Gene FER (Human)

FER

Species: Human
Alias: NCP94, TYK3, FER
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q21.3,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
FER.NA RNA Sugen Kinome 2950 None Fasta, JSON
FER.AA Protein Sugen Kinome 822 None Fasta, JSON
FER.kin_dom Protein Kinase Domain Sugen Kinome 254 None Fasta, JSON

Protein domain

Protein domains of FER.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FCH FER.AA FCH 1-92 35 4.9e-34 120.32 SMART 1-103 (103) Show / Hide 
Range on Protein: 1-92
Range on HMM: 1-103/103
Sequence Identity: 35% (37 aa)

MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQ-------VDKESTVQMNYVSNVS--KSWLLMIQQTEQLSRIMKTHA
|.|.. |  ...||..|..|.|.||..|...|||. |.|...|||..|. |..|       ... ....|. .. .|  |||  |.|||.|.....|.|.
MCFWWELWCDDGHEVLLQRQKWGLRWCEDMMKFMRERAKIEEEYAKMLHKLSKQYFNKKGSCGDWRAHRMTHPEMGSLNKSWEVMLQQTDQMAKHHKQHS

EDL
|||
EDL
FCH FER.AA FCH 1-92 27 6.5e-23 82.52 Pfam 1-97 (97) Show / Hide 
Range on Protein: 1-92
Range on HMM: 1-97/97
Sequence Identity: 27% (27 aa)

MGFGSDL-K--NSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNV--SKSWLLMIQQTEQLSRIMKTHAEDL
|.|.||. .  .......| ........| ...|.. |.....|||  ||.||....|    .  |....  .|.|  |.|.|||.... ...||.|
MSFWSDDYWQWDGFKVLFKRMKQGIQWCEDFAQFFKERAEIEEEYAKKLQKLCKKWFKKKKGSSEYHGTLSSKKAWHQMLQETEQMAQQHQQFAENL
SH2 FER.AA SH2 460-531 41 2.9e-40 120.02 Pfam 1-81 (81) Show / Hide 
Range on Protein: 460-531
Range on HMM: 1-81/81
Sequence Identity: 41% (34 aa)

WYHGAIPRIEAQELLKK----QGDFLVRESHGKPGEYVLSVYSDG---QRRHFIIQYVDNM--YRFEGTGFSNIPQLIDHH
|||| |.| ||..||..     |.||||||  .||.|.|||. ||   . .|..||  ||.  |..... |.....|..|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FER.AA SH2 458-537 38 2.7e-33 117.86 SMART 1-87 (87) Show / Hide 
Range on Protein: 458-537
Range on HMM: 1-87/87
Sequence Identity: 38% (34 aa)

QDWYHGAIPRIEAQELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVD-NMYRFEG---TGFSNIPQLIDHHYTTKQV
| |||| |.| ||..|||..    ||||||.|  .||.||||| ..|. .|..|.  | ..|....   . |... .|..|. .....
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Pkinase_Tyr FER.AA Pkinase_Tyr 563-814 50 6.00000000001e-154 522.0 Pfam 1-270 (270) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-270/270
Sequence Identity: 50% (137 aa)

VILGELLGKGNFGEVYKGTLK-----DKTSVAVKTCKEDLPQEL--KIKFLQEAKILKQY-DHPNIVKLIGVCT-QRQP--VYIIMELVSGGDFLTFLRR
...|. ||.|.||||||||.|     .|. ||||..||.  .|   . .|..||||.||. .|||||.|.|||| |..|  .||.||.. .|| |..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQE-DGGVY-SSSGLKQIPIKWTAPEALNYGRYSSESDVWSF
.   |. |..|.|...... |.|| |||||||||||||||||||.|||| ||.|||..|   . . |  ..|   .||||.|||..|||.....||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLWETFSLGVCP-YPGMTNQQAREQV-ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL
|.|.|| |..|  | ||||.|..  |.. |.|||| .|..||..| ..|..||.|.||.|| |||.. .|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc FER.AA TyrKc 563-814 45 5.2e-147 495.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-280/280
Sequence Identity: 45% (130 aa)

VILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQY--DHPNIVKLIGVCTQR-------QPVYIIMELVSGGDFLTFLRRKK
. ||. || |.||||||||.|  . ||||..|||     .  |..||.|....  .|||||.|.|||||        .|..|.||....|| . .||...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

DELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGG--------VYSSS---GLKQ-IPIKWTAPEALNYGRYSSES
..|..|.|..|....|.|| ||.|||||||||||||||||||.. ||||||.||  . .        .|...   | |  .||.|.|||..|||.....|
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSFGILLWETFSLGVCPYPG-----MTNQQAREQVERGYRMSAPQH--------CPEDISKIMMKCWDYKPENRPKFSELQKEL
||||||...|| |..|  ||||     |.||...|.|..||||  |..        ||... .|| .||...||.|| |||. ...
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FER.AA Fer 563-815 43 1.9e-145 489.52 In-house 1-283 (283) Show / Hide 
Range on Protein: 563-815
Range on HMM: 1-283/283
Sequence Identity: 43% (123 aa)

VILGELLGKGNFGEVYKG--TLKDKT---------SVAVKTCKEDLPQEL-KIKFLQEAKILKQ-YDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFL
|.||. ||.|.|||||||  ||| |           |.||.||......  ...|..||.|... |||||.||..|||...||..|.||...||.....|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RRKKDE-LKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGE-NNVLK--ISDFGMSRQEDGGVYSSS-G--LKQIPIKWTAPEALNYGRYSSESD
. .|.. ............||.|| ||.||||||||.||||||... ....|  |||||||||.....|... .  ....||.|.|||....| ||...|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGILLWETFSLGVCPYPG------MTNQ--QAREQVER-GYRMSAPQHCPEDISKIMM-KCWDYKPENRPKFSELQKELT
|||||...|| |. | .||||      |||.  |||..... ||.|  |.|.|..| .||| .||...||.||...|....| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase FER.AA TK 563-814 26 3.8e-126 425.18 In-house 1-486 (486) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-486/486
Sequence Identity: 26% (127 aa)

VILGELLGKGNFG---EVYKGTLKDK--------------------------TSVAVKTCKEDLPQELKI-------------KFLQEAKILKQYD----
..||. ||.|.||   |||||.....                          | ||||..||. ... .              .||.|| ..|. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVKLIGVCTQR------------QPVYIIMELVSGGD----FLTFLRRKKDE--------------------------------------------
 |||||.|.|||||             .|..|.||....||     ...||.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKLKQLVKFSLDAAAGMLYLESK------NCIHRDLAARNCLVGENNV-----------LKISDFGMS-
                               | ..||. .....|.|| ||.||      |..||||||||||||||||            ||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RQED-GGVYSSSG------------------------LKQIPIKWTAPEALN---------YGRYSSESDVWSFGILLWETFSLG-VCPYPGM
       |  . .. | ...                          ..||.|.|||.||         ||.....|||||||.|.|| |..| . .|.||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------QQAREQVERG--------------YRMSAPQHCP--------------EDISKIMMKCWDYKPENRPKFSELQKEL
.|         |.  |...||              .|| .|.|||              |..  .|..||.|.|| || ||.|...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FER.AA Src 563-814 49 1.5e-116 393.46 In-house 1-255 (255) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-255/255
Sequence Identity: 49% (126 aa)

VILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLR--RKKDELKLKQ
. | . ||.|.||||..|. ...| ||||| |..        |||||.|.|. .|...|.|  ||.|  |.||. |. | |  |..|.  ..  .|.|.|
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ

LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGG--VYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGV
|. ..   |.|| ||||.| ||||||||| ||||||| |. |||  |  . .  .|...    .|||||||||.||||..  ||||||||||.| .. | 
LIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR

CPYPGMTNQQAREQVERGYRMSAPQHCPEDISK-IMMKCWDYKPENRPKFSELQKEL
.|||||||... .||||||||  |..||. . . ||..||. .|| || |  ||. |
VPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FER.AA UTK 563-814 38 1.7e-113 383.36 In-house 1-296 (296) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-296/296
Sequence Identity: 38% (113 aa)

VILGELLGKGNFGEVYKGTLKD------KTSVAVKTCKEDLP-QELKI---KFLQEAK---ILKQYD-HPNIVKLIGVCTQRQPVYIIMELVSGGDFLTF
|.||..||.|.||||.|.....      .  ||||.|... . |  .    .|. ||.   ..|| . |||...|.||||| .| .|..|. ..|| ...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRRKKDELK-------LKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGEN-------NVLKISDFG---MSRQED----------GGVYSSSGLKQ
||| ....        | |......| |.|| ||.|....|||||||||||...       .| ||.|||   |||.               | ... ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIKWTAPEALNYG-RYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERG--YRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL
.||.|.|||||... |... |||||||...||... |  |||||.|.|. .||..|  ||| .|..||... ..|..|| | |..|| | .| ...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FER.AA SFK-Src 563-811 47 3.7e-113 336.82 In-house 1-252 (259) Show / Hide 
Range on Protein: 563-811
Range on HMM: 1-252/259
Sequence Identity: 47% (121 aa)

VILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQL
. | . || | ||.|.||.  ..| ||||| |     .    ||||| ..|.  ||| ..|  |||   |.||| ||.  |  | .|.  .   |.. ||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSA--EEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQL

VKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQ-EDGGV-YSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVC
|    . |.|| ||| .| .|||||||| |||.||| |. ||||||  ..    |    .   ||||||||| |. |.|  |||||||||. |   .|  
VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYPGMTNQQAREQVER--GYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQ
|||||||.    ||.|  |||| .|. ||.   |||. ||  .|..|| |  |.
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLK
Kinase FER.AA TK-Unique 563-814 38 2.7e-105 356.11 In-house 1-294 (294) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-294/294
Sequence Identity: 38% (112 aa)

VILGELLGKGNFGEVYKGTLK------DKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYD-HPNIVKLIGVCTQRQ-PVYIIMELVSGGDFLTFLRRKK
. .|...|.|.||.|..|...      ||. .||||..|... .. | .||.|....|. . |||||...|.||  . |..|||| ...|. ...||...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DE-------------------------LKLKQLVKFSLDAAAGMLYLES--KNCIHRDLAARNCLVGENNVLKISDFGMSR-QEDGGVYSSSGL-KQIPI
..                         ...|.|. |  . | || ||.|  |...||||.|||.|..|..|.||.||||.|  ...||||...  . |||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWTAPEALN--YGRY-SSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHC-PEDISKIMMKCWDYKPENRPKFSELQKEL
.| |||.|   .| | ...|||||||.|.|| |.|| |||||| . . .|....||||  |.|| .... ..|  || ..|| || |... ..|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FER.AA Csk 563-814 45 1.1e-97 330.89 In-house 1-251 (251) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-251/251
Sequence Identity: 45% (116 aa)

VILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQ-PVYIIMELVSGGDFLTFLR-RKKDELKLKQ
. |||  |.|.|| |  |... .  ||||  |.|    .  .|| ||..  |  ||| |.||||  . .  .||.|| .| |  . .|| | .  .. .|
LHLGECIGHGEFGDVMQGEYQNRK-VAVKCIKCDGNGMAQ-AFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQ

LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVY-SSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVC
| ||..| ..|| |||.|. .|||||||| || | .| |.|||| ...|  .   |.||   .||||||||||  ...|. |||||||||||| .| |  
LLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTSG--KFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRV

PYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL
||| .  .   ..||.|||| ||  ||. . |.| .||.  | .|| | .... |
PYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase FER.AA SRM 564-815 47 5.8e-96 321.5 In-house 2-253 (253) Show / Hide 
Range on Protein: 564-815
Range on HMM: 2-253/253
Sequence Identity: 47% (121 aa)

ILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE-LKIKFLQ-EAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE-LKLKQ
 |.  ||.| ||||. |  |..  ||.|  | |   . .. . || | . .|.  |  |..|  ||.   ||||| ||   |  . .||   .  |.. .
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRD---NLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPH

LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCP
|. |    | || |||..| ||||||||| |||.||. |. |||. |     .|| |   .||.|||||||.||. ||  ||||||||||.| |. | ||
LLDFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCP

YPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELT
||||||  .  |..|||||  |  || .. | |..||   || || |  |   ||
YPGMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase FER.AA Tec 563-816 43 1.7e-95 323.53 In-house 2-254 (254) Show / Hide 
Range on Protein: 563-816
Range on HMM: 2-254/254
Sequence Identity: 43% (113 aa)

VILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ--
 .. || |.| || |  | .. .  ||.|. ||    |    |..|||. .   ||. |.| |||.|..|.||. | .. |  | .||..| ... ..  
TFMKEL-GSGQFGVVHLGKWRHQYDVAIKMIKEGSMSE--EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAI

LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQE-DGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVC
| .  .|   || |||... |||||||||||||...| |.|||||.|   |    ||.| |  |.|| .|| ..| |||| ||||.||.| || ||.|  
LLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTK-FPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKM

PYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTI
||. |.| .  |.| .|.|.  |..|.. | .|| .||  ||| || |..| ...| 
PYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase FER.AA Eph 563-814 42 5.5e-95 319.52 In-house 1-264 (264) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-264/264
Sequence Identity: 42% (112 aa)

VILGELLGKGNFGEVYKGTLKDK-----T---SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKD
. . . .| | ||||..|.|| .     .    ||.|| |.  .   .. || || |. |.|||||..| || |...|| |. |    |   .|||.. .
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

ELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQ-EDGG----VYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGIL
...  |||      |.|| || . | .|||||||| || .| | |.||||.||. || .    .| ..| | |||.||||||. |....| |||||.||.
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGK-IPIRWTAPEAIAYRKFTSASDVWSYGIV

LWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL
.||  | |  ||  |.||   . .| |||  .|  ||| . ..|..|| . ...||.|....  |
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase FER.AA S_TKc 563-822 26 4e-56 193.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 563-822
Range on HMM: 1-231/231
Sequence Identity: 26% (72 aa)

VILGELLGKGNFGEVYKGTLKD-KTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSG--GDFLTFLRRKKDE----
  .....||| ||.|||.. |. .  ||.|  |        .....| .|||. .|||||||..|.   . .|..||...|  || ........ .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSS-ESDVWSFGILLWET
 .   .  ..    . .. |. |.. |||||   | |. |  ..||.|||..||                 . ||| |    |.  ..|.||.|..|.| 
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQK-ELTIIKRKLT
.. |  |.|  . |.  ...            ...   ...||... ||.||   |. . |. | .    
LC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FER.AA Pkinase 563-814 23 7e-45 159.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 563-814
Range on HMM: 1-293/293
Sequence Identity: 23% (69 aa)

VILGELLGKGNFGEVYKGTLKDKTS-VAVKTCKEDLPQE--LKIKFL-QEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGG----DFLTFLR-RKK
  .|. .|.|.||.|||.. |.    ||||. | .   .  ...... .|..|.|  .|||||.|..... .. .|..||.. ||    |  .... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DEL--KLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVL----KISDFGMSRQEDGGVYSSSGLKQIP---IKWTAPEALN-YGRYSSESDV
  .    ... .. .  . |. |. |...|||||   |.|. .|...    ||.||| ..| |   | ...  . .   . . ||| .. .  |....|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGILLWETFSLGVCPYPGM----TNQQAREQVERGYRMSAPQHCP-----------------------EDISKIMMKCWDYKPENRPKFSELQKE--L
||.|..|.| .. |  |.||     .    .. ..|  .   . ..|                       |.  ... .|....|. || . .. .   .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF