Gene EphA5 (Human)

EphA5

Species: Human
Alias: Hs.31092, HEK7, EphA5, Hs.194771, TYRO4, EHK1, EPHA5, CEK7
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4q11-q13.2,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA5.NA RNA Sugen Kinome 7858 None Fasta, JSON
EphA5.AA Protein Sugen Kinome 1037 None Fasta, JSON
EphA5.kin_dom Protein Kinase Domain Sugen Kinome 257 None Fasta, JSON

Protein domain

Protein domains of EphA5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA5.AA Ephrin_lbd 60-233 64 1.2e-139 435.39 Pfam 1-190 (190) Show / Hide 
Range on Protein: 60-233
Range on HMM: 1-190/190
Sequence Identity: 64% (123 aa)

EVNLLDSRTVMGDLGWIAFPKNG---------WEEIGEVDENYAPIHTYQVC-KVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKE
||.|.|..|...||||...|.||         |||....|||..||.|||||  |||.|||||| | ||. .||.||..|||||.|||||.||..|||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNMYYFESDD--QNG---RNIKENQYIKIDTIAADES-FTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKC
|||.|| |||   ..|   .|..||||.|||||||||| ||..|.|.|.||||||||..|||||.||||||||.|||.||||||||||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA5.AA EPH_lbd 60-233 64 6.7e-125 422.16 SMART 1-184 (184) Show / Hide 
Range on Protein: 60-233
Range on HMM: 1-184/184
Sequence Identity: 64% (119 aa)

EVNLLDSRTVMGDLGWIAFPKNG--WEEIGEVDENYAPIHTYQVCKVME---QNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLG-TCKETFNM
||.|.|..|..|.|||...|..|  |||....||...||.||||| |||   .||||||.| ||. .||.||..|||||.|||||.||..| .||||||.
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYFESDDQNG---RNIK-ENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKC
|| |||....   .... ||.||||||||||||||. |.||||||.|||||..||||||||||||||.|||.|||||||.||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
FN3 EphA5.AA FN3 358-448 17 4.5e-09 37.4 SMART 1-69 (69) Show / Hide 
Range on Protein: 358-448
Range on HMM: 1-69/69
Sequence Identity: 17% (19 aa)

PSAPRN----AISNVNET------SVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAH----TNYTFEIEA
|..|.|     ...|..|      || |.| ||        . .|.                                .   .| ..    |.|.| . |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR--------------------------------YTVTGLKPGQYPWTEYEFRVRA

V----NGVS
|    .| .
VNGNDAGEG
FN3 EphA5.AA FN3 469-549 22 9.6e-15 56.23 SMART 1-69 (69) Show / Hide 
Range on Protein: 469-549
Range on HMM: 1-69/69
Sequence Identity: 22% (22 aa)

PSPVTN---VKKGKIAKN------SISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPA----SVYVFQIRARTA--AGYG
|.|..|   ..   . ..      |..|||..|      |..|.                      | .||||     . |.|..||...  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA5.AA Eph 675-932 84 1e-224 752.8 In-house 1-264 (264) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-264/264
Sequence Identity: 84% (224 aa)

ITIERVIGAGEFGEVCSGRLKLP-GKREL---PVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG
|.||.|||||||||||.|||||| ||||.   ||||||||.|||||||.|||.||||||||||||||.||||||||.|||||||||||||||.||...||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP--EAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVM
|||||||||||||| .||||||||.||||||||||||.|||||||||||||||||||||  ||.|||||||||||||||||||.||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNML
|||.||||||||.|.|||||||.|.|||||.|||||.||.|||||||||.||.||.|..||..|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA5.AA Pkinase_Tyr 675-932 44 1.2e-148 504.05 Pfam 1-270 (270) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-270/270
Sequence Identity: 44% (121 aa)

ITIERVIGAGEFGEVCSGRLK-LPGKRELPVAIKTLKVGYTEKQ--RRDFLGEASIMGQF-DHPNIIHLEGVVT-KSKP--VMIVTEYMENGSLDTFLKK
||. ...|.|.||||. |..| .|.. ..|||.|.|| |....|  |.||. ||.|| |. .||||. | ||.| ...|  ..||.|||..|.|...|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL-EDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWS
.   ....|. .|..| . |..|| ||......||||||||.|...|.|.|..||||.| . .||    ... |||.||.|.|||.|...|||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIVMWEVVSYGERP-YWEMTNQDVIKAV-EEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNML
.|..|||...||| | |..|.|..|.... |.|||.| |..||. .|.||..||... . || | ||...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA5.AA TyrKc 675-932 40 1e-139 471.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-280/280
Sequence Identity: 40% (118 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF--DHPNIIHLEGVVTKS-------KPVMIVTEYMENGSLDTFL
|| ....| |.||||. |..|      ..||.|.|| .     |.||. ||.|| ..  .||||. | ||.|..       .|.|||.|||..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDD-----PEAAYTTR---GGK--IPIRWTAPEAIAFRKF
.|. ..... .|. .   |..|| ||......||||||||.|...|...|.||||||| ..||      .  |...   |||  .||||.|||.| ..||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVVSYGERPYWE-----MTNQDVIKAVEEGYRLPSPMD--------CPAALYQLMLDCWQKERNSRPKFDEIVNML
|..|||||.|..|||. .||. ||..     |.||.||. |..|||.| | .        ||...||.|..||. . ..|| | ||.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA5.AA TK 675-932 23 6e-125 421.08 In-house 1-486 (486) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

ITIERVIGAGEFG---EVCSGRLKLPG----------------------KRELPVAIKTLKVGYTEKQRR-------------DFLGEASIMGQFD----
||.....|.|.||   ||. |... ..                      . . |||.|.|| | .. |..             ||| ||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIHLEGVVTKS------------KPVMIVTEYMENGS----LDTFLKKNDG---------------------------------------------
 ||||..| ||.|..            .|.|||.|||..|.    |...|.|...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGISAGMKYLSDM------GYVHRDLAARNILINSNLV-----------CKVSDFGLS-
                              |.|. ||. | . |..|| ||...      ..|||||||||.|...|.|           ||..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVLEDDPEAAYTTRG-------------------------GKIPIRWTAPEAIA---------FRKFTSASDVWSYGIVMWEVVSYG-ERPYWEM
     .  .....  |....                         ||.||||.|||...         ..|||..|||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------QDVIKAVEEG--------------YRLPSPMDCP--------------AALYQLMLDCWQKERNSRPKFDEIVNML
.|         |.|.. ...|              .|.| |..||              ...|.||..||... . || |......|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA5.AA Src 675-932 45 4.3e-112 378.68 In-house 1-255 (255) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-255/255
Sequence Identity: 45% (118 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLK-KNDGQ-F
|. .| .|.| ||||  |      . . .||.|||| |    .  .|| || || ...|.....|  |... .|. ||||||..||| ..|| . .|.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY-TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEV
 . ||. |   ...||.||. | |.||||||||.|.. |.|||| |||| |....| .  |    | |.||.||||||| ...||  |||||.|| ..|.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

VSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQ-LMLDCWQKERNSRPKFDEIVNML
|.||  ||  |||..|...|| |||.| |. ||. ||. .|| ||.|.   || |. . . |
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA5.AA UTK 675-932 37 8.70000000001e-109 367.72 In-house 1-296 (296) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-296/296
Sequence Identity: 37% (110 aa)

ITIERVIGAGEFGEVCSGRLKLPG--KRELPVAIKTLKVGYT-EKQRR---DFLGEAS---IMGQFD-HPNIIHLEGVVTKSKPVMIVTEYMENGSLDTF
. . | .|.|.||||. .|.. .     |. ||.|..... . .....   ||. ||    .|.||. |||.. | ||.|...| ||||||||||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LK-------KNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSN-------LVCKVSDFG---LSRVLE-------DDPEAAYTTRG-GK
|         .. ..|  |...| . |..|| ||. .|.|||||||||.|....       .|||..|||   .|| .        ..    |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAFR-KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEG--YRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNML
.||||.||||.. . .||..|||||.|.|.||....| .|| .|.|..|...|..|  ||.|.| |||...|.||..||...   || |...|  .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA5.AA SFK-Src 675-936 43 1e-104 311.33 In-house 1-259 (259) Show / Hide 
Range on Protein: 675-936
Range on HMM: 1-259/259
Sequence Identity: 43% (116 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKK-NDGQFT
|  |.  |.| ||.|  ||          ||.|||| | .  .   || || .| .  ||| | |  | |   |. |.|| | .|||  .|.  .    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS
. ||| |   . .|| || .  .|||||||||.|.  | |||| |||.||||..| |      | | ||.||||||    .|   |||||.|| | |.| 
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWEMTNQDVIKAVEE--GYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLI
||  ||  |||. |.. |.   |||.| |  || ..|..|.||||.|   || |.     ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA5.AA Fer 675-933 35 1e-101 344.2 In-house 1-283 (283) Show / Hide 
Range on Protein: 675-933
Range on HMM: 1-283/283
Sequence Identity: 35% (100 aa)

ITIERVIGAGEFGEVCSGR--LKLPGKRELPV---AIKTLKV---GYTEKQRRDFLGEASIMGQ-FDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFL
.|.. ..| | ||||..||  ||.  .. . |   |.|. |.   . |..|...|. || || . .||||.. . || .   |.||| |.. .||||..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KKNDGQ-FTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINS-NLVCK--VSDFGLSRVLEDDPEAAYTTR--GGKIPIRWTAPEAIAFRKFTSAS
|||...  .. ... |. ....||.||  .. .|||.||||.|.   ....|  .||||.|| ..|. . .|. .    |.||||.|||.. .. .....
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDY-GYDYKMKEKACKVPIRWLAPETWQTGIYSPKT

DVWSYGIVMWEVVSYGERPYWE----MTNQDV----IKA-VEEGYRLPSPMDCPAALYQLML-DCWQKERNSRPKFDEIVNMLD
||||.|...||. . |. || .    |..  |    .|. ...||..| |  .| ...|.|. .||||. . ||...||...| 
DVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA5.AA TK-Unique 675-932 34 3.8e-96 325.72 In-house 1-294 (294) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-294/294
Sequence Identity: 34% (101 aa)

ITIERVIGAGEFGEVCSGRLKLPG---KRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFD-HPNIIHLEGVVTKSK-PVMIVTEYMENGSLDTFLKKND
.....||| |.||.|. | .. .     .   ||.|.|| . |. ...||| |...| . . ||||....|. |||  |.||. ||...|.|...|... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGISAGMKYLSD--MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG--GKI
 .....                     |.   |.  . .|  ||.||.   .. |||||.|||.|.....|||..|||..| ...  . .| . .  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTAPEAIA--FRKF-TSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDC-PAALYQLMLDCWQKERNSRPKFDEIVNML
|||| |||..    . . |. |||||.|..|||....|..|| .| . |.......|||.| |  | . ..|.||  |||.|. .|| |..|...|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA5.AA Frk 675-936 44 3e-92 312.79 In-house 1-260 (260) Show / Hide 
Range on Protein: 675-936
Range on HMM: 1-260/260
Sequence Identity: 44% (118 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLK---KNDGQ
| . | .|.| ||||  |.       . |||.|||| |  . .  ||| || || .  || .|.|  | |  .|..|.|| |..||| ..|.   ..  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG-KIPIRWTAPEAIAFRKFTSASDVWSYGIVMWE
  . ||| |   . ||| || .. |.||||||||.|.. ...||. |||| |||  | |  | .| | ..||.||||||.   |||  |||||.||.. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLI
.. ||  ||  |||..|.. |..|||.| | .||  ||..||.||... . || |. .   |.. .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA5.AA SrcB 675-933 44 9.2e-88 296.97 In-house 1-251 (251) Show / Hide 
Range on Protein: 675-933
Range on HMM: 1-251/251
Sequence Identity: 44% (117 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG-QFT
. ... .||| ||||  |      ...  ||.||.| |    .   ||.|| .| .  |  ...|  ||||  |. |.||||..|.|  ||| ..| . .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR-GGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVV
. .|. |   |. || |.  | |.|||| | |||.   |.||. |||| |..||.    || | | | ||.||||||| |  ||  |||||.||.. |.|
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN---EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIV

SYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLD
 ||  ||  ||| .||...|.|||.| |  ||  ||..|  ||..    || || .  .||
TYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphA5.AA Syk 675-926 37 4.7e-85 288.88 In-house 1-257 (257) Show / Hide 
Range on Protein: 675-926
Range on HMM: 1-257/257
Sequence Identity: 37% (98 aa)

ITIERVIGAGEFGEVCSGRLKLP----GKRELPVAIKTLKVGYTEKQ-RRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKND
.   . || |.|| | .| ..       |. ..||||.||   ...     |. ||..| | ||| |. . | . .  . | | |  | |..  .|... 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIG-ICHAEMMMMVMEMAELGPMHKYLQQHR

GQFTVIQLVGMLR-GISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVM
   |.   . ..   .. ||.||     |||||||||.|       |.||||.|. |  | .    | .|| |..| ||| | ..|| ..|||||.|. |
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFD
||  ||| .|| ||..|.|.| .| | |.. |  ||. .|||| .||  .   || | 
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EphA5.AA S_TKc 675-936 24 3.5e-51 177.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 675-936
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMEN--GSLDTFLKKNDGQ-
 .| |.|| | ||.|. .| |        |||| .|        .... | .|. . .||||..| .|    . . .|.||...  |.| ...||. .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTS-ASDVWSYGI
    |.  .   ... |  ...|. ..| .||||   |||...  . |..||||.|.|          .       . ||| .   ...  ..|.|| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVN-----MLDKLI
...| .. |. |..  . | ..| .            .  . ...  |.||. . ||   |. .     ...  .
ILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA5.AA Pkinase 675-932 23 1.4e-47 169.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 675-932
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK--QRRDFL-GEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENG----SLDTFLK-
..|.|.||.| ||.|. .. |  ||    ||.|..|.  ...  ......  |..||  ..||||. | .... .. . .|.||.|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KNDGQF--TVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVC----KVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA-FRKFTSAS
...| |  .  ..  ... |  |..|. .|| .||||   ||||..| ..    |..||||.....        . .    ... ||| |   .. ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSYGIVMWEVVSYGERPYWEM----TNQDVIKAVEEGYRLPSPMDCP-----------------------AALYQLMLDCWQKERNSRPKFDEIVNM-
|.||.|....|... |. |...     .  | .. ...  . | . |.|                        .. ... .|..|  ..|| ...|..  
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
SAM_1 EphA5.AA SAM_1 963-1027 48 1.4e-30 111.27 Pfam 1-66 (66) Show / Hide 
Range on Protein: 963-1027
Range on HMM: 1-66/66
Sequence Identity: 48% (32 aa)

GSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRR-LGVTLVGHQKKIMNSLQEMK
.  ....|.||||.|.|..|.. ||..||..||...| | |||.. .||||.||.||||.|.| .|
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
Sam7 EphA5.AA sam7 965-1027 35 5.7e-26 90.09 In-house 1-70 (70) Show / Hide 
Range on Protein: 965-1027
Range on HMM: 1-70/70
Sequence Identity: 35% (25 aa)

GAYRSVGEWLEAIKM---GRYTEIFMENGY----SSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMK
   ..|.||||.|.|   ..|.. |...|.    ...|.....|.|||...|.|..||.|||.|..| |.
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM EphA5.AA SAM 962-1029 36 2.3e-25 91.49 SMART 1-67 (67) Show / Hide 
Range on Protein: 962-1029
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

LGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQ
      ..|..|||.|.|..|...|..||...|. ... ..||| ..|.|..||.|||....|.|| |
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 EphA5.AA SAM_2 962-1027 36 3.4e-25 89.32 Pfam 1-71 (71) Show / Hide 
Range on Protein: 962-1027
Range on HMM: 1-71/71
Sequence Identity: 36% (26 aa)

LGSGAYRSVGEWLEAIKM-GRYTEIFMENGYSSMDAV-AQVTLEDL--R-RLGVTLVGHQKKIMNSLQEMK
  . .  .|.|||..|.| ..|...|...|....... |..|..||    |.|.|.|||.|||.|..|.||
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK