Gene LIMK2 (Human)

LIMK2

Species: Human
Alias: LIMK2, PLCB3NP
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 22q12.2,

Classification

Group: TKL
Family: LISK
Subfamily: LIMK

Sequence

Name Sequence Type Origin Length Description Download
LIMK2.NA RNA Sugen Kinome 2914 None Fasta, JSON
LIMK2.AA Protein Sugen Kinome 686 None Fasta, JSON
LIMK2.kin_dom Protein Kinase Domain Sugen Kinome 261 None Fasta, JSON

Protein domain

Protein domains of LIMK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LIM LIMK2.AA LIM 17-47 47 1.9e-11 43.39 Pfam 27-60 (60) Show / Hide 
Range on Protein: 17-47
Range on HMM: 27-60/60
Sequence Identity: 47% (16 aa)

FRCSECQDSLTNW--YYEKDG-KLYCPKDYWGKF
|.|..||..||..  .||.|| |||| ..|. .|
FCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
LIM LIMK2.AA LIM 7-42 27 0.00069 3.35 SMART 10-52 (52) Show / Hide 
Range on Protein: 7-42
Range on HMM: 10-52/52
Sequence Identity: 27% (12 aa)

VP-AYFTSRDL------FRCSECQDSLTNWYYEKDGKLYCPKD
..  . . ..       |.|..|. .|.. .||||||.||...
YGDQVMRAMGKHWHPECFCCCHCNKPLGGTFYEKDGKPYCKHC
LIM LIMK2.AA LIM 50-103 27 2.9e-12 47.99 SMART 1-52 (52) Show / Hide 
Range on Protein: 50-103
Range on HMM: 1-52/52
Sequence Identity: 27% (15 aa)

FCHGCSLLMTG-PFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKC
 |..|.   .|   |.|.. ..||||| |  |.  ...   .  ... ..|| .|
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGG---TFYEKDGKPYCKHC
LIM LIMK2.AA LIM 51-108 30 1.1e-09 37.12 Pfam 1-60 (60) Show / Hide 
Range on Protein: 51-108
Range on HMM: 1-60/60
Sequence Identity: 30% (18 aa)

CHGCSLLMTGPFMV--AGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVV
|.||    .. ..|  | . ..||||| |. |.  ...|| . .. .. ||| .|. .  
CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
PDZ LIMK2.AA PDZ 131-215 21 1.9e-21 76.04 Pfam 1-86 (86) Show / Hide 
Range on Protein: 131-215
Range on HMM: 1-86/86
Sequence Identity: 21% (19 aa)

LISMPAT-TEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQ-TLQLLIE
.....   . |..|||........  .... ..||.... ...  ..||.||.|..|||...| ...... .|| .... ...|.|.
QVTLEKQDKRGGLGFSIKGGNDQRH-DQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
PDZ LIMK2.AA PDZ 140-218 23 1.2e-11 45.97 SMART 1-80 (80) Show / Hide 
Range on Protein: 140-218
Range on HMM: 1-80/80
Sequence Identity: 23% (21 aa)

GRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNA------IHPGDRILEING-TPVRTLRVEEVEDAISQTSQ-----TLQLLIEHDP
|  |||..           . ...| .   .|  .        ..|||||||.|| .||.... |.. |.. |...     ...|......
GGLGFSIVG---------GIFISSVVPG--GPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
Kinase LIMK2.AA LIMK 310-570 69 4.5e-231 773.94 In-house 1-277 (287) Show / Hide 
Range on Protein: 310-570
Range on HMM: 1-277/287
Sequence Identity: 69% (193 aa)

LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKV
||||||||||||||||||||..||.|||||||.|||||||.|||.||||||.||||.||||||||||||.||..||||.||.||.....|| ||||||.|
LIHGEVLGKGFFGQAIKVTHRQTGEVMVMKELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRV

RFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAP------------MEKATTKKRTLRKN---DRKKRYTVVGNPYWMA
|||..||.||.||||||||||||||||||...|..||||||||.||...|||...            |......||||.|.   ||||||||||||||||
RFARDIACGMSYLHSMCIIHRDLNSHNCLVREDRSVVVADFGLARLMIDERKQSCNMTPGGYGSGANMDNPMEPKRTLHKPKSRDRKKRYTVVGNPYWMA

PEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESR
|||.|||||||.||.||||||.|||||.|||.|||.|||.|||||...||||..|..|||.|||....||...|..|
PEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPRTMDFGLNQQEFWEKCCPDQCPPPFFPIMFMCCDMDPDMR
Kinase LIMK2.AA LISK 315-570 47 1.5e-169 555.28 In-house 1-286 (296) Show / Hide 
Range on Protein: 315-570
Range on HMM: 1-286/296
Sequence Identity: 47% (135 aa)

VLGKGFFGQAIKVTHKATGKVMVMKELIR-----CDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK-DKKLNLLTEYIEGGTLKDFLRSMD----PFPW
..||||||...|.||..||.||..|...|     .|.|.||..| ||..|..|.|||...|.||.|. |..|...||||.||.|...|..||    |.||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIK----LDKTVVVADFGLSRLIVEERKRAP-----------MEKATTKKRTLRKN---DRKKRYTVV
.|.|..|..||.||.|||||.||||||.|.|||..     .....|.|||. |....|.....           |......||...|.   .||.|.|..
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTL--DFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESR
|.|||||||||.|.||||..|.|||||||||||..|.||||..|||   ||||....||.|..|.||||.|..|.  ||...|..|
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNR
Kinase LIMK2.AA TESK 314-572 42 3.6e-97 307.43 In-house 1-282 (292) Show / Hide 
Range on Protein: 314-572
Range on HMM: 1-282/292
Sequence Identity: 42% (120 aa)

EVLGKGFFGQAIKVTHKATGKVMVMKELI-RCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLR-SMDPFPWQQKVRFA
| .| |||    ||.|.|.|.|||.|    .     ..  | ||. |  | |||.|.| ||  .. .|  ||||| ||.| . |  |  . .|.||.. |
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLA

KGIASGMAYLHSMCIIHRDLNSHNCLIK-LDKTV---VVADFGLSRLIVEERKRAPMEKAT------------------TKKRTLRKNDRKKRYTVVGNP
 .|| || ||||  . |||| | |||.. .|  .   ||.|||| |..       |    |                   |    .   ||..  ||| |
YDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLEKIPVYCMDSRKEKMAVVGSP

YWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAP
|||||| | |  |||..|.|||||||||||  . |||| .||| .||| ...| |. .| |||. |  ||  || ..| .|..
YWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAFKEM-CPMDCPEPFLQLAFHCCNMDPKDRPV
Kinase LIMK2.AA TKL 316-570 25 3.9e-79 269.22 In-house 1-354 (364) Show / Hide 
Range on Protein: 316-570
Range on HMM: 1-354/364
Sequence Identity: 25% (93 aa)

LGKGFFGQAIKVTHKA--------TGKVMVMKELIR--CDEETQ-------------------------KTFLTEVKVMRSLDHPNVLKFIG--------
.|.|.||.  | ...         |||....| . .  .||.|                          ...  |...|..|.|||...|.|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VLYK----DKKLNLLTEYIEGGT-LKDFLRSMDPFPWQQKVRFAKGIASGMAYLHS--------MCIIHRDLNSHNCLIKLDKT--------------V
 | ..    ...| . .||..||. | ...       |.|..|.|..||.||.||||        . ||||||.|.|.|.. . |              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VVADFGLSRLIVEERKRAPMEKATT---KKRTLRKNDRKKRYTVVGNPYWMAPEMLNGK----------------SYDETVDIFSFGIVLCEIIG--QVY
 ..|||||| . .. .   .....        .. | ||...|..|.|.|||||.|.|.                .|.| .|..||||||.||.   ..|
KICDFGLSRFMSQSGNMNDTMTTMMESAE---HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

ADPDCLPRT------LDFGLNVKLFWEKFVP------------TDCPPAFFPLAAICCRLEPESR
.|... |.       ..| .... .    .|            .|||| .  |.  |.  .||.|
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase LIMK2.AA LISK-DD1 355-570 30 1.4e-60 207.56 In-house 44-280 (290) Show / Hide 
Range on Protein: 355-570
Range on HMM: 44-280/290
Sequence Identity: 30% (78 aa)

EVKVMRS---LDHPNVLKFIGVLYK-------------DKKLNLLTEYIEGGTLKDFLRSMD-------------PFPWQQKVRFAKGIASGMAYLHSMC
|.|. ..   . |||. .|||. ..             .  | ..||.|||| | ..| .               |.||  .|. |..||..||||||  
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

IIHRDLNSHNCLIKLD----KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQ
|||||| | | |.        .  | |||. | . .  .                  .....| .| . |||||.. | |||. .|.||||.|| |.|  
IIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQ----------------NNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITR

VYADPDCLPRTL--DFGLNVKLFWEKFVPTD--CPPAFFPLAAICCRLEPESR
.  |.. ..|..  .|..... |  . .|.|  ||..|  |.  ||  .|. |
KKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNR
Kinase LIMK2.AA STE 310-519 25 4.4e-51 176.02 In-house 1-262 (359) Show / Hide 
Range on Protein: 310-519
Range on HMM: 1-262/359
Sequence Identity: 25% (70 aa)

LIHGEVLGKGFFGQAIKVTHK------ATGKV---------MVMKELIRCDE-----------------ETQKTFLTEVKVMRSLD--HPNVLKFIGVLY
. . |..||| ||.  |  ..       ||.|         | .|..  ...                 | .. .| |.|.|. ..  |||. |..|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------KKLNLLTEYIEGGTLKDFLRSM--------------DPFPWQQKVRFAKGIASG-MAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSR
|.        .|..  ||..||.| |....               ..|| .|  .... |  | ..||||. |||||. . | |.     |  .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

LIVEERKRAPMEKATTKKRTLRKNDR--------KKRYTVVGNPYWMAPEMLNG------KSYDETVDIFSFGIVLCEII
 ....  .    .          |          .||.|.|| | |||||....      | ||. .|| |.|....| .
QLTDSMANI-Q-S---------NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase LIMK2.AA S_TKc 310-578 22 6.2e-51 176.44 SMART 1-220 (231) Show / Hide 
Range on Protein: 310-578
Range on HMM: 1-220/231
Sequence Identity: 22% (63 aa)

LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG--GTLKDFLRSMDP------
   ....||| ||.  |..|| ||... .|..        .... |...... .|||. |...| .  ..| . .||..|  |.|.|..... .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKS
||  .  .... |.....|.||. ||||||   | |.    .. ..||||.|..                           .|..| |..||||.|   .
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------TTFCGTPWYMAPEVL---G

YDE-TVDIFSFGIVLCEIIG--QVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAPPGAAGE
|.   .|. |.|..| | .     .     . ....  .              .| .  .   |.. .|| |     | .
YGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase LIMK2.AA Pkinase 310-515 27 1.6e-48 172.35 Pfam 1-202 (293) Show / Hide 
Range on Protein: 310-515
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQK---TFL-TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGG----TLKDFLR--SM
.  |...|.| ||.  | .|| |||. ..|.. ...|. .|    .. .|...|..|.|||....... . .... . .|| |||     |.|...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DPF--PWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTV----VVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMA
 .|  ....  .... |..|..|.||| |||||| . |.||. . ..     ..||||....                           .|..| |..||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------Y-NNS-MTTFCGTPWYMA

PEMLN-GKSYDETVDIFSFGIVL
|| .. |. |.  ||..|.|..|
PEVIRGGQYYGPKVDMWSCGCIL
Kinase LIMK2.AA TKL-Unique 312-519 29 9e-48 165.02 In-house 1-222 (290) Show / Hide 
Range on Protein: 312-519
Range on HMM: 1-222/290
Sequence Identity: 29% (69 aa)

HGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ--KTFLTEVKVMRSLD-HPNVLKFIGVLY----KDKKLNLLTEYIEGGTLKDFLR-------
 ....| | .|| .|.... . . .. ...   | . .  ..|  ||..|  |. |||.....|.      . ..... .||..||.| | |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---SMDPFPWQQKVRFAKGIASGMAYLHSMC--IIHRDLNSHNCLIKLD-----KTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG
   .  ....||.|..|. ||.|| |||.    |||||| | | |.  .       . ..|||||..   . |    |.  |.             |..|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-----------NQTRCG

NPYWMAPEMLNG--KSYDETVDIFSFGIVLCEII
.. |||||.|..  . |.| .|..|||||| ||.
SFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase LIMK2.AA TK 310-518 16 6.3e-46 151.5 In-house 1-387 (486) Show / Hide 
Range on Protein: 310-518
Range on HMM: 1-387/486
Sequence Identity: 16% (65 aa)

LIHGEVLGKGFFG---QAIKVTHKATG----------------------------KVMVMKELIRCDEETQKT--------------FLTEVKVMRS--L
.. |..||.| ||   .  | . .  .                             | ..||    ..| ..               .. | |.|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNVLKFIGVLYKDKK------------LNLLTEYIEGGT----LKDFLRSMDP---------------------------------------------
.|||.....||  ...             . ...|| ..|     |.|.||. .|                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FPWQQKVRFAKGIASGMAYLHSM------CIIHRDLNSHNCLIKLDKT-----------VVVADFGLSR
                               .. .|.. ..  ||.||.||||.       ..||||  .|||.  ...           . .|||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

---LIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY----------------------------WMAPEMLNGKS---------YDETVDIFSFGI
   .                    |. .... |.......                            ||||| ||..          . .  |..|||.
QGSG-----------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

VLCEI
.. ||
LMWEI
Kinase LIMK2.AA Ciliate-E2 310-515 22 6.3e-44 148.66 In-house 1-286 (365) Show / Hide 
Range on Protein: 310-515
Range on HMM: 1-286/365
Sequence Identity: 22% (66 aa)

LIHGEVLGKGFFG-----QAIKVTH------------------KATGKVMVMKELIRCDEETQKTFLTEVK-------------VMRSLDHPNVLKFIGV
 .  ...|.| ||     . .|| .                  |...|   || ..  . | .|  . . .             ....|.|||..|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LY--KDKKLNLLTEYIEGGTLKDFLRSMD-----------PFPWQQKVRFAKGIAS---------------GMAYLHSMC-IIHRDLNSHNCLIKLDKTV
 .  .|... | .||..||.|.|......           .| ...  .. | |..               .. ||||   |||||.   | |.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

VVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYT-------------VVGNPYWMAPEMLNGKS---------YDETVDIFSFGIVL
 ..|||||. . .....  . |   |. .  |||... ..             ..|.|. ||||.||||.         ||. .||.|.|..|
KIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase LIMK2.AA Pkinase_Tyr 310-455 32 1.6e-40 137.89 Pfam 1-161 (270) Show / Hide 
Range on Protein: 310-455
Range on HMM: 1-161/270
Sequence Identity: 32% (53 aa)

LIHGEVLGKGFFGQAIKVTHK----ATGKVMVMKEL-IRCDEET--QKTFLTEVKVMRSL-DHPNVLKFIGVLY-KDKK--LNLLTEYIEGGTLKDFLRS
.. |..||.| ||.  | | |     |.     | |   ...|   .. |. |.|.|..| .|||.....|| . ...   . . .|| ..| |.|.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

M----DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLI
     .|.. .... ..  ||.||.||.|. .|||||   |||.. ...| ..||||.|.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LIMK2.AA MLK 310-453 29 9.2e-36 121.57 In-house 1-181 (291) Show / Hide 
Range on Protein: 310-453
Range on HMM: 1-181/291
Sequence Identity: 29% (53 aa)

LIHGEVLGKGFFGQAIKVTHKATG---KVMVMKE-LIRC-----DEETQKTFLTEVKVMRSLDHPN----VLKFIGVLYKD-KKLNLLTEYIEGGTLKDF
.   |..|.| ||.  | . ...    |.   |.  .|       .. |. | .|..  | |.|||    . .| ||  .. ... ...||.||| | ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRSMDP--------------FPWQQKVRFAKGIASGMAYLHSMC---IIHRDLNSHNCLIKL------DKTVVVADFGLSR
|.. ..               . ......|. .|.||.|||||    ||||||.||| ||        ..|....|||.||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase LIMK2.AA TyrKc 310-580 24 1.8e-34 121.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 310-580
Range on HMM: 1-280/280
Sequence Identity: 24% (78 aa)

LIHGEVLGKGFFGQ----------AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL--DHPNVLKFIGVLYKD-------KKLNLLTEYIEGG
.  |..|| |.||.          |.|. .. .                .. |. | ..|..|  .|||.....||  ..       . | ...|| ..|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

TLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEE-RKRAPMEKATTKKRTLRKNDRKKRYTV---
 |||.||.  | ....... |.  ||.||.||||...|||||   |||.. ..|| ..|||||| | .. ..                  .|. |..   
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------------ESKDYYRKKEH

-VGNP----YWMAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPD----CLPRTLDFGLNVKLFWEKFVPTD--------CPPAFFPLAAICCRLE
  |.      ||||| .| . . .  |..|||... ||   ||     .    . .. .   .      ..  | .        ||.. . .   |.. .
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ--PPNDYPMSFVCCPDEMYQIMKQCWHED

PESRAPPGAAGEGP
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PEDRPTFSEIHECF
Kinase LIMK2.AA MLK 487-519 38 1.2e-10 33.31 In-house 195-230 (291) Show / Hide 
Range on Protein: 487-519
Range on HMM: 195-230/291
Sequence Identity: 38% (14 aa)

GNPYWMAPEML---NGKSYDETVDIFSFGIVLCEII
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GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase LIMK2.AA Pkinase_Tyr 491-519 41 0.00042 14.52 Pfam 180-208 (270) Show / Hide 
Range on Protein: 491-519
Range on HMM: 180-208/270
Sequence Identity: 41% (12 aa)

WMAPEMLNGKSYDETVDIFSFGIVLCEII
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WMAPECINYGKFTTKSDVWSFGVLMWEIF
PP1_inhibitor LIMK2.AA PP1_inhibitor 590-681 42 1.9e-30 104.06 Pfam 32-123 (155) Show / Hide 
Range on Protein: 590-681
Range on HMM: 32-123/155
Sequence Identity: 42% (39 aa)

RRQGKVTIKYDPKELRKHLNLEEWILEQLTRLYDCQEEEISELEIDVDELLDMESDDAWASRVKELLVDCYKPTEAFISGLLDKIRAMQKLS
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RRHARVTVKYNRKELQRRLDVEKWIDCQLDELYQGQEDDMPELEVNIDELLDLPTDEQRTRKLQEILQNCHNNTEVFIRELLQKLHGLHKQE