Gene DDR1 (Human)

DDR1

Species: Human
Alias: PTK3, EDDR1, NTRK4, DDR, DDR1, trkE, CD167, CAK, RTK6, PTK3A, TRKE, MCK10, NEP
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 6p21.33,

Classification

Group: TK
Family: DDR

Sequence

Name Sequence Type Origin Length Description Download
DDR1.NA RNA Sugen Kinome 3678 None Fasta, JSON
DDR1.AA Protein Sugen Kinome 919 None Fasta, JSON
DDR1.kin_dom Protein Kinase Domain Sugen Kinome 302 None Fasta, JSON

Protein domain

Protein domains of DDR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FA58C DDR1.AA FA58C 30-185 28 1.9e-36 128.33 SMART 1-199 (199) Show / Hide 
Range on Protein: 30-185
Range on HMM: 1-199/199
Sequence Identity: 28% (56 aa)

KCRYALGMQDRTIPDSDISASSSWSD-------STAARHSRLESSDG-----DGAWCPAGSVF------PKEEEYLQVDLQR-LHLVALVGTQGRHAG--
.|...||| . .|||..| ||||...        ..... ||.   .     |.||||.. .       ..  . ..|||.| .|.|..| |...  .  
ECNEPLGMEGGHIPDWQITASSSHYWNRDMPWWYWWPHIARLNGNGSNHDYWDNAWCPWKNDYEDWIFDYHCPHWWLVDLGRKTHRVTGV-TITGRRRRG

-GLGKEFSRSYRLR-YSRDGR---------RWMGWKDRW------GQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRA------DRVMSVCLRVELYGC
 | |..    |..  |. |.|         .|. .||.|      . .|. || |..........|||||| .|..| .      .  . .|.|.|||||
HGWGHDDWWTYYWMMYKDDRRDNNERQNGHTWTTYKDFWIEHGTGNSMVFYGNWDNNHPWHNMFHPPMVARYIRIWPTWWNTNATGWHHNYCMRWELYGC
F5_F8_type_C DDR1.AA F5_F8_type_C 46-182 28 3.2e-30 106.02 Pfam 1-140 (140) Show / Hide 
Range on Protein: 46-182
Range on HMM: 1-140/140
Sequence Identity: 28% (42 aa)

DISASSSWSDSTAARHSRLESSDGD----GAWCP-AGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDG--R-RWMGWKDRWG
 |.|||.||..... ..     ||.    ..|.. . | ...  ...||||.. . .  | .|.| .||   .. ..|.. || ||  .  |   ||  |
QITASSQWSGYWGNGWPPDNAIDGNGYPNTFWHSQKWS-NNDDPQWIQVDLGKPYKITGVVYQWRQDGGN--GWVKKYKIQYSNDGGDESNWTTYKDHDG

QEVISGNEDPEGVVLKDLGPPMVARLVRFYPR-ADRVMSVCLRVEL
  |  || |   .|  .. ||..|| ||..|   .   . ..|.|.
-KVFYGN-DND-PVKNMFFPPIKARYVRIHPTSWNNHNWWAMRWEF
Kinase DDR1.AA DDR 610-911 62 1.3e-224 752.43 In-house 1-306 (306) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-306/306
Sequence Identity: 62% (194 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLK-DPNIIRLLGVCVQDDPLCMITD
|.|.||.|||||||||||||...||... ||...|.||||.|||||.|||||.|.|      ||||.||.|.||..| .|||.||.|||.||.|.|||..
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHA------RNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIME

YMEN-GDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG--MSRNLYAGDYYRV
|||| ||||||...|..|.........|.|..|.|||||........||||||.||...|||||||||||||||....|||.|||  ||||||..|||||
YMENLGDLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRV

QG-----RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLY-ELMLRCWSRESE
.|     |...||||||||.||.|||||.|||||||||.||..|.||.||..|||||||||||.||||.||.||||..||.||. .| .||.|||.|...
EGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQS

QRPPFSQLHRFL
|||.|...|.||
QRPSFEEIHKFL
Kinase DDR1.AA TyrKc 610-911 36 1.9e-130 440.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-280/280
Sequence Identity: 36% (120 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRL--KDPNIIRLLGVCVQD-------
.....|||||.||||.... .                   . |||| |..||          | ||..| .||..|  . |||.||.|||.|.       
ITLGKKLGEGAFGEVYKGTWK-------------------IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYI

DPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG
.||.... ||..|||...| .|. .                  .. . ||. . |||.||.||.  |..|||||.||||||||.|.||.|||.||..| .
EPLMIVMEYMPHGDLKDYLRKHRPK------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDD

-------DYYRV----QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ----LTDEQVIENAGEFFRDQGRQVYLSRPPA----
       ||||.    .|...|||||||.|||  |||||.||||.|||..||.. ..   . |.    .....|||.  . .|    . ..  |      
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVC

CPQGLYELMLRCWSRESEQRPPFSQLHRFL
||. .|..|..|| .. |.|| ||..|...
CPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DDR1.AA Pkinase_Tyr 610-911 38 8e-119 403.05 Pfam 1-270 (270) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-270/270
Sequence Identity: 38% (119 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDP--LCM
..| .|||||.||||.... .               ... . ||||.|...|.. .      | ||..|.|||. | . |||.||.|||. |..|  ...
ITFGKKLGEGAFGEVYKGTWKG------------DPDNTKIPVAVKMLKEGAMHEQN----CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYI

ITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYY-R
.. ||..|||  .| .|                 ... .. ..||. ..|||.|| ||.  |..|||||.|||||.||...||.|||..| .|  ||| |
VMEYMPHGDLLDYLRKHR---------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYR

VQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQP-FGQLTDEQVIENA-GEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRP
..| . |||.||| |||  |||||.||||.|||..||.. ... || .  ...|.|.|    .  |       . .|. ||. .|.||..||  . |.||
KRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYR-------MPCPENCPDEIYDLMKQCWHYDPEDRP

PFSQLHRFL
 ||..|..|
TFSEIHEQL
Kinase DDR1.AA TK 610-911 25 1.5e-116 392.47 In-house 1-486 (486) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

LRFKEKLGEGQFG---EVHLCEVDSPQDLVSLDFPLNVR---------KGHPLLVAVKILRPD-ATKNASFSL---------FSRNDFLKEVKIMSRLK-
... .||||||||   ||...|. .. .. . .||.. .         .| .  ||||.|... |.  . | .             |||.|. .|. .. 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGE---DFLEEAEEMKMMCH

----DPNIIRLLGVCVQD------------DPLCMITDYMENGD----LNQFLSAHQLEDKAAEGAPGDGQAAQGPT-----------------------
     |||.||.|||.|.             |..... ||..||    | ..| ..  . .  .  |..... . |                        
SLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEE

----------------------------------ISYPMLLHVAAQIASGMRYLATL------NFVHRDLATRNCLVGENFT-----------IKIADFG
                                  .. . ||  ..|||.||.||. .      ||||||||.|||||||| .           .||||||
QDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

MS--------RNLYAGDYYRVQG------------------------RAVLPIRWMAWECIL---------MGKFTTASDVWAFGVTLWEVLMLCRAQPF
.|        | .| .|.|....                        .. |||||||.||..          |||||.||||.|||..||......... 
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYY

GQLTD---------EQVIENAGEFFR-------DQGRQVYLSRPPACP--------------QGLYELMLRCWSRESEQRPPFSQLHRFL
|....         ..|.|.  .  |       ..|.   . .|| ||              . .|.||..||... |.|| |||||..|
GGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDR1.AA Trk 610-911 42 9.7e-96 324.37 In-house 1-275 (275) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-275/275
Sequence Identity: 42% (129 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY
...|  |||| || | | |    ..|.  .         ...|||| |. ||..||      | || .| ...  |. ..|... |||. .||| |.  |
IVLKWELGEGAFGKVFLAEC---YNLCPEQ--------DKMMVAVKTLK-DASENA------RKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEY

MENGDLNQFLSAHQLEDKAAEGAPGDGQA--AQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA-GDYYRVQ
|..||||..| .|    .       ..|.  |.||      .|..| |||||| |.| . |||||.||||||||.|  .||.|||||| .|   ||||| 
MKHGDLNKYLRQHGPDAMCYA----QYQPRQAPGP-LTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVG

GRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
..  ||||||  | |.  |||. |||| |||..||..   . ||. ||    |||     .  ||| . | || .||| .|..|| || || .||    .
HHTMLPIRWMPPESIMYRKFTYESDVWSFGVVMWECFTYGK-QPWYQLSNHEVIE-----CIHQGR-HRLERPRRCPQEVYDIMLGCWQREPQQRMNIKD

LHRFL
.|  .
IHDII
Kinase DDR1.AA UTK 610-911 29 4.4e-85 288.96 In-house 1-296 (296) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-296/296
Sequence Identity: 29% (100 aa)

LRFKEKLGEGQFGEVHLCEVDS-----PQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRN---DFLKEVK---IMSRLK-DPNIIRLLGVC
... ..||.|.|||||.....      ....|...                        . ... ...    ||..| .   .|....  ||..||.|||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---------------------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVC

VQDDPLCMITDYMENGDLNQFLS--AHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN-------FTIKI
.|. |....| ||||||| ..|   .....             |..   .   .|. |..||.|| ||.. .||||||| |||||...        ..||
TQEEPWMIVTEYMENGDLRSYLRRHRPTPP-------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKI

ADFG---MSRNLY---------AGDYYRVQGRAVLPIRWMAWECILMG-KFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVY
||||   |||...           .||. |..  .|||||| |..  . .|||.||||.|||..||...   ..|.. ....||... ..  |       
ADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGR-----YR

LSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL
. .|..||  .|.||.|||  . . || | .|  ..
MPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase DDR1.AA Musk 650-911 41 3.6e-80 264.57 In-house 30-282 (282) Show / Hide 
Range on Protein: 650-911
Range on HMM: 30-282/282
Sequence Identity: 41% (110 aa)

LLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL---SAHQLEDKAAEGAP--GDGQAAQGPTI
..|||| |. || |          ||  |  .| .   |||..|||||    |.|.   ||  |||| ||   | |    .  .         .   |  
TMVAVKMLKDDASKQM------QMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPPQL

SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLM
.   .| .|.||| || ||    ||||||||||||..|.  .||||||.||. |  |||. ..    |||||. | |.  .||..|||||.|| |||.  
KCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFS

LCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL
    ||.  .| | ||     . |.  .   || |  ||| .|.|| |||...   || | |.|. .
YA-LQPYYGMTHEEVI----YYIRQGNI---LSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase DDR1.AA TK-Unique 610-911 32 4.8e-75 255.62 In-house 1-294 (294) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-294/294
Sequence Identity: 32% (104 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLK-DPNIIRLLGVCVQDD-PLCMIT
|......|||.||.|. .|| ..           .  ...  |||| |. .||.       .. ||||| ..|. |.  |||...||.|. .| | ..| 
LEVGDVIGEGAFGQVWRGEVWGIW----------KHWDKQKCVAVKMLKDNATDT------DKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIM

DYMENGDLNQFLSAHQLEDKAA-------EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLAT--LNFVHRDLATRNCLVGENFTIKIADFGMSRNLY
 |...|.|  .|   . . .         .... .    .  .||.  |.| | |||.|| |||    ..|||||..||.|..|....||.||||.| .|
EYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVY

AGDYYRVQ-GRAVLPIRWMAWECIL--MGKF-TTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPAC-PQGLYELMLRC
..  |  . ..  .|||||| | ..   | . || ||||.|||..||.. |   .|.... .....|.  . .|       . .|. | .. .|.|| .|
TNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKDIMECIRDGYR-------MPQPEHCCSHEMYNLMKSC

WSRESEQRPPFSQLHRFL
|..| |.|| |.|.   |
WQWEPEERPSFRQIKHRL
Kinase DDR1.AA InsR 652-913 36 6.5e-75 251.03 In-house 34-278 (278) Show / Hide 
Range on Protein: 652-913
Range on HMM: 34-278/278
Sequence Identity: 36% (98 aa)

VAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGP----TISYP
.|.|..  .|      |.  | .||.|  .| . .  ...|||||| .  |   .   |. |||  .| ..  | .         .    .     ... 
CAIKTVNENA------SMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRPEEEF--------NNPGCNRNQHVPCLD

MLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR
 ..  ||.|..|| ||| ..||||||| |||.| . ||.||.|||| | .|  ||||  |.  ||.|||| | .  |.|||.|||| ||| |||.  |  
QMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLG-

AQPFGQLTDEQVIENAGEFF-RDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE
.||   |  |||    ...  .| .   .| .|  ||. ..||| .||   .  || | ..   | .
EQPYQGLSNEQV----LKYIGMDGN---VLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase DDR1.AA Src 652-911 37 2e-72 245.36 In-house 26-255 (255) Show / Hide 
Range on Protein: 652-911
Range on HMM: 26-255/255
Sequence Identity: 37% (98 aa)

VAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLH
|||| |.|.          | ..||.| .||  |. .....|. || |..|   .| ||..| | ..| .                  .| ... | |. 
VAVKTLKPGT--------MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----------------DGEGRHLHLPQLID

VAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA--GDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ
 |||.|.|| ||   |..||||| || |||||   |.||||  | |     | |  .  | .||.|.| |.|. |.||. |||| ||. |.|.    |  
MAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV-

PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYE-LMLRCWSRESEQRPPFSQLHRFL
|    | ..|...    .|       . .|. ||. ||| .||.|| .. |||| |  |. ||
PYPGMTNHEVLQQVERGYR-------MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase DDR1.AA Ror 750-908 47 2.9e-66 226.48 In-house 122-272 (308) Show / Hide 
Range on Protein: 750-908
Range on HMM: 122-272/308
Sequence Identity: 47% (75 aa)

LHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ
||.|.|||.|| ||.   |||||||.|||||||  ..||.||| .|  |..||||.|.....|||||. | |. |||...||.| |||.|||.    . |
LHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGM-Q

PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH
|.      .||    |  |   |.. |. |  ||.  | ||  ||.  .. ||.|.  |
PYYGYSNQEVI----EMIRN--RHL-LPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIH
Kinase DDR1.AA CTKA 753-911 46 2.7e-58 194.45 In-house 137-290 (290) Show / Hide 
Range on Protein: 753-911
Range on HMM: 137-290/290
Sequence Identity: 46% (78 aa)

AAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG-DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF
|.||| || ||| . ||||||| ||||.|   .||||||| .| |  .  || |. . |.|.|||| | .  |||..||||||||| |||..      |.
AMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGE-KPW

GQLTDEQVIENAGEFFRDQGRQVYLSR-------PPACPQGLYELMLRCWSRESEQRPPFSQLHRFL
  ..|  |             | |.|        |. ||| || .|  ||  |  ||| | .| | |
RHMSDQEVC------------QAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase DDR1.AA S_TKc 610-911 19 6.3e-42 146.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 610-911
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY
 .. .|.|.| ||.|..|   .                   .||.||..              .....|..|... . |||..|..|..  | |.|...|
YEILRKIGKGAFGKVYKCRHKK----------------TGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEY

MEN--GDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQG
...  ||| ...  .. . .                ..  .  ....||.... |.  ....||||   | |. |  .|||.|||..| |          
CDGDLGDLFDYIKKRGRHGLRF-------------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------T

RAVLPIRWMAWECILMGKFTT-ASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
  .    .|| | .   .... ..|.|..|..|.|  |||.  ||   ........ |                  .. . ... .|. .. |.||   .
TFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE--MLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-E

LHR---------FL
. .         ..
ALQDEWDIKCHPWF
Kinase DDR1.AA Pkinase 610-919 21 5.2e-35 124.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 610-919
Range on HMM: 1-293/293
Sequence Identity: 21% (74 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKN----ASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCM
.....|.|.| ||.| .|   . ..                .|||||.. . .|     . . |        |..|| ||. |||.||....  .| ..|
YHIGRKIGSGSFGCVYKCHHKGTGK----------------IVAVKIIKKRHEKSWKDQTHRRL-------SEIQIMKRLNHPNIVRLYDWFEDKDHIYM

ITDYMENG----DLNQFLSAHQLEDKAAEGAPGDGQAAQGPTI--SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI----KIADFGMSR
...|.|.|    ||  ..|.                  .. ..  |.  . ... ||..|. |.   ...||||   |.|. .| .|    ||.||| ..
VMEYCEGGLYVMDLFDYIST-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK

NLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQVYLSRPPACP----------
 ..    ..     .  ...|| | |.   . ....|.|..|..|.|  |||.  || .  ...  ..    ..|. |...  ..|  |.          
QFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE--MLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------QGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNT--V
         . . ... .|. .  ..||         ||..|.   .
FHWTFHNWSEECKDFIKWCLCKDPKKRPT--------AEQILQHPWF
Kinase DDR1.AA Ror 610-719 38 8.7e-23 82.03 In-house 1-93 (308) Show / Hide 
Range on Protein: 610-719
Range on HMM: 1-93/308
Sequence Identity: 38% (42 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY
.|| |.|||.||| |.  .      | .. |       |. .||.| .. ||.         . || .|...|..|. |||. ||||| .| |.||.  |
VRFMEELGECQFGKVYKGH------LMGPNF-----MYHCMAVAIKTCKHDASPAQ------WQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEY

MENGDLNQFL
| .|||  ||
MNHGDLHEFL
Kinase DDR1.AA CTKA 610-721 35 6.2e-19 60.13 In-house 1-102 (290) Show / Hide 
Range on Protein: 610-721
Range on HMM: 1-102/290
Sequence Identity: 35% (41 aa)

LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNASFSLFSRNDFLKEVKIMS--RLKDPNIIRLLGVCVQDDPLCMIT
.    |.|||..|.|         |    ||    .||   .|||| |. .||  .      |  || |. . |   .  ||..|||||| |. |. ||.
HCIMFKIGEGHYGQVFRAWLMPDPD----DFKAQRKKGK--DVAVKMLKDHATEED------RRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIM

DYMENGDLNQFLSA
 .|  |||  .| |
EHMQYGDLHCYLRA
Kinase DDR1.AA Src 610-624 60 1.6e-05 14.71 In-house 1-15 (255) Show / Hide 
Range on Protein: 610-624
Range on HMM: 1-15/255
Sequence Identity: 60% (9 aa)

LRFKEKLGEGQFGEV
.....|||.||||||
IKLCRKLGQGQFGEV