Gene LMR3 (Human)
LMR3
Sequence
Protein domains of LMR3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | LMR3.AA | Lmr | 133-411 | 65 | 1.1e-227 | 762.65 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 133-411 Range on HMM: 1-283/283 Sequence Identity: 65% (186 aa) LSYLQEIGSGWFGKVILGEIFS---DYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPE |.|.||||.||||||.|||..| ....||||||||||||.|.||..|..|.||||.|||||||||||.||||.|.||.||||..||||.|||..||.| LNYIQEIGNGWFGKVLLGEVHSLHPGMSKAQVVVKELRASASPQEQMQFLQEVQPYRELQHPNVLQCLGQCVETIPYLLVMEFCPYGDLKNYLRKCRPME GLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPER-LWIPLRWAAPELLGELHGTFMVVDQS ...|..|||...|||||..|||.||||.|.|..||||||||||.|..||||.||||||||..||||||.|... .|.||||.||||..|.|....||||. HMMPDKPPRQTMTLQRMACEIACGLAHMHQHHFVHSDLALRNCQLCADLTVKIGDYGLAHCQYKEDYYITKDQCHWVPLRWIAPELMDEFHQNLLVVDQT RESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYL ..|||||||||.||||||.||||.|.|||.|||.|||.|..||..|.|.|||.|.||.|.|.||..|.|||.|.|....|||| KYSNIWSLGVTMWELFEFAAQPYPHHSDEQVLAQVVREQDIKLPKPQLQLPYSDRWYEIMQFCWMQPDQRPTAEDVHRLLTYL |
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| Kinase | LMR3.AA | TK | 133-408 | 18 | 9.5e-88 | 294.17 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 133-408
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)
LSYLQEIGSGWFG---KVILGEIFS-----------------------DYTPAQVVVKELR--ASAGPLEQRK--------------FISEAQPYRS--L
. .....|.|.|| .| .|| .. . .. .| || |. ... . |.. . .|.. .. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
QHPNVLQCLGLCVET------------LPFLLIMEFCQLGD----LKRYLRAQRPPEGL-----------------------------------------
.|||.....| |.. |....||....|| |. |||. ||..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
--------SPELPPRDLRTLQR----------------MGLEIARGLAHLHSH------NYVHSDLALRNCLLTSDLT-----------VRIGDYG----
.|.|. .|| ... | . ||.|...|||. |.|| ||| ||||...... ..|.|.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
----LAHSNYKEDYYLTPE------------------------RLWIPLRWAAPELLGELHGTFM--VVDQSRESNIWSLGVTLWELFEFG-AQPYRHLS
|| |..|.| . . . ..|.|| ||| | . . . . .| .||.||..||.| .| ...| .|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS
D---------EEVLAFVVR----------QQHVKLARPRLKLPYA-------------DYWYDILQSCWRP-PAQRPSASDLQLQL
. .||. ...| .. .. .|. .. . .||..|.||.. |..||. |.|. ||
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | LMR3.AA | Pkinase_Tyr | 133-408 | 32 | 1.1e-75 | 257.01 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 133-408
Range on HMM: 1-270/270
Sequence Identity: 32% (94 aa)
LSYLQEIGSGWFGKVILGEIF--SDYTPAQVVVKELRASAGPLE--QRKFISEAQPYRSL-QHPNVLQCLGLCV-ETLP--FLLIMEFCQLGDLKRYLRA
.. ....|.| ||.| .|. . | | .| || |. .| . . ...|..||. ..| .|||.....| |. . | ...||....|||. |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
QRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYY-LTPERLWIPLRWAAPELLGELHGTFM
.| .. .| .. .| | ..||.|...|.|.|..| ||| ||||.|....|.|.| ||| |..||| . . .| .| ||| . .
HR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----
VVDQSRESNIWSLGVTLWELFEFGAQP-YRHLSDEEVLAFVVRQQHVKLARPRLKLPY--ADYWYDILQSCW-RPPAQRPSASDLQLQL
. .| .|| ||..||.| .|.|| | .|.|||.... .. . |.. | | ||....|| |..||. |... ||
---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED------GYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
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| Kinase | LMR3.AA | TyrKc | 133-408 | 30 | 2.1e-71 | 244.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 133-408 Range on HMM: 1-280/280 Sequence Identity: 30% (94 aa) LSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSL--QHPNVLQCLGLCVET-------LPFLLIMEFCQLGDLKRYLR .. ....|.| ||.| .|. || || |...| .. |..||. ..| .|||.....| |.. | ...||.. .|||| ||| ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR AQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKE-------DYYLT----PERLWIPLRWAAP . || ...| . . ||.| ..|||.|..| ||| ||||.....||.|.| ||. | . ||| . .. ..|.|| || KHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP ELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRH-----LSDEEVLAFVVRQQHVKLARPRLKLP-----YADYWYDILQSCWRP-PAQRPSA | . .|.| . .| .|| ||..||.| .|.||| .|..||...| . . .| .| | |.| ..||. |..||. ECI--NYGKF-----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY--RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF SDLQLQL |.. .. SEIHECF |
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| Kinase | LMR3.AA | UTK | 133-408 | 27 | 8.6e-69 | 234.45 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 133-408 Range on HMM: 1-296/296 Sequence Identity: 27% (83 aa) LSYLQEIGSGWFGKVILGEIFSDY---TPAQVVVKELR-ASAGPLEQR---KFISEAQ---PYRSLQ-HPNVLQCLGLCVETLPFLLIMEFCQLGDLKRY . ....|.| || | ... . . ..| ||... .... |.. .|. ||. . .. |||||. .|.|. |.....|... ||| | VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSD-------LTVRIGDYG---LAHSNYK--------EDYYLTPE-R || .|| . .. .|... | . ||||...|||...|| ||| ||||.... ....|.|.| ... . |.|| .. . LRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ LWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRP-PAQRPSA .|.|| ||| | . . .. | .||.||..||.. .|..|| ..|...|...|... . ...|. . |.....||.. |. ||.. DRWPIRWMAPEALTHHT------RFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPW---DCPHPVYRLMHRCWHYDPQERPDF SDLQLQL || |. EDLVQQM |
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| Kinase | LMR3.AA | TK-Unique | 133-360 | 33 | 1.4e-56 | 193.65 | In-house | 1-249 (294) | Show / Hide |
Range on Protein: 133-360 Range on HMM: 1-249/294 Sequence Identity: 33% (86 aa) LSYLQEIGSGWFGKVILGEIFS----DYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQ-HPNVLQCLGLCVETL-PFLLIMEFCQLGDLKRYLRAQR | ...||.| || |. ||... . . .|.|| |...| ......| .|.| ...| |||..|||| |... |...|||.|. |.| ||| | LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR P------------------PEGLSPE-LPPRDLRTLQRMGLEIARGLAHLHS--HNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTP-ERLW | |.. ..| . |.|| . . .||.|...|.| .. || ||. ||.|||.|... |.|.|.| |.. | . .. PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH---FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR IPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVL ||.|| ||| | . ||.. . .|..||.||..||.| .||.||. ....... IPIRWMAPESLKCYHGMYH----TTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIM |
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| Kinase | LMR3.AA | InsR | 133-410 | 33 | 5.6e-56 | 186.46 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 133-410
Range on HMM: 1-278/278
Sequence Identity: 33% (97 aa)
LSYLQEIGSGWFGKVILG---EIFSDYTPA--QVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRP
. ..| | | ||.| .| | .| . .. .| . ..| | | .|| . .| || | | . .||. ..|||| |||. ||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP
PEG-LSPELP----PRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTF
|. | .. . | . | ||. |.| | . ..|| ||| |||. |.|| ||| |.. | ||| . | || ||| | . | |
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKD--GVF
MVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYA--DYWYDILQSCWRP-PAQRPSASDLQLQLTY
| .||.|| ||| .|.||| || |.|| .. . | |. | .||... . ||. | ||.. |. |
TT-----HSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNV------LRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
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| Kinase | LMR3.AA | Trk | 133-408 | 32 | 1.9e-50 | 169.23 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 133-408 Range on HMM: 1-275/275 Sequence Identity: 32% (92 aa) LSYLQEIGSGWFGKVILGE---IFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPE . .|.| | ||||.|.| . . . | || |. . . | ||. |||... . |.|.. |.|.. |. . |||..|||.. | IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA GLSPELPP------RDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYK-EDYYLTPERLWIPLRWAAPELLGELHGTF . . .| . . .|| |. . | .|| |.| |||| .| |.|||.|. | ||| . | || || . .| MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESI--MYRKF MVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCW-RPPAQRPSASDLQLQL . || .||.||..|| |..| ||. || || .. | ..| ||| . | |||. || | | || .. |. . TY-----ESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIH-QGRHRLERPR-RCPQE--VYDIMLGCWQREPQQRMNIKDIHDII |
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| Kinase | LMR3.AA | CTKA | 133-408 | 32 | 2.2e-42 | 140.15 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 133-408 Range on HMM: 1-290/290 Sequence Identity: 32% (99 aa) LSYLQEIGSGWFGKVILGEIFSDYT--------PAQVVVKELRASAGPLEQRKFISEAQPYRS---LQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRY . .||.| .| | | | || |.. | . | | || .| . ||||| ||.| | . |||. |.|||. | HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAF-VLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCY LRAQRPPE----------GLSPELPPRDLRTLQR--MGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKE-DYYLTPERLWIPLR ||| || . | ... | .|| | | . || ||| ||||| . .. | | |.. | || . .| | LRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVR WAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLAR--PRLKLPY--ADYWYDILQSCWRP-PAQRPSASD | ||| | . |.| | | .|. || |||.. .| |.||.|| || . .. ||..| .. | | ||.. |.|||. WMAPEALCF--GKF-----SCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAY-------TSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFET LQLQL || | LQRML |
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| Kinase | LMR3.AA | DDR | 133-408 | 28 | 3.7e-41 | 141.24 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 133-408 Range on HMM: 1-306/306 Sequence Identity: 28% (89 aa) LSYLQEIGSGWFGKVILGEIFSDYT------PAQ--------VVVKELRASAGPLEQRKFISEAQPYRSLQ-HPNVLQCLGLCVETLPFLLIMEFCQL-G | . ||.| || | | |... . . | || ||. | . | .|. .. |||. .| |.. | ..|||. | LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG DLKRYLRAQRPPEGLSPELP---------PRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYG--LAHSNYKEDYYLTPE---- ||. .. .. ... . ... . . ... || |...| | | || ||| |||| .....| | | .. . | ||| DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR -RLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFG-AQPYRHLSDEEV-----LAFVVRQQHVKLARPRLKLPYADYWY-DILQSCWR | |.|| |.| . | | | . | .|. |||.|| | | .||| .|.|| | . | .| |..|.. . | . . .||| QRHHMPIRWMAWESI--LLGKF-----TTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPM---CPYEIYNQLMCRCWR P-PAQRPSASDLQLQL . |||| . . . | RDQSQRPSFEEIHKFL |
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| Kinase | LMR3.AA | Musk | 133-363 | 31 | 5.1e-41 | 133.13 | In-house | 1-241 (282) | Show / Hide |
Range on Protein: 133-363 Range on HMM: 1-241/282 Sequence Identity: 31% (79 aa) LSYLQEIGSGWFGKVILG---EIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRP-- | ..|| | || | . | || |.. | | | ||. |||. . || | | | .|. ||| .|.. | IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR PEGLSPELP----------PRDLRTLQR--MGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELL .. . . | |... . | .|| |.| | .|| ||| |||| . |.| |.||.. | .||| | || || .|| . TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI GELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFV . | . || .|. || |||.| .. ||| .. |||. .. --WYNQF-----TYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYI |
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| Kinase | LMR3.AA | Pkinase | 133-408 | 18 | 3.8e-25 | 89.99 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 133-408
Range on HMM: 1-293/293
Sequence Identity: 18% (58 aa)
LSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRAS-AGPLEQRKFIS--EAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLG----DLKRYLRAQ
. .. |||| ||.| .. .. .|.||... . . . ... . |.| ..|.|||...... . . ..||.|. | ||..|...
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-
RPPEGLSPELPPR--DLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTV----RIGDYGLA--HSNYKEDYYLTPERLWIP---LRWAAPEL
. . . ...... ..|.|||...||.. .| || . |.|. .. .. .|.| ||| .. | . .. . ....|||.
-------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEV
LGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHL----SDEEVLAFVVRQQHVKLARPRLKLPY------------------ADYWYDILQSCW
. . .... .||.|..|.|.. | |... . . .. ..| . .| ... .. . |.. .|.
IR------GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL
RP-PAQRPSASDLQLQ--L
.. |..||.| .. .
CKDPKKRPTAEQILQHPWF
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| Kinase | LMR3.AA | Ror | 250-351 | 45 | 9.1e-25 | 88.61 | In-house | 128-222 (308) | Show / Hide |
Range on Protein: 250-351 Range on HMM: 128-222/308 Sequence Identity: 45% (46 aa) IARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQ || | | || .|| ||| |||| ..|.| | ||. | ||| . . | | || .|| . | | | .| ||| ||.||| . .| | IAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAI--MYGKF-----SEDSDIWSFGVVLWEIWSYGMQ PY || PY |
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| Kinase | LMR3.AA | S_TKc | 133-1351 | 4 | 2.3e-15 | 48.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 133-1351
Range on HMM: 1-231/231
Sequence Identity: 4% (58 aa)
LSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQL--GDLKRYLRAQRPP--
|..||.| |||| .. . | .| .|... .....| | .. .|||. .... ... . ..||.| |||..|.. ....
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
-EGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQ
.... ... .|...|...|||. .| || | ||.. .. |.| ||| . . . |||.|
RFPFPE-H-------ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----------GY
SR-ESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPP
.. .. .||.|..|.|.. | |.. ..... ...
GKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-------------------------------------------------------------
RDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPV
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ISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPA
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EVLGERGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPA
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SAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPE
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PPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGV
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TVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRA
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PGPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGG
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PGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKA
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RLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPL
. .| .
--------------------------------------------------------------------------------------------SPEAKDFI
RGLLK-SPR---GADEPEDSELERK-RKMV
|..|. |. .| | .|.. | .
RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | LMR3.AA | Ror | 133-218 | 28 | 2e-13 | 49.86 | In-house | 1-89 (308) | Show / Hide |
Range on Protein: 133-218 Range on HMM: 1-89/308 Sequence Identity: 28% (25 aa) LSYLQEIGSGWFGKVILGEIFSDY---TPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDL .. . |.| . |||| |. .. .. |..| .. | | .. | |.. .|.|||. || | | . . |.. ||| VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDL |
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| Kinase | LMR3.AA | Musk | 385-408 | 28 | 0.007225 | 5.05 | In-house | 258-282 (282) | Show / Hide |
Range on Protein: 385-408 Range on HMM: 258-282/282 Sequence Identity: 28% (7 aa) YDILQSCW-RPPAQRPSASDLQLQL | .. || . || ||. ... . YQLMRRCWQKNPADRPFFCQIHHCI |
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| Kinase | LMR3.AA | TK-Unique | 385-408 | 36 | 0.046199 | 3.05 | In-house | 270-294 (294) | Show / Hide |
Range on Protein: 385-408 Range on HMM: 270-294/294 Sequence Identity: 36% (9 aa) YDILQSCWRP-PAQRPSASDLQLQL | ...|||. | .||| ... .| YNLMKSCWQWEPEERPSFRQIKHRL |
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