Gene KHS2 (Human)

KHS2

Species: Human
Alias: MAPKKKK3, MAP4K3, GLK, KHS2, RAB8IPL1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2p22.1,

Classification

Group: STE
Family: STE20
Subfamily: KHS

Sequence

Name Sequence Type Origin Length Description Download
KHS2.NA RNA Sugen Kinome 4172 None Fasta, JSON
KHS2.AA Protein Sugen Kinome 894 None Fasta, JSON
KHS2.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of KHS2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KHS2.AA KHS 16-273 90 4.2e-206 690.99 In-house 1-258 (258) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-258/258
Sequence Identity: 90% (234 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAY
.||.||.||||||||||||.....||||.||||.|||.||||.||||.|||||.||||||||||||||||||||||.|||||||||||||||||||||||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMF
|.|||||||.||||.||||||||||||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

DLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
||||||||||||||||||||||||.|||..||||||||||||||||||||||||||||
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase KHS2.AA STE20 16-273 52 3.7e-169 568.28 In-house 1-288 (288) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-288/288
Sequence Identity: 52% (152 aa)

FELIQRIGSGTYGDVYKARNVNTGEL----AAIKVIKLEPG----EDFAVVQQEIIMMKDCKHPNIVAYFGSYLRR----DKLWICMEFCGGGSLQDIYH
.||...||.|.||.||||... |||.    .|||...||.     ...  .|.|| .||.|||||||.|.||||.     |.|||.||.||||||.||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---VTG------PLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITA----TIA-KRKSFIGTPYWMAPEVAAVER--
   ..|      |..| ||||. ||.|||| ||||....|||||..|||||..| ||||||||.||.|     |.. ||..|.|||||||||| . ..  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKD--KMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
..||.. || |..||||||.|| .||.||.|||||.|...|.. .||.|||  . ||| .||.||.  |.|.|.|||||..||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase KHS2.AA STE 16-273 36 2.3e-136 459.34 In-house 1-359 (359) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-359/359
Sequence Identity: 36% (133 aa)

FELIQRIGSGTYGDVYKARNVN---------------TGELAAIKVIKLEPG-----------------EDFAVVQQEIIMMKDCK--HPNIVAYFGSYL
.|.|..||.|..| ||||.|..               |||. |||...||.                  |..  ...|| .||.|.  ||||| |.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

R-------RDKLWICMEFCGGGSLQDIYH---VT-----------GPLSELQIAYVSRETLQG-LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSA
.       .|.||||||...|||| ||..    .           ....| ||||. |..|.| ||||||....|||||.|||||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QITATIA----------------KRKSFIGTPYWMAPEVAAVER---KGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSN----------
|.| ..|                ||..|.||| ||||||   ..   ..||.  || | .|.|.||.|. .||..|.|||||.|......          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---FQPPKLKD-----------------KMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ--HPFV
   ..||.|.|                 . ||| .|..|..  |.|.|.|||||..||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase KHS2.AA YSK 16-273 48 4.3e-127 384.85 In-house 1-257 (257) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-257/257
Sequence Identity: 48% (127 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVT--GPLSELQ
|    .|| | .|.|||. .. |..  |||.| ||  ||    .||||    .|. |.|  |.||||.  |||| ||.|||||. |       |.. | .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERK-GGYNQLCDLWAVGITAIELAELQ
|| . || |.|| ||||  | ||||| ||.||. .| |||.||||..||| |  ||  |.||||||||||  .     .|.   | | .||||.|.|  .
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEV--ICQEVSYYDFKADIWSLGITAYEMAKGE

PPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
||  |.||||..||  |.|  ||||... ..| .|  || . | |.|..||.|. || | |.
PPYCDYHPMRVMFLIPKNN--PPKLEGR-SYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase KHS2.AA MST 16-273 49 5.6e-126 402.45 In-house 1-254 (254) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-254/254
Sequence Identity: 49% (130 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYL--RRDKLWICMEFCGGGSLQDIYHVTG-PLSELQ
|... ..| | || |||| .  ||.. |||... .  ||.     || .|..|| ..|| |.|||.      .||.||.||.||. ||   |. .|.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN--EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQP
|| ... |||||.|||.  |.||||| .||||   |. ||||||||.| | | ||| ..|||||||||||     . .|.   | |. ||||||.||  |
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVI---QEIKYDCKADIWSLGITAIEMAEGMP

PMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
| .|.|||||.|.  ..   ||..||  .||  |  ||.  |.||| .|.||| ||||||.
PYSDIHPMRAMFMIPQKP--PPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase KHS2.AA PAKA 16-273 42 1.2e-101 344.0 In-house 1-260 (260) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-260/260
Sequence Identity: 42% (113 aa)

FELIQRIGSGTYGDVYKARNVNTGEL--AAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG-----PL
.. .. || |  | ||.| |. |..    |||.....       .  || .||.|||.||| |  |||  |.||. ||. .||.| |.   .      ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

SELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELA
.| ||||| ||.|||| ..|||.  |||||  ||||  .| ||..|||  ||.|    ||..  ||||||||||  . ||  |..  | |  || |||..
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEV--IRRK-QYDEKVDIWSLGIMAIEMI

ELQPPMFDLHPMRALFLMTKSNFQ-PPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
| .||  .  | ||..| ..   .  |..||. ||| .|. |..  | .....|..|..||.||| 
EGEPPYLNEPPLRAMYLIAT---NGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase KHS2.AA MSN 16-273 50 3e-100 331.76 In-house 1-265 (265) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-265/265
Sequence Identity: 50% (134 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLR------RDKLWICMEFCGGGSLQDIYHVT--GP
|||.. .| |||| ||| | | ||.||||||....  |.  . |   .. |   | ||..|.| ...      ...||. ||||| ||. |. . |    
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVER--KGGYNQLCDLWAVGITAI
| |  |||..|| |.||..||..  .|||||| |.|||.|  ||| |||||||.  |. .| .|||||||||||| | .   .  | .  |||.||||||
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

ELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
|.|| |||. |.||||||||. .    |||||   |||  ||.|.   | || ..||..|..|.|||.
EMAEGQPPLCDMHPMRALFLIPRN--PPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase KHS2.AA S_TKc 16-273 31 6.4e-98 332.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGG--GSLQDIYHVTGP------
.|... ||.|..| |||.|...||.. |||.||         ...|| ..|  .||||| .....   |.|...||.|.|  |.| |. .  |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQ-LCDLWAVGITAIE
..| ..... ......| |.||.| .|||.| .||||..  |.|..|||...|.       ..|.|||..|||||       ||.   || |..|.. .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYE

LAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ-------HPFV
..  .||    .... . ..                | .. .|..  |.|.|.||||| ..||       ||..
MLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KHS2.AA SLK 16-273 42 3.3e-93 314.81 In-house 1-259 (259) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-259/259
Sequence Identity: 42% (112 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIY-HVTGPLSELQIA
.|.|  .| | .| ||||.. ... .|| |.|... .|.      || .. .|||||||  ...|   .|||. .|||.|| .  |   .  || | ||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDLWAVGITAIELAELQP
||.......| .|||.  .|||.|  |||.| .|.|.||||||||. . |. || .|||||||||||| . |  .   |    |.|..||| ||.|.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
|  .. ||| |. . ||  .||.|.   .||..|. |.| .| |.|..|.|...|.||..|
PHHEMNPMRVLLKIQKS--EPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase KHS2.AA PAKL 16-273 43 2.7e-90 306.3 In-house 1-256 (256) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-256/256
Sequence Identity: 43% (114 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRR-DKLWICMEFCGGGSLQDIYHVTG-PLSELQI
||.    | | || ||||    |.   ||||| . .  .   .. || . | || |||| ||||     ...|| |..|  ||  |.  ...  | | ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

AYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIA-KRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQP
. . . || || |||||.  ||||| |||||.  . ||.|||||| |.  .     .. ||||||||||.     |  ||  || |  ||||||.|.  |
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEII---NKQNYNNKCDIWSLGITAIEMADGFP

PMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
|  |. ||||.      |  ||....  .||  |  |.   ..| | ||. .  || ||| 
PHYDMPPMRAMYMIP--NWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase KHS2.AA NinaC 16-273 40 2.5e-87 296.41 In-house 1-267 (267) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-267/267
Sequence Identity: 40% (111 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKD-CKHPNIVAYFGSYLRR-----DKLWICMEFCGGGSLQDI----YHV
.| .  || |||| |.|. |   |..||.|.  ... .|  . .  |   ..| | |||.| ..| | .      |.||. ||.| |||  |.      .
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKI--QHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKC

TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE--RKGGYNQLCDLWAVGI
   ..|  |||. .|.. ||  ||.   .|||.|| ||||| .| ||| |||||||.. |  .|   .|||.|||||| | .  .   |   || |. ||
GRRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGI

TAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
|||||.   ||..|.|||||.|        ||.|    .|.. | .|.   |.|.  |||.   .|.|||.
TAIELGDGDPPFADMHPMRAMFKIPRNP--PPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase KHS2.AA Pkinase 16-273 31 8.1e-82 282.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ-----EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGG----SLQDIYH--V
......||||..| |||.....||.. |.|.||.. .|.  . |.     || .|| ..||||| ..... ..|.....||.|.||    .| |. .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

TGPL--SELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHV----KLADFGVSAQI-TATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDL
 |..  || ..  . ...|.||.|.||.| .|||.| .|||. .|||.    |..|||...|. .      ..| |||..|||||  .    .| . .| 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVDM

WAVGITAIELAELQPPMFDL-----HPMRALFLMTKS---NFQPPKLKDKM--------------KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
|..|.. .|..  .||  .      | ..... ....    |. |.. ...              .|| .. .|.|  |.|.|||||||| .||||..
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase KHS2.AA Pkinase_Tyr 16-158 28 9.5e-26 87.83 Pfam 1-158 (270) Show / Hide 
Range on Protein: 16-158
Range on HMM: 1-158/270
Sequence Identity: 28% (45 aa)

FELIQRIGSGTYGDVYKARNV----NTGELAAIKVIKLEPGED---FAVVQQEIIMMKDC-KHPNIVAYFGSYL-RRDK--LWICMEFCGGGSLQDIYHV
 .... .|.| .|.|||..      ||.   |.|..|    ..    .   .|. .||   .||||| . |  . ...   ..| ||.. .|.| |  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVS
     .||.  ..   ...  .|. ||.||.  |||.   |.|.|.|..|| .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase KHS2.AA TyrKc 16-273 23 1.5e-17 61.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDC--KHPNIVAYFGSYLRR-------DKLWICMEFCGGGSLQDIYHVTG
 .|.. .|.| .| |||..     .  |.|..| .     .   .|. .|.    .|||||. .|  .         . |.| ||.. .|.|.|  . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

P-LSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITAT-------IAKRKSF-IGTP-----YWMAPEVAAVERKGGYN
| |.  .  . .    .|  |||||.  |||.   |.|...|..|| .||| |  |.           .||.   |.       |||||.    ..| ..
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT

QLCDLWAVGITAIELAEL-QPPMFD-----LHPMRALFLMTKSNFQPPKLK--DKM---KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV
   | |. |..  |.  . |.|  .     . . ... .  . .  |.       |     .   .   |.    .|..||| . .  | . 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
CNH KHS2.AA CNH 561-874 31 1.8e-118 400.77 SMART 1-375 (375) Show / Hide 
Range on Protein: 561-874
Range on HMM: 1-375/375
Sequence Identity: 31% (120 aa)

CASSWINPDTRDQ----YLIFGAEEGIYTLNLNEL----HETSMEQLFPRR---CTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAH
|. .|. | |.||    .|..|.|.|||.||.|..    || ..|....||   |.|.|. ||||..||||  .||||.|..||  .|  .  |  |..|
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPH-IQDH

KLPDRILPRKFSVSAKIPETKW-CQKCCV-VRNPYTGHKYLCGALQTSIVLL-EWVEPMQKFMLIK--------------HIDFPIPCPLRMFEMLVVPE
. .....|||.... |||.||  | .||| .....||...||.|.|.|.... .|..||.|||..|              |..||.. |...|.......
MCNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDS

QEYPLVCVGVSR---GRDFNQVVRFE-------------TVNPNSTSSWFTESDTPQT----NVTHVTQLER------DTILVCLDCCIKIVNLQGRLKS
.|.| .|.|..    |  ....| ..             |||.|..|.||....|       .. .|.|...      |..|.| | . ..||..| ...
FERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYG-SEW

SRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEV-TQEISDS----TRIFRLLG----SDRVVVLESRP
.|.....|...|..|. ........|||..|.|.|.. ..|. ||.| |     .|.||||.    .||.....|.|
RRWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH KHS2.AA CNH 566-864 27 3.7e-105 360.47 Pfam 1-336 (336) Show / Hide 
Range on Protein: 566-864
Range on HMM: 1-336/336
Sequence Identity: 27% (94 aa)

INPDTRDQYLIFG-AEEGIYTLNL----NELHETSMEQLFPRRCTWLYVMN--NCLLSI--SGKASQLYSHNLPGLFDYARQM--QKLPVAIPAHKLPDR
..|.|..|.|..| ..||.|..|.    ...|.| ..|.|.||.|..||..  |.|..|  ..|  .||.|.|  |..   |.  .  | ....|.. .|
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRI-ER

ILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQT-----SIVLLEWVEPMQKF-------------MLIKH-IDFPIPCPL-RMFEMLVVPEQE
|.|||| .. |.|.|| |...|..||.|.....||.|. .     .|...||..||.||             ..... ...|.| |.  .|.|.. | ||
IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLP-PMTECFSMHWLP-QE

YPLVCVGVSRGRDFNQVVRFETVNPN--STSSWFTESDTPQ--TNV---------THVTQLERD-TILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQI
.| .|||.         . |. || .  ....|.   . .   ...          .......| ..|.| | | ..||.||...|.. ...|..... .
KPKLCVGC--------QKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRK-HDWEIMWEGMP

ESIVCLQDSVLAFWKHGMQGRSFRSN-EV---TQEISDSTRIFRLLGS
.|..|.....|||.......|..... |.   .|.|.. .. |...||
QSFACCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS