Gene DDR2 (Human)

DDR2

Species: Human
Alias: DDR2, TKT, NTRKR3, TYRO10, MIG20a
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1q21-q23.3,

Classification

Group: TK
Family: DDR

Sequence

Name Sequence Type Origin Length Description Download
DDR2.kin_dom Protein Kinase Domain Sugen Kinome 287 None Fasta, JSON
DDR2.NA RNA Sugen Kinome 3172 None Fasta, JSON
DDR2.AA Protein Sugen Kinome 855 None Fasta, JSON

Protein domain

Protein domains of DDR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FA58C DDR2.AA FA58C 29-185 26 3.4e-44 154.05 SMART 1-199 (199) Show / Hide 
Range on Protein: 29-185
Range on HMM: 1-199/199
Sequence Identity: 26% (53 aa)

ICRYPLGMSGGQIPDEDITASSQWSE-------STAAKYGRLDSEEG-----DGAWCPEIPV------EPDDLKEFLQIDLHT-LHFITLV-GTQGR---
 |..|||| || |||..|||||....        ......||. ...     |.||||. ..         .  .....|| . .|..|.| .|  |   
ECNEPLGMEGGHIPDWQITASSSHYWNRDMPWWYWWPHIARLNGNGSNHDYWDNAWCPWKNDYEDWIFD-YHCPHWWLVDLGRKTHRVTGVTITGRRRRG

--HAGGHGIEFAPM-YKINY------SRDGTRWISWRNRH------GKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHS------MNVCMRVELYG
  .........  | ||...        .|..|. .. .       .  | .|| .. ........||.|||..|..|.. ..      .|.|||.||||
HGWGHDDWWTYYWMMYKDDRRDNNERQ-NGHTWTTYKDFWIEHGTGNSMVFYGNWDNNHPWHNMFHPPMVARYIRIWPTWWNTNATGWHHNYCMRWELYG

C
|
C
F5_F8_type_C DDR2.AA F5_F8_type_C 45-182 29 1.1e-33 117.93 Pfam 1-140 (140) Show / Hide 
Range on Protein: 45-182
Range on HMM: 1-140/140
Sequence Identity: 29% (44 aa)

DITASSQWSESTAA---KYGRLDSE--EGDGAWCP-EIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDG--T-RWISWRNR
 ||||||||.....      ..|    .. ..|.. . .   .| ....|.||   . || | .|.| .||.  ...  ||| || ||  .  |.. .. 
QITASSQWSGYWGNGWPPDNAIDGNGYPN-TFWHSQKWS--NNDDPQWIQVDLGKPYKITGVVYQWRQDGGN--GWVKKYKIQYSNDGGDESNWTTYKDH

HGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPV-TDHSMNVCMRVEL
 | .| .|| .   .   ...|||.||.||..|. .. . . .||.|.
DG-KVFYGN-DND-PVKNMFFPPIKARYVRIHPTSWNNHNWWAMRWEF
Kinase DDR2.AA DDR 563-849 64 2e-223 748.54 In-house 1-306 (306) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-306/306
Sequence Identity: 64% (196 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLK-DPNIIHLLAVCITDDPLCMITEYMEN-G
|.|.||.||||||||||||||||......||..||....|.||||||||.||.|.|||||.||||.||..| .|||..|..||..|.|.|||.||||| |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNQFLSRHEPPNSSSSDVR---------TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG--MSRNLYSGDYYRIQG----
|||||...||..||......         |.||.......||||||||||.|.||||||||||||||||.|.|||.|||  |||||||.||||..|    
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR

-RAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVY-KLMLSCWRRDTKNRPSFQ
 |...|||||.|||||||||||.|||||||||.||.|.||.||||.||.|||||||..||||.||.|.|||.|..||...| .||..|||||...||||.
QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE

EIHLLL
|||..|
EIHKFL
Kinase DDR2.AA TyrKc 563-849 39 6.4e-138 465.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-280/280
Sequence Identity: 39% (123 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRL--KDPNIIHLLAVCITD-------DPLCMI
.|...|||||.||||....                     . ||||||..||    | ||..|..||..|  . |||. |..||...       .||...
ITLGKKLGEGAFGEVYKGTWK-------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

TEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG-------DYYRI---
.|||..|||...| .|.|          ..   |  ...|||.|| ||.| |..|||||.||||||.|.|.||.|||.||..|..       ||||    
MEYMPHGDLKDYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQ----LSDEQVIENTGEFFRDQGRQTYLPQPAI----CPDSVYKLMLSCWRR
 .|...||||||..|.|  |||||.||||.|||..|| ||..|. .. .    .|...|||.  . .|    . ..  | .    ||| .|..|..||..
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHE

DTKNRPSFQEIHLLL
| ..||.|.||| ..
DPEDRPTFSEIHECF
Kinase DDR2.AA Pkinase_Tyr 563-849 42 2.3e-121 411.65 Pfam 1-270 (270) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-270/270
Sequence Identity: 42% (127 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNA--RNDFLKEIKIMSRL-KDPNIIHLLAVCI-TDDP--LCMITEY
.|| .|||||.||||....  |               |. . ||||||. .| . .  | ||..|.|||. | . |||. |..||.  ..|  .....||
ITFGKKLGEGAFGEVYKGTWKG------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEY

MENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY-RIQGRAVLPIRWMS
|..|||  .| .|       .| . ..   |  |..|||.|| ||.| |..|||||.|||||..| ..||.|||..| .|. ||| | .| . |||.||.
MPHGDLLDYLRKHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMA

WESILLGKFTTASDVWAFGVTLWETFTFCQEQP-YSQLSDEQVIENT-GEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL
 |.|  |||||.||||.|||..|| ||... || |  .|.|.|.|    .  |       .|.|  ||| .|.||..||. | ..||.|.|||  |
PECINYGKFTTKSDVWSFGVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYR-------MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDR2.AA TK 563-849 26 3e-119 401.61 In-house 1-486 (486) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

LTFKEKLGEGQFG---EVHLCEVEGMEKFKDKDFALDV---------SANQPVLVAVKMLRADANKNARN-------------DFLKEIKIMSRLK----
.|. .||||||||   ||...|..|. . . |.|...          . .... ||||||..... ...              |||.|  .|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-DPNIIHLLAVCITD------------DPLCMITEYMENGD----LNQFLSRHEPPNSSSSDVRT-----------------------------------
  |||..|..||  .             |.....|||..||    | ..| .. |. . ..|                                      
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VSYTNLKFMATQIASGMKYLSSL------NFVHRDLATRNCLVGKNYT-----------IKIADFGMS-
                               ..   |  |. |||.|| ||.|.      ||||||||.||||||.|..           .||||||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RNLYS------------------------GDYYRIQGRAVLPIRWMSWESIL---------LGKFTTASDVWAFGVTLWETFTFCQEQPYSQL
       | .||                         |||| | .. ||||||..|...          |||||.||||.|||..|| ||..||..| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SD---------EQVIENTGEFFR-------DQGRQTYLPQPAICP--------------DSVYKLMLSCWRRDTKNRPSFQEIHLLL
|.         ..|.|.  .  |       ..|.   .|||. ||              . .| ||..||..| . ||.|...|  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDR2.AA Trk 563-849 43 1.3e-100 340.61 In-house 1-275 (275) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-275/275
Sequence Identity: 43% (128 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDL
. .|  |||| || | | | . .   .||           ..|||| |. || .||| || .| ...  |. ..|. .  ||  .||| |. |||..|||
IVLKWELGEGAFGKVFLAECYNLCPEQDK-----------MMVAVKTLK-DASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDL

NQFLSRHEPPNSSSSDVRT------VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS-GDYYRIQGRAVLPIRWMS
|..|  | |  .   .              ... | |||||| |. |. |||||.||||||||.|  .||.|||||| .||  ||||. ..  |||||| 
NKYLRQHGPDAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMP

WESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL
 |||.  |||. |||| |||..|| ||. . ||. |||   |||     .  |||.  | .|  ||  ||..|| ||.|. . | .  .|| ..
PESIMYRKFTYESDVWSFGVVMWECFTYGK-QPWYQLSNHEVIE-----CIHQGRHR-LERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase DDR2.AA Ror 599-846 45 1.7e-94 320.24 In-house 26-272 (308) Show / Hide 
Range on Protein: 599-846
Range on HMM: 26-272/308
Sequence Identity: 45% (116 aa)

ANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP----PNSSSSD-VRTVSYTNLKFM--A
. .. .||.| .. ||.   . || .||..|..|. |||. || ||  | |.||. ||| .|||  || .. |      ||  |     |  .. |.  |
MYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHSDHGCSSDDDRMVKSSLDHPDFLHIA

TQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQ
.|||.|| ||||  |||||||.||||||   ..||.||| .|  ||.||||.|.....|||||| |.|. |||...||.| |||.||| . .   |||  
IQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGM-QPYYG

LSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH
 |  .||    |  |   |.  || |  ||  .| ||  ||      || | .||
YSNQEVI----EMIRN--RHL-LPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIH
Kinase DDR2.AA TK-Unique 563-849 35 2.2e-90 306.57 In-house 1-294 (294) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-294/294
Sequence Identity: 35% (111 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLK-DPNIIHLLAVCITDD-PLCMITEYMENG
|......|||.||.|. .||.|            .. .... ||||||...|..  . ||||||..|. |.  |||...| .|...| | ..| ||...|
LEVGDVIGEGAFGQVWRGEVWGIW----------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCG

DLNQFLSRHEPPNSSS--------------SDVRT--VSYTNLKFMATQIASGMKYLSS--LNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY-SGDYY
.|  .| .  |. ...              ...||  .|.  |   | |||.||.||.|   ..|||||..||.|.. ....||.||||.| .|  |.| 
NLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYS

RIQGRAVLPIRWMSWESIL--LGKF-TTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAIC-PDSVYKLMLSCWRRDTK
.....  .|||||. ||..   | . || ||||.|||..|| ||. . .||.........|.  . .|       .|||. | .. .|.|| |||... .
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKDIMECIRDGYR-------MPQPEHCCSHEMYNLMKSCWQWEPE

NRPSFQEIHLLL
 |||| .|   |
ERPSFRQIKHRL
Kinase DDR2.AA UTK 563-849 34 7.2e-90 304.88 In-house 1-296 (296) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-296/296
Sequence Identity: 34% (110 aa)

LTFKEKLGEGQFGEVHLCEV-EGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNAR--NDFLKEIK---IMSRLK-DPNIIHLLAVCITDDPLCMITE
. . ..||.|.|||||.... .  |  .. | |..|             .|||... .   ||..| .   .|....  ||.. |..||  . |....||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ----------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTE

YMENGDLNQFLSRHEPPNS-SSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN-------YTIKIADFG---MSRNLY--------
||||||| ..| || |        ..  ...    || .||.|| ||.| .||||||| |||||...       ...||||||   |||...        
YMENGDLRSYLRRHRPTPPACPHWLTLHQRLC---MAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRY

-SGDYYRIQGRAVLPIRWMSWESILLG-KFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRR
 . .||. |..  .|||||. |..  . .|||.||||.|||..||..|.   .||  .|..||... ..  |       .|.|. ||..||.||..||. 
WESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGR-----YRMPCPWDCPHPVYRLMHRCWHY

DTKNRPSFQEIHLLL
|  .||.|...   .
DPQERPDFEDLVQQM
Kinase DDR2.AA Musk 563-849 39 3.9e-89 294.7 In-house 1-282 (282) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-282/282
Sequence Identity: 39% (118 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDL
  .   .||| || |      |.           |   . ..||||||..|| |    ||  |  .| .   |||. || ||    |.|.  |||  |||
IIYVRDIGEGAFGRVFQARAPGL-----------VPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDL

NQFL---SRHEPPNSSSSDV-----------RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV
| ||   | |     ...|               .   .  || ||| || |||   ||||||||||||.. .  .||||||.||. |. |||. ..   
NEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDH

LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLL
 |||||  |||.  .||..|||||.|| ||| | .  .|||  .. | ||  . . ..       |  |  || .||.||  || .   .||.|..||  
IPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYA-LQPYYGMTHEEVIYYIRQGNI-------LSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHC

L
.
I
Kinase DDR2.AA InsR 563-851 35 3.5e-83 279.22 In-house 1-278 (278) Show / Hide 
Range on Protein: 563-851
Range on HMM: 1-278/278
Sequence Identity: 35% (105 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDL
..   ..|.| || | .   .|...     |           .|.| . ..|    | .||.|  .| . .  ... || || .  |   . | |. |||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFG---------RCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDL

NQFLSRHEPPNS-SSSDVR----TVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE
  .|  . | .     ..       ..  .  || .|..|| || ...||||||| |||.| . .|.||.|||| | .|  ||||  |.  ||.|||. |
KSYLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPE

SILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFF-RDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQ
|.  |.|||.|||| ||| |||  |.  ||||  || |||    ...  .| .   .| .|  ||. ...||  ||.   | ||.| .|  .| .
SLKDGVFTTHSDVWSFGVVLWEMVTLG-EQPYQGLSNEQV----LKYIGMDGN---VLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase DDR2.AA CTKA 563-849 35 3.5e-81 272.5 In-house 1-290 (290) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-290/290
Sequence Identity: 35% (109 aa)

LTFKEKLGEGQFGEVHLCEVEGMEK-FKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMS--RLKDPNIIHLLAVCITDDPLCMITEYMEN
.    |.|||..|.|      .    ||           .  .||||||...|.  .|  || |  . |   .  ||.. || ||  . |. ||.|.|  
HCIMFKIGEGHYGQVFRAWLMPDPDDFK-------AQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQY

GDLNQFLSRHEPPN------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG-DYYRIQGR
|||  .| .  |                |     |.     .|| ||| || ||... ||||||| ||||.|.  .||||||| .| | ..  || .. .
GDLHCYLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQ

AVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH
 |.|.|||. | .  |||..||||||||| ||| ...  | |.  .||  | .         .    || |  ||. .| .|  ||.   . ||.|  . 
RVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMG-EKPWRHMSDQEVCQAYT-----SHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQ

LLL
  |
RML
Kinase DDR2.AA Src 600-849 36 1e-76 260.14 In-house 21-255 (255) Show / Hide 
Range on Protein: 600-849
Range on HMM: 21-255/255
Sequence Identity: 36% (92 aa)

NQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMK
|. . |||| |...    . ..||.|..||  |. .....|.||| ...|   .||||..| | ..| .       ... |... ..|  ||.|.|.||.
NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-------DGEGRHLHLPQLIDMAAQVAEGMA

YLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG-DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVI
||.| |..||||| || |||.|   |.||||  | .  . | |  .  | .||.|.  | |. |.||. |||| ||. |.| .|. .  ||   . ..|.
YLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR-VPYPGMTNHEVL

ENTGEFFRDQGRQTYLPQPAICPDSVYK-LMLSCWRRDTKNRPSFQEIHLLL
..    .|       .|.|. |||..|. .|| ||..| . || |  ..  |
QQVERGYR-------MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase DDR2.AA Pkinase 563-845 22 7.6e-42 149.04 Pfam 1-287 (293) Show / Hide 
Range on Protein: 563-845
Range on HMM: 1-287/293
Sequence Identity: 22% (73 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKN--ARNDFL-KEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMEN
.....|.|.| ||.| .|   | .|                .|||| .. . .|    .....  ||.|| ||. |||. |. .. ..| ..|..||.|.
YHIGRKIGSGSFGCVYKCHHKGTGK----------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEG

G----DLNQFLSRHEPPNSSSSDVRTV--SYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI----KIADFGMSRNLYSGDYYRIQGRAVL
|    ||  ..|.        .. ...  |.  .||...||..|..|. | ...||||   |.|. .|..|    ||.||| .. ..    ..     . 
GLYVMDLFDYIST--------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCG

PIRWMSWESIL-LGKFTTASDVWAFGVTLWETFTFCQEQPYSQL----SDEQVIENTGEFFRDQGRQTYLPQPAICP-------------------DSVY
 ...|. | |.   . ....|.|..|..|.| ..   . |...     .    ..    ..|. |...  . |  |.                   ..  
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC--GRPPFPGHCWHDN-HDQMQM---ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

KLMLSCWRRDTKNRPSFQEI
... .|...| | ||....|
DFIKWCLCKDPKKRPTAEQI
Kinase DDR2.AA S_TKc 563-849 19 2.2e-41 144.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 563-849
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMEN--G
 .. .|.|.| ||.|..|   .                   .||.|...        .....||.|... . |||..|. |. . | |.|..||...  |
YEILRKIGKGAFGKVYKCRHKK----------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESIL
|| ... .. ..       .  .    .|.. ||.....|. |....||||   | |. .  .|||.|||..| |            .    .|. | . 
DLFDYIKKRGRHGLR----FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-

LGKFTT-ASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHL---------LL
  .... ..|.|..|..|.| ..   . |..   ....... |                  ....  ..  |...| ..||.  |.            .
--GYGKCKCDWWSCGCILYEMLC--GYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDR2.AA Src 563-577 60 1.6e-05 14.7 In-house 1-15 (255) Show / Hide 
Range on Protein: 563-577
Range on HMM: 1-15/255
Sequence Identity: 60% (9 aa)

LTFKEKLGEGQFGEV
.....|||.||||||
IKLCRKLGQGQFGEV
Kinase DDR2.AA Ror 563-578 56 8.7e-05 15.41 In-house 1-16 (308) Show / Hide 
Range on Protein: 563-578
Range on HMM: 1-16/308
Sequence Identity: 56% (9 aa)

LTFKEKLGEGQFGEVH
. | |.|||.||| |.
VRFMEELGECQFGKVY