Gene BUB1 (Human)
BUB1
Sequence
Protein domains of BUB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Mad3_BUB1_I | BUB1.AA | Mad3_BUB1_I | 4-126 | 34 | 1.5e-60 | 208.39 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 4-126 Range on HMM: 1-133/133 Sequence Identity: 34% (46 aa) PENVLQMLEAHM--QSYKGNDPLGEWERYIQWVEENFPE----NKEYLITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYN----SDLHQFFEFLYNHG |...|..|... .||.|.||| | |||.|.|.|.|. .. |.||||.....|.| ..|.||||........... .. ...|...|.|| LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG IGTLSSPLYIAWAGHLEAQGELQHASAVLQRGI ||| .. .|..|| ..|..|..|.|....|.|| IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI |
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| Mad3_BUB1_I | BUB1.AA | Mad3_BUB1_I | 4-126 | 36 | 4.3e-57 | 200.77 | Pfam | 1-134 (134) | Show / Hide |
Range on Protein: 4-126 Range on HMM: 1-134/134 Sequence Identity: 36% (49 aa) PENVLQMLEAHMQSYK---GNDPLGEWERYIQWVEENFPE----NKEYLITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNS----DLHQFFEFLYNH ....|..|...|.|. |.|||. | |||.|.||..|. ....| ||||...|.|.. ..|.||||.. ..|....| . . ...|...||. LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ GIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGI |||| .. .|..|| .||..|..|.|..|.|.|| GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI |
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| Kinase | BUB1.AA | BUB | 787-1054 | 44 | 8.60000000001e-169 | 567.04 | In-house | 1-311 (311) | Show / Hide |
Range on Protein: 787-1054 Range on HMM: 1-311/311 Sequence Identity: 44% (138 aa) VYVHHLLGEGAFAQVYEATQGDLNDA--------KNKQKFVLKVQKPANPWEFYIGTQLMERLKPS----MQHMFMKFYSAHLFQNGSVLVGELY-SYGT .......|||..|.||.|...|..|. |.......|||||.|||||||..|..||||.. |...||...|.|..|..|....|.. .||| FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT LLNAINLYK---NTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLE-QDDEDDLSAG-------LALIDLGQSIDMKLFPKGTIF ||. ||..| ....|||.. .|. |...||.|.|..|.|||||||||||||.|.|.... .|.....|.| |.|||.|.||||.|||.|..| LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRF TAKCETSG--FQCVEML----SNKPWNYQIDYFGVAATVYCMLFGTYMKVK--NEGGECKPEGLFRRLPHLD-------MWNEFFHVMLN----IPDCHH ...|||.. |.|.||. .|.||.||.||||.|||..|||||.||.|| ..|...|.|..|||....| |||.|||.||| ||||.. KFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQT LPSLDLLRQKL ||... |||.. LPMWHELRQQF |
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| Kinase | BUB1.AA | Ciliate-E2 | 913-1003 | 20 | 2e-11 | 35.46 | In-house | 182-294 (365) | Show / Hide |
Range on Protein: 913-1003
Range on HMM: 182-294/365
Sequence Identity: 20% (27 aa)
IIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSID-------------MKLFPKGT-----------------IFTAKCETSGFQCVEMLSNKP-
||| ||||.| .. . .||.| | . .|... .| | | |... |.|..|.
IIHRDIKPENILF----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY
--------WNYQIDYFGVAATVYCMLFGTY
..|..|.. . . |.|||| .
DNQQKQKGYDYKCDIWSLGVILYEMLFGKP
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| Kinase | BUB1.AA | S_TKc | 787-1063 | 15 | 1e-10 | -19.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 787-1063 Range on HMM: 1-231/231 Sequence Identity: 15% (46 aa) VYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSY--GTLLNAINLYKN .. ..|.|||..|| .. . .... .|. | .. |.... .| . |.| . . .| |. . |.|. | .. YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK----EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR -TPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPW . ...| . ... .. .| |. ||| |.||.| | . . ..| | . . | | | . |.| .. HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GY NY-QIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKK---------VFQ-------QHYT .. .| . ..| || | .. .|... . .|..|. |.| ..| . GKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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| Kinase | BUB1.AA | Ciliate-E1 | 793-989 | 17 | 7e-10 | 28.8 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 793-989
Range on HMM: 1-202/202
Sequence Identity: 17% (38 aa)
LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQK-PANPWEFYIGT--QLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAIN--------LY
.|.| |..|..| | |. . .||... .. | ...| ..|. .| .. . | . . ...... |.... .|.. ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCC-SLKDYLQNHNRLEYWQQ
KNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFIL---GNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLS
... .. . . ... ..... ....|.. |||.||||.| . ||. .. |.|.| |. . .. |..|. ... | .
CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC--------------DFGISKFLKNNQNQQCQY-KGYTHYYYPPEQYN
--------NKPWNYQIDYF
|...||. | .
CPEQEHNKNQKINYKSDIY
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| Kinase | BUB1.AA | CK1 | 898-926 | 58 | 2.8e-09 | 28.63 | In-house | 138-166 (339) | Show / Hide |
Range on Protein: 898-926 Range on HMM: 138-166/339 Sequence Identity: 58% (17 aa) AMRMLYMIEQVHDCEIIHGDIKPDNFILG |..||. .|..||| .|| ||||||| .| AIQMLEALEYMHDCGFIHRDIKPDNFCMG |
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| Kinase | BUB1.AA | CK1-G | 894-926 | 42 | 1.1e-07 | 22.05 | In-house | 98-130 (266) | Show / Hide |
Range on Protein: 894-926 Range on HMM: 98-130/266 Sequence Identity: 42% (14 aa) VISFAMRMLYMIEQVHDCEIIHGDIKPDNFILG |. |. |. .|.||. . | .|.||||| | VCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIG |
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| Kinase | BUB1.AA | CK1 | 901-928 | 55 | 1.7e-07 | 22.12 | In-house | 114-142 (271) | Show / Hide |
Range on Protein: 901-928 Range on HMM: 114-142/271 Sequence Identity: 55% (16 aa) MLYMIEQVHDCEIIHGDIKPDNFILGN-G |. || || . .|| ||||||| | | MIQRIEYVHNKNFIHRDIKPDNFLMGRYG |
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| Kinase | BUB1.AA | CK1-Unclassified | 901-928 | 51 | 2.3e-07 | 17.8 | In-house | 113-141 (244) | Show / Hide |
Range on Protein: 901-928 Range on HMM: 113-141/244 Sequence Identity: 51% (15 aa) MLYMIEQVHDCEIIHGDIKPDNFILG-NG |. ||..| . .|| ||||||| | | MIQRIEYLHNKNFIHRDIKPDNFLMGKLG |
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| Kinase | BUB1.AA | CK1-D | 894-928 | 48 | 1e-06 | 19.55 | In-house | 97-131 (261) | Show / Hide |
Range on Protein: 894-928 Range on HMM: 97-131/261 Sequence Identity: 48% (17 aa) VISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNG |. | |. || .| . || |||||||..| | VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLG |
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| Kinase | BUB1.AA | TTBKL | 898-927 | 43 | 1e-06 | 18.7 | In-house | 108-137 (288) | Show / Hide |
Range on Protein: 898-927 Range on HMM: 108-137/288 Sequence Identity: 43% (13 aa) AMRMLYMIEQVHDCEIIHGDIKPDNFILGN ... || . |.||| .|| |.|| |. .|. GIQCLYALKQMHDCGFIHRDVKPCNCCWGY |
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| Kinase | BUB1.AA | CK1-A | 894-928 | 51 | 2e-06 | 18.77 | In-house | 97-131 (261) | Show / Hide |
Range on Protein: 894-928 Range on HMM: 97-131/261 Sequence Identity: 51% (18 aa) VISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNG |. | |. || || || |||||||..| | VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIG |
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| Kinase | BUB1.AA | CK1 | 787-822 | 30 | 0.002384 | 7.64 | In-house | 1-42 (339) | Show / Hide |
Range on Protein: 787-822 Range on HMM: 1-42/339 Sequence Identity: 30% (13 aa) VYVHHLLGEGAFA-QVYEATQGDLNDAKNK-----QKFVLKV | ...|||.| |.|... | | ||. .....|| WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKV |
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| Kinase | BUB1.AA | TTBKL | 789-824 | 32 | 0.00327 | 6.78 | In-house | 3-34 (288) | Show / Hide |
Range on Protein: 789-824 Range on HMM: 3-34/288 Sequence Identity: 32% (12 aa) VHHLLGEGAFAQVYEATQGDLNDAKN-KQKFVLKVQK . ...|||.|.|||.. | |. |.....|..| IVKMIGEGGFGQVYHVW-----DMKDKKDCAAMKEEK |
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| Kinase | BUB1.AA | Ciliate-E2 | 787-806 | 25 | 0.005873 | 5.97 | In-house | 1-20 (365) | Show / Hide |
Range on Protein: 787-806 Range on HMM: 1-20/365 Sequence Identity: 25% (5 aa) VYVHHLLGEGAFAQVYEATQ .. ..|.|.|..||.... YKFIKKIGQGNFGSVYKCKV |
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