Gene FGFR3 (Human)

FGFR3

Species: Human
Alias: CEK2, ACH, JTK4, CD333, FGFR3, HSFGFR3EX
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 4p16.3,

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
FGFR3.NA RNA Sugen Kinome 4310 None Fasta, JSON
FGFR3.AA Protein Sugen Kinome 808 None Fasta, JSON
FGFR3.kin_dom Protein Kinase Domain Sugen Kinome 277 None Fasta, JSON

Protein domain

Protein domains of FGFR3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FGFR3.AA IG 46-126 16 5.7e-07 30.41 SMART 1-58 (58) Show / Hide 
Range on Protein: 46-126
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

QEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS---GAYSCRQRLTQRVLC--HFSVRVT
.. ..   |. |.|.|  .       ..| .                 |.. |.. |||   | | |. .    . .   . ..|.
PP-VTVKEGETVTLTC-VS-------QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IGc2 FGFR3.AA IGc2 52-116 30 5.1e-05 22.99 SMART 1-56 (56) Show / Hide 
Range on Protein: 52-116
Range on HMM: 1-56/56
Sequence Identity: 30% (20 aa)

GSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQR
 .|..|.| ||   | |     |.| |. |        . ..|.. |.. |||| |.|. |    
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR3.AA I-set 73-110 31 2.346575 3.72 Pfam 33-76 (92) Show / Hide 
Range on Protein: 73-110
Range on HMM: 33-76/92
Sequence Identity: 31% (14 aa)

VWVKDGTGLVP-SERVLVGPQR-----LQVLNASHEDSGAYSCR
.| |||  | | |.|. .         | ..|.  .|.| |.|.
SWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCV
IGc2 FGFR3.AA IGc2 167-235 33 4.6e-17 63.94 SMART 1-56 (56) Show / Hide 
Range on Protein: 167-235
Range on HMM: 1-56/56
Sequence Identity: 33% (23 aa)

PAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG
   ..|...|||.|||.|.|.|.| | .                |.|  ..| |.|.|.|||...|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR3.AA I-set 171-245 36 6.3e-16 56.56 Pfam 17-92 (92) Show / Hide 
Range on Protein: 171-245
Range on HMM: 17-92/92
Sequence Identity: 36% (28 aa)

TVRFRCPAAGNPTPSISWLKNGREFRG-EHRIGGIKLRH-QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDV
|.|| | . |.|.|..||.|.|.. |  ..|.  .. .. .  .| .. | |.| | ||||..|.||.   | .| |
TARFECQVTGDPPPQVSWFKDGQPLRPDSDRH-QMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG FGFR3.AA IG 161-246 18 2.9e-12 48.01 SMART 1-58 (58) Show / Hide 
Range on Protein: 161-246
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR---GNYTCVVENKFGSIRQ--TYTLDVL
 . . | .  ||...| ..     .|.|.                       |.. .| |.|    |.|.|...   |.. .  . || |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FGFR3.AA V-set 140-245 16 0.010001 11.23 Pfam 1-128 (128) Show / Hide 
Range on Protein: 140-245
Range on HMM: 1-128/128
Sequence Identity: 16% (23 aa)

EAEDTG-VDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP----TP-SISWLK-NGR----------------EFRGEHRIGGIKLRHQ-------
  . |.  ..|.  |         .. |.   .|...|    ..    .. .|.| .                    .|.. .  .  | | .       
QSQVTQHPPRGC-PW---------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSK

-QWSLVMESVVPSDRGNYTCVVENK-FGSIRQTYTLDV
  .|| . .. ||| | |.|.| |  ...  . ..| |
NDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG FGFR3.AA IG 260-356 19 3.3e-15 57.78 SMART 1-58 (58) Show / Hide 
Range on Protein: 260-356
Range on HMM: 1-58/58
Sequence Identity: 19% (20 aa)

PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDG---GEYLCRATNFIGVAEK--AFWLS
|  .|...|..|...| |      .|.|.                                  |.. ||.. |    |.| |.||   |....   ..|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLT

VH
|.
VQ
IGc2 FGFR3.AA IGc2 266-345 22 4.6e-07 30.7 SMART 1-56 (56) Show / Hide 
Range on Protein: 266-345
Range on HMM: 1-56/56
Sequence Identity: 22% (18 aa)

VLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIG
  | .|.. |..  .  | |.|.|     |...                     . .|.. ||.. | |.| |.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK-----GQPLP-------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FGFR3.AA I-set 322-355 44 6e-06 22.69 Pfam 59-92 (92) Show / Hide 
Range on Protein: 322-355
Range on HMM: 59-92/92
Sequence Identity: 44% (15 aa)

RLRLANVSERDGGEYLCRATNFIGVAEKAFWLSV
.|.  ||  .| |.| |.|||  | ||. . | |
TLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set FGFR3.AA V-set 253-355 15 9e-05 18.29 Pfam 1-128 (128) Show / Hide 
Range on Protein: 253-355
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

PI-LQAGLPA----NQTAVLGSDVEFHCKVYSDA----QP-HIQWLK-HVEVNGSKVGP---------DGTPYVTVLKS----WISESVEADVRLRLANV
.. ...  |.      |...| .|...|.. .|     .. .|.| . .   ....            .|..|..  ..    . .     |. |.. |.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

SERDGGEYLCRATNF-IGVAEKAFWLSV
.. | | | | ..|. ... ..  .| |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set FGFR3.AA I-set 260-289 30 0.091596 8.5 Pfam 7-36 (92) Show / Hide 
Range on Protein: 260-289
Range on HMM: 7-36/92
Sequence Identity: 30% (9 aa)

PANQTAVLGSDVEFHCKVYSDAQPHIQWLK
| ....  |....| |.|  | .| ..|.|
PKDVEVQEGETARFECQVTGDPPPQVSWFK
Kinase FGFR3.AA FGFR 474-750 75 2.9e-241 807.78 In-house 1-293 (293) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-293/293
Sequence Identity: 75% (220 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
|||||.|||||||||.||||.|||.||..| .||||||||...|||||||||||||||||||||||||||||.|||.|||||.|||...||||.||||||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PPGLDYSFDTC-------KPPEEQ--------LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL
||| ||..|..       ..||.|        ||.|||||||||||||||||||.|||||||||||||||.|.||||.|||||||.|..|||.|||||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL
|.|||||||||||||||||||||.|||||||.|.||.|||.|| ||||.|.|||||||.||.||....|..|..|||..|.||||||||||.|
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FGFR3.AA Pkinase_Tyr 474-750 47 8e-161 545.3 Pfam 1-270 (270) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-270/270
Sequence Identity: 47% (135 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD--LSDLVSEMEMMKMIGKHKNIINLLGACT-QGGP--LYVLVEYAAKGNLREF
.|.|| ||||.||.|..... |   |   . ..|||||||..|....  . |. .|...|| .|.|.||..|.|.|| ||.|  .|. .||...|.|...
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY-KKTTNGRLPVKWMAPEA
||..|            .....|| |||.. ..|.|.|||||.|..||||||||||.||||.||.||.|||||||..| ||| .|...|.||.||||||.
LRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LFDRVYTHQSDVWSFGVLLWEIFTLGGSP-YPGIPVEELFKLL-KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL
......|..|||||||||.|||||.|..| |||.. ||..... ..|.||..| ||. ..|..|..|||. |..||||....|.|
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FGFR3.AA TyrKc 474-750 41 1.4e-156 527.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-280/280
Sequence Identity: 41% (127 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG-KHKNIINLLGACTQG-------GPLYVLVEYAAKGNL
.|||| ||||.||.|. ....          ..|||||||.||    . |. .|...|...| .|.||..|.|.|||.       .||....||...|.|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNL-------DYYKKTT--NG
...||..||                |. |||.| ..|.|.|||||.|..||||||||||.||.|....||.||||.||...        |||.|..  .|
KDYLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R--LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPG-----IPVEELFKLLKEGHRMDKPAN--------CTHDLYMIMRECWHAAPSQRP
.  ||..|||||.......|..||||||||..|||||.|..||||     .. .|.....|.|.||..|.|        |. ..|.||..|||. |..||
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TFKQLVEDL
||....|..
TFSEIHECF
Kinase FGFR3.AA TK 474-750 28 2.5e-138 465.83 In-house 1-486 (486) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-486/486
Sequence Identity: 28% (140 aa)

LTLGKPLGEGCFG---QVVMAEAIGIDKDRA------------------AKPVTVAVKMLK--DDATDKDLSD--------------LVSEMEMMKM-IG
.|||| |||| ||   .| ..|..|......                   ....|||||||  |......  |              ...||.||.. .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHKNIINLLGACTQG------------GPLYVLVEYAAKGN----LREFLRARRPPGLD-----------------------------YSFDTCKPPEE-
.|.||..|.|.||||            .|.....||...|.    ||..||..||.. .                             .| . | |.|. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-----------QLTFKDLVS-------------------CAYQVARGMEYLASQKC------IHRDLAARNVLVTEDNV-----------MKIADFG---
           .||.|||..                   ...|.|.|||||.|..|      .||||||||.||.|.||            ||||||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDVHNLDYYKKTT------------------------NGRLPVKWMAPEALFDRV---------YTHQSDVWSFGVLLWEIFTLG-GSPYPGI
     ||||... |.| ...                        .|.||..|||||.|.|||         .|..|||||||||.|||||.| . .|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PV---------EELFKLLKEG--------------HRMDKPANCT--------------HDLYMIMRECWHAAPSQRPTFKQLVEDL
.          .|....|..|              .|| .|..|.               ..| .|..|||. |..||||.||.| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FGFR3.AA Ret 474-752 47 5.2e-127 428.25 In-house 1-293 (293) Show / Hide 
Range on Protein: 474-752
Range on HMM: 1-293/293
Sequence Identity: 47% (140 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDD-ATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGG--PLYVLVEYAAKGNLREFLR
| |.. |||| ||||| | |. | . ..    |||||||| . |.   . || ||... | .  | ..| |.|||.| .  |. . |||.  | ||||||
LQLDDTLGEGHFGQVVKAQAFHI-RGHPGY-TTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR

ARRPPGLDY--------SFDTCKPP-EEQLT-----FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNG
  |  |. |        .     |  .. ..     .|...| | |. .|| ||.. | .||||||||||| |  ..|| |||| |||   | | |   .
LSRKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKD

RLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR
|.||||||.|.|.| ||| .|||||||||.||| |.|..|||||| | |. ||| |.||| | ||   .| ||| ||   |  || || .  |. .
RIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FGFR3.AA TK-Unique 474-750 46 1e-123 417.3 In-house 1-294 (294) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-294/294
Sequence Identity: 46% (137 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGG-PLYVLVEYAAKGNLREFLRAR
|..|. .||| ||||  .|. ||.     |.. ||||||||.||| | .|. .| .||| .|.|.||...||.||  . | . . ||...|||. .|| .
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

RPP--GL--------DYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS--QKCIHRDLAARNVLVTEDNVMKIADFGLARDVHN-LDYYKKTTNGRLP
||.  .         |   .. ||..| .. |||.. |.|.|.|||||||  .|..||||.|||||.|||.| ||.|||.||||..  .| .... ||.|
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VKWMAPEALF--DRVY-THQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANC-THDLYMIMRECWHAAPSQRPTFKQLVEDL
..|||||.|   ...| | .|||||||||.|||||||. ||||.| ... .....|.||..|..| .|..| .|..||.  |..||.| |..  |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FGFR3.AA Tie 482-750 48 2.8e-106 324.54 In-house 1-267 (267) Show / Hide 
Range on Protein: 482-750
Range on HMM: 1-267/267
Sequence Identity: 48% (132 aa)

EGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSF
|| ||||. |    | ||     . ||.||.|. | ..|  | . |.|.|  .|.| |||||.||| . | ||| .|||  ||| .|||  |    | .|
EGNFGQVMKAM---IKKDGLK--MEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAF

DTCKPP------EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH
   .           |. . ..  |  |||||.||. ..||||||||||.|| |  | |||||||.|     . | |.| |||||.||| |.|   ||| 
AREHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGD---EVYVKKTMGRLPVRWMAIESLNYSVYTT

QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL
.|||||.||||||| .||| || |.   ||.. | .|.||..| ||  ..| .||.||   | .||.| |.. .|
KSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FGFR3.AA UTK 474-750 35 3.4e-106 359.09 In-house 1-296 (296) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-296/296
Sequence Identity: 35% (110 aa)

LTLGKPLGEGCFGQVVMAEAIGID--KDRAAKPVTVAVKMLKDDATDKDLS--DLVSEME---MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLR
. ||..||.| ||.| .|..  ..     ... |.|..   ..||...  .  |.  |     |||.   | |...|.| |||..|.....||...|.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

EFLR-ARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTED-------NVMKIADFG---LARDVH---------N
 .|| .|. |.         .....||  .....|...||||.||.|....||||||||.||...       .| ||||||   ..|.|.         .
SYLRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWE

LDYYKKTTNGRLPVKWMAPEALFDR-VYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG--HRMDKPANCTHDLYMIMRECWHAAPSQRPTF
 .||... ..|.|..||||||| ..  .|..||||||||..|||.| |  ||||.  ..... . .|  .|| .|. | |..|..|..|||. |. ||.|
SYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDF

KQLVEDL
..||. .
EDLVQQM
Kinase FGFR3.AA VEGFR 591-750 59 2.1e-102 346.48 In-house 170-332 (332) Show / Hide 
Range on Protein: 591-750
Range on HMM: 170-332/332
Sequence Identity: 59% (97 aa)

LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD-VHNLDYYKKTTN-GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWE
|| .||.. ..|||||||.|||.|||||||||||.|..|.|| || ||||||.     . |.. .. |||| ||||||..||.||| .|||||.||.|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL
||.||||||||.   ||... ||.| || .|  ||  .| || .|||  | .||.|  ||| |
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FGFR3.AA Src 474-750 40 2.2e-99 336.5 In-house 1-255 (255) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-255/255
Sequence Identity: 40% (112 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
..| . ||.|.|| | |.   |         . |||| || .    .  ..  | . ||   .|.....|.  |.|. | |   || ..|.| ..|..  
IKLCRKLGQGQFGEVWMGYWNGN--------TKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHN--LDYYKKTTNGRLPVKWMAPEALFDR
           .. . .| ...|.. | |||.||.|| |.. |||||||||||| |.|| |.||||||| .     | |   .  ..|.||.||||.  .
-----------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYG

VYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYM-IMRECWHAAPSQRPTFKQLVEDL
..|  |||||||.||.||.| |  ||||   .| .. .. | || .|.||   ||. ||..|||. | |||||. | . |
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FGFR3.AA PDGFR 588-750 58 8.2e-97 311.36 In-house 195-358 (358) Show / Hide 
Range on Protein: 588-750
Range on HMM: 195-358/358
Sequence Identity: 58% (96 aa)

EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLW
.. ||..||.. .||||.|||.|||  |.||||||||||...  | || |||||||. |   |    | |||||||||| .|| ||| ||||||.|.|||
SNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLW

EIFTLGGSPYPGIPVEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL
|||.|||.||||.||.. | |. ||| ||..|.  . . | ||..|| . | .||||.||.. |
EIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FGFR3.AA InsR 474-752 36 2e-95 320.96 In-house 1-278 (278) Show / Hide 
Range on Protein: 474-752
Range on HMM: 1-278/278
Sequence Identity: 36% (105 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
..|....|.| || |    | || .| .     .|.| ....|....  .  .| . || . .......||| |..| | ||  |  ..|.|. .||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PPGLDYSFDTCKPPEE----QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALF
|   .       |. .    . .  .... | ... || |||. | .|||||.|| .| .|   ||.|||..||.   |||.| . | ||| ||||| | 
PEEEF-----NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLK

DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL-KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR
| |.| .||||||||.|||. |||  || |   |.  |   ..|  ...| ||   .. .|. ||.  |. ||||..... |  
DGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FGFR3.AA S_TKc 474-754 23 9.2e-54 185.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 474-754
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK--GNLREFLRA
 ......|.| ||.|  .  ..           ||.|..|         .. .|....|.  .|.||..|....   . ||.  ||.    |.|..... 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

RRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDR
|...||.           ...  .  . .||.....||. |.. |||||   |.|..|  . ||.|||||| .         |       .|||| |   
RGRHGLR----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

VYTH-QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE-----DLDRVL
 |..  .|.||.|..|.| .. |  |.|   ....||...           ....  ..| |..  |..|||  .. .      ..  .
GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FGFR3.AA Pkinase 474-750 21 1.5e-46 165.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 474-750
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLV---SEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG----NLR
...|...|.| ||.|  .  .|  |       .|||| .| . ....        || ..||.. .|.||. |..... .. .|.  ||. .|     | 
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

EFLRARRPPGLDYSFDTCKPPEEQL--TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM----KIADFGLARDVHNLDYYKKTTNGRLPV
.....                .  .  . ... ...||..||.||. |...|||||   |.|. ....     ||.|||||. .  .  .  .|      
DYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP

KWMAPEALF-DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI----PVEELFKLLKEGHRMDKPANCT-----------------------HDLYMIMREC
 .|||| .  .. |.. .|.||.|..|.| .. |  |.||     .  .  .....  . . . ..                         ..  ... |
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WHAAPSQRPTFKQLVED--L
..  |..|||..|....  .
LCKDPKKRPTAEQILQHPWF
Kinase FGFR3.AA VEGFR 474-573 51 1.4e-42 147.73 In-house 1-101 (332) Show / Hide 
Range on Protein: 474-573
Range on HMM: 1-101/332
Sequence Identity: 51% (53 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT---QGGPLYVLVEYAAKGNLREFLR
| |||.||.| ||||. |.|.||.| .  .  ||||||||  ||      |.||..|.. ||.| |  |.||.||   |.||| | |||  .|||  .||
LKLGKMLGRGAFGQVHEASAFGIRKMETCT--TVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLR

ARR
. |
TKR
Kinase FGFR3.AA PDGFR 474-573 48 1.6e-35 111.28 In-house 1-98 (358) Show / Hide 
Range on Protein: 474-573
Range on HMM: 1-98/358
Sequence Identity: 48% (48 aa)

LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR
| .|| || | ||.|| | | |. |  |.   .|||||||  |       | ||  .|   |.| ||.||||||| ||| |.  ||   | | ..|. .|
LQFGKTLGSGAFGKVVEATAYGLSKSQAV--MKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR