Gene FRK (Human)

FRK

Species: Human
Alias: FRK, GTK, PTK5, RAK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 6q22.1,

Classification

Group: TK
Family: Src
Subfamily: Frk

Sequence

Name Sequence Type Origin Length Description Download
FRK.NA RNA Sugen Kinome 2864 None Fasta, JSON
FRK.AA Protein Sugen Kinome 505 None Fasta, JSON
FRK.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of FRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 FRK.AA SH3 45-109 38 4.6e-21 77.23 SMART 1-58 (58) Show / Hide 
Range on Protein: 45-109
Range on HMM: 1-58/58
Sequence Identity: 38% (25 aa)

HYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDR
 |..||.||||.....|||..||...||.   .||| .|.            .|..|||||.| .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNR-------TGQEGWFPSNYVEEID
SH3_1 FRK.AA SH3_1 48-102 33 1.2e-15 55.71 Pfam 1-49 (49) Show / Hide 
Range on Protein: 48-102
Range on HMM: 1-49/49
Sequence Identity: 33% (19 aa)

VALFDYQARTAEDLSFRAGDKLQVLDTLHE-GWWFARHLEKRRDGSSQQLQGYIPS
|||.||||.....|||. ||...|..  .. .||..| .  ..       .|..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQ-------EGWFPS
SH3_2 FRK.AA SH3_2 46-108 23 3.8e-12 45.41 Pfam 1-68 (68) Show / Hide 
Range on Protein: 46-108
Range on HMM: 1-68/68
Sequence Identity: 23% (17 aa)

YFVALFDYQA-RTAED-----LSFRAGDKLQVL---DTLHEGWWFA-RHLEKRRDGSSQQLQGYIPSNYVAED
|.....||.. . ...     |.|..||.. |.   |.  ..||.. . . ..|        |..||..|.|.
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRR-M----RGWFPSQWVEEC
SH2 FRK.AA SH2 116-193 48 1.1e-46 138.88 Pfam 1-81 (81) Show / Hide 
Range on Protein: 116-193
Range on HMM: 1-81/81
Sequence Identity: 48% (39 aa)

WFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGA---VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHY
|..| | |..||..|. ..|. |.||.|||||..|...|||.|.    .||||||.|.|.||...| |. |..|.| |.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 FRK.AA SH2 114-199 42 1.6e-38 135.19 SMART 1-87 (87) Show / Hide 
Range on Protein: 114-199
Range on HMM: 1-87/87
Sequence Identity: 42% (37 aa)

EPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTR--RRIFSTLNEFVSHYTKTSDG
.||..| | |..||. |.  ... |.||.|.|||..|...||| ..  ||||||.|.|.|.....   || |..| | | ||.....|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase FRK.AA Frk 234-491 80 5.6e-194 650.71 In-house 1-260 (260) Show / Hide 
Range on Protein: 234-491
Range on HMM: 1-260/260
Sequence Identity: 80% (208 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ--NDTGSKIHLTQQ
|||..|||||||||||||||||||||||||||||.||||||||||||||.||||||||||||||.|.|||||||||||||||||||  ||.|......|.
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGK
||||||||.|||||||.|||||||||||||||||||.|.||||||||...||||||||||....|.|||||||...|||.||||||||||||.||||||.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF
|||.|||.|.|.||....||.|||.|||||.|.||||||...|..|||||||.|||||||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase FRK.AA Src 234-487 64 3.4e-192 644.77 In-house 1-255 (255) Show / Hide 
Range on Protein: 234-487
Range on HMM: 1-255/255
Sequence Identity: 64% (166 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ-NDTGSKIHLTQQV
|.|...||.|||||||.|.||..|.|||||||||.|.|..||.||||||.|||.||.||||||. |.||||.||.|.||||..||. ...|...||.|..
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKM
|||||||.|||||||.||||||||||||||||.|..|||||||||..|.| .|.|..||. |.|.||||||||. ..|.||||||||||||.||.|||..
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYN-IMLECWNAEPKERPTFETLRWKL
|| ||| ..|.|.. ..||.|.|.|||...|. |||.||...|..|||||.|.|.|
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase FRK.AA SFK-Src 234-491 61 2.1e-189 567.09 In-house 1-259 (259) Show / Hide 
Range on Protein: 234-491
Range on HMM: 1-259/259
Sequence Identity: 61% (160 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD
|.| |.|||||||.|| | ||||| |||||||||.|  . ||.|||.|| ||||.|||||||||   |||||||||. |||  ||..  |    . | ||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDI-YESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKM
||||||.||||||  |..||||||||||||. |. ||.|||..||  . ..|. |. .   | |.|||||||   |.|||||||||||||..||.||| .
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRV--LAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYSGMTGAQVIQMLAQ--NYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF
|| ||| . |.| . .   ||.| | ||| ..|.||..||  || .|||||.|.|..||.|
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase FRK.AA Pkinase_Tyr 234-487 47 1.2e-147 500.67 Pfam 1-270 (270) Show / Hide 
Range on Protein: 234-487
Range on HMM: 1-270/270
Sequence Identity: 47% (128 aa)

IQLLKRLGSGQFGEVWEGLWN-----NTTPVAVKTLKPGSMDPN----DFLREAQIMKNL-RHPKLIQLYAVCT-LEDP--IYIITELMRHGSLQEYLQN
|...| ||.|.||||..| |.     ...|||||.||.|.|...    ||.|||.|||.| .||....||.|||  ..|  |||..|.| ||.| .||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D--TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIY-ESRHEIKLPVKWTAPEAIRSNKFSIKSDVW
    . .. . . ..|..|.|.||.||||.|.|||||||||.||.| |. |..||||||     |.| |  .|.. |||.||.|||.|. .||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGILLYEIITYGKMP-YSGMTGAQVIQML-AQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKL
|||.|..||.|||..| | ||. ..|....  ..||.|.| |||.  |..|..||...|..||||. ....|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FRK.AA Src-Unclassified 234-483 48 4e-141 475.14 In-house 1-280 (284) Show / Hide 
Range on Protein: 234-483
Range on HMM: 1-280/284
Sequence Identity: 48% (137 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPG---SMDPNDFL--------REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDT
..||. || ||||||| | | .   |||||..||    | |  ||        .|||||| .||..|..|||||. | |.|||||.|  |||  .|. ..
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GSKIHLTQQ------------VDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHN-----IYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI
|.  |.               ||.|||||||| ||||. |.||||||||||.|. |     . ||.||||||  |.  .|.|. |   ..|.||.|||..
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARK-KLMQDDNYCMRTGAMFPWKWMAPECF

RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP--SNCPQQFYN-IMLECWNAEPKERPTFETL
   .|||||||||.||||.|| |.|. || ||    |.  .   ||.| |    || . |  ||. ||.. |  ||||.||
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTL
Kinase FRK.AA TyrKc 234-487 41 5.2e-139 469.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 234-487
Range on HMM: 1-280/280
Sequence Identity: 41% (119 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNL--RHPKLIQLYAVCTLE-------DPIYIITELMRHGSLQEYLQNDTGS
|.|.| ||.|.||||..| |.  ..||||.||...    ||.|||.||..|  .|| ...||.||| .       .|..|..|.| ||.|..||..  . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVD-----NEDIYESR---HEIK-LPVKWTAPEAIRSNKFSIKSD
 . . . .... |.|.||.||.|.|.|||||||||.|||| .. |..||||.|  . |     ..| | ..   ..   ||..|.|||.|. .||..|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLYEIITYGKMPYSG-----MTGAQVIQMLAQNYRLPQPSN--------CPQQFYNIMLECWNAEPKERPTFETLRWKL
|||||....|| |||..||.|     |. ..||. . | ||.||| |        ||.  |.||..||...|..||||.... ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FRK.AA SrcA 234-487 57 3.5e-130 413.76 In-house 1-250 (250) Show / Hide 
Range on Protein: 234-487
Range on HMM: 1-250/250
Sequence Identity: 57% (146 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD
|.| .||| |.||||| | || || ||.|||||| | |. || |||||| ||| ||.|||||   |.||||.|| | .||| ..|....| ...| | ||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMP
||||||.||||.|  ||||||| | |.||||. | |.|||||||. . |||  |..|   | |.|||||||    .| |||||||||||| |..| |..|
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIE-DNE--YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP

YSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKL
| ||    |..   . |..| | .||.  ...| .||  .| |||||| |   |
YPGMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase FRK.AA SRM 235-488 52 1.8e-129 435.34 In-house 2-253 (253) Show / Hide 
Range on Protein: 235-488
Range on HMM: 2-253/253
Sequence Identity: 52% (133 aa)

QLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGS-MDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD
 | ..||.| |||||||||    .||.|  |    |   ..  | | || ||| ..| |.|||.. ||.|||||||| |.||.||    .    . . .|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLD

MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMP
.| ||| ||.|||..|||||||||||||||. |. ||.||||||  |   .|||   |. . |.|||||||.    .|.|||||||||||.|. ||| .|
FACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIK---DDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCP

YSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE
| |||    .|     ||.| |  || . .  |||||  .|..||.| .|| || 
YPGMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase FRK.AA TK 234-487 24 1e-126 427.14 In-house 1-486 (486) Show / Hide 
Range on Protein: 234-487
Range on HMM: 1-486/486
Sequence Identity: 24% (121 aa)

IQLLKRLGSGQFG---EVWEGLWNNT--------------------------TPVAVKTLKPG-SMDPND--------------FLREAQIMKNLR----
|.|.| ||.||||   ||..|.|..                           ||||||.||.| .|....              ||.||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLIQLYAVCTLE------------DPIYIITELMRHGS----LQEYLQ--NDTGSK-----------------------------------------
 || ...||.||| .             |..|..|.| ||.    |..||.   .....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IHLTQQVDMAAQVASGMAYLESR------NYIHRDLAARNVLVGEHNI-----------YKVADFGLA-
                               ... |.. |..|.|.||.||.|.      |..||||||||.||||.|.            |.|||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVFKVDNEDIYESRH------------------------EIKLPVKWTAPEAIR---------SNKFSIKSDVWSFGILLYEIITYG-KMPYSGM
     .  .....| | ...                          |||..|.|||...          .||..||||||||.|..|| ||| ...| ||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TG---------AQVIQMLAQN--------------YRLPQPSNCP--------------QQFYNIMLECWNAEPKERPTFETLRWKL
.          ..|...| .               .|.||| .||              . .| .|..||...|..||||..|. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase FRK.AA SrcB 234-488 57 2.3e-126 426.09 In-house 1-251 (251) Show / Hide 
Range on Protein: 234-488
Range on HMM: 1-251/251
Sequence Identity: 57% (146 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD
..| |.||.||||||| | .|| . |||||.|.|.| |. || || .||.| | .|..|||| | | ||||||| | .|.| ..|. | |||..| . .|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMP
|.||.| ||||.| .||||||| | |.|| |  . |.|||||||.   |||  |  |   | |.||||||||    | ||||||||||||.||.|||..|
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIE-DNE--YTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIP

YSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE
| ||| ..||. | . ||.|.| |||.  |||| .||   | |||||. |.  |.
YPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase FRK.AA Src-Echino1 234-487 50 1.8e-120 406.5 In-house 1-252 (252) Show / Hide 
Range on Protein: 234-487
Range on HMM: 1-252/252
Sequence Identity: 50% (129 aa)

IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVD
 .. |..|.|..||||.|.||  |||||||||...| | ||| || .|| .||  ..|.||||  ..||||.||||..|.||.||... . .. .|. .|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMP
| |..|||| ||.|.|..||||||||||||. |. |.|||||||. .   .|.| ...  |||.|||||||.   .| |||||||||||. |..|.|..|
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQ---KDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYP

YSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI-MLECWNAEPKERPTFETLRWKL
| ||.  .|.. ... ||.|.. .||   |.. |. ||  .|. ||||| |   .
YPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase FRK.AA UTK 234-487 36 1.5e-109 370.24 In-house 1-296 (296) Show / Hide 
Range on Protein: 234-487
Range on HMM: 1-296/296
Sequence Identity: 36% (107 aa)

IQLLKRLGSGQFGEVWEGLWNN------TTPVAVKTLKPGSM---DPN---DFLREAQ---IMKNLR-HPKLIQLYAVCTLEDPIYIITELMRHGSLQEY
.||...||.|.|||| .. ...      .  ||||.......   .|    ||..||.   .||... ||....|..||| | |..|.||.|. |.|. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQ------NDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEH-------NIYKVADFG---LARVFK-------VDNEDIYESRHEIK
|.      .. .    |.|...||...|.||.||.|....||||||||.||..|       .. |.||||   ..|  .        .. . | ..|  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPVKWTAPEAIRSN-KFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN--YRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKL
.|..|.||||. .. .|..||||||||....|| |.|..|| ||. .||.. .     ||.|.|  || . |..|..||...| |||.||.|. ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FRK.AA S_TKc 234-491 23 2e-58 201.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 234-491
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

IQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRH--GSLQEYLQNDTG----SKI
 ..|. .|.| ||.|. . ...    ||.| .|      ....|| ||.|. .|| ...|| |.   | .|...|.. .  |.| .|...  .    ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

HLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSI-KSDVWSFGILLYE
.  .   ...|......|. |.. |||||   |.|. |    |..||||||..           . .     . ||| .   ...  |.|.||.|..|||
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRW-----KLEDYF
 .. |. |..  . .......            .... ...  |.. .|..|||   .       |.  .|
MLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FRK.AA Pkinase 234-481 25 5.2e-48 170.61 Pfam 1-285 (293) Show / Hide 
Range on Protein: 234-481
Range on HMM: 1-285/293
Sequence Identity: 25% (75 aa)

IQLLKRLGSGQFGEVWEGLWNNT-TPVAVKTLKPGSMDPND---FLR--EAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHG----SLQEYLQNDTG
.......||| ||.|... . .|   ||||..|  . ...     .|  |.||||.|.||  ..|| ... .| ||...|....|    .| .|.. . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SKI--HLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIY----KVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIR-SNKFSIKSDV
 ..     .  ... |...|..|. |.. |||||   |.|. ...      |..|||||..|.   .  ..  . .     . ||| || ... . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGILLYEIITYGKMPYSGM----TGAQVIQMLAQNYRLPQPSNCP-----------------------QQFYNIMLECWNAEPKERPTFE
||.|..||| .. |. |..|     . .  .||.... . | ....|                       . .  ..  |..  ||.|||.|
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE