Gene BIKE (Human)

BIKE

Species: Human
Alias: DKFZp434K0614, BIKE, HRIHFB2017, BMP2K, DKFZp434P0116
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4q13-q21.21,

Classification

Group: Other
Family: NAK
Subfamily: BIKE

Sequence

Name Sequence Type Origin Length Description Download
BIKE.AA Protein Sugen Kinome 1161 None Fasta, JSON
BIKE.kin_dom Protein Kinase Domain Sugen Kinome 264 None Fasta, JSON
BIKE.NA RNA Sugen Kinome 3895 None Fasta, JSON

Protein domain

Protein domains of BIKE.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase BIKE.AA BIKE 51-314 76 3.8e-215 721.03 In-house 1-267 (267) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-267/267
Sequence Identity: 76% (204 aa)

VTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTG-
||.||.||||||..|||||.|.|..||||||||||..|||||.||..|||..|||||||||.||..|.|...|||..|||||||. ||||.||..||.| 
VTVEEQLAEGGFAMVFLVRDHKGNKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGNGVWECMILMEYCRH-QVVNMMNQRLQQGQ

-FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGG--NYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTK
 |||.||||||||.||||.|||.|.|||||||||||||||.| |  .||||||||||||||||||.|||.|..||.||||..|||||||.||.||.||||
YFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQKHGVNYVKDEIEKYTTMCYRAPEMIDLYSGKEITTK

ADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYF
||||||||.|||||||.|||||||.|||||||||||||.|||..|||||.|||||.|.||||.|||..
ADIWALGCMLYKLCFFCLPFGESQLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase BIKE.AA NAK 51-315 50 6.6e-171 574.07 In-house 1-299 (299) Show / Hide 
Range on Protein: 51-315
Range on HMM: 1-299/299
Sequence Identity: 50% (150 aa)

VTLEESLAEGGFSTVFLVR----------THGGIRCALKRMYVN-NMPDLNVCKREITIMKELSGHKNIVGYLDCAVN-SI-SDNVWEVLILMEYCRAGQ
.| |. |||||||.|.||.          .. |  .|||||... ...|||.||||| .|| |..|.|||.|.|...| .  |...|||..|||||. |.
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

VVNQMNKKLQ-TG--FTEPEVLQIFCDTCEAVARLHQCKT--PIIHRDLKVENILLND---GGNYVLCDFGSATNKFLNPQK-DGVNV---VEEEIKKYT
... |||.|. .|  ||| |.||||||.||.|...|||..  ||||||.|.|||||..    |||.||||||.|.....|..  ...    |...|.|||
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFG-------ESQVAICDGNFT--IPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFA
|..||||||..|| ..||..|.|||||||.|||.||.|.||.       .|..||..||..  ||||||||...|.|||.||.||||.||.|.||....
TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase BIKE.AA NAK-Unclassified 51-311 29 1.5e-96 327.02 In-house 1-399 (405) Show / Hide 
Range on Protein: 51-311
Range on HMM: 1-399/405
Sequence Identity: 29% (119 aa)

VTLEESLAEGGFSTVFLVR---------------THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNV--WEVLILMEYC
.|    ||||||| |.||.                  .   .|||| .   . ||  |||| .|| . .|.||| |.|  ..   .|.   ||..|||||
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC

RAGQVVNQMN------KKL--QTGFTEPEVLQIFCDTCEAVARLHQCKT--------------------------------------------PIIHRDL
  | ..  ||      ..|  || |.| |.|||. |.|.... .||                                               |.||||.
SRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDI

KVENILLN----------------------------------------------------------DGGNYVLCDFGSAT--NKFLNPQKDGVNVVEEEI
|.||.|.                                                           ..|.|.||||||..   .  .  ..  . ....|
KIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQE-MQYLQDWI

KKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFG-ESQVA-------ICD--GNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV
 ..||. |||||||.|| . ||  | |||||||.|||.||.| ||  . | .       |    |....|.|..|| . | ||..|| .|| .|| |.||
NMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIYQV
Kinase BIKE.AA GAK 53-315 38 7.9e-68 224.45 In-house 3-277 (277) Show / Hide 
Range on Protein: 53-315
Range on HMM: 3-277/277
Sequence Identity: 38% (107 aa)

LEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSI--SDN-VWEVLILMEYCRAGQVVNQMN-KKLQ
 .  .||||| .|..    . |   |||||  . |        || .|| |.|| |||   | .  |   |.  . | |.|||||  .| |  .     .
VRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRMECY

TGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQK----DGVNVVEEEIKKYTTLSYRAPEMINLYGGKPI
  |    || ||  .| ||. .|  | ||||||.|.|| |..  .   |||||||| | . |           ||.|. ..||  || |||. ||   ||
KPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPI

TTKADIWALGCLLYKLCFFTLPF-GESQVAICDGNFT--IPD-NSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFA
  | ||||.||.|| .|.   ||   .  .|  || .  ||    .|.   | ||| .| ..|. |.|| .|    
GHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMC-FHDLIRACLQVNPDERLDIAMVVEYM
Kinase BIKE.AA S_TKc 51-317 24 5.4e-46 160.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 51-317
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

VTLEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRA--GQVVNQMNKKLQ
 .. . . .|.|..|...| .. | ..|.|..        .  .||| |.|.  .|.||| ..|. ..       .. . ||||    | .   . |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

----TGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPI
     .|.| ..  ... .|.|.. .|.    ||||||| |||||..  .  .||||.|.                      |. |.|||..      . 
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL------GY

TT-KADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSY-------FAFK
.. |.|.|..||.|| ..    ||   . .. .           |.    .|| .|. |||.|| . ..           . 
GKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BIKE.AA CAMK 56-311 19 7.4e-40 125.63 In-house 1-419 (425) Show / Hide 
Range on Protein: 56-311
Range on HMM: 1-419/425
Sequence Identity: 19% (83 aa)

SLAEGGFSTVFLVRTH-GG------------IRCALKRMYVNNMP----------------------------DLNVCKREITIMKELSG------HKNI
 | .|.|..|.|..    .             ..| | .  . ..                            |.   .||| ||| |.|      |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYLDCAVN-----------SISD-NVWE----VLILM---EYCRAG----QVVNQMNKKLQ-------------TGFTEPEVLQIFCDTCEAVARLHQC
.  ..   .           . |.  . .    . . |   |||  |     . .   .. .               ||| |. ..|   |.||. .|..
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

KTPIIHRDLKVENILLNDG-----------------GNYVLCDFGSATNK------FLNPQKDGVNVVEEE-----------IKKYTTLSYRA-PEMINL
.  |.||||| |||||.|                  .|  ..||| |. .      | .. ..| . . ..                |..| | ||..| 
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

YG-----------GKPITTKADIWALGCLLYKLCFFTLPFGESQV------------------AICDGNFT-IPD-------------NSRYSRN-----
 |            .... |.|.|..|..|| .   ..|| ..                     |. |... .|.              .. | .     
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFV

---IHCLIRFMLEPDPEHRPDIFQV
     .||| ||..|||.|. | |.
SQECKDLIRKMLQVDPEKRMTIEQC
Kinase BIKE.AA TKL-ciliate1 128-311 23 1.6e-36 122.49 In-house 76-275 (279) Show / Hide 
Range on Protein: 128-311
Range on HMM: 76-275/279
Sequence Identity: 23% (48 aa)

ILMEYCRAGQVVNQMNKKLQ--TGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATN-KFLNPQKDGVNVVEEEIKKY
| ||.|  |  .  . .| .      .   . .  |    .  ||. . |.||||||..|||.    .|  |.|.. ..  |   ...    . .|... 
IIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRN

TTLSYRAPEMIN--LYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNS------------RYSRNIHCLIRFMLEPDPEHRPDIFQ
||  ..||| .   .. ..||..|.||.|.| ..| |||   || ....   ..   ...               .. |.| |.  ... .|  ||.  .
TTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPF-QQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNE

V
.
I
Kinase BIKE.AA Pkinase 51-314 23 5.6e-35 124.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-293/293
Sequence Identity: 23% (74 aa)

VTLEESLAEGGFSTVFLVRTHGG-IRCALKRMYVNNMPD--------LNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAG-QVVN
 .... . .|.|..|.. . .|  .. |.|.. . .  .        |    .|| |||.| .|.||| ..|.  .  .|...   . ||||. |   | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFED--KDHIY---MVMEYCEGGLY-VM

QMNKKLQ----TGF--TEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNY----VLCDFGSATNKFLNPQKDGVNVVEEEIKKYT----T
     ..    ..|  .| |.  ..  ...... .|..   ||||||| ||||... |.      .||||.|  .            .     .|    |
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGT

LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES---------QVAICDGNFTIPDNSRYS---------------------RNIHCLIRF
. |.||| |.  ||.....|.|.|..||.|| ...  .|| ..         |.   ..   .. .. ..                     ..   .|. 
PWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

MLEPDPEHRP---DIFQVSYF
.|..||. ||   .|.|  .|
CLCKDPKKRPTAEQILQHPWF
Kinase BIKE.AA CAMKL 51-311 25 1.5e-34 107.59 In-house 1-291 (297) Show / Hide 
Range on Protein: 51-311
Range on HMM: 1-291/297
Sequence Identity: 25% (78 aa)

VTLEESLAEGGFSTVFLVRT-HG-GIRCALKRMYVNNMPD----LNV-----------CKREITIMKELS--GHKNIVGYLDCAVNSIS--DNVWEVLIL
 .... | .|.|..| | .     |.. | | .  . . .    ..             .||| ||| |.  .|.||.  ...  ..    ..  .. . 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

MEYCRAGQ--VVNQMNKKLQTG--FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGG--NYVLCDFGSAT----NKFLNPQKDGVNVVEE
||||  |     .   |.   .  ..|.|  ..|.  ..||. .|...  |.|||.| ||||| . |  |  ..||| ..    .           .. .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-----------IFGP

EIKKYT---TLSYRAPEMINL----YGGKPITTKADIWALGCLLYKLCFFTLPFGESQV------------AICDGNFTIPDNSRYSRNIHCLIRFMLEP
. |  |   ...| |||...     | |.    |.|||..| .|| . . .||| .  .             |  | . .|  .. |   . ||| ||..
GQKLKTFCGSPPYMAPEIFQGNNKPYDGP----KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQV

DPEHRPDIFQV
.||.|| | |.
NPEKRPTIHQI
Kinase BIKE.AA Ciliate-E2 51-314 19 2.4e-31 104.82 In-house 1-365 (365) Show / Hide 
Range on Protein: 51-314
Range on HMM: 1-365/365
Sequence Identity: 19% (76 aa)

VTLEESLAEGGFSTVFLVRT--HGGIR-----------------CALKRMYVNNM--PDLNVCKREITIMK---------------ELSGHKNIVGYLDC
  . . . .|.|..|....    .                    .. |  ....|   ...  |.|| ||.               |.  |.||. . .|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

AV--NSISDNVWEVLILMEYCRAG---QVVNQMNKKLQTG------FTEPEVLQIFCDTCE---------------AVARLHQCKTPIIHRDLKVENILL
    .  .     . . ||||  |   .  ....|| .        ||| |...|.   ..               |.  ||. .  |||||.| ||||.
FQEKDDNN-----IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF

NDGGNYVLCDFGSAT-NKFLNPQKDGVNVVEEEIKKYT------------------------TLSYRAPEMINLYG------GKPITTKADIWALGCLLY
       ..||| .. ..  | .. . ..  ....                           |. | |||..|  .      .|. ..|.|||.||..||
-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

KLCFFTLPFGESQVAICDGNFTIP----------------DNSRYSRNIHCLIRF----MLEPDPEHRPD----IFQVSYF
 ..|  .||   |  |..... .|                ..   | .   ||.     ||. ||| |..    |..  .|
EMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase BIKE.AA Ciliate-E2-Unclassified 52-314 19 7.3e-31 104.3 In-house 2-352 (352) Show / Hide 
Range on Protein: 52-314
Range on HMM: 2-352/352
Sequence Identity: 19% (71 aa)

TLEESLAEGGFSTVFLVRT--HGGIRCALKRMYVNNMPDLNVCKR---------EITIMK-------------ELSGHKNIVGYLDCAVNSISDNVWEVL
.. . . .|||..|....   ..    |.| | .... . .  ..         |. ..|             .|. |.... . .. .    .|   . 
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN---IY

ILMEYCRAG---QVVNQMNK-----------KLQTG-FTEPEVL-----QIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGG---NYVLCDFGSATN
| ||||. |   |  ....|           ..|.  ||| ...     ..|   ...   ||. .  |||||.| ||||....|   .  ..|||.. .
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

KFLNPQKDGVNV--------VEEEIKKYTTLSYR----APEMINLYGGKPIT----TKADIWALGCLLYKLCFFTLPFG---------------------
   |...|  |          ..   .  |..|     |||..    |.        |.|||.||..|| ..| ..||.                     
YQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ---GQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRK

ESQVAICDGNFTIPDNSR----YSRNIHC--LIR----FMLEPDPEHR---PDIFQVSYF
. .  |...|. .|  .     .  . ..  .|.     ||. .|. |   ..|..  .|
QLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase BIKE.AA STE 51-310 21 1.2e-30 105.48 In-house 1-350 (359) Show / Hide 
Range on Protein: 51-310
Range on HMM: 1-350/359
Sequence Identity: 21% (77 aa)

VTLEESLAEGGFSTVFLVRTHG----------------GIRCALKRMYVNNM-----------------PDLNVCKREITIMKELSG-HKNIVGYLDCAV
 .. | . .|.| ||.. . |                 | ..| |.| ..|                   ...  ..|| |||...  |.||| |..| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NSISDNVW--EVLILMEYCRAGQVVNQMNKKLQTGFT------------EPEVLQIFCDTCEA-VARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGS
.   .. .  |. | |||. .| .   ...|  .|..            |...  | ......  . ||. .  |||||.|  ||||       ||||| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

ATNKFL-----------NPQKDGVNVVEEEIKKYT-----TLSYRAPEMINLYG---GKPITTKADIWALGCLL-----YKLCFFTLPFGESQVAIC---
...              .      ..  | ... .     |  . |||.|.  |    |. .||.||| |||..      |  .....  .   .|    
CGQLTDSMANIQSNNIID------CI--ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNY

-------------DGNFTIPD-----------------NSRYSRNIHCLIRFMLEPDPEHRPDIFQ
             ..  ..||                  ...| . .  |.  |. ||..||.  |
HMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase BIKE.AA TyrKc 51-316 20 1.7e-09 -69.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 51-316
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

VTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKEL-SGHKNIVGYLDCAVNS----ISDNVWEVLILMEYCRAGQVVNQMNKK
.||.. | || | .|.. .    | .| | .  .    .    ||. ||..|   |.|||  . ... .    ..  .  ..|.|||.  |   .   |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMY--IEPLMIVMEYMPHGDLKDYLRKH

LQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQ-KDGVNVVEEEIKK----YTT--LSYR--APEMI-
  . .. .. |..  . ..  . ||.   ..|||||   |.|.....    .||| .  ...    . |  . .. ..|     .   | .|  ||| | 
RPK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLS--RDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECIN

-NLYGGKPITTKADIWALGCLLYKLCFF-TLPFGE--------SQVAICDGNFTIPDNSRY---------SRNIHCLIRFMLEPDPEHRPDIFQVSYFAF
 . .     ||| |.|. | ... .. .   |  .        ..|  .  .   ..   .         .  .. ...   . ||| ||   .. .  |
YGKF-----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF