Gene INSR (Human)

INSR

Species: Human
Alias: INSR, HHF5, CD220
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.3,

Classification

Group: TK
Family: InsR

Sequence

Name Sequence Type Origin Length Description Download
INSR.NA RNA Sugen Kinome 9059 None Fasta, JSON
INSR.AA Protein Sugen Kinome 1382 None Fasta, JSON
INSR.kin_dom Protein Kinase Domain Sugen Kinome 268 None Fasta, JSON

Protein domain

Protein domains of INSR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain INSR.AA Recep_L_domain 52-164 39 4.7e-45 153.21 Pfam 1-121 (121) Show / Hide 
Range on Protein: 52-164
Range on HMM: 1-121/121
Sequence Identity: 39% (49 aa)

NCSVIEGHLQILLMFKTRPEDFRDL---SFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFF--NYALVIFEMVH--LKELGLYNLMNITR--G
||.||.|.|.|.....      ..    .||..  ||.|||..|. ..... ..||||..|||  ||   ||||.|... .  |.||...||.||||  |
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNG

SVRIEKNN--ELCYLAT-IDWSRIL
.|.|..|.  .|||. | |.|. |.
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like INSR.AA Furin-like 179-340 45 9.6e-86 281.77 Pfam 1-182 (182) Show / Hide 
Range on Protein: 179-340
Range on HMM: 1-182/182
Sequence Identity: 45% (85 aa)

NEECGDICPGTAKGKTNCPATVINGQFVERCWTHS--HCQ----KVCPTICKSHGCT--AEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPP
|.||.|.||||..... |. |.||| ...|||...  |||    ||||. || ..||  ..| |||..||| |..|...|.|||||.|| .|.||..|||
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

----------------PYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMN--SSNLLCTPCLGPCPKVCH
                 .|.|..||||.|..|..|      |....|..|||||..|..|||||||.|  .... |.|| |||||||.
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKL------SHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU INSR.AA FU 231-274 40 2.6e-13 51.45 SMART 1-48 (48) Show / Hide 
Range on Protein: 231-274
Range on HMM: 1-48/48
Sequence Identity: 40% (20 aa)

EGLC--CHSECLGNCSQPDDPTKCVACRNFYLD---GRCVETCPPPYYH
.| |  ||.||.. |. |. |..|..|...|.    |.||..||| ||.
DGVCKPCHPECATGCWGPG-PDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU INSR.AA FU 277-321 23 0.166365 0.21 SMART 1-48 (48) Show / Hide 
Range on Protein: 277-321
Range on HMM: 1-48/48
Sequence Identity: 23% (12 aa)

DWRCVNFSFCQDLHHK-CKNSRRQGCHQ----YVIHN-NKCIPECPSGYTM
| .|     | .     |  ..   |      |..|. ..|...||.||  
DGVC---KPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain INSR.AA Recep_L_domain 359-474 41 3.4e-49 167.12 Pfam 1-121 (121) Show / Hide 
Range on Protein: 359-474
Range on HMM: 1-121/121
Sequence Identity: 41% (51 aa)

GCTVINGSLIINIRGGNNLAAELEA---NLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIG-NYSFYALDNQN--LRQLWDWSKHNLTITQGK
.||||.|.|.|..|...|    ||     ...|.||.|||.|.|.|.|..||||..|| |||..|. . ||..| .||.|  |..||.|. .|.|. .|.
NCTVIYGNLEITWRDEHNE---LEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGG

LFFHYNP--KLCLSEIHKMEEVSG
...|.||  |||..... |... .
VYIHNNPHPKLCYTHTEIMWWMIY
FN3 INSR.AA FN3 492-600 10 0.369937 1.04 SMART 1-69 (69) Show / Hide 
Range on Protein: 492-600
Range on HMM: 1-69/69
Sequence Identity: 10% (13 aa)

QASCEN-ELLKFSYIRTSFD----KILLRWE-PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKP
  . .| . |... . .. .     . |.|. |             . |.                                             .||||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------------IVGYR------------------------------------------YTVTGLKP

W----TQYAIFVKTL----VTFS
.    |.| . |.      .  .
GQYPWTEYEFRVRAVNGNDAGEG
FN3 INSR.AA FN3 622-831 8 4.2e-09 37.48 SMART 1-69 (69) Show / Hide 
Range on Protein: 622-831
Range on HMM: 1-69/69
Sequence Identity: 8% (18 aa)

PSVPLDP--ISVSNSSS-------QIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSC
|. | .|  ..|.. .|       .. |.||||      |..|                                                         
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------------------

PKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGL
                                                                                               ...||
----------------------------------------------------------------------------------------------YTVTGL

RHF----TGYRIELQACNQ--DTPE
.      | |.. ..| |   . . 
KPGQYPWTEYEFRVRAVNGNDAGEG
FN3 INSR.AA FN3 851-934 18 5e-06 27.25 SMART 1-69 (69) Show / Hide 
Range on Protein: 851-934
Range on HMM: 1-69/69
Sequence Identity: 18% (18 aa)

DDIVGP---VTHEIFENN------VVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPG-----NYSVRIRATSL--AGNG
 . ..    .. .   ..       |.| |..|      || |.                         ....||.||     .|..|.|| .   || |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR-------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase INSR.AA InsR 1023-1292 73 7.89999999999e-230 769.8 In-house 1-278 (278) Show / Hide 
Range on Protein: 1023-1292
Range on HMM: 1-278/278
Sequence Identity: 73% (205 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAET--RVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP
|.|.||.|||||||||||.|..|...|...  |.|.|||||.||.|||||||||||||| |.||||||||||.|.|||..||||.|..|||||||||.||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

EAE-NNPGRP----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTT
|.| ||||..    .|.|..|.||||||.||||||.||||||||||.|||||.||||||||||||||||||.|||||||||.||||||||||||||||||
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTT

SSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD
.||.|||||||||...|.||||||||||||||.. |||..|..|.||||....||.||||..||||||||.|...|.|
HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase INSR.AA Pkinase_Tyr 1023-1290 46 9.5e-155 524.72 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-270/270
Sequence Identity: 46% (128 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRE--RIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQP--TLVVMELMAHGDLKSYLR
||....||.|.||.||.| ...  ... .. ||||...|.|. ..  | .|..||..|| .  ....|||.||.. .|.|   ..|||.|.||||..|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY-RKGGKGLLPVRWMAPESLKDGVFTT
. |      ....|.|.....||...||.||.|| .|...|||||||||.|.....|||.|||..||||..||| ||.|.| ||..|||||....|.|||
KHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

SSDMWSFGVVLWEITSLAEQP-YQGLSNEQVLKFV-MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL
 || |||||..||| .. ||| |.|.|||.|....  ||. ...|.|||. . |||..||...|..|||| ||.. |
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase INSR.AA TyrKc 1023-1290 41 1.8e-141 477.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-280/280
Sequence Identity: 41% (124 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF--TCHHVVRLLGVVSKG-------QPTLVVMELMAHGDLKS
|||...|| | || ||.| ..        . ||||...|.|    | .|..||..|. .     ..|||.||....       .| ..|||.|.|||||.
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYET-------DYYRK----GGKGLLPVRW
|||. ||.          .........  ||.||.||  |...|||||||||.|....||||.|||..||||.        |||||    |||..||.||
YLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG-----LSNEQVLKFVMDGGYLDQPDN--------CPERVTDLMRMCWQFNPKMRPTFLEIVNL
||||....|.||| || |||||..||| .. .||| |     .||..|...|..|....||.|        ||. . ..|..||...|..|||| ||. .
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase INSR.AA TK 1023-1290 26 8.9e-124 417.08 In-house 1-486 (486) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-486/486
Sequence Identity: 26% (131 aa)

ITLLRELGQGSFG---MVYEGNARDII--------------------KGEAETRVAVKTVNE--SASLRERIE-----------FLNEASVMKGFT----
|||...||.| ||   .||.| .|...                    |....|.||||.. |  ..| .|...           ||.||..|| .     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-CHHVVRLLGVVSKG------------QPTLVVMELMAHGD----LKSYLRSLRPEAEN--------NPGRPP---------------------------
 . ..|||.||...|            .| ..|||.|.|||    |..|||. ||.. .        ....||                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PTLQEMIQMAAEIADGMAYLNAK------KFVHRDLAARNCMVAHDFT-----------VKIGDFGMT-
                               .|..... |.. ||.||.|| .|      .|||||||||||.|... .           .||.|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDIYETDYYRKGG------------------------KGLLPVRWMAPESLKDGV---------FTTSSDMWSFGVVLWEITSLAEQPYQG-L
       ||||. |.|.. .                        .| ||.||||||.|.|.|         ||| ||.|||||..||| .....|| | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------EQVLKFVMDGGYL--------------DQPDNCP--------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL
||         ..|.... .|| |               ||..||              | . |||..||...|. |||| .... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase INSR.AA UTK 1023-1290 38 3.3e-110 372.45 In-house 1-296 (296) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-296/296
Sequence Identity: 38% (116 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERI---EFLNEAS---VMKGFT-CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSY
. |.|.|||| ||.|... ....   . | .||||. . .... .|.    .|..||    .|| |  . .|.||.||.....|...|.|.|. ||| ||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD-------FTVKIGDFG---MTRDIY---------ETDYYRKGGK
||. ||...  . .   || ....||. ||.||.||  ..||||||||||| |...        ..||.|||   |.|...         |..||.. . 
LRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GLLPVRWMAPESLKDG-VFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG--YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL
. .|.||||||.| ..  |||.||.||||||.||| . . .|| |.||.||...|..||   . .|. ||..| .||. ||. .| .||.| ..|  .
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase INSR.AA Sev 1023-1290 48 4.90000000001e-106 354.31 In-house 1-277 (277) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-277/277
Sequence Identity: 48% (134 aa)

ITLLRELGQGSFGMVYEGNARDII-KGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE
 .|.| || | || |||| | ||   || | |||.||    .   | .||| || .|  |    .| ..||   . |  ..||.|  ||| .|||  |  
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

AENNPG-RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV------AH-DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVF
.  ||      || ... |   |. |  ||    |||||||.||| |      .|   .|||||||  ||||  ||||| | ||||||||||||| ||.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL
|| || |.||.  ||| .|  |||   ||  ||..|  || |.||..||. .  .|| ||.  |  ||.|  . | |
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase INSR.AA ALK 1023-1292 43 3e-104 352.66 In-house 1-273 (273) Show / Hide 
Range on Protein: 1023-1292
Range on HMM: 1-273/273
Sequence Identity: 43% (119 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEA
|||.| ||.| || ||.|  . .     .  ||.||  |..|  .   |..|| .|  |    |||..|.  . || ..| |.|. ||.||.||  ||. 
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

E-NNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFT---VKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMAPESLKDGVFTTSS
|  .|   . | .  .| .  .| |  ||  ..|.||| |||||          .||.|||| ||| | .|||||||. ..|| || || . ||.||. .
ESLQPS--QLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKT

DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD
|.||||| .||| ||   || | .|..|..||  || .| | ||| .|  .|. |||  |  ||.|  |.  ...
DVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase INSR.AA Trk 1023-1290 41 5.2e-101 341.87 In-house 1-275 (275) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-275/275
Sequence Identity: 41% (115 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEA
| | .||| | || |. ..  ..   .  . |||||  . ||   | .|  || ..     .|.|.. ||   ..| | | | | ||||. |||.  | |
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKD-ASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

----ENNP--GRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE-TDYYRKGGKGLLPVRWMAPESLKDGVFTT
    ...|   . | |...|   | .|| || |.    |||||.|.|||.|...  |||||||| ||.|. ||||| |... ||.||| |||     ||.
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTY

SSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGY-LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL
 || ||||||.||. .   ||. .|||  |  ... |   |..|  ||. | |.|. |||  |..| .  .| ...
ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase INSR.AA TK-Unique 1023-1290 36 2.6e-100 339.56 In-house 1-294 (294) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-294/294
Sequence Identity: 36% (107 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAET-RVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQ-PTLVVMELMAHGDLKSYLRSLR
.......|.|.|| |. | .. |.|.. .. .||||.....|.. .. .||.|...||  ..| ..|..||.  | . |.. .|| .. |.| .|||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PE-------------AENNPGRPPPT-LQ--EMIQMAAEIADGMAYLNA--KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY-ETDYYRKGGKGLLPV
|.             ....| .|... ..   ... | .|| ||.||    ||.|||||.|||.....|...||.||||.||.| ...| .....| .|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMAPESLK--DGVF-TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC-PERVTDLMRMCWQFNPKMRPTFLEIVNLL
|||||||||  .|.. || || |||||..||| .| ..|| |........ . ||  ..||..| ..... ||. ||| .|..||.| .|.. |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase INSR.AA Musk 1023-1290 41 2.2e-98 325.72 In-house 1-282 (282) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-282/282
Sequence Identity: 41% (117 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEA
|   |..|.| || |.   |   . .|.|| ||||   . ||      |  ||  |  |    .|.||||   |.|    .| || |||  .|.|  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

ENN--------------PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESL
 .               || |.    .  .||..|| |||||. ..||||||| |||..     ||| |||. | ||  |||.  .    |.|||.|||.
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

KDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL
 .  ||. || |..||.|||| | |.||| |.. | |.... .|  |  |.|||  |  ||| ||| ||  || | .| . .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase INSR.AA CTKB 1023-1283 43 6e-88 298.5 In-house 1-260 (269) Show / Hide 
Range on Protein: 1023-1283
Range on HMM: 1-260/269
Sequence Identity: 43% (116 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTC-HHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE
| |   || | ||.|| | |. |.   | | ||.| . .|.|     .|. |  .|.       .|||||.  .  | |.|.|||| ||||  ||  || 
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVTPVAIKMLQDSSS-EATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPK

AENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWS
        |     .  ||| .||||||.  |. ||||||||||.|  .. | |||||. ||.|   ||   .   ||.|||.|||. |||.|| || ||
TSKPSALSP---RRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRDVYMREYYKMQASNPLPIRWMSPESINDGVYTTQSDVWS

FGVVLWEITSLAEQPYQG-LSNEQVLKFVMDGGY-LDQPDNCPERVTDLMRMCWQFNPKMRPTF
.|.|.|||   |  || . ..|  |   . |. | . ||  ||  . |||  ||   |  |. |
YGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISF
Kinase INSR.AA FGFR 1023-1290 36 1.1e-85 290.96 In-house 1-293 (293) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-293/293
Sequence Identity: 36% (107 aa)

ITLLRELGQGSFGMVYEGNARDIIKG--EAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHH-VVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLR
 ||   || | || |  . |  | .   |.|. |||| . .... .. .    |  .||    |  ...|||. . . |  |. |. .|| |. .||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PEA-ENNPGRP--------PPTLQ------------EMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLL
| . .  .  .        .|. |            . ...|  .| || ||  .| .||||||||  |  |.  || |||  ||| ..||||| . | |
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLS-NEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL
|. |||||.| | |.|. || ||.|| ||||  . .||| .    |.  |. . |  .. | ||.. .  .|. || |.|. |||| ..|  |
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase INSR.AA S_TKc 1023-1298 22 7.2e-45 156.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 1023-1298
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAH--GDLKSYLRSLRP
 ..||..|.|.|| || .  ..        .||.| ..        . ...| ...|   . ..|.|..|    .   .|||.. .  |||..|... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTT-SSDM
.  . |     .  .   ....|.....|.  ....||||   | .. .  ..||.|||. | .                 .|||| |    ... ..|.
HGLRFPF----PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVN-LLKDDLHPSF
||.|..|.|  .  . |..    ....| ..           .. . |..| |.|..|. |||  |. .  ..  .|| |
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase INSR.AA Pkinase 1023-1290 20 8e-37 131.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1023-1290
Range on HMM: 1-293/293
Sequence Identity: 20% (65 aa)

ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLR-ERIEFLN--EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHG----DLKSYL
....| .|.|||| ||.  ....  |.   .||||... .     .... ..  |...|| . . ..|||....  ..   .|||.. .|    ||..|.
YHIGRKIGSGSFGCVYK--CHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RSLRPEAENNPGRPPPTL----QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV----KIGDFGMTRDI-YETDYYRKGGKGLLPVRWMAPE
.           .   ..    .| . .. .|. |..|. .....||||   |... .. ..    ||.|||  . . |  .   ..  | .  ..||||
ST----------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPE

SLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL----SNEQVLKFVMDGGYLDQPDNCP-----------------------ERVTDLMRMCWQFNPK
 .. .   ....||||.|..|.|  .  . |..|     .    .. .   .. . . ..|                       |   |... |....||
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

MRPTFLEIVNL--L
 |||. .|..   .
KRPTAEQILQHPWF