Gene FMS (Human)

FMS

Species: Human
Alias: FIM2, CD115, CSF1R, FMS, CSFR, C-FMS, CSF-1R
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 5q33.1-q35 ,

Classification

Group: TK
Family: PDGFR

Sequence

Name Sequence Type Origin Length Description Download
FMS.NA RNA Sugen Kinome 4006 None Fasta, JSON
FMS.AA Protein Sugen Kinome 972 None Fasta, JSON
FMS.kin_dom Protein Kinase Domain Sugen Kinome 329 None Fasta, JSON

Protein domain

Protein domains of FMS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FMS.AA IG 27-102 22 2.4e-08 34.96 SMART 1-58 (58) Show / Hide 
Range on Protein: 27-102
Range on HMM: 1-58/58
Sequence Identity: 22% (18 aa)

VPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNT---GTYRCTEPGDPLGGSA--AIHLYVK
 | ..||.| ||||.|  . .. |                  |   |......   |||.|.       ...   ..|.|.
PP-VTVKEGETVTLTC-VS-QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG FMS.AA IG 112-196 16 0.000649 20.25 SMART 1-58 (58) Show / Hide 
Range on Protein: 112-196
Range on HMM: 1-58/58
Sequence Identity: 16% (15 aa)

AQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQS---QDYQCSALMGGRKVMS-ISIRLKVQ
 . |.| | ... |.|  .       ...                     .|| ....  |    .|.| |   . .. |  ...|.||
PP-VTVKEGETVTLTC-VS------QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 FMS.AA IGc2 215-285 16 4.8e-08 33.96 SMART 1-56 (56) Show / Hide 
Range on Protein: 215-285
Range on HMM: 1-56/56
Sequence Identity: 16% (12 aa)

IRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQG
. |..... |   . . . ..   . ...|.             .  ||..  | . ..|.|.|.|.|  |
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FMS.AA IG 209-296 13 3.1e-07 31.3 SMART 1-58 (58) Show / Hide 
Range on Protein: 209-296
Range on HMM: 1-58/58
Sequence Identity: 13% (13 aa)

PAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHA---GNYSCVASNVQGKHST--SMFFRVV
|  ..  .|| ... | .|       ...                         |.. .| ....   |.| |.|.   |...   .   .| 
PP-VTVKEGETVTLTC-VS------QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG FMS.AA IG 308-399 14 0.004016 17.62 SMART 1-58 (58) Show / Hide 
Range on Protein: 308-399
Range on HMM: 1-58/58
Sequence Identity: 14% (14 aa)

NLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEA---GRYSFLARNPGGWRA-LTFELTLR
   ..| .|| ..|.  |.       . |.                            | . ...|. .   | |   |.  |   .  ...|| .
PP-VTVKEGETVTLTC-VS------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IGc2 FMS.AA IGc2 410-492 20 0.000355 14.92 SMART 1-56 (56) Show / Hide 
Range on Protein: 410-492
Range on HMM: 1-56/56
Sequence Identity: 20% (17 aa)

FINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQ--TYECRAHNSVG
 . .| || | |.|.| ||..|.  . . .                              . ||..  . ..  .|.|.| |..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FMS.AA IG 404-504 11 0.062254 7.73 SMART 1-58 (58) Show / Hide 
Range on Protein: 404-504
Range on HMM: 1-58/58
Sequence Identity: 11% (12 aa)

VSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN-----QTYECRAHNSVGSGSW-A
 . ..    .. || | .|     ...|.                                       ||.  .. .      || |.|.   |...   
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQ

FIPISAG
.. ..  
GTTLTVQ
Kinase FMS.AA PDGFR 582-910 64 9.80000000001e-272 882.49 In-house 1-358 (358) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-358/358
Sequence Identity: 64% (232 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEA
||||||||.|||||||||||.||.|..||.||||||||.|||..||||||||||||||||||.||||||||||||||...||||||||||||.|.||...
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

MLGP--------SLSPGQDPEGGVDYKNIHLEKK--------YVRRDSGFS----SQGVDTYVEMRPV---STSSN--DSFSEQDLD----KEDGRPLEL
....        ..|..|||.. ..|||.|..|.        ....||...    ..|||.||.|...   |..||  ||..|||..    ..| ..|..
FHQHHPEKPKKETWSNQQDPHNFSFYKNVHHHKENDGDYMDMSSCEDSQYVPMLMHKGVDKYVDMQRNNYMSPHSNYEDSYIEQDVKNELMEDDSNVLTY

RDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLG
.|||.||.|||.||.|||||||.|||.|||||||..|.|.||.||||||||||||||.|||||||||||||||||||||||.||||||||||||||||||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

LNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL
.|||||..|.|||||..|.||.||||..||..||.|||.||...|..||||||.|.||
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FMS.AA Pkinase_Tyr 582-910 39 1.7e-158 537.41 Pfam 1-270 (270) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-270/270
Sequence Identity: 39% (133 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE--KEALMSELKIMSHLGQHENIVNLLGACT-HGGP--VLVITEYCCYGDLLNFLR
..|||.||.||||.|...|..|  ...  ..||||||| .|. ..  .|..|.|.|||..||.|.|||.|.|.|| .|.|  .....||...||||..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIH
..                                                                  ||..|| . |||... |.|.||..|.||||||
KHR-----------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH

RDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY-IVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP-YPGILVNSKFYKLV-KDGY
||.||||.|.|...|.||.||||||||.||..|  ..|...||.||||||.|.....|..|||||.|.|.||||..|  | |||.  |. .|... .|||
RDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGY

QMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL
.|..|  .|. ||..|. ||. .| .||||..| ..|
RMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FMS.AA VEGFR 582-910 48 7.79999999999e-153 514.03 In-house 1-332 (332) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-332/332
Sequence Identity: 48% (164 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH---GGPVLVITEYCCYGDLLNFLRRK
|. || ||.||||.|.||.|||. |.     |||||||..| |.|. |||||||.. |.|.| | ||.||.||    .||..|| ||||.| |.|.|| |
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

AEA-MLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHR
... .. |..|| . .        .|  .|  ||||| |.|.. .    ..   |  |   ... .     || . ||. .| ||| || ||||..||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHK-RRRDSGNSFQSSFG--SFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHR

DVAARNVLLTNGHVAKIGDFGLARD-IMNDSNYIVKGN-ARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM
| ||||.||.   | || ||||||. |  | .|  ||. .||| |||||||||| ||| .|||||||..||||||||  ||||. .. .|..  |||| |
DLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRM

AQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL
  | ...  || ||. ||  ||  ||.|      |
RAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FMS.AA TyrKc 582-910 33 3.7e-140 472.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-280/280
Sequence Identity: 33% (121 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG-QHENIVNLLGACTHG-------GPVLVITEYCCYGDLLN
...||.|| ||||.|...|.         ..|||||||. |    .|..|.|..||..|| .|.|||.|.|.||..       .|.....||...|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKN
.||.. .                                                                     | ..|||.|. |.|.||..|.|||
YLRKHRPK--------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKN

CIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-------SNYIVKG--NAR--LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI---
||||| ||||.|....|..||.||||.||| .|       . | .|.  ...  ||..|||||.|.....| .|||||.|...||||..|  ||||.   
CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ

-LVNSKFYKLVKDGYQMAQPAF--------APKNIYSIMQACWALEPTHRPTFQQICSFL
 . |.  ...||.|| | ||.         .|. .|.||. ||. .|  ||||..|....
MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FMS.AA TK 582-910 25 1.7e-129 436.47 In-house 1-486 (486) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

LQFGKTLGAGAFG---KVVEATAFGLG--------------------KEDAVLKVAVKMLKSTAHADEKEALM----------------SELKIMSH-LG
...||.||.|.||   .| .....|..                    ||... .|||||||........| ..                .|.|.|.| ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHENIVNLLGACTHG------------GPVLVITEYCCYGD----LLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVE
.|.|||.|.|.||.|            .|.....||...||    |...||.. . .  .. .|.  .......| .|..         .   |.   . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHC---------M--KGD---I-

MRPVSTSSNDSFSEQDLDKED-----GRPLELRDLLH-------------------FSSQVAQGMAFLASK------NCIHRDVAARNVLLTNGHV----
 .  . |. .  .|.. ...|     . || ..|||.                   .. |.|.||..|.||      |..|||.||||.|.....|    
TY-SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWH

-------AKIGDFG--------LARDIMNDSNYIVKG------------------------NARLPVKWMAPESIFDCV---------YTVQSDVWSYGI
       .||.|||        ||||| .|..| .|.                        ...||..|||||...| |         .| .|||||.|.
FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

LLWEIFSLG-LNPYPGILV--------NSKFYKLVKDG--------------YQMAQPAFAP--------------KNIYSIMQACWALEPTHRPTFQQI
|.||||..|   .|.|.          |  .......|              ..|.||. .|              . .| .|| ||...| .||||.|.
LMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQL

CSFL
 ..|
HEQL
Kinase FMS.AA TK-Unique 582-910 35 5.3e-111 375.07 In-house 1-294 (294) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-294/294
Sequence Identity: 35% (123 aa)

LQFGKTLGAGAFGKVVEATAFGLG-KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGG-PVLVITEYCCYGDLLNFLRRKA
| .|...| |||| |  ....|.  ..|.  .|||||||  |.  .| ....|...|..||.|.|||..||.||  . |.. | ||| .|.|...||...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

EAMLGP----SLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLD----KEDGR--PLELRDLLHFSSQVAQGMAFL
 || ..     |                                                       |    ... |  |. ..||.||  |.|.||..|
PAMRQHQTYGNLK-----------------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYL

AS--KNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVK-GNARLPVKWMAPESIF--DCVY-TVQSDVWSYGILLWEIFSLGLNPYPGILVNS
||  |...|||..|||||||...|.||.|||.|||....  |. . .  |.|..||||||.   . .| | .|||||.|.|.||||.||  ||||.   .
ASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD

KFYKLVKDGYQMAQPAFA-PKNIYSIMQACWALEPTHRPTFQQICSFL
 . ....||| | ||.   .. .|..|. || .||..||.| || . |
-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FMS.AA Src 582-910 33 4.4e-92 312.21 In-house 1-255 (255) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-255/255
Sequence Identity: 33% (111 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEA
... . ||.| || | .      |. .   ||||| ||.     . ||.  | .||  | .||..|.|.  |. . |.. .||| . | || .|..    
IKLCRKLGQGQFGEVWM------GYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

MLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA
                                                              ...|| |.|..|. .. |||.|||.| |.| |||| ||
--------------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAA

RNVLLTNGHVAKIGDFGLARDIMN--DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPA
||||  .. |.|..|||||| ..   | .|  .  |..|.||.||| |   ..|. |||||.||||.||.. |  ||||   |    . |. || | .|.
RNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPG-MTNHEVLQQVERGYRMPCPH

FAPKNIYS-IMQACWALEPTHRPTFQQICSFL
  |...|  ||. ||  .|  ||||  ...||
NCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FMS.AA UTK 582-910 27 4.1e-89 302.36 In-house 1-296 (296) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-296/296
Sequence Identity: 27% (98 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH-ADEKE---ALMSELK---IMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNF
.|.|..||.|||| | .|..        ...|||| ....|   .|.|    .| | .   .|...  |.|...|.| || ..| ...|||.. |||...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNC
||| ...                                                               ...  | |...|......| ||..|.|...
LRRHRPTPP-------------------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGF

IHRDVAARNVLLTNGH-------VAKIGDFG---LARDIMN--------DSNYIVK-GNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLN
.|||.||||.|..  .       |.||.|||   ..|.. .        .|.|  . .. |.|..|||||.. .   .| .|||||.|...|||.. |  
VHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRL

PYPGILVNSKFYKLVKDG--YQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL
|||| . | .  . | .|  |.|..|.  | ..| .|..||. .|  ||.|... ...
PYPG-MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FMS.AA FGFR 753-910 53 1.3e-82 280.82 In-house 136-293 (293) Show / Hide 
Range on Protein: 753-910
Range on HMM: 136-293/293
Sequence Identity: 53% (85 aa)

RDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLG
.||  .  |||.|| .|||. ||||| |||||| | ..| || |||||||| .   |  ..| |||.||||||. || |||.||||||||.|||||. .|
KDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYG

LNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL
  |||.|.     ||. | |. |  |.  ...|| .|  ||  .|  |||| |.   |
GQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FMS.AA KIN6 750-910 41 1.8e-66 218.62 In-house 141-305 (305) Show / Hide 
Range on Protein: 750-910
Range on HMM: 141-305/305
Sequence Identity: 41% (69 aa)

LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH---VAKIGDFGLARDIMNDSNYIVKGNAR-LPVKWMAPESIFDCVYTVQSDVWSYGILL
. ..||. |. |...|| .|.||||||||.||||||.| |     .||.||||.| .  |..  . .  | ||.||||||..    . . |||||.|.|.
IRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLM

WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL
.|.||||  |||..          . |  ...|  .|..|| ||| ||.  |  || | ..   .
FEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase FMS.AA Ret 748-912 42 2.8e-64 218.45 In-house 125-293 (293) Show / Hide 
Range on Protein: 748-912
Range on HMM: 125-293/293
Sequence Identity: 42% (72 aa)

RPLE-----LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG
...      . ... |  |. .||..|..   .||| ||||||.  | . || |||| ||.  |  |. .   |.||||||.|| .| |||..|||||.|
DVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFG

ILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE
.|.|||  .| ||||||    . . | |.|| |  |      .|.||  ||. ||  || |  | . .  
VLCWEIVTMGANPYPGIPPE-RLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FMS.AA Tie 750-910 48 4.9e-61 184.24 In-house 111-267 (267) Show / Hide 
Range on Protein: 750-910
Range on HMM: 111-267/267
Sequence Identity: 48% (78 aa)

LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF
|  . .||| . ||.|| .|. |.|||||.||||.|  .  |.|| ||||.|    |  |. |   ||||.||| ||.   ||| .|||||||.||||| 
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIV

SLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL
|||  || |.   ...|. .  ||.| ||     ..| .|. ||   |  ||.| ||   |
SLGGTPYCGMTC-AELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FMS.AA Pkinase 582-910 20 9e-43 152.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-293/293
Sequence Identity: 20% (75 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKE---ALM-SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG----DLLN
...|...|.|.||.| ...  | ||     .|||| .|   |.....   ..  ||..|| .| .|.||| |..... .. . ...|||  |    ||  
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPL--ELRDLLHFSSQVAQGMAFLAS
....                                                                   ......  . ... ..  |...|.... |
YIST-------------------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHS

KNCIHRDVAARNVLLTNGHVA----KIGDFGLARD--IMNDSNYIVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNPYPGI----L
...||||.   |.|. |  .     ||.|||||.   . |.|.. . |  .    .|||| |  .  |.  .|.||.|..|.| .. |  |.||      
MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW----YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN

VNSKFYKLVKDGY---QMAQPAFAP-------------------KNIYSIMQACWALEPTHRPTFQQICSF--L
 ... ........       |   .                   ..  ...  |... |. |||..||.    .
-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FMS.AA FGFR 582-678 45 3.7e-36 120.7 In-house 1-99 (293) Show / Hide 
Range on Protein: 582-678
Range on HMM: 1-99/293
Sequence Identity: 45% (45 aa)

LQFGKTLGAGAFGKVVEATAFGLGKE--DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRK
|  ||.|| |.||.|. |.|.|. ..  ..  .|||||||. .. ..   | ||. .|   |.|.||.||||.|| .||  || |||  | |  ||| .
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRAR
Kinase FMS.AA Tie 591-677 43 4.2e-29 85.19 In-house 2-85 (267) Show / Hide 
Range on Protein: 591-677
Range on HMM: 2-85/267
Sequence Identity: 43% (38 aa)

GAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRR
| ||.|. |.   . |.  ...||.||.|  |  |..   | || .|  .|.| ||.||.||| | | . | .||  || ||.|||.
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRK
Kinase FMS.AA S_TKc 582-910 18 1.5e-28 102.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 582-910
Range on HMM: 1-231/231
Sequence Identity: 18% (64 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCY--GDLLNFLRRKA
 ......| ||||||  ..  .        .||.|..|        | ...|..|...  .|.|||.|.... . . . ...|||    |||. ..... 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

EAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDV
   |.                                                               .|.   .  ..  |........ |.. ||||.
RHGLR---------------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDL

AARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTV-QSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQP
   |.||..  . ||.|||||| .                 .|||| .    |.   .|.|| |..|.| .. |  |.|      . .|...        
KPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--------

AFAPKNIYSIMQACWALEPTHRPTFQQICS---------FL
   ..   .... |.  .|..|||  ..           ..
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FMS.AA Ret 582-676 41 4.8e-26 85.92 In-house 1-97 (293) Show / Hide 
Range on Protein: 582-676
Range on HMM: 1-97/293
Sequence Identity: 41% (41 aa)

LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST-AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGG--PVLVITEYCCYGDLLNFLR
||...||| | ||.|| |.|| .        |||||||   |   |  .| ||. .   .  | ... |.|||.  .  | ..| ||| || |  |||
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLR
Kinase FMS.AA KIN6 613-684 40 6.1e-14 42.25 In-house 47-123 (305) Show / Hide 
Range on Protein: 613-684
Range on HMM: 47-123/305
Sequence Identity: 40% (31 aa)

VAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR-RKAEAM----LG
.||||| | |   ..  .| |   |  || |. .||.||  |   ... . |||| .||| .|| |. ..|    ||
CAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLG