Gene CHK2 (Human)

CHK2

Species: Human
Alias: PP1425, LFS2, CHK2, RAD53, HuCds1, CDS1, CHEK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 22q11.2-q12.1,

Classification

Group: CAMK
Family: RAD53

Sequence

Name Sequence Type Origin Length Description Download
CHK2.NA RNA Sugen Kinome 1991 None Fasta, JSON
CHK2.AA Protein Sugen Kinome 586 None Fasta, JSON
CHK2.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of CHK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FHA CHK2.AA FHA 156-235 25 2.3e-15 62.19 Pfam 1-73 (73) Show / Hide 
Range on Protein: 156-235
Range on HMM: 1-73/73
Sequence Identity: 25% (22 aa)

YWFGRDKSCEYCFDEPLLKRTDKYRT-YSKKHFRI-FREVGPKNSYIAYIED--HSGNGTFV--NTELVGKGKRRPLNNNSEIALS
...|||..| . .|        . ..  |..|..| ... |       ||.|  .| |||||  | . ...|....|.....| . 
WTIGRDPDCDIVLD--------NDPSFVSRHHCEIRRYDNG-----RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG
FHA CHK2.AA FHA 155-218 23 1e-05 26.29 SMART 1-49 (49) Show / Hide 
Range on Protein: 155-218
Range on HMM: 1-49/49
Sequence Identity: 23% (16 aa)

NYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHS---GNGTFVNTELV
 . .||.. | .  ..|.          |..|..|. . .       ||.|..    |||.|| . |
TWTIGRHS-CDIQLPHPS---------ISRHHCQIR-DGD-------YIIDLGEHSTNGTYVNGRRV
Kinase CHK2.AA RAD53 263-529 53 1.4e-215 649.37 In-house 1-305 (305) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-305/305
Sequence Identity: 53% (164 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA--EDYYIVLELMEGGELFDKVVGNK
|.|||.||||..|.||||.|.|||.|||||||.|.||.|.. .... . .|..|.||||||||||||.|...||.  ..||.|||||.|||||.|.|.||
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

R----LKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC---------------LIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS
|    ..|.|||.|||||..||.|||.|||.||||||||.|...|.|.|               ||||||||.||..||.|.|.|.||||.|.||||..|
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

VGT------------AGYNRAVDCWSLGVILFICLSGYPPFSEHRTQ----VSLKDQITS-GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEAL
 |.            .||...|||||.|.||.|||.||||||...||    ..|..||.. |||.|....|...||.|.||.|..|.|||..|.|..|||
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

RHPWL
.|||.
NHPWM
Kinase CHK2.AA CAMK 268-529 28 7.6e-126 407.73 In-house 1-425 (425) Show / Hide 
Range on Protein: 268-529
Range on HMM: 1-425/425
Sequence Identity: 28% (119 aa)

TLGSGACGEVKLAFER-KTC-----------KKVAIKIISKR---------------KFAIGSAR-----EADPALNVETEIEILKK-------LNHPCI
|||.|. |.|||....  |.           .|||||||.|.               .. ..  .     ..    ||. ||||.||       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKIKNFFD--------------------AEDYYIVL---ELMEGGEL----FDKVVGN---------------KRLKEATCKLYFYQMLLAVQYLHENGI
||.  ...                     ...|.|.   |...||||    ||..| .               .|..|. .. || |.. ||.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENVLLSSQEED--------------CLIKITDFGHSKILGE------------------------TSLMRTLCGTPTYLA-PEVLVSVG----
.||||||||.||.. ..|              . |||.||| .... .                        . .|.| |||| | | |||| . |    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------TAGYNRAVDCWSLGVILFICLSGYPPFSEHR------------TQVSLKDQITSGKYNFIPEV------------WAEVSEK--------ALD
         .|....|.||.||||.|.|.||||| .              ..  |. .|..|||.|.|.             | ..|.         . |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVKKLLVVDPKARFTTEEALRHPWL
|..|.|.|||. |.| |..|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CHK2.AA CAMK1 263-529 42 1.7e-119 349.04 In-house 1-276 (276) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-276/276
Sequence Identity: 42% (118 aa)

YIMSKTLGSGACGEVKLAFERKT---CKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK---LNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDK
|.  |..|.|| .||.|. ...|    |..|||.|.|.||  .. .      ..|.||||.||   ..|| |||.. .. . ...|.|.||. ||||||.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ-K-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

VVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIK--ITDFGHSKILGETS-LMRTLCGTPTYLAPEVLVS-VGTAGYNRAV
.| ..   |    .   | | ||.|.|..|| |||||||| |.....||  ||  | ||| |||... . || | |||| | |||||       .|  |.
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKAC

DCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEK-ALDLVKKLLVVDPKARFTTEEALRHPWL
|.|| |||..| | ||||| . . .  | ..|....|.|.   | ..|.. | |..|..|.|||| |.| |..|.|||.
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase CHK2.AA S_TKc 263-529 36 1.4e-102 347.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-231/231
Sequence Identity: 36% (102 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEG--GELFDKVVGNK
| . ...|.|| |.|... ..|| ..||||||.                ... ||.|||| .|| |.|.. .|. ...|.|.|...|  |.|||  . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRG

R------LKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNR-AVDC
|      . | ... |.||...|..|.|..|||||||||||.||..      |||.||| ...|      .|.|||| |.|||||      ||.. ..| 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL------GYGKCKCDW

WSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALR-------HPWL
||.|.||...|.|||||.   ..  . ..|               |. |.|...|.|..||. | |  |||.       |||.
WSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CHK2.AA CDPK 263-529 40 3.8e-100 307.81 In-house 1-271 (271) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-271/271
Sequence Identity: 40% (115 aa)

YIMSKTLGSGACGEVKLAFER-KT-CKKVAIKIISKR--KFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLE--LMEGGELFDK
|...|.||.|. |.|... .. ||  ..||.|||.|.  |..           ..  ||||||.| ||.||||  |. |   ||||.|  . .||||||.
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQ-------QQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDY

VVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC----LIKITDFGHSKILGET-----SLMRTLCGTPTYLAPEVLVSVGTAG
.. .....|    ....| | ||.| |.|.|.||||||||.|. | ..|      ||. |.| ||. .         |.. ||||.|.|||||       
IIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVL----QKK

YNRAVDCWSLGVILFICLSGYPP-FSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL
||  .| ||.||||.| |.|||| . . . ..  |  .  |||.|  . |...|. | ||..|.|..||| |.. ..|| ||| 
YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEK--VKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase CHK2.AA CAMKL 263-529 36 1e-96 309.18 In-house 1-297 (297) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-297/297
Sequence Identity: 36% (111 aa)

YIMSKTLGSGACGEVKLAFE-RKTCKKVAIKIISKRKFA-IGSAR--------EADPALNVETEIEILKKLN---HPCIIKIKNFFDAED-------YYI
|.. |||| |..|.||||   | | .||||||| |.|   .  ..        |.|.  ... ||.|.|.||   || |||.   .. ..       .|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM--RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VLELMEGGE--LFDKV--VGNKR--LKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE-----TSLMRTLCGTP
|.|. .|||  |||..   |..|  ..|  .. || |.. ||.|.|..||.|||.||||.||...     |||.||| | .  .       ...| ||.|
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

TYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRT-------QVSLKDQITSGKYNF-IPEVWAEVSEKALDLVKKLLVVDPKARFTTE
 | |||.. .      |  ..||.||.||||.  . || || .          .  |. .| .| |.. |.    .||  . || .|.|.|.|. |.| .
PYMAPEIFQGNNKPYDG--PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWY---HVS-DCRDLIRKMLQVNPEKRPTIH

EALRHPWL
. ..|||.
QIMNHPWM
Kinase CHK2.AA Pkinase 263-529 36 1.1e-92 319.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-293/293
Sequence Identity: 36% (109 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGG----ELFDKVV
|   ...|||. |.|... ...|.|.||.|||.||  .  . ....  |   .||.|.|.||||.|.... .| |  ..|.|.|..|||    .||| . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--GNKRL--KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC--LIKITDFGHSKI--LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNR
   ....   | .|| |.||.| ...|.|..|||||||||||.|.. .. ..   .||.||| .|   .   | | |.|||| |.||||.   |  .| .
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGP

AVDCWSLGVILFICLSGYPPFSEH-----RTQVSLKDQITSGKYNFIPEVWAEVS-----------------EKALDLVKKLLVVDPKARFTTEEALRHP
.|| ||.|.||.. |.|.|||..|     ..|  . ..| .... |  . | ..|                 | ..|..|..| .||| | | |..| ||
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

WL
|.
WF
Kinase CHK2.AA Ciliate-E2a 263-529 37 2.3e-87 257.21 In-house 1-275 (275) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-275/275
Sequence Identity: 37% (105 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKR
|   | .|.|. | |.||  ..| |. |.|...| |...    . ..  ... || |...|.|| |||.  ..  |. ||.|.|. |||||.|| . .||
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQ----QKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKR

LKEA--TCKLYFYQML-LAVQYLHENGIIHRDLKPENVLLS--SQE--EDCLIKITDFGHSKIL--GETSLMRTLCGTPTYLAPEVLVSVG---TAGYNR
..|     . .  |.|  ...|.| ..|.||||||||.|.   |..  ..  ||| ||| ..     |   | . |||| |.||||| .        |  
FFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDT

AVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEV-WAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL
 .| ||.|||..| |.|.|||    ..  |. |.   |..|   . | ..|  . ||.||.|..||| |.| ..|| ||| 
KCDMWSCGVIFYILLCGKPPFKGKTYNEILQ-QNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase CHK2.AA Ciliate-E2 263-529 28 9.5e-85 287.86 In-house 1-365 (365) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-365/365
Sequence Identity: 28% (108 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK--------------FAIGSAREAD-PALNVETEIE--------------ILKKLNHPCIIKIKN
|.  | .|.|. | |...  .|. |..|||||  .|              .|. . .. .  ... |  |               ||..|||| |||.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

FF---DAEDYYIVLELMEGGELFDKVV------------GNKRLKEATCKLYFYQMLL---------------AVQYLHENG-IIHRDLKPENVLLSSQE
.|   | . .|.|.|. .||.|||               . |...|  .| ...| |                |..|||... |||||.||||.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

EDCLIKITDFGHSKILGET--------------------------------SLMRTLCGTPTYLAPEVLVSVG------TAGYNRAVDCWSLGVILFICL
    |||.||| ||.. .                                  . .|.|||| |.|||.| . .        ||. ..| |||||||...|
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGYPPFSEHRTQVSLKDQITSGKYNFIPE--------------VWAEVSEKALDLVKK----LLVVDPKARFT-TEEALRHPWL
.|.|||          .||  .|..| ..               | ..|... || ||    .|..||. |.|  |..| |||.
FGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CHK2.AA MARK 263-529 39 1.5e-80 263.06 In-house 1-262 (262) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-262/262
Sequence Identity: 39% (109 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFD--AEDY--YIVLELMEGGELFDKVVG
| | ||.| |....||||  ..| .||||||. | |     ...     ||. ||||.|||.|| |||    ..   |    |...|. .||||.| .. 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMK-----NVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKA

N--KRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQE--EDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCW
    ||.|  .. .| |.. ||.|.|...|.|||.||||.|. ..       |||.||| | .  . ..  | |||| | |||.. .    |  ..|| |
HPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHN---IKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDG--PKVDIW

SLGVILFICLSGYPPFSEHR-TQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL
||||.|.. ..|| || .   ... |. .|..|||  ||     || .. .|...||.|.|. | | || ..|||.
SLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD-IPCH---VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase CHK2.AA CAMK-Unique 263-529 25 5.4e-80 263.74 In-house 1-363 (363) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-363/363
Sequence Identity: 25% (95 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISK----RKFAIG--------SAREADPALNVETEIEILKKLNHPCIIKIKNF-----FDAE-------
|.| . .|.|. |.|. .. |.| || |.|.. |    .|  .         .  |       . |..|.|...||.|||.  .      |..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------DYYIVLELMEGGELFDKVVG--------------------NKRLKE--ATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE-----
        ..|||.|. .||.|||...                     . .. |  .   ... . | || |.|...|.|||||.||..... .      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------DCLIKITDFGHSKILG---ETSLMRTLCGTPTYLAP--------------EVLVSVGTAGYNRAV----DCWSLGVILFICLSGYPPFSEHR
        .  ||..||| .. .    . ..| | |||| |.||              ||.   .  .| . .    |.||||||... |.|.||| .  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI---NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC

TQ-------VSLKDQITSGKY-NFIPEVWAE---VSEKALDLVKKLLVVDPKARFTTEEALRHPWL
         ... . |..|.| ||  ..|     .|. | |.||....|||. | . .|.| |.|.
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase CHK2.AA RSK 264-529 31 1.6e-75 257.19 In-house 1-278 (278) Show / Hide 
Range on Protein: 264-529
Range on HMM: 1-278/278
Sequence Identity: 31% (89 aa)

IMSK-TLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLN-HPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNK
.  . ..| |.   ..    ..| .  | |...|.|..         .  . ||..||.  . || |.. .  |. |.. |...|...|||||..    |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKD----TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEK

R---LKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEED-CLIKITDFGHSKI--LGETSLMRTLCGTPTYLAPEVLV--SVGTAGYNRAVD
.   . | ... |...  |||..||. |||||||||||.|. ... .   ||.|||| .|.  . ..... | |.|  |.|||.|     .  |...|.|
HFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACD

CWSLGVILFICLSGYPPFSE-HR-TQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFT-----TEEALRHPWL
 |||||...  |.|.|||    . ..  . ..| .||...  . |...|. | ||..|.| .||. | .     .|| ..|||.
WWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CHK2.AA TyrKc 263-529 22 5e-16 36.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 263-529
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKL--NHPCIIKIKNFFDA--------EDYYIVLELMEGGEL
  . |.||.|| ||| ..  .    .||.| . . .                 |..|..||  .||.|...              | ..||.|.|..| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

FDKVVGNKR-LKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGET-------SLMRTL---CGTP----TYLAPE
 |    ... |. ..   . .|     .|||....|||||   |.|....     .||.||| |. ...        .  |.    .|        .|||
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLVSVGTAG-YNRAVDCWSLGVILF-ICLSGYPPFSEH----RTQVSLKDQITSGKYNFIPEV-----WAEVSEKALDLVKKLLVVDPKARFTTEEALRH
..      | .. . | || || .. |.  | .| ..      .   .  .. .|..  .|.        . ...  .. |.    ||. | | .|   |
CI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

PWL
  .
ECF
Kinase CHK2.AA Pkinase_Tyr 263-413 27 4.4e-15 51.71 Pfam 1-156 (270) Show / Hide 
Range on Protein: 263-413
Range on HMM: 1-156/270
Sequence Identity: 27% (46 aa)

YIMSKTLGSGACGEVKLAFER----KTCKKVAIKIISKRKFAIGSAREADPA----LNVETEIEILKKL-NHPCIIKIKNFFD--AED--YYIVLELMEG
 .. |.||.|| |||...  .    .|. .||.|.. |          |..          |..|.|.| .|| |..         |   .|||.|.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH

GELFDKVVG----NKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFG
| | |        ...|.  .   . .|   . .||.....|||||   |.|...   .  .||.|||
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFG