Gene BTK (Human)

BTK

Species: Human
Alias: AGMX1, IMD1, PSCTK1, BPK, ATK, XLA, MGC126261, MGC126262, AT, BTK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: Xq22.1,

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
BTK.AA Protein Sugen Kinome 659 None Fasta, JSON
BTK.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON
BTK.NA RNA Sugen Kinome 2624 None Fasta, JSON

Protein domain

Protein domains of BTK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BTK BTK.AA BTK 135-171 56 1.2e-24 89.13 SMART 1-37 (37) Show / Hide 
Range on Protein: 135-171
Range on HMM: 1-37/37
Sequence Identity: 56% (21 aa)

NSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENR
|....||||||||.||..|||.||.|||.||......
NNHRMQKYHPCFWMDGHWLCCQQTCKNAPGCCPCHPH
BTK BTK.AA BTK 140-171 59 1.3e-16 66.29 Pfam 1-32 (32) Show / Hide 
Range on Protein: 140-171
Range on HMM: 1-32/32
Sequence Identity: 59% (19 aa)

QKYHPCFWIDGQYLCCSQTAKNAMGCQILENR
||||||||..|...||.||.|||.|||  ...
QKYHPCFWMNGHWSCCHQTDKNAPGCQPCHHW
PH BTK.AA PH 4-133 19 2.2e-16 61.75 Pfam 1-92 (92) Show / Hide 
Range on Protein: 4-133
Range on HMM: 1-92/92
Sequence Identity: 19% (25 aa)

VILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQ
||.|  ..|..      .  ..||| | |.  .|.||. |       ..||||........... .                             |. ||
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK-----YRPKGSIPLSDCQVTKVPDN---------------------------KRPHCFQ

VVYDEG-PLYVFSPTEELRKRWIHQLKNVIR
... ..  .|.. ..|| ...|.. .. ..|
IRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH BTK.AA PH 4-135 19 3.2e-16 61.14 SMART 1-82 (82) Show / Hide 
Range on Protein: 4-135
Range on HMM: 1-82/82
Sequence Identity: 19% (26 aa)

VILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQ
||.|   .|.|         ..||| | |. . |.||. .       ..||||.....|..| .                                  |.
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK-------KPKGSIPLSDCTVRE-P---------------------------------CFE

VVYDEGPLYVFSPTEELRKRWIHQLKNVIRYN
... .. .|.. ..|| ...|.. ....|. |
IHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN
SH3 BTK.AA SH3 217-273 44 6e-23 83.49 SMART 1-58 (58) Show / Hide 
Range on Protein: 217-273
Range on HMM: 1-58/58
Sequence Identity: 44% (26 aa)

KKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAE
..|.||||| . |...| ..||| . .||...  ||..| . .||||..|||||.| .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 BTK.AA SH3_1 220-266 44 2.8e-22 78.01 Pfam 1-49 (49) Show / Hide 
Range on Protein: 220-266
Range on HMM: 1-49/49
Sequence Identity: 44% (22 aa)

VALYDYMPMNANDLQLRKGDEYFILEESNL-PWWRARDKN-GQEGYIPS
||||||.......|...|||.....|.|.   ||..|..| ||||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 BTK.AA SH3_2 218-272 23 1.5e-07 29.29 Pfam 1-68 (68) Show / Hide 
Range on Protein: 218-272
Range on HMM: 1-68/68
Sequence Identity: 23% (16 aa)

KVVALYDYMP-MNAND-----LQLRKGDEYFIL----EESNLPWWRA-RD-KNGQE--GYIPSNYVTEA
..... || |  ..|.     |...|||   ..    ....  ||.. .  ..|..  |..||..| | 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-NWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 BTK.AA SH2 281-362 30 1.8e-38 114.77 Pfam 1-81 (81) Show / Hide 
Range on Protein: 281-362
Range on HMM: 1-81/81
Sequence Identity: 30% (26 aa)

WYSKHMTRSQAEQLLKQ-EGKEGGFIVRDSS-KAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYH
|| ....|..||.||.. ....| |.||.|. . | ||.||. ...   . ...||....|.. .||....| |....||....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 BTK.AA SH2 279-368 36 8.6e-35 122.83 SMART 1-87 (87) Show / Hide 
Range on Protein: 279-368
Range on HMM: 1-87/87
Sequence Identity: 36% (34 aa)

YEWYSKHMTRSQAEQLLKQE-GKEGGFIVRDSSK-AGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAE--KHLFSTIPELINYHQHNSAG
..||  ...|..||||||.. ...| |.||||.. .|.|..||. |      | ..||...... ..||..|  .. |... ||.|..|||. |
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase BTK.AA Tec 402-653 73 1.8e-213 715.5 In-house 1-254 (254) Show / Hide 
Range on Protein: 402-653
Range on HMM: 1-254/254
Sequence Identity: 73% (186 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ--LL
|||.||||.||||||..||||.||||||||||||||||..|||||||||.|||.|||||||||..||||.|.||||..|||||||||..|.||...  ||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYE
|||.||||.|.|||...|.|||||||||||.||.||||||||..||||||.||||||.||||.|.||||..||..|||||.|||||||||..|.||||||
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

RFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILD
...|||..||..||.|||||||.|...|.|||.|||||..|||||..||..|..
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase BTK.AA Pkinase_Tyr 402-651 44 6.00000000001e-148 501.7 Pfam 1-270 (270) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-270/270
Sequence Identity: 44% (119 aa)

LTFLKELGTGQFGVVKYGKWR-----GQYDVAIKMIKEGSMSE----DEFIEEAKVMMNL-SHEKLVQLYGVCT-KQRP--IFIITEYMANGCLLNYLRE
.||.|.|| |.||.|. |.|.     ....||.||.|||.|.|    ..|..|||.|..| .|...|.|||||| ...|  |.|..|||..|.||.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

M---RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV-LDDEY-TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAF
    .... ...||.|| .....|||||||.. |||||||||||....|||..||||.|..  ||.| ... |.|.|..| .||...|.||..|||.|.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLMWEIYSLGKMP-YERFTNSETAEHI-AQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI
|||||||...|..| |.  .|.|  |.|  .| |. .|.......|..| .|||.....||||. ... .
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase BTK.AA TyrKc 402-651 40 8.10000000001e-141 475.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-280/280
Sequence Identity: 40% (115 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL--SHEKLVQLYGVCTKQ-------RPIFIITEYMANGCLLNYLREMRHR
.|..|.|| |.||.|  |.|.  ..||.||.||..  . .|..||..|..|  .|. .|.||||||.|        |..|..|||..|.|..|||. |..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD-------EYTSS---VGSK--FPVRWSPPEVLMYSKFSSKSDI
.....||..| .... ||||.||.. |||||||||||.....||.|||||||.. ||       .| ..    |.|  .|.|| .||...|.||..|||.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WAFGVLMWEIYSLGKMPYER-----FTNSETAEHIAQGLRLYRPHL--------ASEKVYTIMYSCWHEKADERPTFKILLSNI
|.|||.||||...|..||.       .|.|  |.. || |. .|.         .....|.|| .||||....||||. . . .
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BTK.AA Src 402-651 45 4.2e-119 401.97 In-house 1-255 (255) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-255/255
Sequence Identity: 45% (115 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR--EMRHRFQTQQLL
......||.|||| | .|.|.|. .||.| .|.|.|| . | .||..| .|.|||||||| ||..  ||.|.||||..|.|| ||.  .  .. . .||.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVL--DDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMP
.|   | | |.||||... |||||||| ||... |.|| |||| | .   ||||... |.|||..|  || . | .|. ||| | ||.|..|| . |..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YERFTNSETAEHIAQGLRLYRPHLASEKVYT-IMYSCWHEKADERPTFKILLSNI
|.  || |. ... .| |. .||   ...|  ||  |||.....||||..| .  
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase BTK.AA SFK-Src 402-655 45 3e-118 352.17 In-house 1-259 (259) Show / Hide 
Range on Protein: 402-655
Range on HMM: 1-259/259
Sequence Identity: 45% (118 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLRE-MRHRFQTQQLLE
    | || |||| |  |.| .. .||.|  | |.||..|| .|| ||  | |..|.||| |||   ||.|||| |..| || ||.|   .  . .||  
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVL-DDE-YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPY
|  .|   | ||| . | |||||||| || |  |.|| |||.|| .  ||| ||   | |||..|  ||   ...|| |||.|.||.|| ||  .| .||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

ERFTNSETAEHIAQ--GLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVM
.  || |    . .  | |.  |    .. | ||  || ...|.||||  |.  . |  
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase BTK.AA TK 402-651 25 4.90000000001e-117 394.09 In-house 1-486 (486) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

LTFLKELGTGQFG---VVKYGKWRGQ--------------------------YDVAIKMIKEG-SMSEDEFIE--------------EAKVMMNLS----
.|..|.|| ||||   .|  |.|||.                           .||.||.||| .||..||..              || .|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HEKLVQLYGVCTKQ------------RPIFIITEYMANGC----LLNYLREMR----------------------------------------------
 |. .|.||||||..            .|. |..|||..|.    |..|||. |                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------HRFQTQQLLEMCKDVCEAMEYLESK------QFLHRDLAARNCLVNDQGV-----------VKVSDFG---
                             |.. ..||| || .....||||.||      .| |||||||||||....|           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRYV-LDDEYTSSV------------------------GSKFPVRWSPPEVLM---------YSKFSSKSDIWAFGVLMWEIYSLG-KMPYERF
     |.|..  ||.|...                         | |.|.|| .||.|.         | ||..|||.|.||||||||...| ...|.  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------SETAEHIAQG--------------LRLYRPHLAS--------------EKVYTIMYSCWHEKADERPTFKILLSNI
.|          |  |.. .|              .|. .| ...              | .| .| .|||.....||||. |.. .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase BTK.AA UTK 402-651 33 4.4e-98 332.15 In-house 1-296 (296) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-296/296
Sequence Identity: 33% (99 aa)

LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIKEGSMSEDE------FIEEAK---VMMNLS-HEKLVQLYGVCTKQRPIFIITEYMANGCLLNY
. ....|| |.||.|  ....      .. |||.|  ........|      |.|||.   .|.... |.....|.||||.. |. |.||||.|| |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LREMRHRFQ-------TQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG-------VVKVSDFG---LSRYVL----------DDEYTSSVGSK
||  |. .          |.|.|. |. ..|.||.|..| |||||||||||....       |.|..|||   .||.|           ...|....  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPVRWSPPEVLMYS-KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQG--LRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI
 |.||  ||.| .  .|..|||.|.|||..|||.. |..||.  .| .... .  |  .|. .|.  .. ||..| .|||   .|||.|. |.. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase BTK.AA Src-Unclassified 402-651 40 1.1e-96 327.46 In-house 1-284 (284) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-284/284
Sequence Identity: 40% (114 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEG---SMSEDEFI--------EEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR
.  |..|| |||| | ||||||  |||.|  ..|    ||   |         .||..|  ..| .||.||.||..  |..|||||| || || .|||  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

HRFQTQQLL-------------EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG-----VVKVSDFGLS--RYVLDDEYTSSVGSKFPVRWSPPEVLM
 .    |..              .   |   |.|||||.  |||||||| |. .       |||| ||||   . . ||.|    |..||. |  ||   
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRP--HLASEKVYT-IMYSCWHEKADERPTFKILLSNI
| .|| |||.| .|.| |||  .|. ||    | |. ||.  | |. .|  |.  . .|  ||  |||.  . ||||  |    
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase BTK.AA Abl 402-651 46 2.3e-95 318.6 In-house 1-252 (252) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-252/252
Sequence Identity: 46% (117 aa)

LTFLKELGTGQFGVVKYGKW-RGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLL
..  . || ||.| |  | | | .  ||.| .|| .|  .||..|| .| .. |. |||| ||||.  | .||||.|..| ||.||||  |.  .   ||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYE
 |   .  .|.|||...|.||||||||||| .. .||| ||||.| . || ||   | |||..|  || | | |||||||.||||||.|||   |  || 
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

RFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI
    |.  . . .| |. ||.   .||| .|  ||. .. .||.|| .  ..
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase BTK.AA Frk 402-655 42 9.4e-95 321.1 In-house 1-260 (260) Show / Hide 
Range on Protein: 402-655
Range on HMM: 1-260/260
Sequence Identity: 42% (111 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR---EMRHRFQTQQL
. ....||.|||| |  |.|  .  ||.| .| |.|  ..|. ||..| .| | ||.||| ||| . ||.|||| | .| |..||.   .  .. | |||
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDE--YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGK
..|   |   | ||||. ..|||||||| ||... ..|. |||| |  . |.|  | | .| .||..|  ||   |.||. |||.|.||.|. ||   |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVM
|||   || |  . ...| |. .|    ...| ||  |||.....||||  |   . | .
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase BTK.AA Csk 402-651 42 2.5e-93 316.38 In-house 1-251 (251) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-251/251
Sequence Identity: 42% (108 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGS-MSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQR-PIFIITEYMANGCLLNYLRE-MRHRFQTQQL
|. ... | | || |. |.....  ||.|.||. .    . |. ||.||  |.|. |||| ||  .|   ..|..|||..| |..|||   || ....||
LHLGECIGHGEFGDVMQGEYQNR-KVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQL

LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSS--VGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKM
|    ||||.|.|||.|.| |||||||| || .. | |||||||..   .. ...    ..|||. |  || |  .|||.|||.| ||.|.||||| |  
LKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK---EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRV

PYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI
|| |   ..  .|.  | |   |    ..||..| .|||  . .||||. ...  
PYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase BTK.AA SrcB 402-653 44 2.8e-90 305.59 In-house 1-251 (251) Show / Hide 
Range on Protein: 402-653
Range on HMM: 1-251/251
Sequence Identity: 44% (112 aa)

LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLE
| . | ||.|||| |  | ....  ||.| .|.|.|| . |..|| || .| |..||.|| | ||  ||.|||||||.|||| .|. .   . .  .|..
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
|   . | | |.| . ..|||| | | || .  . |. |||| | . |.|||   | |||..|  || . .  |  |||.|.||.|. ||   |..||  
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILD
 ||.|  . . .| |. ||    | .| ||  ||.|...|||||  | | .||
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQS-VLD
Kinase BTK.AA S_TKc 402-655 22 9.8e-51 175.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 402-655
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

LTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMAN--GCLLNYLREMRHR-----F
 ..|...| | ||.|. ..... .  ||||.||      . .. | .....  |. .|.||.|.     .....||. .  | |. |.......     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSS-KSDIWAFGVLMWEIYS
   .   ... .|.|.||. |....||||   | |...  ..|..||||.| .     |. .|. .   . .||||   ...  |.|.|..|....| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPW---YMAPEVL---GYGKCKCDWWSCGCILYEMLC

LGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLS-----NILDVM
 |. |..  .  .. ..|            |. .  ..  |..   ..|||   .|      ..   .
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BTK.AA Pkinase 402-651 20 2.5e-46 164.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 402-651
Range on HMM: 1-293/293
Sequence Identity: 20% (61 aa)

LTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDEFIE-----EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG----CLLNYLR-EMR
..... .| | ||.|. ....|  . ||.| ||  . .... ..     |...| .|.|.  |.||....  . | ...||. .|     |  |.. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HRF--QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVV----KVSDFGLSR---YVLDDEYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDI
 .|  . ...  ... .....||. |. ..||||   |.|....|..    |..||||..   |  .  .|. .|.    .. .|||.. ... ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP---WYMAPEVIRGGQYYGPKVDM

WAFGVLMWEIYSLGKMPYERF----TNSETAEHIAQGLR--LYRPHLAS---------------------EKVYTIMYSCWHEKADERPTFKILLSN--I
|..|....| .. |. |.       .  .  . |.. ..  | ..   .                     |    ....|.. .  .|||.. .|    .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF