Gene IRAK2 (Human)

IRAK2

Species: Human
Alias: IRAK2, IRAK-2, MGC150550
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p24-p25.3,

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK2.NA RNA Sugen Kinome 3469 None Fasta, JSON
IRAK2.AA Protein Sugen Kinome 625 None Fasta, JSON
IRAK2.kin_dom Protein Kinase Domain Sugen Kinome 268 None Fasta, JSON

Protein domain

Protein domains of IRAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK2.AA Death 14-94 25 4.1e-18 63.05 Pfam 1-87 (87) Show / Hide 
Range on Protein: 14-94
Range on HMM: 1-87/87
Sequence Identity: 25% (22 aa)

DDLCRNM--DALSEWDWMEFASYVITDLTQLRKIKS-MERVQGVSITRELLWWWGMR---QATVQQLVDLLCRLELYRAAQIILNWK
. ||| .  |..  .||...|..   . .... |..  ..    | |...|| | .|   .|||..|...|........|..| .| 
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase IRAK2.AA IRAK 210-479 34 3.6e-157 528.45 In-house 1-317 (317) Show / Hide 
Range on Protein: 210-479
Range on HMM: 1-317/317
Sequence Identity: 34% (110 aa)

FNQNRKISQGTFADVYRGHRHGKP--FVFKKLRETACSSPGSIERFFQA---ELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGS
|.....|..|.|..||||......  ...|||.|.|..|.......||.   ||..|.||.|||..|..|.|..||.|...||||.||||.|||..|.|.
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

DP---LPWPQRVSICSGLLCAVEYLHGLE----IIHSNVKSSNVLLDQNLTPKLAHPMAHLCP----VNKRSKYTMMKTHLLRTSAAYLPEDFIR--VGQ
.|   |.|.||.|||.|..|....|| ..    |||...||.|.||||..|||......| ..    ......||.|.|...|....|.|..|||  .||
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTAS-----------------------------LCSRKTGVENVMAKEICQKYLEKG
|||..|..|.||||.|||||..|....|...|....|...|......                             ...|.......|.||.||.....|
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

AGRLPEDCAEALATAAC
..|....|..| ...  
HHRANRRCDMAWVMQQL
Kinase IRAK2.AA TKL 216-411 18 1.5e-47 164.32 In-house 1-285 (364) Show / Hide 
Range on Protein: 216-411
Range on HMM: 1-285/364
Sequence Identity: 18% (54 aa)

ISQGTFADVYRGHRHG----------KPFVFKKLRETACSSPGSIE-----------------------RFFQAELQICLRCCHPNVLPVLGFCAARQF-
| .|.|. ||.|. .|          |. . ||.... ...  ...                        |.  |. ...|..|||... .|.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLE--------IIHSNVKSSNVLLDQNLT-------------
            . ... |. .||| ..|.         |.||.... .  ....|||  .        ||| . ||.|.|.|.|.|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKLAHPMAHLCP----VNKRSKYTMM----------KTHLLRTSAAYLPEDFIR----------------VGQLTKRVDIFSCGIVLAEVLTG
 .|...     .      ......|||          .|.  . . ....   .|                 .. ....|..| |||| |.||.
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR
Kinase IRAK2.AA Pkinase 210-352 22 9.4e-22 77.99 Pfam 1-154 (293) Show / Hide 
Range on Protein: 210-352
Range on HMM: 1-154/293
Sequence Identity: 22% (35 aa)

FNQNRKISQGTFADVYRGHRHGKP--FVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANG----SLQDRLQGQGG
.   ||| .|.|. ||..|..| .  .. |...    .|   ....  .|.|| .|..|||..  ....  ..   .. .|. .|    .| |....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

SDPL--PWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTP----KLA
. ..  .. .  ...  .|...||.|   |||  .|..|.|.|.| ..    |..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase IRAK2.AA TK 210-352 12 6.2e-19 59.39 In-house 1-293 (486) Show / Hide 
Range on Protein: 210-352
Range on HMM: 1-293/486
Sequence Identity: 12% (38 aa)

FNQNRKISQGTFA---DVYRGHRHGK---------------------------PFVFKKLRETACSSPGSIER--------------FFQAELQICL-RC
    .|. .| |    .||.|  .|.                           |   | |.|.. .|.   .               . ... . |.  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

CHPNVLPVLGFCAAR------------QFHSFIYPYMANGS----LQDRLQ--GQGGSD-----------------------------------------
 |||..  .| |               .    .  ||..|.    |.| |.    ....                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLPWPQRVSICSGLLCAVEYLHGL------EIIHSNVKSSNVLLDQNLT-----------PKLA
                              .|. .|.. .|  . |. |||| .       ..| ..   |.|...|..            |.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
Kinase IRAK2.AA S_TKc 210-459 17 8.2e-15 40.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 210-459
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

FNQNRKISQGTFADVYRGHRHG--KPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMAN--GSLQDRLQGQGGSD
.   ||| .|.|. ||... ..  . .  |...           . .. |.||. .  |||.   ....   ..  ..  |. .  |.| |... .|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

P---LPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKL-----AHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTK-RV
.   .|  .  ...  ..||.||.| . |||  .| .|.|||.  . |.     |  .                 . .  .  |..   .   . .| ..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL---GYGKCKC

DIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENV---MAKEICQ--------KYL
|. |||..|.| |.| |  .    .  . ....   ...  .. ..   ..      | |. |         ..
DWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK2.AA RIPK 216-352 27 1.3e-14 46.17 In-house 1-151 (290) Show / Hide 
Range on Protein: 216-352
Range on HMM: 1-151/290
Sequence Identity: 27% (41 aa)

ISQGTFADVYR-GHRHGKPFVFKKLRE-TACSSP--GSIERFFQAELQICLRCCHPNVLPVLGFCAARQF------HSFIYPYMANGSLQDRLQGQG--G
.. | |  |..  ||| .  | ||      |  .   . .     | ..  .  . ...|..|||   ..       .    ||.|||| . |. .    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

SDPLPWPQRVSICSGLLCAVEYLHGLE--IIHSNVKSSNVLLDQNLTPKLA
  |.||| |  .     |.. |||.    |||   | .|.|.| |.  |.|
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIA
Kinase IRAK2.AA STE 211-352 21 3.2e-14 46.72 In-house 1-189 (359) Show / Hide 
Range on Protein: 211-352
Range on HMM: 1-189/359
Sequence Identity: 21% (42 aa)

NQN-RKISQGTFADVYRGHRH-----------------GKPFVFKKLRETACSSP-------------GSIERFFQAELQICLRCC--HPNVLPVLGFCA
 .. .|| .|.|  ||.. .|                 |. .  |...   |..               ...  .. |..|. .|   |||.   .| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-------ARQFHSFIYPYMANGSLQDRLQ---GQGGSDP--------LPWPQRVSICSGLLCA-VEYLHGLEIIHSNVKSSNVLLDQNLTPKLA
       ...    .  ||..||| | ..   | |....        .| .|   ||  .| .  .||| . |||  .|..|.||      ||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLC
Kinase IRAK2.AA MLK 210-352 20 2.2e-13 42.94 In-house 1-175 (291) Show / Hide 
Range on Protein: 210-352
Range on HMM: 1-175/291
Sequence Identity: 20% (36 aa)

FNQNRKISQGTFADVYRGHRHGKP-----FVFKKLR---ETACSSPGSIERFFQAELQICLRCCHPN----VLPVLGFCAARQFH-SFIYPYMANGSLQD
..  ..|  |.| .|..|  ..|        .|. |   . . |. ... . |. |  .  . .|||    . ...| |.  . |   .  |...||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLQG-QGGSD----------PLPWPQRVSICSGLLCAVEYLHGLE---IIHSNVKSSNVLLDQ------NLTPKLA
 | | .....            .  . ....     ...||| ..   |||   ||.|.|.|.      ..| | .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKIC
Kinase IRAK2.AA CAMK 215-352 12 2.9e-12 35.08 In-house 1-238 (425) Show / Hide 
Range on Protein: 215-352
Range on HMM: 1-238/425
Sequence Identity: 12% (29 aa)

KISQGTFADVYRGHRHGKP--------------FVFKK-------------------LRETACSS-----PGSIERFFQAELQICLRCC-------HPNV
.. .|.|. |... .   .              .  |                    .. . |..      .. ..... |..|. ..        |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LPVLG--------------------FCAARQFHSFIY---PYMANG----SLQDRLQGQGG------------SDPLPWPQRVSICSGLLCAVEYLHGLE
.  .                     |   ...  ..     |. .|     | |... .|.            .  ..  .   .   ...||.|.| . 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHSNVKSSNVLLDQN-----------------LTPKLA
|.|   |  |.|||.|                  . |..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase IRAK2.AA TK-Unique 265-353 20 2.6e-11 35.4 In-house 62-176 (294) Show / Hide 
Range on Protein: 265-353
Range on HMM: 62-176/294
Sequence Identity: 20% (24 aa)

CHPNVLPVLGFCAARQ-FHSFIYPYMANGSLQDRLQGQGGS-----------------------DPLPWPQRVSICSGLLCAVEYLHG--LEIIHSNVKS
.|||..  || |   .  .  |..|...|.||. |.  ..                        .|.   . .... .. |. |||..   .|.| .. .
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCA

SNVLLDQNLTPKLAH
.||||  ... |...
RNVLLTEDKVCKICD
Kinase IRAK2.AA TKL-Unique 214-348 26 7.9e-11 34.6 In-house 3-150 (290) Show / Hide 
Range on Protein: 214-348
Range on HMM: 3-150/290
Sequence Identity: 26% (40 aa)

RKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERF-FQAELQICLRCC-HPNVLPVLGFCA----ARQFHSFIYPYMANGSLQDRLQ-------G
 || .|... ||.|  .|.|   |.. .   ... ..... |  |. .  .   |||..   |.|.    .    ...  |.  ||| | |.        
NKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

QGGSDPLPWPQRVSICSGLLCAVEYLHGLE--IIHSNVKSSNVLLDQNLT
   . .|.. |||..      . .||| .|  ||| . ||||.|.|.|..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSN
Kinase IRAK2.AA TyrKc 210-459 18 5.3e-10 -60.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 210-459
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

FNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRC--CHPNVLPVLGFCAAR-------QFHSFIYPYMANGSLQDRLQG
   ..|.  | |  ||.|.    .   |.|.| |       .. |  |..|  .    |||..  .| |          . .  .  ||..|.|.|.|. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHP-MAHLCPVN----KRSKYTMMKTH-LLR--TSAAYLPEDFIRVGQL
 ..   |.... .|.|    |  ||||   .||      |.|.. |.| | .   ..           ...| ..|.|   .       ..   |. |  
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TKRVDIFSCGIVLAEVLTGIPAMDNN-----RSPVYLKDLLLSD-IPSSTASL-------CSRKTGVENVMAK------------EICQKYL
|   |..| |... |..|       .      |.  .  .. .   .   ..        |.  . . ..| .            . . ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP--DEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK2.AA Pkinase_Tyr 210-333 24 7.3e-10 34.02 Pfam 1-134 (270) Show / Hide 
Range on Protein: 210-333
Range on HMM: 1-134/270
Sequence Identity: 24% (33 aa)

FNQNRKISQGTFADVYRGHRH------GKPFVFKKLRETACSSPGS--IERFFQAELQICLRC-CHPNVLPVLGFCA-ARQF--HSFIYPYMANGSLQDR
   ..|. .| | .||.|. .      . |   |.|.|   ...    .| |.. |..|      |||..  .| |   ..   .  . .||..|.| | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LQGQ-GGSDPLPWPQRVSICSGLLCAVEYLHGLEIIH
|. .  . .||. .. ...|    .. |||.   .||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
Kinase IRAK2.AA LISK 215-352 29 1.1e-09 27.43 In-house 1-147 (296) Show / Hide 
Range on Protein: 215-352
Range on HMM: 1-147/296
Sequence Identity: 29% (44 aa)

KISQGTFADVYRGHRH--GKPFVFKKLR---ETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAA--RQFHSFIYPYMANGSLQDRLQGQGG-SDP
.|..| |. ||.|     |.. . |..    ....    . ..|.. |.|.  .  |||..   | |    .|.| ..  |.  | |...|   .  . |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDP--EYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLH-IVTEYINGGDLHQYLKDMDKHKIP

LPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQN----LTPKLA
|||||||.|  .  |. .|||   |||   || |.|...|     . |..
LPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVC
Kinase IRAK2.AA Pkinase 393-413 47 0.000671 14.87 Pfam 190-210 (293) Show / Hide 
Range on Protein: 393-413
Range on HMM: 190-210/293
Sequence Identity: 47% (10 aa)

TKRVDIFSCGIVLAEVLTGIP
...||..|||..|.|.|.| |
GPKVDMWSCGCILYEMLCGRP
Kinase IRAK2.AA LISK 395-414 50 0.006294 5.12 In-house 219-238 (296) Show / Hide 
Range on Protein: 395-414
Range on HMM: 219-238/296
Sequence Identity: 50% (10 aa)

RVDIFSCGIVLAEVLTGIPA
..|.|| |||| |  |.. |
SCDVFSFGIVLCEIITRVKA
Kinase IRAK2.AA MLK 383-411 35 0.0262 3.97 In-house 202-232 (291) Show / Hide 
Range on Protein: 383-411
Range on HMM: 202-232/291
Sequence Identity: 35% (11 aa)

PEDF--IRVGQLTKRVDIFSCGIVLAEVLTG
|| .  .| .. .. .|..| |.|| |.||.
PEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR