Gene EphA8 (Human)

EphA8

Species: Human
Alias: EPHA8, HEK3, KIAA1459, EEK, EphA8
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1p36.1,

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA8.NA RNA Sugen Kinome 4996 None Fasta, JSON
EphA8.AA Protein Sugen Kinome 1005 None Fasta, JSON
EphA8.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of EphA8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA8.AA Ephrin_lbd 31-204 62 5.1e-134 417.82 Pfam 1-190 (190) Show / Hide 
Range on Protein: 31-204
Range on HMM: 1-190/190
Sequence Identity: 62% (119 aa)

EVNLLDTSTIHGDWGWLTYPAHG---------WDSINEVDESFQPIHTYQVC-NVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKE
||.|.||.| ..|.||.|||..|         |. ....||   ||.||||| |||.||||||||| |..|.||.|.| |.|||.|||||.|||.|||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLYYLESDR--DLG---ASTQESQFLKIDTIAADES-FTGADLGVRRLKLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRIYYKKC
||||||.|||.  |.|   .. .|.|. |||||||||| ||  |.| | .||||||||.||||||||||||||.|||.|..|.|.|||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA8.AA EPH_lbd 31-204 62 1.8e-120 407.43 SMART 1-184 (184) Show / Hide 
Range on Protein: 31-204
Range on HMM: 1-184/184
Sequence Identity: 62% (115 aa)

EVNLLDTSTIHGDWGWLTYPAHG--WDSINEVDESFQPIHTYQVCNVMS---PNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLG-TCKETFNL
||.|.||.|..|..||.||| ||  |. . ..||  .||.||||||||.   ||||||||| |..|.||.|.| |.|||.|||||||||.| .|||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYLESDRDLG---ASTQ-ESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRIYYKKC
|| ||| | .      . |....|||||||||||| .|.| |..|.||||||.|||||.||||||||.|||.|..|.|..||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA8.AA GCC2_GCC3 273-307 25 0.000534 15.97 Pfam 11-49 (49) Show / Hide 
Range on Protein: 273-307
Range on HMM: 11-49/49
Sequence Identity: 25% (10 aa)

CVACELGFYKSAPGDQLCARCPPH-S---HSAAPAAQAC
|..|. |.|..  | . |  |||. .   . .. ... |
CEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTSESDC
FN3 EphA8.AA FN3 329-419 19 1.4e-08 35.78 SMART 1-69 (69) Show / Hide 
Range on Protein: 329-419
Range on HMM: 1-69/69
Sequence Identity: 19% (21 aa)

PSAPVN---LISS-VNGT------SVTLEWAPPLDPGGRSDITYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAH----MNYSFWIEA
|..| |   |  . |. |      ||||.| ||        ..|                                    | .| ..     .|.|.. |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------------------YTVTGLKPGQYPWTEYEFRVRA

V----NGVS
|    .| .
VNGNDAGEG
FN3 EphA8.AA FN3 440-521 26 8.7e-15 56.37 SMART 1-69 (69) Show / Hide 
Range on Protein: 440-521
Range on HMM: 1-69/69
Sequence Identity: 26% (26 aa)

PSQVVV---IRQERAGQT------SVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPG----TRYVFQVRARTS--AGCG
|. .     .| .  . |      ||.| |..|      |..|.                      .||.|||||    |.|.|.|||...  || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA8.AA Eph 635-892 76 1.3e-213 715.9 In-house 1-264 (264) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-264/264
Sequence Identity: 76% (203 aa)

IHIEKIIGSGDSGEVCYGRLRVP-GQRDV---PVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDG
|.|||.||.|. ||||.|||..| |.|.|   |||||.|||||||.||.|||||||||||||||||||||||||..| .|||||||||||||.|||.|||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDP--DAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVM
|||..||||||||...||.||||..||||||||||.||.||||||||||||||||||||  .|.|||.|||||||||||||||.|.|.|||||||.|.||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVL
|||..|||||||.|.|.|||...|.|||||.||.||.||||||||||.|||..||.|.||||.|
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA8.AA Pkinase_Tyr 635-892 45 1.1e-142 483.86 Pfam 1-270 (270) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-270/270
Sequence Identity: 45% (122 aa)

IHIEKIIGSGDSGEVCYGRLR-VPGQRDVPVAIKALKAGYTERQ--RRDFLSEASIMGQF-DHPNIIRLEGVVT-RGRL--AMIVTEYMENGSLDTFLRT
|.. | .|.|  |||. |...  |.. ..|||.| || |....|  |.||..||.|| |. .||||.|| ||.| .|.    .||.|||..|.|...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVL-EDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWS
|   ....|. .|..| . . .|| ||.. ...||||||||.||..|.|.|..||||.| . .||    ....|||.||.|.|||.|... |...|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVMWEVLAYGERP-YWNMTNRDVISSV-EEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVL
|||.|||.. ||| | |..|.| .|.  . |.|||.|.|..||  ...||..|||.| ..||.||.|.. |
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA8.AA TyrKc 635-892 40 3.6e-128 433.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-280/280
Sequence Identity: 40% (117 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQF--DHPNIIRLEGVVTRG-------RLAMIVTEYMENGSLDTFL
|. .|..|.|  |||. |...      ..||.| ||..     |.||..||.|| ..  .||||.|| ||.| .          |||.|||..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDD----PDAAYTTT----GGK--IPIRWTAPEAIAFRTF
| | ....  .|. .   . .||.||.. ...||||||||.||..|...|.||||||| ..||        | ..    |||  .||||.|||.| ...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SSASDVWSFGVVMWEVLAYGERPYWN-----MTNRDVISSVEEGYRLPAPMG--------CPHALHQLMLDCWHKDRAQRPRFSQIVSVL
...||||||||.|||.. ||. ||..     |.|..||  |..|||.| |          || ...|.|..||| | ..||.||.|.. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA8.AA TK 635-892 24 1.9e-119 402.28 In-house 1-486 (486) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-486/486
Sequence Identity: 24% (121 aa)

IHIEKIIGSGDSG---EVCYGRLRVPG----------------------QRDVPVAIKALKAGYTERQRR-------------DFLSEASIMGQFD----
|...| .|.|  |   ||. |..| ..                      .  .|||.| ||.| .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIRLEGVVTRG------------RLAMIVTEYMENGS----LDTFLRTHDG---------------------------------------------
 ||||.|| ||.|.|            .  |||.|||..|.    |...||....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTIMQLVGMLRGVGAGMRYLSDL------GYVHRDLAARNVLVDSNLV-----------CKVSDFGLS-
                              |.|  ||. | . . .||.||...      ..|||||||||.||..|.|           ||..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVLEDDPDAAYTTTG-------------------------GKIPIRWTAPEAIA---------FRTFSSASDVWSFGVVMWEVLAYG-ERPYWNM
     .  ....|  |....                         ||.||||.|||...         ...|...||||||||.|||.. || | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TNRDVIS-----------------------SVEEGYRLPAPMGCP--------------HALHQLMLDCWHKDRAQRPRFSQIVSVL
.|.||..                       .|....|.|.|..||               ....||..|||.| ..||.|||... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA8.AA UTK 635-892 37 1.8e-108 366.64 In-house 1-296 (296) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-296/296
Sequence Identity: 37% (111 aa)

IHIEKIIGSGDSGEVCYGRLRVPG--QRDVPVAIKALKAGYT-ERQRR---DFLSEAS---IMGQFD-HPNIIRLEGVVTRGRLAMIVTEYMENGSLDTF
... . .|.|  |||. .|.. .     .. ||.|..... . .....   ||. ||    .|.||. |||..|| ||.|..   ||||||||||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRTHDG-------QFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSN-------LVCKVSDFG---LSRVLE-------DDPDAAYTTTG-GK
||.|         ..|  |...| . . .|| ||.  |.|||||||||.||...       .|||..|||   .|| .        .. .  |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIAFR-TFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEG--YRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVL
.||||.||||.. . .|...|||||||||.||....| .|| .|.|..|. .|..|  ||.|.| .|||.. .||..|||.| . ||.| ..|...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA8.AA Src 635-892 44 1.6e-104 353.55 In-house 1-255 (255) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-255/255
Sequence Identity: 44% (116 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLR-THDGQ-F
|. .. .|.|  ||| .|  .      ..||.| ||.|    .  .|| || || ...|.....|  |....    ||||||..||| ..|. . .|.  
IKLCRKLGQGQFGEVWMGYWNG----NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAY-TTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEV
 . ||. |   | .|| ||.   |.|||||||||||. |.|||| |||| |....| |  |   .| |.||.||||||| ...|.  |||||||. ..|.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

LAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQ-LMLDCWHKDRAQRPRFSQIVSVL
  ||  ||  |||..|.  || |||.| |..||  |.. .|| |||||  ||| |  . ..|
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA8.AA SFK-Src 635-896 43 1.7e-99 295.55 In-house 1-259 (259) Show / Hide 
Range on Protein: 635-896
Range on HMM: 1-259/259
Sequence Identity: 43% (116 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRT-HDGQFT
|  ||  |||  |.|  ||          ||.| || | .  .   ||.|| .| .  ||| |.|  | | |    |.|| | .|||  .|.  |    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

IMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLA
. ||| |   | .|| || .  .||||||||||||  | |||| |||.||||..|       .| | ||.||||||    .||  |||||||. | |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWNMTNRDVISSVEE--GYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALI
||  ||  |||  |.  |.   |||.|.| .|| .....|.||| .    || |      ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA8.AA TK-Unique 635-892 32 5.5e-93 315.22 In-house 1-294 (294) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-294/294
Sequence Identity: 32% (97 aa)

IHIEKIIGSGDSGEVCYGRLRVPG---QRDVPVAIKALKAGYTERQRRDFLSEASIMGQFD-HPNIIRLEGVVTRGR-LAMIVTEYMENGSLDTFLRTHD
. ....||.|  |.|. | .. .     ... ||.|.||.. |. ...|||.|...| . . ||||....|. |.     ||. ||...|.|...|||  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GQ-------------------------FTIMQLVGMLRGVGAGMRYLSDLGY--VHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTG--GKI
..                          .  .|.  . ..  || ||. . .  |||||.|||||. ...|||..|||..| ...  . .| ...  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTAPEAIA--FRTF-SSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGC-PHALHQLMLDCWHKDRAQRPRFSQIVSVL
|||| |||..    ... .. ||||||||.|||.. .|..|| .| ..|..  ...|||.| | .| .|....||  ||.... .|| |.||...|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA8.AA Fer 635-893 32 2.5e-88 299.77 In-house 1-283 (283) Show / Hide 
Range on Protein: 635-893
Range on HMM: 1-283/283
Sequence Identity: 32% (93 aa)

IHIEKIIGSGDSGEVCYGR----LRVPGQRD-VPVAIKALKA---GYTERQRRDFLSEASIMGQ-FDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFL
....|..|.|. |||. ||    .  ... . ..||.|  |    . |. |...|. || || . .||||.... || .     ||| |.. .||||..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RTHDGQ-FTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS-NLVCK--VSDFGLSRVLEDDPDAAYTT-TGGKIPIRWTAPEAIAFRTFSSASD
.. ...  .. ... |. .. .||.||   . .|||.||||.|..  ....|  .||||.|| ..|.  . .   .  |.||||.|||.. ....|...|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGVVMWEVLAYGERPYWN----MTNRDV----ISS-VEEGYRLPAPMGCPHALHQLML-DCWHKDRAQRPRFSQIVSVLD
||||||..||. . |. || .    |..  |    .   ...||..| | ..| .. |.|. .||.||  .|| ...|.  | 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA8.AA Frk 635-896 42 8.2e-86 291.4 In-house 1-260 (260) Show / Hide 
Range on Protein: 635-896
Range on HMM: 1-260/260
Sequence Identity: 42% (113 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLR---THDGQ
|.. . .|||  |||  |.  .     .|||.| ||.|  . .  ||| || || .  || .|.|  | |.    .|.|| |..||| ..|.    .  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSR-VLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWE
  . ||| |   | ||| || .  |.|||||||||||. ...||. |||| | .. |. |   . .| ..||.||||||.    |.  |||||||... |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALI
.. ||  ||  |||..|.  |..|||.| | .||  | ..||.|||.|  .|| |  .   |.  .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA8.AA Tec 635-894 41 2.1e-80 273.45 In-house 1-254 (254) Show / Hide 
Range on Protein: 635-894
Range on HMM: 1-254/254
Sequence Identity: 41% (111 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAG-YTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFT
. . | .|||  | | .|..|   |.|  ||||..| |   |    ||. || .|    ||. ..| || .  |   |||||||.|.|  .||.| ..| 
LTFMKELGSGQFGVVHLGKWRH--QYD--VAIKMIKEGSMSE---EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

IMQ--LVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSR-VLEDDPDAAYTTTG-GKIPIRWTAPEAIAFRTFSSASDVWSFGVVMW
  .  | .|   |  || ||   ...|||||||| ||... | ||||||..| || |.    ||  .  | |..| .||   .  .|| ||||.||| ||
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQ----YTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDA
||   |  || ||.| .|.  | .|.||  |  |.  . | | .|||    .|| |.|  . .  
EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphA8.AA Csk 635-892 40 1.1e-79 271.09 In-house 1-251 (251) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-251/251
Sequence Identity: 40% (107 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAG-YTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGR-LAMIVTEYMENGSLDTFLRTHDGQ-
.|. . || |  | |  | ..  ..    ||.| .|    .  |   || |||.| |  ||| ..| ||.        ||.||| .|.|  .||.   . 
LHLGECIGHGEFGDVMQGEYQ--NRK---VAVKCIKCDGNGMAQA--FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHV

FTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTT---GGKIPIRWTAPEAIAFRTFSSASDVWSFGVVM
.|  ||      |..|| ||     |||||||||.||.  .| |||||||..      .. ..     .||.|| ||||||     ||. |||||||. .
ITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK------EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILL

WEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVL
||.  .|  ||  .  .||   || |||  || ||| . ...| .||| . |.|| | |... |
WEIYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase EphA8.AA S_TKc 635-896 21 3.7e-45 157.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 635-896
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMEN--GSLDTFLRTHDGQ-
 .| ..||.|  |.|. .| .     .  |||| .|        .....| .|. . .||||..| .|        .|.||...  |.| .... . .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSS-ASDVWSFGV
    |.  .   ... .  .. |. ..| .||||   |.|.|.  . |..||||.|.|          |       . ||| .    ..  ..|.||.|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVS-----VLDALI
...| |. |. |..   . ...  .            .. . ...  |..|| ..||   ..        ..  .
ILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA8.AA Pkinase 635-892 23 4.4e-42 149.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 635-892
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTER--QRRDFL-SEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENG----SLDTFLR-
.||...|||| .|.|. .. .  |.    ||.| .|   ..   ...... ||..||  ..||||.|| .......   .|.||.|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

THDGQF--TIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVC----KVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA-FRTFSSAS
  .| |  .  ..  ... .  |. |. . | .||||   |.|.|.| ..    |..||||.....        .|.    ... ||| |   .  ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSFGVVMWEVLAYGERPYWNM----TNRDVISSVEEGYRLPAPMGCP-----------------------HALHQLMLDCWHKDRAQRPRFSQIVSV-
|.||.|....|.|  |. |...     . .| .  ...  . | .  .|                        .. ... .|..|| ..|| . ||.   
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
SAM_1 EphA8.AA SAM_1 931-992 39 9.7e-26 94.13 Pfam 1-66 (66) Show / Hide 
Range on Protein: 931-992
Range on HMM: 1-66/66
Sequence Identity: 39% (26 aa)

GG---LTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRA-LGITLMGHQKKILGSIQTMR
..    .|..||.||.|..|.|||.. ||... ..|.| ..| .. .|.||.||.|||. |||...
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphA8.AA SAM 927-994 36 3.2e-20 74.43 SMART 1-67 (67) Show / Hide 
Range on Protein: 927-994
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

SGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQ
       .|.|||.||.|..|.|.|.. |...  ...... .|   .|||. ||.|||| .||.|..|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphA8.AA sam7 934-992 34 5.4e-19 65.36 In-house 5-70 (70) Show / Hide 
Range on Protein: 934-992
Range on HMM: 5-70/70
Sequence Identity: 34% (23 aa)

TVGDWLDSIRM---GRYRDHFAAGGY----SSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMR
.|..||..|.|   ..|.|.| . |.    ... ....|. .| ...|||. ||.|||. .|| ||
DVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_2 EphA8.AA SAM_2 934-992 35 2.3e-17 62.42 Pfam 8-71 (71) Show / Hide 
Range on Protein: 934-992
Range on HMM: 8-71/71
Sequence Identity: 35% (23 aa)

TVGDWLDSIRM-GRYRDHFAAGGYSSLGMV-LRMNAQDV--R-ALGITLMGHQKKILGSIQTMR
.|..||.||.| ..|.| | . |.... .. ..|...|     ..|||. ||.|||. .|| |.
DVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK