Gene CYGD (Human)

CYGD

Species: Human
Alias: GUCY2D, CYGD, retGC, ROS-GC1, LCA1, LCA, GUC2D, GUC1A4, retGC-1, CORD5, RETGC-1, retGC1, CORD6
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 17p13.1,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
CYGD.NA RNA Sugen Kinome 3641 None Fasta, JSON
CYGD.AA Protein Sugen Kinome 1103 None Fasta, JSON
CYGD.kin_dom Protein Kinase Domain Sugen Kinome 274 None Fasta, JSON

Protein domain

Protein domains of CYGD.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor CYGD.AA ANF_receptor 72-408 18 8.4e-56 196.49 Pfam 1-364 (364) Show / Hide 
Range on Protein: 72-408
Range on HMM: 1-364/364
Sequence Identity: 18% (71 aa)

RPDLAARLAAARLNRDPG-LAGGPRFEVALLPE----PCRTPGSLGAVSSALARVSGLVGPVNPAACRPAELLAEEAGIALVPW--GCPWTQA----EGT
.. .|.|.|  ..|.||| |  | ....  . .     | ....... . .  .| ...||.....|.|.  .|....| .. |   ||.       . .
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYP

----TAPAVTPA-ADALYALLRA-FGWARVALVTAPQDL--WVEA---GRSLSTALRARGLPVASV--TSMEPLDLSGAREALRKVRD--GPRVTAVIMV
    |.|  |   ..|. ....  |||..||..   .|   |..     . . ..||..|...  .  .|| . . . ....|.|..|  ....  ..| 
YFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVIVMC

MHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYALSPGPEALAALANSSQLRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQVSP
... ..| ..|| ....|.|||...|. |... |. ....  .  .  ....   .|.| ..||..| | |   .. . ..|...        . .....
CYPDDMG-LLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-WWYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK--------TDTEMNY

LFGTIYDAVFLLARGVAEARAAAGGRWVSG--------AAVARHIRD-AQVPGFCGDLGGDE------EPPFVLLDTD
 ....|||| |.|... ... . ...|..|        .........  .  |..||.  |.       . ......|
YAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase CYGD.AA RGC 556-807 33 3.6e-114 385.59 In-house 1-300 (300) Show / Hide 
Range on Protein: 556-807
Range on HMM: 1-300/300
Sequence Identity: 33% (103 aa)

EGDRVWLKKFPGD---QHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIK
|||.||.||.. .   .|. ....... . ....|.|.|.. ..|...   .|..    .||...|.|.|.||||||.|....||.|||||.|.. |..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYH----PGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVK

GIRYLHHRGV-AHGRLKSRNCIVDGRFVLKITDHGHG-----RLLEA-------------QKVLPEPPRAEDQLWTAPELLR----DPALE-----RRGT
|..||||. .  ||.|||.|| ||.|.|.||||.|..     .. .              |.  .| |  ...||||||.||    ..  .     .|||
GMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGT

LAGDVFSLAIIMQEVVCRSA-----PYAML----ELTPEEVVQRVRSPPP-----LCRPLVSMD------QAPVECILLMKQCWAEQPELRPS-MDHTFD
 .|||.|..|||.|...|.      |..|.    ||.|.|....|. ||.     ..||....|      ... ... ||..||||.|| ||. .|  ..
QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK

LFKN
..|.
QLKT
Kinase CYGD.AA RGC 556-807 33 3.6e-114 385.59 In-house 1-300 (300) Show / Hide 
Range on Protein: 556-807
Range on HMM: 1-300/300
Sequence Identity: 33% (103 aa)

EGDRVWLKKFPGD---QHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIK
|||.||.||.. .   .|. ....... . ....|.|.|.. ..|...   .|..    .||...|.|.|.||||||.|....||.|||||.|.. |..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYH----PGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVK

GIRYLHHRGV-AHGRLKSRNCIVDGRFVLKITDHGHG-----RLLEA-------------QKVLPEPPRAEDQLWTAPELLR----DPALE-----RRGT
|..||||. .  ||.|||.|| ||.|.|.||||.|..     .. .              |.  .| |  ...||||||.||    ..  .     .|||
GMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGT

LAGDVFSLAIIMQEVVCRSA-----PYAML----ELTPEEVVQRVRSPPP-----LCRPLVSMD------QAPVECILLMKQCWAEQPELRPS-MDHTFD
 .|||.|..|||.|...|.      |..|.    ||.|.|....|. ||.     ..||....|      ... ... ||..||||.|| ||. .|  ..
QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK

LFKN
..|.
QLKT
Kinase CYGD.AA TKL 587-805 20 7.8e-25 86.35 In-house 82-364 (364) Show / Hide 
Range on Protein: 587-805
Range on HMM: 82-364/364
Sequence Identity: 20% (62 aa)

LRHENVALYLG--------------LFLARGAEGPAALWEGN---LAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHH--------RG
|||.|. ...|              .              |.   |. | | | .||| ..|        |  . .. ||  .|. |||         ..
LRHPNIVQFMGYCCCPPCGCVCMHPV--------------GPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPP

VAHGRLKSRNCIVDGRFV--------------LKITDHGHGRLLEAQKVLPEPP------------------RAEDQLWTAPELLR-----------DPA
..|  |||.|. ||  .               .||.| |  | ..  .                        .     | |||.||           |. 
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-

L--ERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTP-----------EEVVQRVRSPPPLCRPL-----VSMDQAPVECILLMKQCWAEQPELRPSMDH
   ..  . . ||.| .|.. |...|  ||. .   |           . |... . ||.  ...     .  ...| . . ||..||.. || |||.. 
FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQE

TFDLF
  . .
ILKRL
Kinase CYGD.AA TK 612-805 15 2.2e-20 64.35 In-house 127-486 (486) Show / Hide 
Range on Protein: 612-805
Range on HMM: 127-486/486
Sequence Identity: 15% (58 aa)

EGNLAVVSEHCTRGS----LQDLLAQREIK----------------------------------------------------------------------
.. . .| |..  |.    |.| | ..  |                                                                      
QEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCL

-----LDWMFKSSLLLDLIKGIRYLHHR------GVAHGRLKSRNCIVDGRFV-----------LKITDHG--------HGRLL---EAQKVLPEPPRA-
     |.   .    ... .| .||| .      .. |. |  ||| |. . |            ||.| |        . | .   .   .  .. .. 
TCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGR

------------------EDQL---WTAPELLRDPAL-----ERRGTLAGDVFSLAIIMQEVVCRS-APYA--ML-------ELTPEEVVQRVRS-----
                   ..|   |.||| |.|        ... | . ||.|. . | |.. .  .||.  |        . ...||....|.     
PMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLC

--------------PPPLCRPLV--SMDQAP-----VECILLMKQCWAEQPELRPSMDHTFDLF
              .||.| . .   | . |      |  .||.|||...|| ||...   . .
RSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CYGD.AA TKL-Unique 612-799 27 2e-17 58.14 In-house 72-284 (290) Show / Hide 
Range on Protein: 612-799
Range on HMM: 72-284/290
Sequence Identity: 27% (59 aa)

EGNLAVVSEHCTRGSLQDLLA---------QREIKLDWMFKSSLLLDLIKGIRYLHHRG--VAHGRLKSRNCIVDGR-----FVLKITDHGHGRLLE--A
..|.  |.| | .||| |.|.          ...||..  . .. .|  .|  ||||..  ..|. |||.|  || .     .  || | |  ...    
PPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKIN

QKVLPEP------PRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSA------PYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECI
.. . |.       |    .| |||.||..   .  .   ||.| .|.. | . |        ||   ....|.. . |..     || ....  | |  
KMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY--SEKSDVYSFGIVLWEIATRKITKTYKKPY--QGMDQEQWCEMVHYMEENYRPPIPNH-CPKEYR

LLMKQCWAEQPELRPSMD
 |..|||. .|. ||| |
DLIQQCWHHDPSQRPSFD
Kinase CYGD.AA Pkinase 584-805 17 6.6e-14 50.25 Pfam 54-293 (293) Show / Hide 
Range on Protein: 584-805
Range on HMM: 54-293/293
Sequence Identity: 17% (45 aa)

LQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRG----SLQDLLA-QREIKL--DWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDG
...|.|.|.  ... |            .... .| |.|  |    .| |..  .|. ..  ..    . .. ...|. |.| .|. |  ||. |. .| 
MKRLNHPNIVRLYDWFED----------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDN

RFVL----KITDHGHGRLLEAQKVLPEPPRAEDQ----LWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAML----ELTPEEVVQRVRS--
. ..    ||.| |  ....    .   . . .      . |||..|     .  . . |..|. .|. |..|.  |.       .... ....|...  
NGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPP

----PPPLCRPL-----------VSMDQAPVECILLMKQCWAEQPELRPSMDHTFDL--F
     | .|..            .  . .. ||. ..| |..  |. ||. .. .    |
LHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CYGD.AA TESK 612-674 41 1e-13 39.27 In-house 65-127 (292) Show / Hide 
Range on Protein: 612-674
Range on HMM: 65-127/292
Sequence Identity: 41% (26 aa)

EGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIV
.| |  . |    |.| .|||. |. | |  |  | .|  .|..||| .|| |  | |.|| |
QGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLV
Kinase CYGD.AA Src-Echino1 615-805 27 2e-13 42.48 In-house 69-252 (252) Show / Hide 
Range on Protein: 615-805
Range on HMM: 69-252/252
Sequence Identity: 27% (54 aa)

LAVVSEHCTRGSLQDLLAQREIK-LDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPEL
. .| |   .|.||| | . . | .       .  ..  |. ||  . | |  |  || .|.   | || | |  |...      .        ||||| 
IYIVTELMSNGNLQDYLKRGKCKHVKMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEA

LRDPALERRGTLAGDVFSLAIIMQEVVC-RSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILL-MKQCWAEQPELRPSMDHTFDLF
    ||  | |.  ||.|  |.| |.|     ||   ...  ||...|     .   .  |.. |     . | .||   |  || ...  | |
----ALYGRFTIKSDVWSFGILMTEMVTFGRYPYP--GMMNREVLDQVD----RGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase CYGD.AA TKL-ciliate2 587-806 26 1.7e-11 34.06 In-house 53-273 (273) Show / Hide 
Range on Protein: 587-806
Range on HMM: 53-273/273
Sequence Identity: 26% (65 aa)

LRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLH--HRGVAHGRLK----------------
||| |. ..||          |     | ... | | ||||  || .....| |  .  . ||  .|. |||  .  . |  ||                
LRHPNIVMFLG----------ACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITL

----SRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAML--ELTPEEVVQRVRS
    | | .||  |  |.|| |  |       .    .     | ||| ..        |   |||| .||. |.  |  ||     .   |.|..    
IKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTN--KIGTYQWMAPEVIKAFYY----TEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNN--

PPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFK
     || .  .  | .   ||..|| .. .||||..     ..
----LRPTIPKN-CPPQFADLMQRCWDNNQNLRPSFNEIIKELE
S_TKc CYGD.AA S_TKc 517-805 15 2e-11 -9.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 517-805
Range on HMM: 1-231/231
Sequence Identity: 15% (49 aa)

GGTSRKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLA
    ||. .|. ..   .   ...                | .| .|. .          ..   . |.. .|.|.  ... |             ..| 
YEILRKIGKGAFGK--VYKCRHKK---------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLY

VVSEHCTR--GSLQDLLAQREIK-----LDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQL--
.| |.|    |.| |.. .|  .     ..     ...  ..... |.| .|. |  ||  |  .|   ..||.| |  |.|             . .  
MVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCG

---WTAPELLRDPALERRGTL-AGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFD
   . |||.|         .  . |. |. .|. | .|.  |.     ..... ....               . |.. ....|.   || ||.    . 
TPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

---------LF
          |
DEWDIKCHPWF
TyrKc CYGD.AA TyrKc 510-805 19 5e-10 -60.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 510-805
Range on HMM: 1-280/280
Sequence Identity: 19% (66 aa)

ITFLHP---------HGGTSRKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSK----LQEL--RHENVAL
||...          . || .                                      |  |.   |         . .| .    . .|  .|.|.  
ITLGKKLGEGAFGEVYKGTWK------------------------------------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVR

YLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQ
 .|  .  |      .  . | .| |..  |.|.| |  .. || .  . |  ..  .| .|||.... |  |  ||| |. ... ||.| |  | ..  
LYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDD

-------KVLPE--PPRAEDQL---WTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLE----LTPEEVVQRVRSPPPLCRPLV-----SM
       ..        . . |   |.||| .     ... | . ||.|  . | |.  . ..    .    ....||...|..   . .|       . 
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-

DQAPVECILLMKQCWAEQPELRPSMDHTFDLF
  .| |   .|||||.|.|| ||..    ..|
VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CYGD.AA Dicty5 618-695 25 7.1e-10 30.17 In-house 77-158 (260) Show / Hide 
Range on Protein: 618-695
Range on HMM: 77-158/260
Sequence Identity: 25% (21 aa)

VSEHCTRGSLQDLLAQREI----KLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQK
|.| | .||| ..| ...      . .  . .. .|  ...|.||  .. |  ||| |  .  ..  || | |  |  ....
VTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRY
Kinase CYGD.AA DRK 617-686 34 3e-09 27.54 In-house 74-145 (258) Show / Hide 
Range on Protein: 617-686
Range on HMM: 74-145/258
Sequence Identity: 34% (25 aa)

VVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRG--VAHGRLKSRNCIVDGRFVLKITDHG
.. |   ||||   |    |..||    .. .|  ||. ||| .   . |  ||| |  ||  .  |. | |
ICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFG
Kinase CYGD.AA DRK 708-747 47 2.1e-05 14.31 In-house 168-203 (258) Show / Hide 
Range on Protein: 708-747
Range on HMM: 168-203/258
Sequence Identity: 47% (19 aa)

WTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYA
||||| ||    . | |   ||.| ||.  |.| |  ||.
WTAPEVLR----NQRYTEKADVYSFAIVLWECVTRQDPYF
Kinase CYGD.AA Dicty5 783-809 37 5.7e-05 13.03 In-house 234-260 (260) Show / Hide 
Range on Protein: 783-809
Range on HMM: 234-260/260
Sequence Identity: 37% (10 aa)

LMKQCWAEQPELRPSMDHTFDLFKNIN
| | || . | .|||     . |. | 
LIKKCWQQKPHNRPSFKEICKYFESII
Kinase CYGD.AA Pkinase_Tyr 783-805 43 0.000226 15.43 Pfam 248-270 (270) Show / Hide 
Range on Protein: 783-805
Range on HMM: 248-270/270
Sequence Identity: 43% (10 aa)

LMKQCWAEQPELRPSMDHTFDLF
||||||...|| ||..      .
LMKQCWHYDPEDRPTFSEIHEQL
Kinase CYGD.AA DRK 781-807 40 0.000435 9.78 In-house 232-258 (258) Show / Hide 
Range on Protein: 781-807
Range on HMM: 232-258/258
Sequence Identity: 40% (11 aa)

ILLMKQCWAEQPELRPSMDHTFDLFKN
| ||. || | |  ||||.        
IQLMNDCWNEDPQHRPSMQECLERLEA
Kinase CYGD.AA TESK 708-742 37 0.004508 5.04 In-house 202-232 (292) Show / Hide 
Range on Protein: 708-742
Range on HMM: 202-232/292
Sequence Identity: 37% (13 aa)

WTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCR
| ||| ||.   ...     ||||  |.. |.. |
WMAPEVLRGEWYDEK----ADVFSFGIVLCEIIAR
Kinase CYGD.AA Pkinase_Tyr 584-684 24 0.004536 11.02 Pfam 57-154 (270) Show / Hide 
Range on Protein: 584-684
Range on HMM: 57-154/270
Sequence Identity: 24% (26 aa)

LQEL-RHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQR---EIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFV
. .| .|.|.  ..|  . .|  .       .. .| |..  |.| | | ..   . .|.   . .  ..  ||  ||. ..  |  |  ||| |.  .|
MKQLGHHPNIVRLYGVCTDQGEPN-------QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNV

LKITD
 ||.|
VKICD
Kinase CYGD.AA Dicty5 728-746 42 0.151857 1.08 In-house 185-203 (260) Show / Hide 
Range on Protein: 728-746
Range on HMM: 185-203/260
Sequence Identity: 42% (8 aa)

DVFSLAIIMQEVVCRSAPY
||.| .|.  |.  |  ||
DVYSFGIVLWEMFTRKEPY
CYCc CYGD.AA CYCc 844-1039 47 6.2e-105 355.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 844-1039
Range on HMM: 1-231/231
Sequence Identity: 47% (109 aa)

LEKQKTDRLLTQMLPPSVAEALKTG-TPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHD-----VYKVETIGDAYMVASGL
 ||||.||||.||||..||. || | .||.|. .. ||..|.||||||.......|..||..|||.|| || ||. |.     .||||||||||||.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PQRNG-------------------QRHAAEIANMSLDILSAVGTFRMRHM----PEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL
| ||.                   ..|| .||...||......|| ..|     |. |.|.|||.|.||.|.||||..|||||.||||||.||||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PYRIHVNLSTVGIL------RALDSGYQVEL
| .|||  .|  .|      |  . ....| 
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc CYGD.AA Guanylate_cyc 871-1058 39 4e-89 307.18 Pfam 1-214 (214) Show / Hide 
Range on Protein: 871-1058
Range on HMM: 1-214/214
Sequence Identity: 39% (85 aa)

VEPEYFEQVTLYFSDIVGFTTISAMSE----PIEVVDLLNDLYTLFDAIIGSH--DVYKVETIGDAYMVASGLPQR-----NGQRHAAEIANMSLDILSA
|... ...||..|.|||||| ... ..    |...|..|||.|| || ... |  ..|||.||||.||..||||..     ..  ||. .|.|.||.. .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VGTFRMRHMPEVP-----VRIRIGLHSGPCVAGVVG--LTMPRYCLFGDTVNTASRMESTGLPY--RIHVNLSTVGILRALD-SGYQV--ELRGRTELKG
.....  | .  |     ...|||.|.||.||||.|  . |||||..|||||.||||||||.|.  .|||  .|. .|....   ...  . ||  ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGAE---DTFWLVG
|| .    |..| |
KGKMGEMETYFLHG
HNOBA CYGD.AA HNOBA 835-865 51 9.2e-11 40.49 Pfam 204-234 (234) Show / Hide 
Range on Protein: 835-865
Range on HMM: 204-234/234
Sequence Identity: 51% (16 aa)

IRERTEELELEKQKTDRLLTQMLPPSVAEAL
... ..||| ||.|||.|| .|.|.|||. |
LEQMHRELEEEKKKTDDLLYSMFPKSVANRL