Gene JAK3 (Human)

JAK3

Species: Human
Alias: JAKL, LJAK, JAK3, L-JAK, JAK-3, JAK3_HUMAN
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.11, Secondary Group: TK, Secondary Family: JakB,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
JAK3.NA RNA Sugen Kinome 5449 None Fasta, JSON
JAK3.AA Protein Sugen Kinome 1124 None Fasta, JSON
JAK3.kin_dom Protein Kinase Domain Sugen Kinome 276 None Fasta, JSON
JAK3.kin_dom2 Protein Kinase Domain Sugen Kinome 273 None Fasta, JSON

Protein domain

Protein domains of JAK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 JAK3.AA B41 20-254 20 3.8e-43 150.56 SMART 1-232 (232) Show / Hide 
Range on Protein: 20-254
Range on HMM: 1-232/232
Sequence Identity: 20% (53 aa)

STEAGALHVLLPARGPGPPQRLSFSFG-DHLAEDLCVQAAKASGILPVYHSLFALATEDL---SCWFPPSHIFSVEDASTQ-------VLLYRIRFYFPN
| .   ..|... ..      |.| ..    ..|||.....  ||.|..| .|.|. ||    ..| .  | ... .. ..       .|..|..||.|.
SPKPRFCRVYFMDGT-----TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLD--HWKTIMKQDVKWHKSEPWTLHFRVKFYPPD

WFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQR-------PGELLKTVSYKACLPPSLRDL
|.|           .  . ..|  .......| |.|...||.|.      . ||| ||.|.. ... .. .        . ...| .||| .||....| 
WHG-----------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDS

IQ---GLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETF
|.   . .. .. ..|. .... ...  |.  .. .. ||.  ..|..|.  .| |
IKQSFMHYQMHHKEWRKRIMEWHKNH--CGMTPEEAKLKYLQICQRWPPMYGVEHF
Kinase JAK3.AA SH2 373-463 25 4e-13 50.85 SMART 1-87 (87) Show / Hide 
Range on Protein: 373-463
Range on HMM: 1-87/87
Sequence Identity: 25% (23 aa)

AEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVG-LSRPHSSLRELLATCWDGGLH
 . .||.|. . | ..||..| ..|....| | ..  .. |.|...      .| ..|||...| . . .  .|...|| ||..      | 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase JAK3.AA Jak 314-380 14 0.095286 2.21 In-house 74-144 (299) Show / Hide 
Range on Protein: 314-380
Range on HMM: 74-144/299
Sequence Identity: 14% (10 aa)

EHRLVTVTRTDNQILEAEFPGLPEALSFVA----LVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPI
.|..... . |. ... |.  . ......     . ... ..| |....|.|...... ..|    .||..
YHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDV
Kinase JAK3.AA Jak 521-779 37 9.60000000001e-135 453.94 In-house 1-299 (299) Show / Hide 
Range on Protein: 521-779
Range on HMM: 1-299/299
Sequence Identity: 37% (111 aa)

LEWHENLGHGSFTKIYRGCRHEVVD-----GEARK--TEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVC--MAG-DSTMVQEFVHLGAIDM
|.|||.||.|.|...||.......|     .....  ..|..||.. .|......| ...|.|||.|. |.|..||||  ... ...||.|....|..|.
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLR----KRGHLVPA--SWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGA--DGSPPFIKLSDPGVSPAVLSLEML--TDRIPWVAPECLRE-A
||.    .. . |..  .||.|. ||......|||||...||.|.||..|..|||.  .. .||.||.||..|. ....||.  ..||||.|||||.. .
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

QTLSLEADKWGFG-ATVWEVF----------------SGVTMPISALDPAKKLQFYEDRQQLPAPK--WTELALLIQQCMAYEPVQRPSFRAVIRDLNS
..|.|..|||.|| .| ||..                .. ..|....|...||.|||....||.|.  |.|.. |.|||..|.| ||||||..|||||.
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK3.AA Pkinase_Tyr 521-777 26 2.1e-65 222.15 Pfam 1-270 (270) Show / Hide 
Range on Protein: 521-777
Range on HMM: 1-270/270
Sequence Identity: 26% (74 aa)

LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM--DAKHKN-CMESFLEAASLMSQV-SYRHLVLLHGVCM-AGDS---TMVQEFVHLGAIDMYL
..  . ||.|.| ..|.|  .   |..  |..|  |..  .| |.. |.|.|.. |..|.|  .  ..| |.|||.  |..    .| |.. .|  . ||
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RKR---GHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAV-------LSLEMLTDRIPWVAPECLREAQTL
||.   .. .. ...||   | | ...|||.|.. |  . || .|...      . ..| .| | . ..        . .     |.| ||||...    
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-F

SLEADKWGFGATVWEVFSGVTMP-ISALDPAKKLQFY-EDRQQLPAPK--WTELALLIQQCMAYEPVQRPSFRAVIRDL
. . | | || . ||.|.   .|    ....  ...  ||....|.|.  . |.  |..||..|.| .||.|......|
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK3.AA TK 521-777 15 8.4e-47 154.48 In-house 1-486 (486) Show / Hide 
Range on Protein: 521-777
Range on HMM: 1-486/486
Sequence Identity: 15% (77 aa)

LEWHENLGHGSFT---KIYRGCRHEVVD-------------------GEARKTEVLLKVMDAKHKNCMES--------------FLEAASLMSQVS----
..  . ||.| |    ..|.|  ..  .                   .|  ||.|  |.. ... . .|               ||| |. |.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-YRHLVLLHGVCMAGD-------------STMVQEFVHLGA----IDMYLRKRGHL--------------------------------------------
   ..| |.|||. |.               .| |....|      . ||||. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPASWKLQVVKQLAYALNYLEDK------GLPHGNVSARKVLLAREGA-----DGSPPFIKLSDPG---
                               ..  ..|    |.| .. ||..|      .. |... || .|.....      ||..|..|..| |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----VSPAVLSLE------------------------------MLTDRIPWVAPECLREAQ--------TLSLEADKWGFGATVWEVFS-GVTMPISAL
      . .. | .                                   | | |||||.. .        . . . | | || ..||.|. | ...   .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DP------------AKKLQF---------------YEDRQQLPAPKW------------TELALLIQQCMAYEPVQRPSFRAVIRDL
.              ..|.                ..  |   .| |            .|...|.||| .|.| .||.|... . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK3.AA Ack 521-777 28 7.5e-18 56.81 In-house 1-266 (266) Show / Hide 
Range on Protein: 521-777
Range on HMM: 1-266/266
Sequence Identity: 28% (80 aa)

LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAK---HKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDS-TMVQEFVHLGAIDMYLRKRG
.  .| || |.|    ||       |.    .|  |.         |||..||  .. | .   .||| |.||  . ..  || |. ..|.    |||  
ITLCEKLGDGCFGVVWRGEWTN-PGGK--HIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRK--

HLVPASWKLQVV----KQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLE----MLTDR-----IPWVAPECLREAQTLS
|. .|   . .      |.| .. ||| |.. |  . || .||..         .| .| | . | .  |    |   |     ..| ||||||   . |
HCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDD-----RKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRH-RQFS

LEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYE-DRQQLPAPKW--TELALLIQQCMAYEPVQRPSFRAVIRDL
   | | || | ||.||.  .|  .. ..  ||  . ... || |.    ..  .  || . .|  ||.| |.  .|
HASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK3.AA EGFR 521-718 28 5.3e-17 52.83 In-house 1-196 (258) Show / Hide 
Range on Protein: 521-718
Range on HMM: 1-196/258
Sequence Identity: 28% (58 aa)

LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVM-DAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLV
|     || | | ..|.|    . .||  |  |  ||. ..  ..  | .|. |  |  |   ||| | ||||. . ..|  .  .|..  |.|.    .
LKKVKVLGSGAFGTVYKGIW--IPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNI

PASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSP--AVLSLEMLTDR----IPWVAPECLREAQTLSLEADKWGFGA
 .   |    | |  ..|||.. . | .  || ||.       ||  .|  | |..    . . |.  .     | |.| ||... .    . | | .| 
GSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVK------SPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHH-RCYTHQSDVWSYGV

TVWEV
|.||.
TCWEL
Kinase JAK3.AA TyrKc 521-777 20 1.8e-16 43.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 521-777
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQV--SYRHLVLLHGVCMA--------GDSTMVQEFVHLGAIDM
..  . ||.| | ..|.|            ..|  |.. . .   .| |.. |..|...  .  ..| |.|||.         .   .| |.. .|. . 
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSL-------EMLT------DR--IP--WVAP
||||... .. . .|.   | |   .||..|.. |    || .|.....       .| || | | .. .        .. .       .  .|  | ||
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ECLREAQTLSLEADKWGFGATVWEVFSGVTMPISA-----LDPAKKLQFYEDRQQLPAPKW----------TELALLIQQCMAYEPVQRPSFRAVIRDL
||.    . . . | | || . ||.|.   .| .      ....  ... ...  .| |.           .|.  ...|| ...| .||.|.......
ECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase JAK3.AA TKL 527-777 14 1.3e-15 52.66 In-house 1-364 (364) Show / Hide 
Range on Protein: 527-777
Range on HMM: 1-364/364
Sequence Identity: 14% (53 aa)

LGHGSFTKIYRG-CRHEVVDGEARK----TEVLLKVMDAKHKNC---------------------------MESFLEAASLMSQVSYRHLVLLHGVCMAG
.| |.| ..|.| .| . .  .  .    ..|  |..  .. ..                           .. . | . .||. .  ..|.. |.|...
IGSGGFGEVYKGKWRGWGG-KC--PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCP

DS--------------TMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLED--------KGLPHGNVSARKVLLAREGADG--------SP
..               .| |... |    ||         . ... ... | ..|||          ... | .   . .|. . . .         ..
PCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

PFIKLSDPGVSP---------------------AVLSLEMLTDRI---PWVAPECLREAQ---------------TLSLEADKWGFGATVWEVFSGVTMP
 ..|..| | |                      . .. ...  ..    | |||.||...               . |  .| . ||   ||.... . |
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-P

ISALDP----------AKKLQFYEDRQQLPAP--------------KWTELALLIQQCMAYEPVQRPSFRAVIRDL
 . ...          .   . .......| |               ..... |.|.|....| .||||  ..  |
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK3.AA UTK 521-721 21 3.8e-13 41.32 In-house 1-236 (296) Show / Hide 
Range on Protein: 521-721
Range on HMM: 1-236/296
Sequence Identity: 21% (50 aa)

LEWHENLGHGSFTKIYRGCRHEVV--DGE-ARKTEVLLKVMDAKHKNC-MES-FLEAAS---LMSQVS-YRHLVLLHGVCMAGDSTM-VQEFVHLGAIDM
..  . ||.| |  .... . ..    .| ...  |. .  || .. .     |.| |    .|.|..  .... | |||...  .| | |.   |  . 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPY-PDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

YLRKRGH-------LVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPP--FIKLSDPG---VSPAVLS-----------LEMLTDR
|||. ..       ..    .|. . . | ...||. .|. |... || .|... . ..     ..|..| |    | .| .           ..| ...
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

IP----WVAPECLREAQTLSLEADKWGFGATVWEVFSG
 .    | |||.| .. . ..  | | || ..||....
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase JAK3.AA Frk 521-781 21 9.9e-13 40.1 In-house 1-260 (260) Show / Hide 
Range on Protein: 521-781
Range on HMM: 1-260/260
Sequence Identity: 21% (59 aa)

LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDS-TMVQEFVHLGAIDMYLR---KRG
..    || | | ... |           .| | .| . .   .  . ||  | .| .. .  |. |. ||   .   .. | .. |..  ||.   ..|
IQLIRRLGSGQFGEVWEGLWNN-------TTPVAVKTLKPGTMDPND-FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG

HLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEM------LTDRIP--WVAPECLREAQTLSLEADK
. .     ...  |.|  . |||..   |  . || ||.  .        .|. | |.   ..  .          |.|  | |||  .  .  .. .| 
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNI------CKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNK-FTIKSDV

WGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELAL--LIQQCMAYEPVQRPSFRAVIRDLNSLI
| ||  . |.     || . .  |. ||  .    .| |   .  |  ....|   .| .|| |  .   |.  .
WSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK3.AA S_TKc 521-781 18 2.4e-12 4.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 521-781
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHL--GAIDMYLRKRGHL
 | .. .|.|.| | |..  ..       . .| .|...       |...   .....    ..| |..|.  ..  || |..    |    |..|||. 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH

-----VPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRI---PWVAPECLREAQTLSL-EADKW
      |  .   ...|.. ||.|. ..|  |  .    .|| .         ||..| |..  .      |  .    ..||| |      .  ..| |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWW

GFGATVWEVFSGVT-MPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIR-----DLNSLI
 .| ...| ..| .  |       ||.               |.  .|..|. ..| .||.   . .      .   .
SCGCILYEMLCGYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK3.AA Syk 521-659 28 1.2e-11 36.33 In-house 1-143 (257) Show / Hide 
Range on Protein: 521-659
Range on HMM: 1-143/257
Sequence Identity: 28% (41 aa)

LEWHENLGHGSFTKIYRGCRHEV-VDGEARKTEVLLKVMDAKHKN--CMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGH
|.  . .|.| |  .  |   .    || .  .| .|.  | | .    . |.  |..| |    . | . |.| |    ||.| . ||.   || . .|
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

LVPASWKLQVVK-QLAYALNYLEDKGLPHGNVSARKVLLAREG
 ..|.  | ..  | |    ||| |   |    || |||  ..
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRH
Kinase JAK3.AA TK-Unique 521-720 23 9.2e-10 29.96 In-house 1-234 (294) Show / Hide 
Range on Protein: 521-720
Range on HMM: 1-234/294
Sequence Identity: 23% (56 aa)

LEWHENLGHGSFTKIYRGCRHEVVD--GEARKTEVLLKVMDAKHKNCME--SFLEAASLMSQVS-YRHLVLLHGVCMAGD--STMVQEFVHLGAIDMYLR
||  ...| |.|  ..||   ||.   ..  |. . . .|  .. .. .   ||  ...|...    ..| . |.|.  |    .. |... |  . |||
LEVGDVIGEGAFGQVWRG---EVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

KRG----------------HLVPASWKLQVVK---------QLAYALNYLED--KGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSP-----AVLSL
...                | .|..  .  ..         |.| ...||.   |.  |....|| |||..         .|..| | ..      |.| 
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE------DKVCKICDFGMARDVYTNGVYSM

EMLTDRIP--WVAPECLR-EAQTL-SLEADKWGFGATVWEVFS
.    |||  | ||| |.   ..  . . | | || . ||.|.
MCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase JAK3.AA Pkinase 688-777 16 3.4e-05 19.43 Pfam 175-293 (293) Show / Hide 
Range on Protein: 688-777
Range on HMM: 175-293/293
Sequence Identity: 16% (20 aa)

IPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISAL----DPAKKLQFYEDRQQ----LPAPKW---------------------TELALLIQQ
....||| .|..|  . ..| |..| ...|...|   | .      . . ..| .. . .     . |.|                      |.  .|  
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR-PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CMAYEPVQRPSFRAVIRD--L
| .. | .||... .  .  .
CLCKDPKKRPTAEQILQHPWF
Kinase JAK3.AA TK-Unique 755-777 43 0.000117 12.13 In-house 272-294 (294) Show / Hide 
Range on Protein: 755-777
Range on HMM: 272-294/294
Sequence Identity: 43% (10 aa)

LIQQCMAYEPVQRPSFRAVIRDL
|...|  .|| .|||||...  |
LMKSCWQWEPEERPSFRQIKHRL
Kinase JAK3.AA Syk 690-720 48 0.001632 7.94 In-house 175-204 (257) Show / Hide 
Range on Protein: 690-720
Range on HMM: 175-204/257
Sequence Identity: 48% (15 aa)

WVAPECLREAQTLSLEADKWGFGATVWEVFS
| ||||     . |   | |.|| | || ||
WYAPECI-YYYKFSHKSDVWSFGVTMWEMFS
Kinase JAK3.AA UTK 755-777 30 0.001853 7.7 In-house 274-296 (296) Show / Hide 
Range on Protein: 755-777
Range on HMM: 274-296/296
Sequence Identity: 30% (7 aa)

LIQQCMAYEPVQRPSFRAVIRDL
| ..|..|.|  ||.|. .   .
LMHRCWHYDPQERPDFEDLVQQM
Kinase JAK3.AA Src 755-777 34 0.201138 0.54 In-house 233-255 (255) Show / Hide 
Range on Protein: 755-777
Range on HMM: 233-255/255
Sequence Identity: 34% (8 aa)

LIQQCMAYEPVQRPSFRAVIRDL
...||   .| ||| |      |
IMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK3.AA Jak 822-1097 39 4e-153 515.01 In-house 1-299 (299) Show / Hide 
Range on Protein: 822-1097
Range on HMM: 1-299/299
Sequence Identity: 39% (117 aa)

LKYISQLGKGNFGSVELCRYDPLG------DNTGA--LVAVKQLQHS-GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRD
||....||.|.||.|..||||...      |...   .|.||..||. .|....||.|||.|.. .....||||.||...........||||...|.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

FLQ----RHRARLDA--SRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAH---VKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNI
.|.    ||. ....  ...... .|||.||.||...|..|.|..||||||..|.|   |||..|.|.. .. ||.||.........|.|||||.|... 
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FSR--QSDVWSFG-VVLYELF-TYCDKSCSPSAEFLRMMGCERDV-PALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDM
|..  ..|.|||| |.|.|.. .|||.|.||.|.||.|.||..   . .||.|...|.|.|||.|. |..|...||..||...|..|||| .. ..|..
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK3.AA Pkinase_Tyr 822-1095 41 5.4e-122 413.78 Pfam 1-270 (270) Show / Hide 
Range on Protein: 822-1095
Range on HMM: 1-270/270
Sequence Identity: 41% (117 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQ--QRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQ-SLRLVMEYLPSGCLRDFLQR
.. . .||.|.||.| ........|||.  |||| | ... ..|  ..|| ||..|.| | | . ||.. || .  |.. .. .|||| | |.|.|.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYY-VVREPGQSPIFWYAPESLSDNIFSRQSDVWS
|   . .|. ..|| .. ||.|||||| |..|.||||||||.||... .|||.|||||...  ..||| ..|. |  ||.|.|||......|. .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELL-EEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQL
|||...|.|||...      ..  |   |        ..|.. |.|.|.|.|. ||.|...|||.||.. |.|||.||..  ||
FGVLMWEIFTYGEQP-----TYPGMSNEE--------VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK3.AA TyrKc 822-1095 37 1.1e-107 364.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 822-1095
Range on HMM: 1-280/280
Sequence Identity: 37% (112 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKAL--HSDFIVKYRGVSYGPGR-----QSLRLVMEYLPSGCLRDFL
.. . .|| |.|| | .....         |||| |...    ..|| ||..|.. |  | . ||.  ||   .||     . | .|||| | |.|.|.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD------KDYYVVRE--PGQ--SPIFWYAPESLSDNIF
..|| .|  . || .. ||..||||| |..|.||||||||.|| .. .|||.||||.. .  |      ||||...|   |    || |.|||.. ...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPA--------CPAEVHELMKLCWAPSPQDRPSFSALGPQL
. .||||||||...|.|||...  .  ..   ||  .       ...|....| |.| ||         ||.|....|| ||.  | |||.||..  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQ-------EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase JAK3.AA TK 822-1095 21 2.2e-93 313.42 In-house 1-486 (486) Show / Hide 
Range on Protein: 822-1095
Range on HMM: 1-486/486
Sequence Identity: 21% (108 aa)

LKYISQLGKGNFG---SVELCRYDPL---------------------GDNTGALVAVKQLQHSGPDQQRDFQR-----------------EIQILK--AL
.... .||.|.||    | .... ..                     ....   ||||.|    ...|..|.                  |.....  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HSDFIVKYRGVSYGPGR----------QSLRLVMEYLPSGC----LRDFLQRHRAR--------------------------------------------
| . ||.  ||.  ..           . . .|||| | |.    |||.|...| .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDASRLLLYSSQICKGMEYLGSR------RCVHRDLAARNILVESEAH-----------VKIADFG---
                               |.  .|| .. ||..||||| |.      ..|||||||||.|| .. .           .||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLPLDKDYYVVREPG-----------------------QSPIFWYAPESLSDNI---------FSRQSDVWSFGVVLYELFTYCDKSCSP--
     ||. .. |.|||.....|                       . || |.|||.| |..         |. .||||||||...|.|||...   .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

-------SAEFLRMMGCERDVPALCRLLELL-----------EEGQRLPAPPACP--------------AEVHELMKLCWAPSPQDRPSFSALGPQL
       .         . |.  ....|.             ... |.|.|| ||              .|...||. ||.. |.|||.||.|  ||
SNQDVWKD---------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK3.AA EGFR 822-1023 40 5.2e-62 204.61 In-house 1-199 (258) Show / Hide 
Range on Protein: 822-1023
Range on HMM: 1-199/258
Sequence Identity: 40% (83 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR
|| .  || | || |    . | |.|    ||.| | ...|| .. .. .|  ..  . .. .|.  ||  .   ....||  |.| ||| |... |. .
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMH---SQMQLVTQYMPYGCLLDYVRQHKDN

LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
. .  ||... || |||.||  .| |||||||||.|| | .||||.||||||||. |.. | . . |  || | | |...  ..  ||||||.|| . ||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

FTY
 |.
MTF
Kinase JAK3.AA UTK 822-1023 32 3.9e-59 200.94 In-house 1-236 (296) Show / Hide 
Range on Protein: 822-1023
Range on HMM: 1-236/296
Sequence Identity: 32% (78 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGA-LVAVKQLQHSGPDQQR-----DFQREIQ---ILKALH-SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLR
..   |||.|.|| | ..|...  .  .  .||||..||....||      || .| .   ..|..|    ...  ||    .   . .|.|| . | ||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

DFLQRHRA----RLDASR---LLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE-------AHVKIADFG---LAKLLP-------LDKDYYVVREP-
..|.|||     . .. .   .| ....|  ||.|| |...|||||||||.|| .          .||||||   ......        . .||. . . 
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GQSPIFWYAPESLSDN-IFSRQSDVWSFGVVLYELFTY
.. || |.|||.| ..  |...|||||||||..|..|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase JAK3.AA TK-Unique 822-1023 31 8.1e-54 183.95 In-house 1-235 (294) Show / Hide 
Range on Protein: 822-1023
Range on HMM: 1-235/294
Sequence Identity: 31% (74 aa)

LKYISQLGKGNFGSVELCRYDPLG--DNTGALVAVKQLQ-HSGPDQQRDFQREIQILKALH-SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH
|.  ...|.|.|| |  . . ..   ..    ||||.|. .. . ...|| .|||..|.|     ||.  |..  .. ..  ..|||.| |.|...|.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

RAR-------------------------LDASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSP
|                           ..  .|. .  ||..||||| |  ...|||||.|||.|. .   .||.|||.|. .  ...|   .. |  |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

IFWYAPESLS--DNIF-SRQSDVWSFGVVLYELFTY
| | |||||.  .... . .||||||||...|.||.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL
Kinase JAK3.AA S_TKc 822-1098 24 1.2e-53 185.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 822-1098
Range on HMM: 1-231/231
Sequence Identity: 24% (73 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPS--GCLRDFLQRHRA
 . . ..||| ||.| .||       || .||.|..        ....|||||||  | ..|||. .| .    ..| .||||..   | |.|...... 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

R-----LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSR-QSDVWSF
.     ..  .   |  |||...||. |.. .||||   |||. .  |.||.|||||..|                 .. ||| |    ...  .|.||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLYELFT----YCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGP------QLDML
|..|||...    ..       .. ....|                           . |. .... |.   |..||.   .        .   .
GCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK3.AA Syk 822-1023 38 6.1e-53 180.57 In-house 1-205 (257) Show / Hide 
Range on Protein: 822-1023
Range on HMM: 1-205/257
Sequence Identity: 38% (80 aa)

LKYISQLGKGNFGSVELCRYDPL---GDNTGALVAVKQLQ--HSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR
|    ..|.||||||    |      |.     ||.| |   |. | ..  | || |.   |   .||.  |.  ..   .. .|||  . | . ..|| 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAE---MMMMVMEMAELGPMHKYLQQ

HRARLDA-SRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGV
||    | . | |  .|.  || || ..  |||||||||.| . .   || |||. | | .| .||. .  |  |. |||||.    .|| .||||||||
HRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGV

VLYELFTY
 . | | |
TMWEMFSY
Kinase JAK3.AA Src 822-1023 37 9.1e-52 174.14 In-house 1-196 (255) Show / Hide 
Range on Protein: 822-1023
Range on HMM: 1-196/255
Sequence Identity: 37% (78 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVK-YRGVSYG-PGRQSLRLVMEYLPSGCLRDFLQ--RH
.| . .||.|.|| |    .     |    |||| |      .. .|..|.||.| |  . .|. |  .| . |       | ||   |.| |.|.  . 
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEP----IYIVTEYMSHGSLLDYLKKDGE

RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVL
  .|   .|.  . |. .||.||.|.. .||||||||.||  .  .|.||||||.|.  |.| |. |.    || | ||| .. . |.  |||||||. |
GRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILL

YELFTY
.|..||
TEIVTY
Kinase JAK3.AA Ack 822-1023 38 1.5e-51 172.2 In-house 1-207 (266) Show / Hide 
Range on Protein: 822-1023
Range on HMM: 1-207/266
Sequence Identity: 38% (80 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS---GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHR
..   .|| | ||.|     .    ..   |||| |       |  . || || .|. .|    .|.  ||  .     |..|.|  | | | | |  | 
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM--LMMVTELAPCGSLLDCLRKHC

A--RLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE-AHVKIADFGLAKLLPLDKDYYVVREPG--QSPIFWYAPESLSDNIFSRQSDVWSF
    .  ..|. .. ||..|| ||...||.||||||||||. |    |||.||||   |.. .|||.  ..     |. | |||.|    ||  ||||.|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF

GVVLYELFTY
|| | | |.|
GVTLWEMFSY
Kinase JAK3.AA TKL 828-1095 21 1.7e-51 177.36 In-house 1-364 (364) Show / Hide 
Range on Protein: 828-1095
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGKGNFGSVELCRYD------PLGDNTGALVAVKQLQHS------------------------GPDQQRDFQREIQILKALH---SDFIVKYRGVSYGPG
.|.| || |   ..       | . .||  ||||..                            |.... ...|.. .. ..    . ||.. |..  |.
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

-----------RQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR--------CVHRDLAARNILVESEAH-------------
              | .|||| | |.|...|.        ....  . .|..||.|| |..         .||||  .|||| .  .             
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKIADFGLAKLLPLDKD---------------YYVVREPGQS-PIFWYAPESLSDN----------------IFSRQSDVWSFGVVLYELFTYCDKSCS
 .||.||||.. .  ...                .  .   |   . | ||| | ..                 .| ..||.|||.||.|..| |     
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

PSAEFL-RMMGCERDVPALCRLLELLEEGQRLPAP------------PACPAEVHELMKLCWAPSPQDRPSFSALGPQL
| ...  ..| . . .     .    ..|.|.| |            | || .. .||. ||.. |..||||. .  .|
PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK3.AA Frk 822-1023 37 2.8e-43 147.71 In-house 1-198 (260) Show / Hide 
Range on Protein: 822-1023
Range on HMM: 1-198/260
Sequence Identity: 37% (78 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ---RH
...| .|| | || |   ..     |  . ||||.|. .|    .|| || ||.| | |.  |  |         . . .. | .  | | ..||   ..
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLK-PGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTV---EEPIYIITELMRHGSLQEYLQAINDK

RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAK-LLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVV
  ..    |.  . |.  || || |.  .||||||||.||. .  .||||||||. |.  ..| |  |   . || | |||    | |. .|||||||..
GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGIL

LYELFTY
|.|. ||
LTEIITY
Kinase JAK3.AA Pkinase 822-1022 28 9.5e-38 134.56 Pfam 1-207 (293) Show / Hide 
Range on Protein: 822-1022
Range on HMM: 1-207/293
Sequence Identity: 28% (61 aa)

LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRD--FQR--EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSG----CLRDF
.. ....|.|.||.| .|.    |.    .||||..  .. . . |    |  ||||.| |....||..... .   .... .||||.. |     | |.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

LQ-RHRARL--DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV----KIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLS-DNIFS
.. . . ..  .   .  |  ||..|.||. |....||||   |||. .. |.    ||.||||||..      ..        ... ||| .  ..  .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RQSDVWSFGVVLYELFT
. .|.||.|..|||...
PKVDMWSCGCILYEMLC
Kinase JAK3.AA Ack 1051-1095 45 1.5e-18 59.19 In-house 221-266 (266) Show / Hide 
Range on Protein: 1051-1095
Range on HMM: 221-266/266
Sequence Identity: 45% (21 aa)

LELLE-EGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQL
|.... ||.||| |..|| .. ..|. ||.. |.|||.|||.  ||
LQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK3.AA UTK 1049-1095 36 4.6e-16 51.44 In-house 248-296 (296) Show / Hide 
Range on Protein: 1049-1095
Range on HMM: 248-296/296
Sequence Identity: 36% (18 aa)

RLLELLEEG--QRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQL
.... ...|  .|.|.|..||..| .||. ||...||.||.|  |  |.
QVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase JAK3.AA Syk 1050-1089 37 8.9e-16 50.77 In-house 218-257 (257) Show / Hide 
Range on Protein: 1050-1089
Range on HMM: 218-257/257
Sequence Identity: 37% (15 aa)

LLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFS
.....| | |.. |. ||.|. .||..||   . ||| |.
VMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase JAK3.AA Src 1051-1095 41 6.8e-15 46.98 In-house 210-255 (255) Show / Hide 
Range on Protein: 1051-1095
Range on HMM: 210-255/255
Sequence Identity: 41% (19 aa)

LELLEEGQRLPAPPACPAEVHE-LMKLCWAPSPQDRPSFSALGPQL
|. .| | |.| |. ||.|..| .|. ||  .|..|| |  |   |
LQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK3.AA TK-Unique 1048-1095 36 2.6e-13 42.36 In-house 246-294 (294) Show / Hide 
Range on Protein: 1048-1095
Range on HMM: 246-294/294
Sequence Identity: 36% (18 aa)

CRLLELLEEGQRLPAPPAC-PAEVHELMKLCWAPSPQDRPSFSALGPQL
....|....| |.| |. | . |...||| ||  .|..||||...  .|
KDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase JAK3.AA Frk 1051-1099 36 3.3e-11 34.75 In-house 212-260 (260) Show / Hide 
Range on Protein: 1051-1099
Range on HMM: 212-260/260
Sequence Identity: 36% (18 aa)

LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLW
|. ...| |.| || || .. |.|  ||   |. || |  |  .|.  .
LQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK3.AA EGFR 1052-1096 40 4e-09 26.27 In-house 214-258 (258) Show / Hide 
Range on Protein: 1052-1096
Range on HMM: 214-258/258
Sequence Identity: 40% (18 aa)

ELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLD
.|||.|.||| || |   |  .|  ||   .. || |  |  ...
DLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK