Gene eEF2K (Human)

eEF2K

Species: Human
Alias: eEF2K, EEF2K, eEF-2K, HSU93850, MGC45041
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 16p12.3-p13.1,

Classification

Group: Atypical
Family: Alpha
Subfamily: eEF2K

Sequence

Name Sequence Type Origin Length Description Download
eEF2K.NA RNA Sugen Kinome 7412 None Fasta, JSON
eEF2K.AA Protein Sugen Kinome 725 None Fasta, JSON
eEF2K.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of eEF2K.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase eEF2K.AA Alpha 127-318 36 5.9e-126 360.43 In-house 1-215 (215) Show / Hide 
Range on Protein: 127-318
Range on HMM: 1-215/215
Sequence Identity: 36% (78 aa)

DEVLIKMASQPFGRGAMR------ECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHK------PPKQVDIMQMCI
....|.|.|.||..||||      .|....|.....|..|||.. .||....|..|.|..............||..||..|.      |.||........
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

IELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVR----DDNIRLTPQAFSHFTFERSGHQLIVVDIQ-GVG-DLYTDPQIHT----ETGTDFGDGNLGVRG
..............|.|.||.|.|||.|.|.|.    |.......|||||.|...|..||.|||.| ||| ...||||||.    ..|..|||||.|..|
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEG

MALFFYSH--ACNRIC
|. |||.|  .||..|
MFRFFYTHHVQCNHYC
Alpha_kinase eEF2K.AA Alpha_kinase 121-318 34 3.6e-113 383.18 SMART 1-255 (255) Show / Hide 
Range on Protein: 121-318
Range on HMM: 1-255/255
Sequence Identity: 34% (89 aa)

TGEWLDDEVLIKM-ASQPFGRGAMRECFRTKKLSNFLH--AQQWKGASNYVAKRYIEPVDRDVYFE--------DVRLQMEAKLWGEEYNR---HKP-PK
...|. .|. .|. ...||..||||.|......|...|   ..|. ...|..|.|....|...||.        ||..||..|.|..|.|.   |.| ||
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQHNPCPK

QVDIMQMCIIELK-------DRPGKPL----------------FHLEHYIEGKYIKYNSNSGFVRDDNIRLT-----------PQAFSHFTFERSGHQLI
..|..........       ||.....                ||.|...||...|||.|.|.|.|.. ..|           .|||||.|.|.|.||..
KIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQML

VVDIQGV----GD--LYTDPQIHTET--GTDFGDGNLGVRGMALFFYSHACNRIC
|.|||||    ||  .|||||||||   |. ||.||||..|.. || .| || ||
VCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase eEF2K.AA Alpha_kinase 138-318 35 5.4e-82 283.51 Pfam 1-225 (225) Show / Hide 
Range on Protein: 138-318
Range on HMM: 1-225/225
Sequence Identity: 35% (82 aa)

FGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIE----PVD------RDVYFEDVRLQMEAKLWGEEYNRH-----KPPKQVDIMQMC-IIELKDRP
|..||||.|||.....     ..|.  .|.|||.|..     ..      .| ||.|.. || .. | |..|.      .||........| ..||.|..
FAQGAMRWCFRMFDTW----DPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

G---------------KPLFHLEHYIEG-KYIKYNSNSGFVRDDNIRLTP-----QAFSHFTFERSGHQLIVVDIQGVG--D---LYTDPQIHTETGTD-
.               ......|.|||| ...|||.|.|.|.| . | .|     |||||||..||..|..|.||||||  .   ..|||||||. |   
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYE

--F--GDGNLGVRGMALFFY-SHACNRIC
  |  |.|||| .|.  ||  .| ||.||
MDFDEGMGNLGQEGIEKFFQNQHKCNHIC
Kinase eEF2K.AA VWL 229-323 45 1.5e-39 115.56 In-house 108-206 (206) Show / Hide 
Range on Protein: 229-323
Range on HMM: 108-206/206
Sequence Identity: 45% (45 aa)

EHYIEGKYIKYNSNSGFV--RDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVG-DLYTDPQIHTETG-TDFGDGNLGVRGMALFFYSHACNRICESMGL
| |||| | ||| |.|..  .|.   .  |||||||.  |  .. .||.||..  . ||||||.      ||.||||  ||  ||..| || .| .. |
ENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQKLQL
Kinase eEF2K.AA Alpha-Unclassified 167-318 30 1.8e-29 93.19 In-house 44-215 (215) Show / Hide 
Range on Protein: 167-318
Range on HMM: 44-215/215
Sequence Identity: 30% (52 aa)

YVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNR----HKPPKQV-DIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSG----FVR-DDNIRLTPQ
|| | | |       | ||  || |. .  |.|.       | |.  |     | . |.  | .  .| |..| . ||..|.|    ||. ..      .
YVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPPIFLIHREDKNIKGCISVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCC

AFSHFTFERSGHQLIVVDIQG-VG------DLYTDPQIHTETGTDFG--DGNLGVRGMALFFYSH--ACNRIC
...|.|.. ..|..||.| || |.         |||||||     ..  ..| | |..  .| .|   || .|
TYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHT-IRQRYQGFKTNCGMRFIDYWFNNHHVQCNHYC
Kinase eEF2K.AA ChaK 226-318 36 2.7e-10 36.95 In-house 120-219 (219) Show / Hide 
Range on Protein: 226-318
Range on HMM: 120-219/219
Sequence Identity: 36% (36 aa)

FHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQ-IHTE----TGTDFGDGNLGVRGMALFFYSHACNRIC
| .|... | . ||| | |   .    .     ||||.|.|     |.|.|.||||.  |||  |  |     .  ||  |||   .  |   | ||  |
FTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC