Gene ATM (Human)

ATM

Species: Human
Alias: TEL1, ATD, ATE, ATDC, ATC, ATA, DKFZp781A0353, ATM, MGC74674, AT1, TELO1, TRIM29
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 11q23,

Classification

Group: Atypical
Family: PIKK
Subfamily: ATM

Sequence

Name Sequence Type Origin Length Description Download
ATM.AA Protein Sugen Kinome 3056 None Fasta, JSON
ATM.NA RNA Sugen Kinome 13147 None Fasta, JSON
ATM.kin_dom Protein Kinase Domain None 304 None Fasta, JSON

Protein domain

Protein domains of ATM.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TAN ATM.AA TAN 5-166 20 1.2e-51 180.81 Pfam 1-168 (168) Show / Hide 
Range on Protein: 5-166
Range on HMM: 1-168/168
Sequence Identity: 20% (35 aa)

LNDLLI--CCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECL-RIAKPNVSASTQASRQKKMQEISSLV
.....|  ||..|..|....|....................  |..... . ..|...|..|...|.||...  | .... |.||..|............
MSTHDINKCCNLLQSDKIKDRNDALDNLEHILKSNPRNSQF--HHNRNRLNDKQWHKIFEALFRCIEKEKRKYCRNRNKKKSQSTANSSENRLSSCAYAL

KYFIKCANR--RAPRLKCQELLNYIMDTVKDSS---NGAIYGADCSNILLKDILSVRKYWCEISQQQWLE
..|. |...  . .|.........|.||..|..     . .. |.| .||...||....||.....||. 
RLFVECGCHDIKFKRKHYMAIVDHITDTFPDPDSGSLCEPCSVDYSKCLLSTLLSYPPHWCHLMRHQWEH
FAT ATM.AA FAT 2096-2489 14 4.6e-63 211.39 Pfam 1-408 (408) Show / Hide 
Range on Protein: 2096-2489
Range on HMM: 1-408/408
Sequence Identity: 14% (66 aa)

EELHYQAAWRNMQWDH-C---------------------TSVSKEVEGTSYHESLYNALQSL--RDREFS--TFYESLKYARVKEVEEMCK-RSLESVYS
 .|...||||..|||  .                      ....|   .... |...|...|  . ..|.   ...  . ||   ..|...  . || ..
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDE---PTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNR

LYPTLSRLQAIGELESIGELFSRSVT---------HRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELS
 ||.. |.|.. ||| | . .|. ..            . ..   |.|. .  | ........|...|....... ...| ||.. ...  ....  . .
HYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM-NSFCYRGPHEDMWMWIKFA

ILARTFKNTQLPERAIFQIKQYNSVSCG-----VSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASC--AANNPSLKLTYTECLRVCGNWLAETCLEN
 |.|   ..|| |...... .|..  ..      ..|. .... .||...|  |...|......  ...  ..|| ...  .|.                
NLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTY----------------

PAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKI-QTNRYTVKVQRELELDELA
             ||  |   | .    .. |.... .... . .|  .|.||. ...|.|.. |.  .. ... ...   . ... ..  ....... .
-----------NLEVINNTNLEYFYTKLLA-MRCYHKQGMWQWKLY--EEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQ

LRALKE----DRKRFLCKAVENYINCLLSGEE--HDMWVFRLCS
 .....    ........||.... .. ....  .. . .||..
PQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Kinase ATM.AA ATM 2713-3016 98 2e-302 978.26 In-house 1-304 (304) Show / Hide 
Range on Protein: 2713-3016
Range on HMM: 1-304/304
Sequence Identity: 98% (300 aa)

RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKS
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||..||.|||||||||||||||||||||||||||||||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNEDGAHKRYRPNDFSAFQCQKKMMEVQKKS

FEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTR
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
FEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTR

DIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMR
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMR

LQEK
||||
LQEK
Kinase ATM.AA PIKK 2706-2952 45 3.9e-144 485.15 In-house 25-290 (290) Show / Hide 
Range on Protein: 2706-2952
Range on HMM: 25-290/290
Sequence Identity: 45% (121 aa)

GSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFS--------
|.|||| ..|.||..|||||....|.||..||.||...|..||.|.|.||.|.|.|||.|..||....|...|.........|.|.......        
GHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIRHEQEAQMNYQTCMYR

---------AFQCQKKMMEVQKKSFEEKYEVFMDVCQN-FQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH
         ..|.|...|..|.....||.|||....|| ....|......||.||.||.|.| .||||.|....|||||||||||..||.|..|..|.||
DWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVH

IDLGVAFE-QGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVL
||.|..|| ....||.||.|||||||..|..||..|||||||||||..|..||...|||.|..||.
IDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase ATM.AA PI3Kc 2713-3016 26 3.2e-115 390.0 SMART 1-336 (336) Show / Hide 
Range on Protein: 2713-3016
Range on HMM: 1-336/336
Sequence Identity: 26% (90 aa)

RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH--------------------KRYR
. ..|..||||||. |.|.|...|...|...|.|.|.|....||..|.....|..||.. .... . ... .. ..                     .| 
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY-

PNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDP-AIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG
........|...||. .....|...  .. .|....||.. ...|.| ||  .|.| |  .|||.|  ..|.||||.|||| .||.. ... ...|||.|
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

VAFEQGKILPTP-----ETVPFRLTRDIVDGMG----ITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPL-FDWTMNPLKALYLQQRPEDE--TE
 .|..|. .|..     |.||||||.|.|..||    ..|..| ||.||......|| .........|...|||. ..|.|.. .  ||.|| . .  ..
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSD

LHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEK
 . .  .....|.  ... ..|... .  ....... 
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase ATM.AA PI3_PI4_kinase 2711-2962 22 3.5e-64 224.34 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2711-2962
Range on HMM: 1-300/300
Sequence Identity: 22% (67 aa)

ERRQLVKGRDDLR--QDAVMQQVF-----------------------QMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNN-E
. ....|| ||||  ||. | | .                       ...|.... . ..|.|.... .|...|.. ..|..||   .... | . .  .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

DGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDP-AIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILI--NEQ
 ..|| .  ...  . ..... .  .   ... . .|  .... |... . .... |.  .|.| |  ..||.|  ..|.||||.||||  ||..  .. 
KCKHKHFNKEHK-MWMKMWPDWWHLM-RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKT

SAELVHIDLGVAFE--QGKILPTPETVPFRLTR------DIVDGM------GITGVEGVFRRCCEKTMEVMRNSQETLLTIV-------EVLLYDPLFDW
. .|.||| | .|.  ..| .. ||.||||.|.      ..|..|      . .| .| ||..|.......|  .. ...         | ...|.|..|
TGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMW

TM
..
RS
Kinase ATM.AA ATR 2681-2952 32 5.6e-61 206.37 In-house 1-267 (267) Show / Hide 
Range on Protein: 2681-2952
Range on HMM: 1-267/267
Sequence Identity: 32% (88 aa)

VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFL
  |  |     .   .  || |   |||||    . | .||||.|   ... .. | ....  | |.| . . || |.|| ......||   |. .   |
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

VNNEDGAHKRYRPND-FSAFQCQKKMMEVQKKSFEEKYEVF-MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILI
        | ..     . |.  .. |. . .   ||  ||   .     |.|. .   .|.||  |.  | .| || |  ..||||.|||||| .||||
-------DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILI

NEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVL
..   |.||.|  . | .|. .  ||.||||||. .| |||  . .|.||| || .| .||. .. .. ...  
DKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase ATM.AA FRAP 2844-2962 48 4.6e-42 146.05 In-house 132-251 (251) Show / Hide 
Range on Protein: 2844-2962
Range on HMM: 132-251/251
Sequence Identity: 48% (58 aa)

IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ
||||.|  |||| || |..||||||||||  ||... ..  .|||| |  ||   .    || .|||||| .|  | ..|.|| .|  ||  |.|.|   
IWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHK

ETLLTIVEVLLYDPLFDWTM
| .. . |   ||||| | .
ESVMAVLEAFVYDPLFYWRL
Kinase ATM.AA DNAPK 2861-2962 33 3.3e-22 77.5 In-house 199-301 (301) Show / Hide 
Range on Protein: 2861-2962
Range on HMM: 199-301/301
Sequence Identity: 33% (35 aa)

IVGYILGLGDRHVQNILINEQSAELVHIDLGVAFE-QGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFD
| ..||| ||||  | ..|    . . || | .|   .  || ||  ||||||  .  |   .. |...      |  .|     |.  ..|   ||.||
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

WTM
|  
WKN
Kinase ATM.AA SMG1 2842-2904 50 4.3e-20 63.13 In-house 180-242 (242) Show / Hide 
Range on Protein: 2842-2904
Range on HMM: 180-242/242
Sequence Identity: 50% (32 aa)

PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPE
|  |.    .| || |  |.||||.||||||. |.||     | ||||  . ||.|| |  ||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase ATM.AA FRAP 2711-2769 42 1e-16 58.06 In-house 1-59 (251) Show / Hide 
Range on Protein: 2711-2769
Range on HMM: 1-59/251
Sequence Identity: 42% (25 aa)

ERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
|   | ||..|.|||    | | . |.||. |.||.|. | |  | ..||| ..| . |
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGW
Kinase ATM.AA DNAPK 2681-2782 32 7.8e-14 46.55 In-house 2-103 (301) Show / Hide 
Range on Protein: 2681-2782
Range on HMM: 2-103/301
Sequence Identity: 32% (33 aa)

VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFL
| |  |         .  || |   | | .|   ..||  |||||    | ||  |  .        | |   || ..|.  | | .||   ||   . |
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

VN
 |
NN
Kinase ATM.AA SMG1 2699-2776 33 2e-06 17.25 In-house 10-87 (242) Show / Hide 
Range on Protein: 2699-2776
Range on HMM: 10-87/242
Sequence Identity: 33% (26 aa)

PKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPI
|| .  .|||||    | || .||  |  . |   . ||.          .     | | ||  |||.. |  |  |.
PKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL
FATC ATM.AA FATC 3024-3056 48 5.8e-16 54.17 Pfam 1-33 (33) Show / Hide 
Range on Protein: 3024-3056
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

TVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV
. ||| .||. |||.| ||.||.....|| .|.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW