Gene ErbB2 (Human)

ErbB2

Species: Human
Alias: ErbB2, ERBB2, Hs.103992, NGL, c-erbB2, TKR1, HER-2, Hs.323910, c-erb B2, c-erbB-2, HER2, NEU, HER-2/neu
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 17q21.1,

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
ErbB2.NA RNA Sugen Kinome 4624 None Fasta, JSON
ErbB2.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
ErbB2.AA Protein Sugen Kinome 1255 None Fasta, JSON

Protein domain

Protein domains of ErbB2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain ErbB2.AA Recep_L_domain 52-173 37 1.3e-44 151.76 Pfam 1-121 (121) Show / Hide 
Range on Protein: 52-173
Range on HMM: 1-121/121
Sequence Identity: 37% (50 aa)

GCQVVQGNLELTYLPTN----ASLSFLQDIQEVQGYVLIAHN--QVRQVPLQRLRIVRGTQLFED-NYALAVLDNGDPLNNTTPVTGASPGGLRELQLRS
.|.|. ||||.|.  ..      |||.. |.|. ||.||...   .   ....|||.||.|||.| ||||...|| .              ||.||....
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM-------------GLQELWMWN

LTEILK--GGVLIQRNP--QLCYQDT-ILWKDIF
|..|.   ||| |..||  .||| .| |.|..|.
LKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like ErbB2.AA Furin-like 189-343 42 1.5e-77 254.88 Pfam 1-182 (182) Show / Hide 
Range on Protein: 189-343
Range on HMM: 1-182/182
Sequence Identity: 42% (77 aa)

SRACH--------PCSPMC-------KGSRCWGESSEDCQSLTRTVCAGGCA--RCKGPLPTDCCHEQCAAGCTGPK-HSDCLACLHFNHSGICELHCPA
.| |.        ||.| |        |.||||.....|| ||..||. .|   ||.|| |..||||||..|||||. ..||.|| ||.|.|.|  .|| 
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

LVTYNTDTFESMPNPEGRYTF-GASCV--TACP-------YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCY
...|| .||...|||.|.|.| |. ||    ||       .||. ...|.|...||  ..|.. |..|. ||.|..||  |||
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENE-ENNTMMCEPCEGPCPKVCY
FU ErbB2.AA FU 232-275 34 4.6e-09 37.35 SMART 1-48 (48) Show / Hide 
Range on Protein: 232-275
Range on HMM: 1-48/48
Sequence Identity: 34% (17 aa)

PTDC--CHEQCAAGCTGPKHSDCLACLHFNHS---GICELHCPALVTYN
 . |  ||..|| ||.||.  .|..| |...    |.|   ||   .| 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCP-PGYYP
Recep_L_domain ErbB2.AA Recep_L_domain 366-486 29 6.8e-30 102.22 Pfam 1-121 (121) Show / Hide 
Range on Protein: 366-486
Range on HMM: 1-121/121
Sequence Identity: 29% (38 aa)

GCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNG-AYSLTLQGLG---ISWLGLRSLREL
.| .|.|.| ...... ..         .| | .|....||||||.|  . ..| .||.|.||..|||| |...  |.|         .. |....|...
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNI

GS--GLALIHHNT--HLCFVHT-VPWDQLF
 .  |   ||.|    ||..|| . |....
TRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU ErbB2.AA FU 501-552 32 1.6e-09 38.91 SMART 1-48 (48) Show / Hide 
Range on Protein: 501-552
Range on HMM: 1-48/48
Sequence Identity: 32% (18 aa)

EDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQE---CVEECRVLQGLPR
...|     .||  ||  .||||||.||. |. .. ...   ||..|   .|  .
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like ErbB2.AA Furin-like 501-528 33 0.002171 11.73 Pfam 1-39 (182) Show / Hide 
Range on Protein: 501-528
Range on HMM: 1-39/182
Sequence Identity: 33% (13 aa)

EDECV----GEGLACHQLC------ARGH-CWGPGPTQC
. ||     |.   ||. |       .|. ||||.| .|
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHC
FU ErbB2.AA FU 557-606 39 1.7e-08 35.45 SMART 1-48 (48) Show / Hide 
Range on Protein: 557-606
Range on HMM: 1-48/48
Sequence Identity: 39% (21 aa)

ARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPF---CVARCPSGVKP
...| ||||||       .| || .|||..|.|... .    ||. ||.|  |
DGVCKPCHPECAT-----GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like ErbB2.AA Furin-like 576-601 44 6.68885 0.29 Pfam 73-99 (182) Show / Hide 
Range on Protein: 576-601
Range on HMM: 73-99/182
Sequence Identity: 44% (12 aa)

CFGPE-ADQCVACAHYKDPPFCVARCP
| ||  .  |||| |. .   ||..||
CTGPNNDTDCVACRHFYHNGTCVDQCP
Kinase ErbB2.AA EGFR 720-977 79 4.2e-202 677.1 In-house 1-258 (258) Show / Hide 
Range on Protein: 720-977
Range on HMM: 1-258/258
Sequence Identity: 79% (205 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGS
|.||||||||||||||||||||.|||||||||||||||.|.||||.|.||||||||.| .|...||||.|..|..|||||.||||||||.||......||
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

QDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFG
|.|||||.||||||.|||. |.||||||||||||||||||||||||||.||..||.||||.|||.||||||||.|..|..||||||||||||.|||||||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

AKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFS
.|||||||||||||||||||||||||||||||||.||||||||...||.|.||..||.
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ErbB2.AA Pkinase_Tyr 720-976 43 1.3e-133 453.13 Pfam 1-270 (270) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-270/270
Sequence Identity: 43% (117 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKA--NKEILDEAYVMAGV-GSPYVSRLLGICL--TST--VQLVTQLMPYGCLLDHVRE
... |.||.||||.||||.| .|..| |||||.|.|.|......   .. . || .|      | . ||.|.|.       . .|. .||.|.|||. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETE-YHADGGKVPIKWMALESILRRRFTHQSDVWSY
.   ...|  .|||..|.||||||.|||. ...||||||||.||...|.|||.||||||..  |..  . ..|||.||||||.|.|  ..||..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTVWELMTFGAKP-YDGIPAREIPDLL-EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
||. ||..|.|..| | |..  |. ... |.|.|.|.|. |. ..|..| .||. | | ||.|.|.....
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ErbB2.AA TyrKc 720-976 38 1e-128 434.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-280/280
Sequence Identity: 38% (112 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV--GSPYVSRLLGICLT--------STVQLVTQLMPYGCLLDH
... |.||.||||.||||.|.       |.||.|.|.|..     .....|| .|  .    | . ||.|.|..          . .|. .||.|.|.|.
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDID------ETEYHAD---GGK--VPIKWMALESILRRR
 |..|..|  .|||..| |||.||.||.. ...||||||||.||.....|||.||||.| .. |      .  |..    |||  .||.|||.|.|  ..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FTHQSDVWSYGVTVWELMTFGAKPYDG-----IPAREIPDLLEKGERLPQPPI--------CTIDVYMIMVKCWMIDSECRPRFRELVSEF
||..|||||.||. ||..|.|..|| |     ....|.  ....|.|.||||         |. ..|.|| .||. | |.||.|.|....|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ErbB2.AA TK 720-976 22 1.8e-110 371.69 In-house 1-486 (486) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-486/486
Sequence Identity: 22% (112 aa)

LRKVKVLGSGAFG---TVYKGIWIPD---------------------GENVKIPVAIKVLRENTSPKANKEIL-------------DEAYVMAGVG----
.. .|.||.|.||   .||||.|...                     .|..|.|||.|.|.| ..  .. ...              || .|.       
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-SPYVSRLLGICLTST-------------VQLVTQLMPYGC----LLDHVRENRGR--------------------------------------------
  | . ||.|.|. .              . .|. .||.|.    |.|. |..|..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGSQDLLNWCMQIAKGMSYLEDV------RLVHRDLAARNVLVKSPNH-----------VKITDFG---
                               |  ..|| .|.|||.||.||..       ..|||||||||.|| . |.           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLLDIDETEYHAD------------------------GGKVPIKWMALESIL---------RRRFTHQSDVWSYGVTVWELMTFGAKPYDG-I
     ||| .. |.  | ..                        |||.||.||| |...          ..||..|||||.||..||..|.|..|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA---------REIPDLLEKG--------------ERLPQPPICT--------------IDVYMIMVKCWMIDSECRPRFRELVSEF
.          .|. ..|..|               |.|||| |.               ..| .| .||  | | ||.|..|....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ErbB2.AA Ack 720-976 37 2.9e-86 291.0 In-house 1-266 (266) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-266/266
Sequence Identity: 37% (101 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLREN--TSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTV-QLVTQLMPYGCLLDHVRENRG-
..  . ||.| || | .| |     .  |.||.|.||    ..|..  . | |. .|     | . || |. |..   ..|| | | | |||  |.  . 
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

-RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSP-NHVKITDFGLARLLDIDETEYHADGGK---VPIKWMALESILRRRFTHQSDVWSYGV
  .    |...|||||.||.|||  |..||||||||.|. |. . ||| |||| | | . |  |   . .   ||. |.| |..  |.|.| ||||..||
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGV

TVWELMTFGAKPYDGIPAREIPDLLE-KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
| ||  ..| .|. | .. .|  ... .|||||.|. |  |.| .|..||  . . ||.| ...  .
TLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase ErbB2.AA Src 720-976 39 7.9e-83 281.24 In-house 1-255 (255) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-255/255
Sequence Identity: 39% (103 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHVR-ENRGR-
.. .. ||.| || |..|.|     | ...||.|.|.. |   ...  | || .|  .  . . .|. .| .   .  || .|  |.|||  . . .|| 
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEY-HADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
|  ..|.    |.|.||.|||  ...|||||||||||   | .|. |||||||.. |. ||    | |.||||.| | |...|||  |||||.|.  .|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM-IMVKCWMIDSECRPRFRELVSEF
.|.|  || |   .|  . .|.| |.|.|. |   .|. || .||  | | || |  | . .
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ErbB2.AA TK-Unique 720-976 32 2e-82 280.13 In-house 1-294 (294) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-294/294
Sequence Identity: 32% (96 aa)

LRKVKVLGSGAFGTVYKGIWIPDG--ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG-SPYVSRLLGICLTST--VQLVTQLMPYGCLLDHVRENR
|.  .|.|.||||.|..|   ..   .. .. ||.| |..| ..   .. |.|. .|  .|  |.. ..||.| .|.  ....   .|.|.|... |..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GR-------------------------LGSQDLLNWCMQIAKGMSYLED--VRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADG--GKVP
.                          . ..||.... |||.||.||.    . |||||.|||||. . . .||.|||.|| ..  ...|   .  |..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IKWMALESIL--RRRF-THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPIC-TIDVYMIMVKCWMIDSECRPRFRELVSEF
|.|||.||..  .. . | .|||||.||. ||..|.|| || |.|...| .....| |.|||. | . ..| .|  ||  . | || ||......
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ErbB2.AA Syk 720-970 37 6.8e-82 278.38 In-house 1-257 (257) Show / Hide 
Range on Protein: 720-970
Range on HMM: 1-257/257
Sequence Identity: 37% (96 aa)

LRKVKVLGSGAFGTVYKGIWIPD---GENVKIPVAIKVLRENTSPKA-NKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRG
| . . .|.| ||.| ||        || . |.||||.|..  . .|  .|.. || ||..   |.. |..|||.     .|  . . | ...   ..| 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

RLGSQDLLNWCM-QIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD-GGKVPIKWMALESILRRRFTHQSDVWSYGVTVW
    .  |     |.| || |||    |||||||||||       || |||. . |  |...| |  .|| |.|| | |.|  . | |.|||||.||| |
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

ELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFR
|    |.||| ..   |. ...|.|.|...|. |  ..| .| |||  . . || | 
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase ErbB2.AA UTK 720-976 31 2.3e-81 276.65 In-house 1-296 (296) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-296/296
Sequence Identity: 31% (92 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKI-PVAIKVLR-ENTSPKANK---EILDEAY---VMAGVG-SPYVSRLLGICLTST-VQLVTQLMPYGCLLDH
..  . ||.||||.|.|. . .. | ..   ||.||.. . .....     ... ||    .|. .   |.| ||.|.|. .    .|| .|. | |.. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VRENRGRLG-------SQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSP-------NHVKITDFG---LARLLD---------IDETEYHADGGK
.| .|  ..       . ..| ....|| ||.||.  ..|||||||||.|| .        . .|| |||   ..|..           .. ..... ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPIKWMALESILRR-RFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKG--ERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
.||.||| |..  . |||..|||||.||..||..|.|..|| |. ....   ...|   |.|.|. |  .||..|..||. | . ||.|..||...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ErbB2.AA FAK 720-981 36 1.9e-80 269.28 In-house 1-285 (285) Show / Hide 
Range on Protein: 720-981
Range on HMM: 1-285/285
Sequence Identity: 36% (103 aa)

LRKVKVLGSGAFGTVYKGIWIPDGE-----------------------NVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQL
    ...| | || ||.|...                             || ||||  ......    . . |||.|     | . .|.|||    . .
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

VTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD-GGKVPIKWMALESIL
.  |..|| |    . |. .|    |. .| |... |.|||  . |||| ||||||| ||. ||  |||| |... |.. |.|   || |||||. ||| 
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKASPKGKLPIKWMSPESIN

RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMAR
 ||||  |||| .|| .|| . .| ||. ..   ..   .|.||||| || |    | .| .||  |   ||||.||. . . .  
FRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase ErbB2.AA RTKB 720-976 37 1.8e-70 236.76 In-house 1-264 (264) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-264/264
Sequence Identity: 37% (99 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS-PYVSRLLGICLTSTVQLV-TQLMPYGCLLDHVRENRGR-
..  . ||.|||| |...     . | .  .| |||.   |  .  ....|  ||  .|  | |  ..| ||  . ...   |  .| | |  |. |.  
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQ

-----LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQS-DVWSYGV
     | .. |.  |.|||.||..|.    .||||.|||||| .  | || |||.|| .| .. |  ..  . |||||| ||. .|..| .| ||||.||
HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCT--RLPIKWMAPESWAHRIYTTKSGDVWSFGV

TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
| ||  ..|. ||   . ..| ..||.| |||.|      .. || .||... . || | |||..|
TMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase ErbB2.AA Abl 720-976 41 2.6e-70 233.66 In-house 1-252 (252) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-252/252
Sequence Identity: 41% (107 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGIC-LTSTVQLVTQLMPYGCLLDHVRE-NRGRL
.   . || | .| ||.|.|       .  ||.| |.|.|   . .| | || .|  .  | . .|||.|   .   ..|  |.|| |||..|| .|  |
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDT--MEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

GSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMT
 .  ||    ||| ||||||    .|||||||| ||   . ||. ||||||..  |    || | | |||| | ||.   .|  .|||| .|| .||. |
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHA-GAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT

FGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEF
.|  || ||   .. ..|||| |. .|. |  .|| .| .||  .   ||.|.|.  ..
YGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ErbB2.AA S_TKc 720-977 20 6.2e-43 149.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 720-977
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPY--GCLLDHVRENRGR-
 ......|.||||.|||....      .  ||||...        . |. |  ..   . |.. .|.... .. . .|. ...   | |.|. ...... 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH-QSDVWSYGVT
    .   .   .. ||.... |. . . .||||   |.|. .  |.||.||||||.|         .   .   .|| | .    ...  .|.|| |..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS--------EFS
..|... |  |..     ..  ...|          . ..  .. ||.  | | ||   |.          .. 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ErbB2.AA Pkinase 720-976 20 2.9e-39 139.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 720-976
Range on HMM: 1-293/293
Sequence Identity: 20% (62 aa)

LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILD----EAYVMAGVGSPYVSRLLGICL-TSTVQLVTQLMPYG----CLLDHV
.......|||.||.|||.... .|.     ||.|...   . | .|.. .    |...|. ...|.. ||....   . . .|. ... |     | |..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-ENRGRL--GSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHV----KITDFGLARLLDIDETEYHADGGKVPIKWMALESIL-RRRFTHQ
. ...|..    ... ... ||..|. |. . . .||||   |.|... .|.    ||.|||||...|       ...  . . .|| | |. ..  .. 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGVTVWELMTFGAKPYDGI----PAREIPDLLEKGER----LPQPPICT-------------------IDVYMIMVKCWMIDSECRPRFRELVSE
.|.||.|....|... |  |..|     . ..   ....  .     . |  |.                    .   .. .|.  | ..|| .....  
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
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PWF