DNAPK

Species: Human
Alias: p350, DNAPK, HYRC1, DNA-PKcs, DNPK1, HYRC, PRKDC, XRCC7
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 8p11.1-q11.22,

Classification

Group: Atypical
Family: PIKK
Subfamily: DNAPK

Sequence

Name Sequence Type Origin Length Description Download
DNAPK.AA Protein Sugen Kinome 4128 None Fasta, JSON
DNAPK.NA RNA Sugen Kinome 13509 None Fasta, JSON
DNAPK.kin_dom Protein Kinase Domain None 353 None Fasta, JSON

Protein domain

Protein domains of DNAPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT DNAPK.AA HEAT 293-323 22 0.000496 17.82 Pfam 1-31 (31) Show / Hide
Range on Protein: 293-323
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

LFEVLLKWCAHTNVELKKAALSALESFLKQV
....|||.. ... | ..||...| ......
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT DNAPK.AA HEAT 1009-1040 21 0.141289 9.32 Pfam 1-31 (31) Show / Hide
Range on Protein: 1009-1040
Range on HMM: 1-31/31
Sequence Identity: 21% (7 aa)

LLEAILDGIVDPVDSTLRDFCGRCIREFLKWS
.|...| .. || |.  |. . .|. .... .
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC

HEAT DNAPK.AA HEAT 1059-1089 12 1.391634 5.88 Pfam 1-31 (31) Show / Hide
Range on Protein: 1059-1089
Range on HMM: 1-31/31
Sequence Identity: 12% (4 aa)

LFKRLYSLALHPNAFKRLGASLAFNNIYREF
..  | ..  .|..  |. |  .. .... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

NUC194 DNAPK.AA NUC194 1813-2210 52 8.4e-255 857.56 Pfam 1-446 (446) Show / Hide
Range on Protein: 1813-2210
Range on HMM: 1-446/446
Sequence Identity: 52% (236 aa)

SFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTK--LNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCIT----
. .||...||...|||||||.|....||| ...|..|...|||||   || .|..||.|||..|| . |||||||||..| ....||| ..||  |    
NNVRQTMLDRYCCTLLWHCSYDTIVQFFSRHIKDIMDMIMSRFTKYLTNEWEFEHQIIKKMCCYKMIEVMYSRLPKDEIHSDDCCINQAYYGSDHTTLGA

--EGNELTKTLIKLCYDAFTENM-AGENQLLERR--RLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRY---NFPVEVEVPM
  |||||||.|.|.|.||||||| .|..||||.|  |.||||||||.|..| |.|.|||||..|||.|.||||..|.|||||..| |   .||.|.||||
PIEGNELTKALMKSCHDAFTENMPTGDSQLLEKRLCRKYHCAAYNCLIALISCTFTELKFYHVFLFRENPEKNEYIWENLIDCDRCYLYDEFPQEIEVPM

ERKKKYIEIRKEAR------EAANGDSDGPSYMSSL-SYLADSTLSEEMSQFDFSTGVQS--YSYSSQD-----PRPATGRFRRREQRDP--TVHDDVLE
||||||..||||||      .|.|. .| |.|.||  ||..|| ||.|||||||||||||  ..|||||       ...  ||..|. .    . ||| |
ERKKKYVAIRKEARVQSDQVDAWNSHQDEPKYLSSQLSYMMDSSLSQEMSQFDFSTGVQSSTFNYSSQDDGIIMQKASQHHFRKQEIAEDMSMTQDDVME

LEMDELNRHECMAPLTALVK-HMHRSLGPPQG-----EEDSVPR----DLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLA
|||||.|.|||||..... | ||||.   |..     .... |     |.|.||||||.||||. ..||||||.||..||.|..||||||.|..||.||.
LEMDEINQHECMATMCGCIKFHMHRNNITPKVSILFGDQGAQPKPTVGDMPPWMKFLHQKLGNQQQHLNIRLFIAKVIINCEQWFRPYAKFWIGPLMQLI

A----SENNGGEGIHYMVVEIVATILSWTGLATPT----GVPKDEV
     ...|||.|.|||||.|..||||||..|||.    |...||.
VKLIECDGNGGRGLHYMVVDICVTILSWTSIATPQDGGGGNTRDEH

FAT DNAPK.AA FAT 3023-3470 18 1e-102 344.17 Pfam 1-408 (408) Show / Hide
Range on Protein: 3023-3470
Range on HMM: 1-408/408
Sequence Identity: 18% (89 aa)

NPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVD--RAKYYIQNGIQSFMQNYSS-IDV
.|..... |. ....|||....|... | || || || | ||||...  |   . .. ...|....|| .... |  .|..|| ...| ....... .. 
APLAAEAAWRLGQWDETYMDEYISVMKK-LL-GE-DQ-L-TFIDEDSPDE---PTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPG

LLHQSRLTKLQSVQALTEIQEFISFISKQGNL------SSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGD
.. .........||.|.|..|.| ..|. ..       .|.  .|....||..|.|. |......|..|.|.|....|||.....               
ESYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM---------------

PSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDW----LVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDE
           ... ... .. . |..|. ...||.....|..| ||.|........||    ...|. .|... ......           .. . | .
-----------NSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQ----------QEAFQHL-R

NNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQ-RAFQHLSEAVQAAEEEAQPPSWSCGPAAG
  .|....... ......|. |.||                          .|......  |.. ..|.. |.. ..........|| ..  |  .   .
EFTSCHMQHDLGVHNNNEIN-GLTY--------------------------NLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDE

VIDAYMTLADFCDQQLRKEEENASVIDSAELQAYP------------------ALVVEKMLKALKLNSN-EARLKFPRLLQ
....|||   |..|...| ..|  .   ...|.|.                    .|........|... ..| ...|||.
ILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW

Kinase DNAPK.AA DNAPK 3716-4015 69 9.3e-262 875.87 In-house 1-301 (301) Show / Hide
Range on Protein: 3716-4015
Range on HMM: 1-301/301
Sequence Identity: 69% (210 aa)

HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDL
|||||||||||||||||||||||||||||||||||..||.||||||||.||||||||.|...|..|.||.||||||...|||.|||||||..|||.|||.
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI

LLNTMSQEE-KAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICIS
|.|.|.|.. |..|.|..|.|||.|.|||..|..||||..|..||.|.||...|.||||.|.|.|.|...||||||||..|..|.||.||....|.||||
LNNEMQQKMGKKEYISQDREPPCMYRDWLKQMDRKHDVAEYHIMYQGENRDKIVQSFRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICIS

HWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWK
||||||||||||||||.||.|..|.|||||.||||||||||||||||||||.|||||.|||..|.||.||.|...|||.|...|||..|||...||||||
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

N
|
N

Kinase DNAPK.AA PIKK 3718-4005 43 2.5e-171 575.47 In-house 1-290 (290) Show / Hide
Range on Protein: 3718-4005
Range on HMM: 1-290/290
Sequence Identity: 43% (126 aa)

RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLL
||...|..|||||....||.|.|||||..|.|.|.||.|||||||||.||||.||..|..|..|..|.|..|||||.||..|.|||||..|.||||... 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NTMSQEE-KAAYLSDPRAPPCEYKDWLTKMS-GKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISH
....... .... .......|.|.|||..|| .||.......||......|.|..||......|.|..|..|.|....||.....|.....|.|..|...
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

WILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVF
.|||.||||..|.|..|.||....||||..|.||.|.|||||..||||||...|.| ||...|.......|.....|.... |.....||
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase DNAPK.AA PI3Kc 3749-4068 24 9.5e-100 338.6 SMART 1-336 (336) Show / Hide
Range on Protein: 3749-4068
Range on HMM: 1-336/336
Sequence Identity: 24% (84 aa)

PFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLL--------------NTMSQEEKAAYLSDPRA
....|.|.|||||.|. |.|..|| |...|..|..| |..|.|...|. .. |.|||  |..||  ..                .| . . ..  . . .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ-K-N

PPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSP-EAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAME
 .    .|...   .      |.||. ....|....|..  .... . |.  |......| |.. . |..|..|.|  |. ..||||||||..|.|. |.
MY--MMIWHQQACHW------MMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMK

TGGVIGIDFGHAFGSATQFLPVP-----ELMPFRLTRQFINLML----PMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPS-FDWKNFEQKMLKK
|| ...|||||.||.. ...|..     |..|||||......|     |... |........|.||.|... |..|.. ..|. |  ..|. . .|..|.
TGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKY

GGSWIQEINVAEKNWYPRQ----KICYAKRKLAGANPAVITCDELLLGH
 ......... .......     .... .  ... ..............
LRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase DNAPK.AA PI3_PI4_kinase 3747-4015 24 3.3e-93 320.76 Pfam 1-300 (300) Show / Hide
Range on Protein: 3747-4015
Range on HMM: 1-300/300
Sequence Identity: 24% (79 aa)

EHPFLVKGGEDLR--QDQRVEQLF-----------------------QVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMS
..||..|||.|||  ||.|..|..                       ..||... .|... .| .|...|...|. .. |.|||..|..|.. .. ..| 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

QEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSP-EAFLALRSHFASSHALICISHWILGI
... ... .. .   . ..||...|                 |...|  |..|..|.| . | . |....... |.... |..|..|.| .|. ..|||.
KCKHKHFNKEHKMWMKMWPDWWHLM-----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGN

GDRHLNNFMV--AMETGGVIGIDFGHAFG-SATQFLPVPELMPFRLTR------QFINLM------LPMKETGLMYSIMVHALRAFRSDPGLLTNTM---
||||..|.||   ..|| ...|||||.|. ........||..|||.|.      .....|       |....|.. ....||.||.|.. .|..|..   
GDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKA

----DVFVKEPSFDWKN
    . .|. ....|. 
VMRGECMVHDGLPMWRS

Kinase DNAPK.AA ATR 3717-3816 36 2.2e-23 76.16 In-house 1-100 (267) Show / Hide
Range on Protein: 3717-3816
Range on HMM: 1-100/267
Sequence Identity: 36% (36 aa)

VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLL
  |||||. | ..|||..||.| ..| | . .  . |  .|||.| |  .  ...| .. .|    .| ...|||.|.|. .. ..||| .||.||. .|
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL





Kinase DNAPK.AA ATR 3887-4005 31 4e-20 64.87 In-house 150-267 (267) Show / Hide
Range on Protein: 3887-4005
Range on HMM: 150-267/267
Sequence Identity: 31% (37 aa)

FVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVH
| |    |. . . |. .  | | .|.  .|.|.|||| .| ..   .| .. .|.   |.|  ||  |||..|||||.  .. | |||  ||    .. 
FNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEV

ALRAFRSDPGLLTNTMDVF
 .. .|     .   .| |
IMMCMRDHRDDIMSVWDCF

Kinase DNAPK.AA FRAP 3747-3816 40 5.6e-18 62.72 In-house 1-70 (251) Show / Hide
Range on Protein: 3747-3816
Range on HMM: 1-70/251
Sequence Identity: 40% (28 aa)

EHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLL
|. || || ||.||| || |||  .| .|. .    .. | .. ||..|.  . ||| | ..  ||. |.
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILI

Kinase DNAPK.AA FRAP 3891-3971 39 1.3e-15 53.98 In-house 127-207 (251) Show / Hide
Range on Protein: 3891-3971
Range on HMM: 127-207/251
Sequence Identity: 39% (32 aa)

STSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM
| . |  .  |  .  | | . .  .|||.||||. | |    || .. ||||  |  | .    ||. ||||||  .| |
SPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAM

Kinase DNAPK.AA ATM 3751-3818 41 2.2e-15 45.22 In-house 3-70 (304) Show / Hide
Range on Protein: 3751-3818
Range on HMM: 3-70/304
Sequence Identity: 41% (28 aa)

LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLN
|||| .|||||  . | ||. | .|       .| | . || |||.  | | .||   |.     | |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLIN

Kinase DNAPK.AA SMG1 3726-3807 32 1.8e-13 40.84 In-house 1-82 (242) Show / Hide
Range on Protein: 3726-3807
Range on HMM: 1-82/242
Sequence Identity: 32% (27 aa)

VTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLE
.|..    .||...  | | .  |.| || |||  | |. |   ..| . |            | ||| |.  | ||| | .
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD

Kinase DNAPK.AA ATM 3907-3971 41 2.5e-11 32.04 In-house 143-206 (304) Show / Hide
Range on Protein: 3907-3971
Range on HMM: 143-206/304
Sequence Identity: 41% (27 aa)

SHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM
| |   |  .|||.||||  | ..      .. || | ||    . || || .||||||  .  |
SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF-EQGKILPTPETVPFRLTRDIVDGM

Kinase DNAPK.AA SMG1 3879-3957 34 6.1e-08 22.23 In-house 165-242 (242) Show / Hide
Range on Protein: 3879-3957
Range on HMM: 165-242/242
Sequence Identity: 34% (27 aa)

PADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPE
| .|| .      | |. .      .| | | . .  .|.|.||||| | .. | || |. ||.   |    . | |||
PPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICF-EKGKKLNVPE

FATC DNAPK.AA FATC 4096-4128 45 1.1e-11 40.48 Pfam 1-33 (33) Show / Hide
Range on Protein: 4096-4128
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

SGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
 .|| | || .| ..||||. | . . || ||.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW