 564-801
Range on HMM: 21-290/290
Sequence Identity: 24% (68 aa)

VAVKRVNRKRIELT------RKVLFELKHMRDVQNEHLTRFVGACTDP-----PN-ICILTEYCPRGSLQDILENES------ITLDWMFRYSLTNDIVK
||.| .. | .. .       ... | |||   ..||  .  | | ..     .. . | .|| . ||| . |  ..      . ..  .|  .   |. 
VAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCR--MIHEISC

GMLFLHNGA--ICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQG--H-----TVYAKKL------WTAPELLR--MASPPVRGSQAGDVYSFGII
|| .||.    |  |  || .|  ||. |  || | || ...     ..  .       ...|.        .||..|   ..|    . . |||||.|.
GMCYLHSMNPPII-HRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIV

LQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQS---HLEELGLLMQRCWAEDPQERPPFQQIRLTL
. |.  .  ..  .....    |. .. .|  |.  |         |.|..  ||||||. ||..|| || ..   
MWEVLTQKHPYEDRKCMM---MIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase ANPa.AA Dicty4 594-681 35 2.2e-22 71.61 In-house 59-160 (277) Show / Hide 
Range on Protein: 594-681
Range on HMM: 59-160/277
Sequence Identity: 35% (36 aa)

HLTRFVGACT----DPPNICILTEYCPRGSLQDILEN------ESITLDWMFRYS---LTNDIVKGMLFLHN-GAICSHGNLKSSNCVVDGRFVLKITDY
..  | ||||     |. .|| |||.|.|.|  .| .      .||.|||  . .   .  |...||  ||.   .  |  |||.|  ||  .. |..| 
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF

GL
||
GL
Kinase ANPa.AA MLK 557-681 25 4.1e-18 59.53 In-house 18-179 (291) Show / Hide 
Range on Protein: 557-681
Range on HMM: 18-179/291
Sequence Identity: 25% (42 aa)

AYYKGNL-----VAVKRVN---RKRIELT----RKVLFELKHMRDVQNEH----LTRFVGACTDPPN-ICILTEYCPRGSLQDILENES-----------
.......     ||||||.   .  .  |    ...  | .| | .. .       .|.|.|..||.  ||..|||. ||| ..| ...           
GRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK

----ITLDWMFRYSLTNDIVKGMLFLHNGAI--CSHGNLKSSNCVVD------GRFVLKITDYGL
    ...| ... .|  .. .|| .||. |     |  |||.| ..|      .  .|||.| |.
NDRVYDHDHAMNWAL--QCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT
Kinase ANPa.AA Dicty4-Unclassified 600-733 31 2e-17 56.17 In-house 65-202 (263) Show / Hide 
Range on Protein: 600-733
Range on HMM: 65-202/263
Sequence Identity: 31% (46 aa)

GACTDP----PNICILTEYCPRGSLQDILE------NESITLDW--MFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDL
|.|  |      .|| .|  ..| |  .        . .| ||     .| .  || .|| .||   .  |  .||||  .|  |  || | |.   |  
GYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAF--DIAQGMQHLHTRNFI-HRDIKSSNILMDKHFNIKIADFGIS--RVI

DPEQGHTVYA-KKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIA
|  .  |  |    |..|| |.  |      |. ||||....| | |
DFNFNMTTIAGTPKWESPECLMHES----YNQKSDVYSYAMMLYELA
Kinase ANPa.AA Pkinase 561-801 20 2.2e-17 62.52 Pfam 24-293 (293) Show / Hide 
Range on Protein: 561-801
Range on HMM: 24-293/293
Sequence Identity: 20% (57 aa)

GNLVAVKRVNRKRIELTRKVLF----ELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRG----SLQDILE-NESITL--DWMFRYSLTNDIVKGMLF
| .||||........   ..      |.. |. .. ..  |. ....|...|.. .|||. |    .| |...  .. ..  ..    .    |..|. .
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHNGAICSHGNLKSSNCVVDGRFVL----KITDYGL-ESFRDLDPEQGHTVYAK-KLWTAPELLR---MASPPVRGSQAGDVYSFGIILQEIALRSGVFH
.|.   . |  ||..|. .| . ..    ||.| || . |. . . .  |...    . |||..|   . .|.|      |..|.|.|| | ...   | 
CHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV------DMWSCGCILYEMLCGRPPFP

VEG----LDLSPKEIIERVTRGEQPPFRPSLALQSHL---------------EELGLLMQRCWAEDPQERPPFQQIRLT--L
 .       ......|.|. ... .  .| .   |                 ||.  .. .|.. ||..|| ..||     .
-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
TyrKc ANPa.AA TyrKc 497-801 22 1.5e-16 44.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 497-801
Range on HMM: 1-280/280
Sequence Identity: 22% (76 aa)

MQLEKELAS----ELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDV--
 .|.|.| .    | .. .|                                                   |||| ..       .  . |.. |. .  
ITLGKKLGEGAFGEVYKGTWK------------------------------------------------IQVAVKMLKEDA---REDFMREARIMCKLGG

QNEHLTRFVGACTDP-------PNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLES
..... |..|.||..       . ..|..||.| |.|.| | .   .| .    |   .| .|| .||   .  |  |   || |. ... ||.| ||  
HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCI-HRDLAARNCLVGENHTVKISDFGL--

FRDLDPE----QGHTVYA------KK--L---WTAPELLRMASPPVRG--SQAGDVYSFGIILQEIALRSGVFHVE---GLDLSPKEIIERVTRGEQPPF
 ||.. .      . .|       .|  |   |.||| .        |  . . ||.|||. . ||  . .  . .     ..|..|.||.| .|. .| 
SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQ

RPSLALQSHL------EELGLLMQRCWAEDPQERPPFQQIRLTL
 |.      .      .|.  .|..||.||| .|| |..|.  .
PPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc ANPa.AA S_TKc 550-803 15 3.9e-13 15.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 550-803
Range on HMM: 1-231/231
Sequence Identity: 15% (44 aa)

FQVFAK----------TAYYKG--NLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPR--GSLQDILENESI-----T
...  |           .. |.   .||.|...       .... |.. ..  . ... .. ... |  .... .|||.   |.| |....         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQ-AGDVYSFGIIL
..     ...  |.... ..|.  |. |  || .|  .|   ..||.| ||  .        .|.     . |||.|         .  . |..|.|.||
FPE-HARFYMYQICCALEYCHSHGII-HRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCIL

QEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRL-------TLRK
 | . .   |.       ........                  .|.  ....|.  ||..||   ..             
YEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ANPa.AA Pkinase_Tyr 557-652 25 9.7e-12 40.39 Pfam 18-129 (270) Show / Hide 
Range on Protein: 557-652
Range on HMM: 18-129/270
Sequence Identity: 25% (28 aa)

AYYK------GNLVAVKRVNRKRIEL---TRKVLFELKHMRDV-QNEHLTRFVGACT--DPP-NICILTEYCPRGSLQDILENE---SITLDWMFRYSLT
...|      .  |||| .. .  .     .. . |.| |.   ..... |..|.||  . | .|.| .||.| |.| | | .       |.     .  
GTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMC

NDIVKGMLFLHN
 .| ||| .|..
WQIAKGMEYLES
Kinase ANPa.AA TKL-Unique 779-801 47 1.1e-08 26.97 In-house 268-290 (290) Show / Hide 
Range on Protein: 779-801
Range on HMM: 268-290/290
Sequence Identity: 47% (11 aa)

LMQRCWAEDPQERPPFQQIRLTL
|.|.||. ||..|| |..|.  |
LIQQCWHHDPSQRPSFDEIIHRL
Kinase ANPa.AA Pkinase_Tyr 779-801 47 1.2e-08 29.88 Pfam 248-270 (270) Show / Hide 
Range on Protein: 779-801
Range on HMM: 248-270/270
Sequence Identity: 47% (11 aa)

LMQRCWAEDPQERPPFQQIRLTL
||..||..||..|| |..|.  |
LMKQCWHYDPEDRPTFSEIHEQL
Kinase ANPa.AA MLK 774-801 46 2.8e-08 24.98 In-house 264-291 (291) Show / Hide 
Range on Protein: 774-801
Range on HMM: 264-291/291
Sequence Identity: 46% (13 aa)

EELGLLMQRCWAEDPQERPPFQQIRLTL
| .  ||..|| .|| .|| |.||   |
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase ANPa.AA DRK 779-803 48 4.9e-07 19.92 In-house 234-258 (258) Show / Hide 
Range on Protein: 779-803
Range on HMM: 234-258/258
Sequence Identity: 48% (12 aa)

LMQRCWAEDPQERPPFQQIRLTLRK
||..|| |||| || .|..   |  
LMNDCWNEDPQHRPSMQECLERLEA
Kinase ANPa.AA Dicty4 779-803 44 2e-06 17.48 In-house 251-277 (277) Show / Hide 
Range on Protein: 779-803
Range on HMM: 251-277/277
Sequence Identity: 44% (12 aa)

LMQRCWAEDPQERPPFQQIRLT--LRK
|.|.|| .||| || |..|     |  
LIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase ANPa.AA Dicty4-Unclassified 779-801 43 0.000113 11.89 In-house 241-263 (263) Show / Hide 
Range on Protein: 779-801
Range on HMM: 241-263/263
Sequence Identity: 43% (10 aa)

LMQRCWAEDPQERPPFQQIRLTL
|   || .||. || . ||   |
LIKWCWHNDPNKRPTMNQIIQYL
Kinase ANPa.AA Dicty4 700-733 41 0.000263 10.46 In-house 182-211 (277) Show / Hide 
Range on Protein: 700-733
Range on HMM: 182-211/277
Sequence Identity: 41% (14 aa)

LWTAPELLRMASPPVRGSQAGDVYSFGIILQEIA
.|.||| ..      .  .. |||||||.| ||.
CWMAPEVMMHQ----PYNEKADVYSFGIVLWEIL
Kinase ANPa.AA MLK 721-732 50 0.246062 0.55 In-house 218-229 (291) Show / Hide 
Range on Protein: 721-732
Range on HMM: 218-229/291
Sequence Identity: 50% (6 aa)

DVYSFGIILQEI
||.|.|..| |.
DVWSWGVVLWEM
CYCc ANPa.AA CYCc 840-1034 48 2.3e-114 387.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 840-1034
Range on HMM: 1-231/231
Sequence Identity: 48% (111 aa)

EEKRKAEALLYQILPHSVAEQLKRGE-TVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFD-----VYKVETIGDAYMVVSGL
.||.|.. ||.|.||..||.|||.|. .|.....|.|||.|.||||||.|....||||||..|||.||.|| .||...     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PVRNGR-------------------LHACEVARMALALLDAVRSFRIRHR----PQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE
| ||.                     ||...| .||  ......| ..|.    |...||.|||||||||..||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALKIHLSSETKAVL-------EEFGGFELEL
. .||.|.||. .|        ..|.||.| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc ANPa.AA Guanylate_cyc 867-1053 46 4e-110 376.97 Pfam 1-214 (214) Show / Hide 
Range on Protein: 867-1053
Range on HMM: 1-214/214
Sequence Identity: 46% (99 aa)

VQAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVIDNF--DVYKVETIGDAYMVVSGLPVR-----NGRLHACEVARMALALLDA
|.|. .|.|||.|.|||||||......    |||.|..|||.||||| ..|..  ..|||.||||.||.|||||..     ... ||. .| |||.....
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VRSFRIRHRPQEQ-----LRLRIGIHTGPVCAGVVG--LKMPRYCLFGDTVNTASRMESNGEAL--KIHLSSETKAVLEEFGGFELEL----RGDVEMKG
...... | ..|.     ...|||||||||.|||.|  ..|||||..|||||.||||||.|...  |||.| ||...|.. ..|. |.    ||....||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGK---VRTYWLLG
|||   . ||.| |
KGKMGEMETYFLHG
HNOBA ANPa.AA HNOBA 840-861 54 6.6e-09 33.78 Pfam 213-234 (234) Show / Hide 
Range on Protein: 840-861
Range on HMM: 213-234/234
Sequence Identity: 54% (12 aa)

EEKRKAEALLYQILPHSVAEQL
|||.| ..|||...|.|||..|
EEKKKTDDLLYSMFPKSVANRL