Gene BRK (Human)

BRK

Species: Human
Alias: FLJ42088, BRK, PTK6
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 20q13.3,

Classification

Group: TK
Family: Src
Subfamily: SRM

Sequence

Name Sequence Type Origin Length Description Download
BRK.NA RNA Sugen Kinome 2519 None Fasta, JSON
BRK.AA Protein Sugen Kinome 451 None Fasta, JSON
BRK.kin_dom Protein Kinase Domain Sugen Kinome 254 None Fasta, JSON

Protein domain

Protein domains of BRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 BRK.AA SH3 11-71 29 3.3e-17 64.39 SMART 1-58 (58) Show / Hide 
Range on Protein: 11-71
Range on HMM: 1-58/58
Sequence Identity: 29% (18 aa)

PKYVGLWDFKSRTDEELSFRAGDVFHVARK-EEQWWWATLLDEAGGAVAQGYVPHNYLAERE
|... |.|.......||||..||...| .| .. ||.... .       .|..|.||..| .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNR----TGQEGWFPSNYVEEID
SH3_2 BRK.AA SH3_2 12-70 22 4.5e-08 31.17 Pfam 1-68 (68) Show / Hide 
Range on Protein: 12-70
Range on HMM: 1-68/68
Sequence Identity: 22% (16 aa)

KYVGLWDFKS-RTDEE-----LSFRAGDVFHVA----RKEEQWWWA-TLLDEAGGAVAQGYVPHNYLAER
.|. . |... .  .|     |.|..|||..|     .. ..|||. . .   | ..  |..|.....| 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETI-WGGRRM-RGWFPSQWVEEC
SH3_1 BRK.AA SH3_1 14-64 30 6e-08 29.92 Pfam 1-49 (49) Show / Hide 
Range on Protein: 14-64
Range on HMM: 1-49/49
Sequence Identity: 30% (16 aa)

VGLWDFKSRTDEELSFRAGDVFHVARKEEQ--WWWATLLDEAGGAVAQGYVPH
| | |.. ....||||. ||..||  |..   || . ...       .|..|.
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNT----GQEGWFPS
SH2 BRK.AA SH2 76-161 43 3.4e-33 117.52 SMART 1-87 (87) Show / Hide 
Range on Protein: 76-161
Range on HMM: 1-87/87
Sequence Identity: 43% (38 aa)

EPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNE--AVSFLSLPELVNYHRAQSLS
.||..| |||.||.. |...|.  |.||.| ||.   |||||||. . |.||.| | . |. .. |   ..| || ||||...  .|.
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 BRK.AA SH2 78-155 44 4.6e-30 90.08 Pfam 1-81 (81) Show / Hide 
Range on Protein: 78-155
Range on HMM: 1-81/81
Sequence Identity: 44% (36 aa)

WFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQ---AVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYH
|..| |||.|| |.|...||  |.||.| ||    ||.|||||      |.||.| | ..| . . . . | ||.|||...
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase BRK.AA SRM 191-442 79 1.9e-225 755.26 In-house 1-253 (253) Show / Hide 
Range on Protein: 191-442
Range on HMM: 1-253/253
Sequence Identity: 79% (201 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELL
||||||||.||||||.|||||..|.||||||.||||.||.|||.|||||||||||||..|.||.|||||||||||||.||.|...|||||||.||...||
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVY-LSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYP
|.|.||||||||||.||||||||||||.|||.|.||||||||||||||.|.| .|||||||||||||||....|||.|||||||||||||||..||.|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLS
||.|||.|...|.|||||||.||||.||||||.|||||||||||||.|||.|.
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase BRK.AA Src 191-441 54 9.20000000001e-173 580.24 In-house 1-255 (255) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-255/255
Sequence Identity: 54% (140 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLR-DSDEKVLPVSEL
..||||||.|.||||..|.|.....||.|...... ....... |.|.||||||.....||||.| ..|.||.||.|..||||. |. |.... |.. .|
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL

LDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIK--EDVY-LSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQV
.|.|.||||||.||||.|||||||||||.||||| .|||.|||||||||  .|.|  .|....|.|||||||...|....|||||||||||.|....|.|
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK-LMLTCWCRDPEQRPCFKALRERL
|||||.|||.. .|..||||||| .||..... .|| ||..||||||.|. |.. |
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase BRK.AA TyrKc 191-441 40 2.9e-139 469.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-280/280
Sequence Identity: 40% (117 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKL--RHKHILALYAVVSVG-------DPVYIITELMAKGSLLELLRDSDE
 || .|||.| ||||..| ||  .|||.|..  |    .... .|.. |.||  .|..|..||.|.. .       .|..|..|.|..|.|.. ||.. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKED-------VYLSH----DHN--IPYKWTAPEALSRGHYSTKS
| |....||...||.|.|| ||.|.|.|||||||||.|||||  .|..||||.| |..|        | ..    . .  .|..|.|||..  | ..|||
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSFGILLHEMFSRGQVPYPG-----MSNHEAFLRVDAGYRMPCPLE--------CPPSVHKLMLTCWCRDPEQRPCFKALRERL
||||||... |.|..|| ||||     ||| |.. .|..|||||.| .        ||. ....|..|| .|||.||.|....|..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BRK.AA Pkinase_Tyr 191-441 44 2.8e-136 462.19 Pfam 1-270 (270) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-270/270
Sequence Identity: 44% (121 aa)

FTLCRKLGSGYFGEVFEGLWK-----DRVQVAIKVI--SRDNLL--HQQMLQSEIQAMKKL-RHKHILALYAVVS-VGDP--VYIITELMAKGSLLELLR
 |. .|||.| ||||..| ||     ....||.|..  . .     .. ... |.. ||.| .|..|. ||.|..  |.|  .||..|.|..|.||. ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DS--DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLI-KEDVYLSHDHN---IPYKWTAPEALSRGHYSTKSDVW
.   |.. |....||...||.|.|| ||||.|.|||||||||.||.||  .|..||||||.| ..| | .. .    .| ||.|||... | ..||||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGILLHEMFSRGQVP-YPGMSNHEAFLRV-DAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL
|||.|. |.|..|. | ||||||.| . .. . |||||||  ||. ...||. ||  |||.|| |....|.|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase BRK.AA SFK-Src 191-445 49 8e-128 381.11 In-house 1-259 (259) Show / Hide 
Range on Protein: 191-445
Range on HMM: 1-259/259
Sequence Identity: 49% (128 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELL
  | .||||| ||.|. | | .  .||.|         .  || | | ||||||     ||||   | |.|||||||. ||||  |..   . | .  | 
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQ-EAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLV

DIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLI-KEDV-YLSHDH-NIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVP
| | ||| || ||| ||..||||||||.|||.|  |||||||..| . ..|  |  |.    | ||||||| .   .|.||||||||||. |.   | .|
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YPGMSNHEAFLRVDA--GYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFT
||||.| |   .||   |||||||  ||.  .|.|. ||   |. || |  |. ..  | 
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase BRK.AA TK 191-441 24 1.7e-114 385.46 In-house 1-486 (486) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-486/486
Sequence Identity: 24% (119 aa)

FTLCRKLGSGYFG---EVFEGLWKDR--------------------------VQVAIKVISRDNLLHQQMLQS--------------EIQAMKKLR----
 || .|||.| ||   ||..|.|..|                          ..||.|..  ..  .|.. .               | ..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKHILALYAVVSVG------------DPVYIITELMAKGS----LLELLRDSDEK--------------------------------------------
 |..|. ||.|.. |             |..|..|.|..|.    |.. ||....|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------VLPVSELLDIAWQVAEGMCYLESQ------NYIHRDLAARNILVGENTL-----------CKVGDFG---
                               |.. .|| ..||.|.|| ||.|.      |..||||||||.|||||             ||..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI--KEDVYLSH------------------------DHNIPYKWTAPEALS---------RGHYSTKSDVWSFGILLHEMFSRGQVPYPG-M
     ||| |  ..| | ..                        .  .| .|.|||.|           |...|||||||||.|..|.|..||.||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------HEAFLRVDAG--------------YRMPCPLECP--------------PSVHKLMLTCWCRDPEQRPCFKALRERL
||         .| . .. .|              .|||.|  ||              . .. ||. || .|||.|| |..|.|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase BRK.AA SrcA 191-441 53 2.1e-111 353.39 In-house 1-250 (250) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-250/250
Sequence Identity: 53% (135 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELL
 .| |.|| | ||||. | |    .|||| .    .  .  |. | | ||||||  .  ||||||  .|.||.|| |.|||||. |.| . | | . .| 
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLE-EAQIMKKLRHDKLVQLYAVVSE-EPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLV

DIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYP
|.| |||||| |.|  ||||||| | ||||||| .||. ||||||||... | ..     | |||||||   | .  ||||||||||| |.  .| ||||
DMAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP

GMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL
|| | |    |. ||.|||| .|| |.| ||  || .||| || |  |   |
GMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase BRK.AA Frk 191-445 50 7.4e-107 361.3 In-house 1-260 (260) Show / Hide 
Range on Protein: 191-445
Range on HMM: 1-260/260
Sequence Identity: 50% (133 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLR--DSDEKVLPVSE
  | |.|||| ||||.||||   . ||.| .    .  . .|. | | ||||||  .. ||||  | .|.||||||| .|||.| |.  .   . . . .
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLR-EAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ

LLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLAR-LIKEDV--YLSH-DHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRG
|.|.| ||| || ||||||||||||||||.||||.  ||. |||||| |.|..   | |. .  .| |||||||    ....||||||||||| |.   |
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

QVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFT
..||||| | |    ||.|||||.| .||. . ..|| ||  ||..|| |  |. .|  . 
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase BRK.AA Src-Unclassified 191-441 43 5.9e-105 354.99 In-house 1-284 (284) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-284/284
Sequence Identity: 43% (123 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRD---NLLHQQML-------QSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSD
  | |||| | ||||. | |.  | ||.|    .    .   . |         | | |||.||  . .|||| |   | |||||.| .||||  ||  .
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

EKVLPVSEL------------LDIAWQVAEGMCYLESQNYIHRDLAARNILVGENT-----LCKVGDFGLA--RLIKEDVYLS-HDHNIPYKWTAPEALS
 . |.  ..             ||| ||| || ||||  |.||||||||.|.|.|      . || |||||  .|. .| |    .   | ||.|||.  
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCP--LECPPSVHK-LMLTCWCRDPEQRPCFKALRERL
 |  |.||||||.|||| |..  ||.||||| | |.   |  ||||| |    || ..   .|. ||  ||..|| |  |   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase BRK.AA UTK 191-441 34 5.4e-102 345.16 In-house 1-296 (296) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-296/296
Sequence Identity: 34% (103 aa)

FTLCRKLGSGYFGEVFEGLWKD------RVQVAIKVISRDNLLHQQML--------QSEIQAMKKLR-HKHILALYAVVSVGDPVYIITELMAKGSLLEL
  | |.||.| ||||... ...       ..||.|| ...    |..         . |.| ||... | ..| |..|.. . | .|.||.|..|.|. .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRDSDE----KVLPVS--ELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGEN-------TLCKVGDFG---LARLIK-----------EDVYLSHDHN
||.. .      . ..  ..|. ||..|.|| ||.|....||||||||.||...       ..||..|||   ..|...           . .. .|.  
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPYKWTAPEALSRG-HYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAG--YRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL
.| .|.|||||  . ...|||||||||....|....|..|||||||......| .|  |||||| .|| .| .||. ||  ||. || |. |....
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase BRK.AA SrcB 191-442 46 2.7e-94 319.4 In-house 1-251 (251) Show / Hide 
Range on Protein: 191-442
Range on HMM: 1-251/251
Sequence Identity: 46% (117 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELL
  | .|||.| ||||. | ... ..||.| . .  .  .  |. |   ||.| |...  |||||.   |.||||| ||||.||. |.  .   |..  |.
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLA-EANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLI

DIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYP
|.. |.|||| |.| .||||||| | |||| |  .||. ||||||.| .. |  ..    | |||||||.  | .  ||||||||||| |.   |..|||
DMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

GMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLS
||.| |    .. |||||.| .||. . ..|  ||   ||.|| |  |.  | 
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase BRK.AA Src-Echino1 192-441 44 7.9e-94 318.03 In-house 2-252 (252) Show / Hide 
Range on Protein: 192-441
Range on HMM: 2-252/252
Sequence Identity: 44% (113 aa)

TLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLD
 . .|.|.| .|||..|.|.   .||.| .     . .  .  |   |||.||. |. .||| |  .|.||.|||| .|.|.. |.. . | . ...|.|
RMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKT-MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

IAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPG
.  ..| || ||.|.|..||||||||.|||.  .||. ||||||....||| ..    .| |||||||   | .  ||||||||||. ||   |..||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MSNHEAFLRVDAGYRMPCPLECPPSVHKL-MLTCWCRDPEQRPCFKALRERL
| |.|   .|| ||||| . .|| |.... |. || .|| ||| |. | . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase BRK.AA S_TKc 191-445 26 1.9e-58 201.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-445
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

FTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAK--GSLLELLRDSDE----KV
... ||.|.| ||.|. . .|.   .||||.|.       .....||| .|| .|..|  || |    | .|...|..    |.|......       ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYST-KSDVWSFGILLHEMFS
.|  .   ...|..... |. |.. |||||   |||. |    |..||||||..       .       . ||| |   .|.. |.|.||.|..| ||..
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

RGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRE-----RLSSFT
 |. |.|   .... ...            .|..  ..  |...|||.||    . .     ..  . 
-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BRK.AA Pkinase 191-441 24 3.2e-49 174.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-293/293
Sequence Identity: 24% (74 aa)

FTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNLLH--QQMLQS--EIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKG----SLLELLRDSDE
... ||.||| ||.|... .|.  . ||.|.|....  .  .| .    ||| ||.|.|..|. || ..  .| .|...|.. .|    .| .... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KVL--PVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLC----KVGDFGLARLIKEDVYLSHDHNIP---YKWTAPEALS-RGHYSTKSDVW
...  .  |. ....|...|. |. |.. |||||   |||. .|  .    |..|||||....     ..  . .   . . ||| .  . .|..|.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGILLHEMFSRGQVPYPGM----SNHEAFLRVDAGYRMPCPLECP-----------------------PSVHKLMLTCWCRDPEQRPCFKALRER--L
|.|..|.||.. |. |.||     . |.   ...   . | . ..|                       ..  ...  |.|.||..|| .. . .   .
SCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF