Gene LATS1 (Human)

LATS1

Species: Human
Alias: LATS1, wts, WARTS
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards ,
Annotation: Consensus chromosomal location: 6q25.1,

Classification

Group: AGC
Family: NDR
Subfamily: LATS

Sequence

Name Sequence Type Origin Length Description Download
LATS1.NA RNA Sugen Kinome 4756 None Fasta, JSON
LATS1.AA Protein Sugen Kinome 1130 None Fasta, JSON
LATS1.kin_dom Protein Kinase Domain Sugen Kinome 306 None Fasta, JSON

Protein domain

Protein domains of LATS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UBA LATS1.AA UBA 101-138 28 4e-11 43.7 Pfam 1-38 (38) Show / Hide 
Range on Protein: 101-138
Range on HMM: 1-38/38
Sequence Identity: 28% (11 aa)

VNPQMLQDLQAA-GFDEDMVIQALQKTNNRSIEAAIEFI
....|.. |..  ||... ...||...|| ..|.|.|..
IDEEMVKQLMEMTGFSMMQCKKALRACNN-NVERAVEWL
UBA LATS1.AA UBA 102-140 25 0.000432 20.62 SMART 1-38 (38) Show / Hide 
Range on Protein: 102-140
Range on HMM: 1-38/38
Sequence Identity: 25% (10 aa)

NPQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISK
. . .. |   |||.. ..|||...|.  .|.|....  
YEEKIDQLMEMGFDREECVQALRACNWN-VEMAMNWLFS
Kinase LATS1.AA NDR 705-1010 55 3.3e-236 737.09 In-house 1-350 (350) Show / Hide 
Range on Protein: 705-1010
Range on HMM: 1-350/350
Sequence Identity: 55% (194 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEAD--NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMS---LLIRMGI
|..||..|.||||||.|.|| ||...|| |..||.... .||||||.|||||.||||  |.|||.||||||||..||.||.|.||||||.   ||..|.|
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTG---------------------FRWTHDSKYYQ-SGDHPRQDSMDFSN
|.|..|||||||..||.|||||||.|||||||||.|||.||||||||||||||                     |.|||.|.||| ...| .||.||..|
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

EWGDPSSCRCGD-----R---LKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLR-TGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTS
.......|.|.      .   .|.|..|. .|..||||.|.||||.|.||||... |||.|.|||||.|.|..|||||.|||.. || ||.||..||.. 
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----HIPPQAKLSPEASDLIIKLCR-GPEDRLGKNG--ADEIKAHPFF
.     |.||.|.||||| ||| .||   |. |||..|  .||||.||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase LATS1.AA AGC 705-1010 32 7.79999999999e-186 485.7 In-house 1-395 (395) Show / Hide 
Range on Protein: 705-1010
Range on HMM: 1-395/395
Sequence Identity: 32% (139 aa)

FVKIKTLGIGAFGEVCLARKV------DTKALYATKTLRKKD-VLLRN--QVAHVKAE------------RDILAEAD----------NEWVVR-LYYSF
|  .|..| |.||.|.|.||.      ||. .|| | |.||. .....  .|.|...|            |.||....          . ..|. |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKDN--LYFVMDYIP--------GGDMMSLLIRMG-----IFPESLARFYIAE-------LTCAVESVHK-MGFIHRD-IKPDNILIDRDGHIKLTDFG
||||.  |||||.|.|        ||.....|. .|     .|.|. ||||.||       ...|.|. |. ||.|||| .||.|||.|.||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------FRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQ-----------RCLAHSLVG--TPNYIAP
||.                 |.| |..|| |..      .||   .             | .... .....           | ......|  ||.|.||
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-QKS------NMD-T-N-------------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAP

EVLLRTGYTQLCDWWS--VGVILFEMLVGQPPFLAQTPL----------ETQMKVI------NWQTSL------HIPPQAKLSPEASDLIIKLCR-GPED
|.|    |.. |||||  .|....|||.|.||| ...|           |.  |..      ||.  .      ..|.. ..|||| ||| ||.   ||.
EIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEK

RLGKN-------GADEIKAHPFF
||| .       ||.|||.||.|
RLGCGGNDFGDKGAEEIKNHPWF
Kinase LATS1.AA DMPK 705-850 48 4e-106 263.17 In-house 1-147 (270) Show / Hide 
Range on Protein: 705-850
Range on HMM: 1-147/270
Sequence Identity: 48% (71 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG-IFPES
|  .|  | |.||||.. |   |.  || | . |.. | | ..| .. ||||.. .. .|...|.| |||...||.||.| ||||. .|. | .  .||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
.||||.||.. |. |.|.||..||||||||.|.|| ||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase LATS1.AA S_TKc 705-1010 32 3.9e-101 343.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 705-1010
Range on HMM: 1-231/231
Sequence Identity: 32% (103 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPG--GDMMSLLIRMGI---
. .....| ||||.|...|...|. ..| | ..           |.. |..|| . . ...|.||..||| |.||.||.|..|  ||..... ..|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLER
   |||  ||||.... ||.|  |..|.||||.||.|||.|.  |||..||||.. .                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

RAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQ-LCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPED
           ....|||.|.|||||   ||.   |||||.|.||.|||.|.|||     ... .|.|              |||| |.| |...  ||.
-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEK

RLGKNGADE----IKAHPFF
|..   | .    ||.||.|
RPTA-EALQDEWDIKCHPWF
Kinase LATS1.AA RSK 708-1010 35 8.3e-99 334.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 708-1010
Range on HMM: 1-278/278
Sequence Identity: 35% (114 aa)

IKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ-VAHVKAERDILAEAD-NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGI---
.| || |..|.| | ||.   ||. .|| | |.|. .  |.  ..|...||.||..      .|.|.|.||... || .|.|..||..   | . ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDR---DGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLER
| |. |.||.||...|||  |. |.||||.||.||| |    .|||||||||.|  |                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

RAARQHQRCLAHSLVGTPNYIAPEVLL----RTGYTQLCDWWSVGVILFEMLVGQPPFLA---QTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIK-L
   | ..  .... ..| .|.|||.|     . |... ||||| ||...|||.|.||| .   ... |.  .. . . || .|  ..||.|| ||| | |
---RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKML

CRGPEDRLG--KNGADEIKAHPFF
.| |..|||  ...|.|||.||.|
HRDPHKRLGCGPQDAEEIKQHPWF
Kinase LATS1.AA AktR 705-1010 33 2.8e-89 302.89 In-house 1-268 (268) Show / Hide 
Range on Protein: 705-1010
Range on HMM: 1-268/268
Sequence Identity: 33% (108 aa)

FVKIKTLGIGAFGEVCLARKV-DTKALYATKTLRKKDVLLRNQVAHVKAERDILA-EADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPE
|. .| || ||||.| |..|  |.. .|| | ..||.   |||  |.  ||.|.. ....   |.|.|.||.|..|.|.|.|.|||.. . | . . | |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SLARFYIAELTCAVESVHKM-GFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQ
. ||||.|.   |.|  |.    | ||.||.|||.| |||.|.|||||                                                   |
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK------------------------------------------------LQ

HQ---RCLAHSLVGTPNYIAPEVLLR-TGYTQLCDWWSVGVILFEMLVGQPPFLA-QTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIK--LCRGPED
 .   . .|.|..||| |.|||....  |..  .|||..|. ..||..|.||| . ..  . |.. |     . .|. ...|... |||    ||. |. 
FMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ--QNKFPYPSYFSSQCKDLIQRKLLCKNPNK

RLG--KNGADEIKAHPFF
|||  .||..||| ||.|
RLGYYCNGWEEIKSHPWF
Kinase LATS1.AA MAST 705-849 46 6.3e-81 246.85 In-house 169-316 (337) Show / Hide 
Range on Protein: 705-849
Range on HMM: 169-316/337
Sequence Identity: 46% (69 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQD--KDNLYFVMDYIPGGDMMSLLIRMG-IFP
|  || .. ||.| |.|... .|. ..| |.... | ...||| .|..||.||....|..|| ..||||   |. |..||.|  |||  |||  .|  .|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL
|..|..||||.  ..|  |..| .|||.||||.||| .||||||||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS1.AA MAST 705-849 48 4e-79 254.67 In-house 157-301 (334) Show / Hide 
Range on Protein: 705-849
Range on HMM: 157-301/334
Sequence Identity: 48% (70 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESL
|  || .. ||.| |.|... .|. ..| |...| | ...|.| .|..||.|||...|..|| ..|||| |..|..||.|  |||  |||  .| |.|..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL
|..||||.  ..|  |..| .|||.||||.||| .||||||||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS1.AA CRIK 707-848 52 1.2e-72 230.88 In-house 2-145 (272) Show / Hide 
Range on Protein: 707-848
Range on HMM: 2-145/272
Sequence Identity: 52% (76 aa)

KIKTL-GIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG-IFPESL
 .|.| | | ||.| . |   |   || | ..|| || . ||. .. ||||.. .  .|. .| | |||.|||| .| | ||||  ||. | .  | |..
EVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDENM

ARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFG
|||| |||. || |.|.||..||||||.|||||| ||||| |||
ARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFG
Kinase LATS1.AA Akt 705-850 50 2.3e-68 217.62 In-house 235-382 (264) Show / Hide 
Range on Protein: 705-850
Range on HMM: 235-382/264
Sequence Identity: 50% (75 aa)

FVKIKTLGIGAFGEVCLARKVDTKALY-ATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPES
|  .| || |.|| | |..| ||. .| | | |.|.  . .|||.|.|.|| ||   ..  .| |.||||..|.|||||||..||.  ..| | ..|.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LARFYIAELTCAVESVHKMGFIHRD-IKPDNILIDRDGHIKLTDFGLC
 ||||.||. .| |  |... | ||  || |||.|.||||.|||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase LATS1.AA ROCK 705-850 51 1.2e-59 201.73 In-house 1-145 (263) Show / Hide 
Range on Protein: 705-850
Range on HMM: 1-145/263
Sequence Identity: 51% (75 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESL
|  || .| |||||| | |.  .|  || | | | ... |   |    ||||.| |  ||.|.|.| |||.  || ||||.||||...|.    . ||  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

ARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
|||| .|.  |....| |||||||.||||.|.|. ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase LATS1.AA DMPK 911-1010 46 2e-54 132.44 In-house 162-270 (270) Show / Hide 
Range on Protein: 911-1010
Range on HMM: 162-270/270
Sequence Identity: 46% (51 aa)

VGTPNYIAPEVL--LRTG----YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINW-QTSLHIPPQAK--LSPEASDLIIKLCRGPEDRLGKNGA
|||| ||.||||  . ..    |   ||||||||...|||.|. || | .  ||  |  |  ...|  |.. |  .|.|| ||| .|   .|.|||.||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

DEIKAHPFF
...|.||||
EDFKCHPFF
Kinase LATS1.AA MAST 911-1010 50 2.8e-45 135.89 In-house 229-337 (337) Show / Hide 
Range on Protein: 911-1010
Range on HMM: 229-337/337
Sequence Identity: 50% (55 aa)

VGTPNYIAPEVLLRTG-YTQLCDWWSVGVILFEMLVGQPPFLAQTPLE-TQMKVINWQTSLHIPPQ------AKLSPEASDLIIK-LCRGPEDRLGKNGA
.||| ||||||.|..| | .  ||||.|.|..| ||| ||| . || | .  ..|| .  .  |.        ..|||| |||.| |   | .||| |||
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

DEIKAHPFF
|||| ||||
DEIKQHPFF
Kinase LATS1.AA Pkinase 705-850 35 3e-45 161.09 Pfam 1-159 (293) Show / Hide 
Range on Protein: 705-850
Range on HMM: 1-159/293
Sequence Identity: 35% (56 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVK-AERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGG----DMMSLLI--RM
.......| |.||.|.......|  ..| |...|..     ...|.. .|  |... . . .||||..|.|||..|.||.| .||    | ....   | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GIF--PESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHI----KLTDFGLC
| |  .|  ..||. .. ...|  |.||.||||.||.|||||..|||    |..||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase LATS1.AA MAST 909-1010 46 1.2e-41 131.85 In-house 223-334 (334) Show / Hide 
Range on Protein: 909-1010
Range on HMM: 223-334/334
Sequence Identity: 46% (52 aa)

SLVGTPNYIAPEVLLRTG-YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTS-LHIPPQ------AKLSPEASDLIIKLCRG-PEDRLGKN
...||| ||||||.|..| . .  ||||.|.|..| ||| |||   || |.  ...|       .|.        ..|||| |||.||    |..||| |
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

-GADEIKAHPFF
 ||||.| ||||
NGADEVKQHPFF
Kinase LATS1.AA ROCK 911-1010 49 7.2e-36 119.46 In-house 160-263 (263) Show / Hide 
Range on Protein: 911-1010
Range on HMM: 160-263/263
Sequence Identity: 49% (51 aa)

VGTPNYIAPEVLLRTG----YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKA
|||| ||.||||   |    | . |||||||| ..|||||. || |..   |  |... ..||. |.....| .| ||| |     |.|||.|| |.||.
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase LATS1.AA Pkinase 907-1010 27 3.7e-26 93.58 Pfam 168-293 (293) Show / Hide 
Range on Protein: 907-1010
Range on HMM: 168-293/293
Sequence Identity: 27% (36 aa)

AHSLVGTPNYIAPEVLL-RTGYTQLCDWWSVGVILFEMLVGQPPFLAQ------TPLETQMKVINWQTSLHIPPQAKLS-----------------PEAS
.....|||.|.||||.. ...|.. .|.||.|.||.||| |.|||  .      ....   ..   ... ..|     |                 .|. 
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

DLIIK-LCRGPEDRLGKNGADEIKAHPFF
|.| . ||. |..|..   |..|. ||.|
DFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase LATS1.AA CRIK 911-1010 35 1.1e-24 75.3 In-house 162-272 (272) Show / Hide 
Range on Protein: 911-1010
Range on HMM: 162-272/272
Sequence Identity: 35% (41 aa)

VGTPNYIAPEVL--LRT------GYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVIN------WQTSLHIPPQAKLSPEASDLIIKLCRGPEDRL
|||| |.|||||  . .       |   |||||.|.| .|| .|. ||   .  .|  ...|       |  |  |   |.||.. |||  |  ..  ||
VGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAYEMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL

GKNGADEIKAHPFF
.  .   .. ||||
KYEQ---LCCHPFF
Kinase LATS1.AA Akt 907-950 44 7.9e-23 69.74 In-house 159-203 (264) Show / Hide 
Range on Protein: 907-950
Range on HMM: 159-203/264
Sequence Identity: 44% (20 aa)

AHSLVGTPNYIAPEVLLRTGYTQLCDWWS-VGVILFEMLVGQPPF
. .. ||| |.|||.|. .|.|. .|||. .|....||. |.|||
TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase LATS1.AA Akt 969-1010 44 1.4e-14 42.91 In-house 220-264 (264) Show / Hide 
Range on Protein: 969-1010
Range on HMM: 220-264/264
Sequence Identity: 44% (20 aa)

LHIPPQAKLSPEASDLIIKLC-RGPEDRLG--KNGADEIKAHPFF
. .|.  ..|||. |||..|. . |. |||  .|.|.|||.||.|
VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase LATS1.AA TyrKc 705-1010 21 4.2e-11 -43.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 705-1010
Range on HMM: 1-280/280
Sequence Identity: 21% (73 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEA--DNEWVVRLYYSFQDK-------DNLYFVMDYIPGGDMMSLLI
 ...|.|| ||||||....        | |.|..        ..    |  |. .   ... .||||    ..       . |. || | |.||  . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RMGI-FPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKP-
. .  .. .    .     |  |  |....||||.   |.|.......| .||||         |..  ..|           ..|       .|  .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL---------SRDIYDDD-----------QQG-----ESKDYYRKK

---LER--RAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML-VGQPPFLA-----QTPLETQMKVINWQTSLHIPPQAKL-----
    ..     |                 |||..    .|   | || || ..|..  ||.|         .. |    ||..  . . .|| .      
EHKGGKTMLPIR---------------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE----VIEYVKQGYRMPQPPNDYPMS

---SPEASDLIIKLC--RGPEDRLGKNGADEIKAHPFF
    |..   |.| |  . ||||   .       | .|
FVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase LATS1.AA Pkinase_C 1029-1084 28 4.4e-09 35.25 Pfam 1-46 (46) Show / Hide 
Range on Protein: 1029-1084
Range on HMM: 1-46/46
Sequence Identity: 28% (16 aa)

KITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFF
....||||||||| .         ..| ..|| . |    .   ..|  ||.....
QVKSPTDTSNFDPEF---------TDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase LATS1.AA Pkinase_Tyr 820-850 35 1.8e-05 19.13 Pfam 128-158 (270) Show / Hide 
Range on Protein: 820-850
Range on HMM: 128-158/270
Sequence Identity: 35% (11 aa)

HKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
. ...||||.   |.|.......| .||||.
ESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase LATS1.AA S_TK_X 1011-1082 22 4.9e-05 19.77 SMART 1-79 (79) Show / Hide 
Range on Protein: 1011-1082
Range on HMM: 1-79/79
Sequence Identity: 22% (19 aa)

KTIDFSSDL---RQQSASYIPKIT----HPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHA-----FYEFTFRR
. ||.   .   ..  . ..|||.    .|||||||||  ... ..    . .....| .   . . .|       | .||...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM----LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase LATS1.AA Pkinase_Tyr 705-723 47 0.010831 9.74 Pfam 1-19 (270) Show / Hide 
Range on Protein: 705-723
Range on HMM: 1-19/270
Sequence Identity: 47% (9 aa)

FVKIKTLGIGAFGEVCLAR
 ...|.|| ||||||....
ITFGKKLGEGAFGEVYKGT