Gene ITK (Human)

ITK

Species: Human
Alias: MGC126258, ITK, PSCTK2, MGC126257, EMT, LYK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 5q33-q35,

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
ITK.NA RNA Sugen Kinome 4430 None Fasta, JSON
ITK.AA Protein Sugen Kinome 620 None Fasta, JSON
ITK.kin_dom Protein Kinase Domain Sugen Kinome 250 None Fasta, JSON

Protein domain

Protein domains of ITK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BTK ITK.AA BTK 113-149 54 7e-22 79.94 SMART 1-37 (37) Show / Hide 
Range on Protein: 113-149
Range on HMM: 1-37/37
Sequence Identity: 54% (20 aa)

NNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPT
||... ||||.|||||.|.||.| .|.|.||. ..| 
NNHRMQKYHPCFWMDGHWLCCQQTCKNAPGCCPCHPH
PH ITK.AA PH 5-111 24 6.4e-18 67.26 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5-111
Range on HMM: 1-92/92
Sequence Identity: 24% (26 aa)

ILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNY-LLYVFAPDRESRQRWV
. .| .| ||.      . ...| |.|||.   | |..|..    ..|||| || .........        .. ||... .   .|..|.. |....|.
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK---YRPKGSIPLSDCQVTKVPDN------KRPHCFQIRT-DRRTYYFQAESEEEMNDWM

LALKEETR
 |...  |
QAIQSACR
PH ITK.AA PH 5-113 26 7.1e-17 63.31 SMART 1-82 (82) Show / Hide 
Range on Protein: 5-113
Range on HMM: 1-82/82
Sequence Identity: 26% (29 aa)

ILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVL
...| .| |||         ..| |.|||.  .| |..|.     ..|||| || ....| .             |...| .  .|..... |..|.|. 
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK-----KPKGSIPLSDCTVRE-P------------CFEIHH-DRTYYFQCESEEEMQEWMQ

ALKEETRNN
|... ..||
AIQKAIHNN
BTK ITK.AA BTK 118-149 50 1.3e-16 66.33 Pfam 1-32 (32) Show / Hide 
Range on Protein: 118-149
Range on HMM: 1-32/32
Sequence Identity: 50% (16 aa)

PKYHPNFWMDGKWRCCSQLEKLATGCAQYDPT
.||||.|||.|.|.||.|..|.|.||. ....
QKYHPCFWMNGHWSCCHQTDKNAPGCQPCHHW
SH3_1 ITK.AA SH3_1 177-223 36 1.3e-18 65.68 Pfam 1-49 (49) Show / Hide 
Range on Protein: 177-223
Range on HMM: 1-49/49
Sequence Identity: 36% (18 aa)

IALYDYQTNDPQELALRRNEEYCLLDSSEI-HWWRVQDRN-GHEGYVPS
.|||||| ..|.|| ....... ... |.  .||.... | |.||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3 ITK.AA SH3 174-230 34 5.8e-18 66.93 SMART 1-58 (58) Show / Hide 
Range on Protein: 174-230
Range on HMM: 1-58/58
Sequence Identity: 34% (20 aa)

TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDR-NGHEGYVPSSYLVEKS
 .|.||||||  .|.|| ..... . .|. .. .||... . .| ||..||.|. |. 
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 ITK.AA SH3_2 175-229 17 3.3e-10 38.62 Pfam 1-68 (68) Show / Hide 
Range on Protein: 175-229
Range on HMM: 1-68/68
Sequence Identity: 17% (12 aa)

VVIALYDYQT-NDPQE-----LALRRNEEYCLL---DSSEIHWWRVQDR--NGHE--GYVPSSYLVEK
..... ||.  ....|     | .....  ...   | . ..||.....  .|..  |..||... | 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 ITK.AA SH2 239-323 34 6.4e-37 110.22 Pfam 1-81 (81) Show / Hide 
Range on Protein: 239-323
Range on HMM: 1-81/81
Sequence Identity: 34% (30 aa)

WYNKSISRDKAEKLLLD-TGKEGAFMVRDSR-TAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYH
|| ..||| .||.||.  ....|.|.||.|. | | ||.||...      .. .|||.|..|..    ||....  |.|.. |....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP----GDRVKHYRIQRTDNG--GYYITGRHKFCSLQELVEHY
SH2 ITK.AA SH2 237-329 37 8.9e-32 112.81 SMART 1-87 (87) Show / Hide 
Range on Protein: 237-329
Range on HMM: 1-87/87
Sequence Identity: 37% (36 aa)

YEWYNKSISRDKAEKLLLDT-GKEGAFMVRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAE--KYVFDSIPLLINYHQHNGGG
..||   |||..||.||.   ...|.|.||||.. .| |..||..|        ..|||.|....|  ..||..|  .. |.|.  |.|..||| .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-------GKVKHYRIRRNDD--GKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase ITK.AA Tec 363-614 72 4.5e-210 704.18 In-house 1-254 (254) Show / Hide 
Range on Protein: 363-614
Range on HMM: 1-254/254
Sequence Identity: 72% (183 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAET--LL
|||..|.||||||.||||.| ....||||.|.||.||||||||||.|||||||||||||||||..|.||..|.|.||||||..|||.... |....  ||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

GMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYE
.||.||||||||||..|.|||||||||||||...|.|||||||||.|||||||||.||||||||..||||..||||||||||.||||||||||.||.|||
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

NRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAE
|.|||||||..|.|.|||.|.|.|.|.||||.|||.|.||.||.|..||||..|
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase ITK.AA Pkinase_Tyr 363-612 45 3.3e-142 482.26 Pfam 1-270 (270) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-270/270
Sequence Identity: 45% (123 aa)

LTFVQEIGSGQFGLVHLGYWL-----NKDKVAIKTIREGAMSE----EDFIEEAEVMMKL-SHPKLVQLYGVCL-EQAP--ICLVFEFMEHGCLSDYLRT
.|| ...|.|.|| |..|.|      .| .||.|...||||.|    |||..||..|..| .||..|.|||||. .. |  |..|.|.|.||.| ||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Q---RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV-LDDQY-TSSTGTKFPVKWASPEVFSFSRYSSKSDVWSF
.   .. .  ..||.||.....||.|||.   ||||||||||||.|| |.|..|||..| .  ||.| ....|.|.|.|| .||.........|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLMWEVFSEGKIP-YENRSNSEVVEDI-STGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL
||||||.|. |..| |.. ||.||.| |   | |. .|....  .|..| .||.. ||||| || ...||
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ITK.AA TyrKc 363-612 41 6.5e-135 455.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-280/280
Sequence Identity: 41% (117 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKL--SHPKLVQLYGVCLEQ-------APICLVFEFMEHGCLSDYLRTQRGL
.|. ...|.|.|| |..| |    .||.|...|.|  .|||..||..|.||  .|| .|.|||||..|        |...|.|.|.||.| ||||  |. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDD--------QYTSST--GTK--FPVKWASPEVFSFSRYSSKSDV
.  ..|| .|.....||.||.. ..|||||||||||||||...|.||||..|.. ||         |....  |.|  .|..| .||.. ......||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGVLMWEVFSEGKIPYEN-----RSNSEVVEDISTGFRLYKPRL--------ASTHVYQIMNHCWKERPEDRPAFSRLLRQL
|||||.|||.|. |. ||..      ||.||.|.. .|.|. .|          ... .||||  ||.| ||||| || . ...
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ITK.AA Src 363-612 46 2.3e-118 399.53 In-house 1-255 (255) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-255/255
Sequence Identity: 46% (119 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR-TQRGL-FAAETLL
.......|.|||| |  ||| .. |||.||...| || |.| .||..| ||.|.|||||| || .  ||  | |.|.||.| |||. ...|     ..|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

GMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL--DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIP
 |   | |||||||.  .||||||||| ||||| | || |||  | .   || |....| |||.||  || ... |.. ||||||||.|..|... |..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YENRSNSEVVEDISTGFRLYKPRLASTHVYQ-IMNHCWKERPEDRPAFSRLLRQL
|.  .| ||.. .. |.|. .|.     .|. || .||...||.|| | .|   |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ITK.AA SFK-Src 363-616 46 6.7e-116 345.09 In-house 1-259 (259) Show / Hide 
Range on Protein: 363-616
Range on HMM: 1-259/259
Sequence Identity: 46% (120 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRT--QRGLFAAETLL
    .  |||||| |  | | |.  ||.|| . ||||.| | .|| || || ||.|.||| ||    ||  . | |  | | |||.    |.|    .| 
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSL-RMPQLV

GMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ--YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIP
 |  .|  ||||||.   .|||||||| |||.| |.|| |||| | . .|.  ||  .| |||.||  ||  . .|.| ||||||||.|| |.   | ||
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YENRSNSEVVEDIST--GFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIA
|.  .| ||.  .    | |. .|       |.||  ||...|.|||.|  |. |. .  
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase ITK.AA TK 363-612 24 4.7e-115 387.33 In-house 1-486 (486) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-486/486
Sequence Identity: 24% (118 aa)

LTFVQEIGSGQFG---LVHLGYWLNKD--------------------------KVAIKTIREG-AMSEEDFIE--------------EAEVMMKLS----
.|.....|.||||    |..| | ...                          .||.|...|| |||.|.|..              |||.|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLVQLYGVCLEQ------------APICLVFEFMEHGC----LSDYLRTQRGL--------------------------------------------
 || .|.|||||...             |...| |.|.||.    | ||||. |.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FAAETLLGMCLDVCEGMAYLEEA------CVIHRDLAARNCLVGENQV-----------IKVSDFGMT-
                               .  ..|| ||.....||.||..        ..|||||||||||||| |           .|..|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RFV-LDDQYTSST------------------------GTKFPVKWASPEVFS---------FSRYSSKSDVWSFGVLMWEVFSEG-KIPYENR
       | .  || |....                        |.|.|..| .||..          . ....|||||||||||||.|. | . .|.. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------SEVVEDISTG--------------FRLYKPRLAS--------------THVYQIMNHCWKERPEDRPAFSRLLRQL
||          ||.| . .|              .|. .| ...              . .|..|  ||.. ||||| || |..||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ITK.AA UTK 363-612 32 5.2e-97 328.58 In-house 1-296 (296) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-296/296
Sequence Identity: 32% (97 aa)

LTFVQEIGSGQFGLVHLGYWLN------KDKVAIKTIREGAM---SEE---DFIEEAE---VMMKLS-HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDY
. . ...|.|.|| ||.. . .      ...||.|. ...|.   ..|   ||.|||    .|.... ||....|.|||. . |...| |.|| | |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRTQRG-------LFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGEN-------QVIKVSDFG---MTRFVL---------DDQYTSSTG-TK
||..|        ..  ...|.|..|. .||.||..  ..|||||||||||...       .|.|..|||   |.| |          ...|  ... ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPVKWASPEVFSFS-RYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTG--FRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL
 |..| .||..    |...|||||||||..||... |. ||.. || .|.. .. |   |. .|.  .  ||..|. ||.  |..|| | .|. |.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ITK.AA Abl 363-612 43 7.9e-93 310.03 In-house 1-252 (252) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-252/252
Sequence Identity: 43% (109 aa)

LTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR-TQRGLFAAETLL
..  . .| ||.| |  |.|   |. ||.||..| .|  ..|..|| .| .. || |||| |||   .|  .. ||| .| | |||| ..| .  | .||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

GMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYE
 |   .  || |||.   ||||||||||||||....|| |||..|.. || ||   | |||.||  ||   . ..||||||| ||||.||.   |  || 
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

NRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL
    |.| . .  |.|. .|.   ..||..| .||. .. |||.|  . ...
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ITK.AA SrcB 363-613 44 3.1e-92 312.33 In-house 1-251 (251) Show / Hide 
Range on Protein: 363-613
Range on HMM: 1-251/251
Sequence Identity: 44% (113 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLG
| .|. .|.|||| | .||. |. |||.||...|.|| | |..|| || .| | .||.|| |     || .. |.|..||| |.|.|. |   . . |. 
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYEN
|   . |||||.|.   ||||| | | || |  . |. |||. | . |. ||   | |||.||  ||   |  .  ||||||||.|. |.   |.|||  
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

RSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLA
..|.||.. .. |.|. .|      .|.|| .|||||||.|| |  |   | 
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase ITK.AA Frk 363-616 41 4.7e-91 308.82 In-house 1-260 (260) Show / Hide 
Range on Protein: 363-616
Range on HMM: 1-260/260
Sequence Identity: 41% (109 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR--TQRGL-FAAETL
. .....|||||| |  | | |.  ||.||.. |.|  .||. || .| || ||||.||| ||  . || .. | |.|| | .||.  ...|     ..|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQ--YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGK
. |   |  ||||||.   ||||||||| ||||....|. |||. | .. |..  | | .| .||.||  ||    .... ||||||||.|. |.   |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIA
.||    | ||.. .. |.|. .|     ..|.|| .||.. |. || |  |  .| .  
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase ITK.AA Csk 363-612 43 9.8e-91 307.75 In-house 1-251 (251) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-251/251
Sequence Identity: 43% (110 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREG-AMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQA-PICLVFEFMEHGCLSDYLRT-QRGLFAAETL
|.  ..|| | || | .| ..|. |||.| |..      . |. || || .|.|| |||| || |.|   . .| |.|  | | ||||.  | ..  . |
LHLGECIGHGEFGDVMQGEYQNR-KVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQL

LGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS--TGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKI
|   .||||||.|||.  ..|||||||| || |  | |||||| ..   ......   |. |||.|| .|| .  ...|.||||||||.|.||..| | .
LKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK---EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRV

PYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL
||   . ..||. .  |.|   |     |||..|. ||   | .|| | ... ||
PYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase ITK.AA Src-Unclassified 363-612 36 7.4e-90 304.83 In-house 1-284 (284) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-284/284
Sequence Identity: 36% (104 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREG---AMSEEDFI--------EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQR
.  . ..| |||| | .| | .|  ||.|| |.|    || | |         .|| .| |..|..||.||.|| .  |.  . |.|  | | ..||.  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

-GLFAAETL------------LGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQ-----VIKVSDFGMT--RFVLDDQYTSSTGTKFPVKWASPEVFS
  .   . .              .   |  || |||.   .|||||||| |.|.|      | || |||    . . || |   || .||.||  || | 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKP--RLASTHVYQ-IMNHCWKERPEDRPAFSRLLRQL
    | ||||||.|.| ||..  |..||    | ||.| .. |.|. ||  ..    .|. ||  || ..|. || | .|   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase ITK.AA S_TKc 363-613 24 3.1e-53 184.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 363-613
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

LTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEH--GCLSDYLRTQRGL-----F
 .....||.| || |..... . . .|||| |.      |... | ....|  || .|.||.|. .   ...|.|....  | | ||.. ...      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS-KSDVWSFGVLMWEVFS
   .   ..  .|....|. .  .|||||   | |. |  .||..|||. |..     |.  || .   . .|||.    |.  |.|.||.|....| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPW---YMAPEVL---GYGKCKCDWWSCGCILYEMLC

EGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLR--------QLA
 |. |..     .. . |            |  . .....|..  ||.||    .|.        .  
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ITK.AA Pkinase 363-612 22 6e-43 152.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 363-612
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIREGAMSEEDFIE-----EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHG----CLSDYLR-TQR
..... |||| || | .... .  | ||.|.|.    ...  ..     |...| .|.||  |.||... .   |..|.|..|.|     |.||..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GLF--AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVI----KVSDFGMTR---FVLDDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDV
| |    ...  ... ...|..|. .  .|||||   |.|. .| .|    |..|||  .      .  .|. .|| .   ...|||    . |..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGVLMWEVFSEGKIPYENR-------SNSEVVEDISTGFRLYKPRLAS-------------------THVYQIMNHCWKERPEDRPAFSRLLRQ--L
||.|....|... |. |. ..        .  .... .. ..   | . |                       .... |..  |..|| .  .|    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF