Gene MAP2K7 (Human)

MAP2K7

Species: Human
Alias: PRKMK7, MAP2K7, MAPKK7, JNKK2, Jnkk2, MKK7
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19p13.3,

Classification

Group: STE
Family: STE7
Subfamily: MEK7

Sequence

Name Sequence Type Origin Length Description Download
MAP2K7.NA RNA Sugen Kinome 3455 None Fasta, JSON
MAP2K7.AA Protein Sugen Kinome 442 None Fasta, JSON
MAP2K7.kin_dom Protein Kinase Domain Sugen Kinome 268 None Fasta, JSON

Protein domain

Protein domains of MAP2K7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K7.AA MEK7 136-403 67 2.3e-217 728.42 In-house 1-269 (269) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-269/269
Sequence Identity: 67% (185 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP----IP
|...|.||.|.||.|||||....|...|||||||.|||||||||||||||....|||||||||||.|.|..||.|.||.|.||..||.||...|    ||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

ERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCP
|.|.|||.|||..||.|||||||..||||||||||||.||.|||||||||||.|||||.||||||.|||||||||||||..|.||||||||||||.|   
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITL---

SPSQVELATGQFPYKNCKTDFEVLTKVLQE--EPPLLPGHMG--FSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
    |||||||.||..|...||..||.|..  |||.||.||.  ||.||..||..||.||||.||||..|..|.||
----VELATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K7.AA STE7 136-403 49 2.8e-166 558.69 In-house 1-288 (288) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-288/288
Sequence Identity: 49% (147 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNK-EENKRILMDLDVVLKSHDCPYIVQCFGTFITNTD--VFIAMELMG-TCAEKLKKRMQ----
|| .||.|.| .|.|.|||....|...|||..|.. |. ||.|.|||.|||. |..|||||||..| |.|. |  ..|.||.|. .| .|. ||.     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSK-AKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVW
    |.|||.||||..||..|.| ||.|||..|||||||||||...|||.|||||||.|.||||. |.|...||..||||||||.   .|..||.|.|||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG---NKQHYDVRSDVW

SLGISLPCPSPSQVELATGQFPYKNCKT-----------------DFEVLTKVLQE-EPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE-HSFI
||||..       .|.|||..|| |..|                  ||.||....| .|| ||   .|| .||.||. ||.||...|||| .|.. |.||
SLGITM------GIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K7.AA MEK4 136-403 46 8.99999999999e-120 392.66 In-house 1-275 (275) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-275/275
Sequence Identity: 46% (131 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGN------KEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRM---
|. ||| | |  | | ||.....| ..|||. | . .        | || ||..||| || .|||||. .|      |  | |||| .   |. |.    
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

-QGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLG
 .  ||| |.|. ||..|.|| ||||.| .||||||||||||| .| .|||||||.| |||| |||. |||  |||||||||    .. |||| ||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDP-EQNMDGYDIRSDVWSLG

ISLPCPSPSQVELATGQFPYKNCK--TDFEVLTKVLQEEPPLLPGHMG---FSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
| .       .|.|||.|||.  .    |. .. | . .|| |   .    .| .. .|.  ||||| ..|||| .|....|.
ITM-------YEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K7.AA MEK3 136-403 47 1.8e-117 396.55 In-house 1-264 (264) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-264/264
Sequence Identity: 47% (131 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQG----PIP
.. . | | |  | | ||| | .| ..||| .| . |  | ||.|||.|.   | |||| |. .|      || | ||.| ||  |. ..        ||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

ERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKP-DYDIRADVWSLGISLPC
| ||||. . ||.|| |..|.  ||||||||||.|.   ||.|.||||||| |||| |||  |||  |||||||||   ...  ||...||||||| .  
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDP--EMNQKGYDVKSDVWSLGITM--

PSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
     .|.|.| .|| | .| |. |. |  | || ||   ||| |.| |.. || |.   ||.| .|.||.|.
-----IEMAIGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K7.AA STE 136-403 26 1.6e-95 323.67 In-house 1-359 (359) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-359/359
Sequence Identity: 26% (100 aa)

LENLGEMGSGTCG-QVWKMRFR-----KTGHV---------IAVKQMR----------------RSGNKEENKRILMDLDVVLKSHD-CPYIVQCFGTFI
.|.... |.|..|  . .|.       ||| |         .|.|||.                .. |.|| ..||.....  |... .|.||...|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TN-------TDVFIAMELMG-TCAEKLKKRMQ-------------GPIPERILGKMTVAIVKA-LYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGIS
 .       ....|.||.|.  ..... |.               ...|| ........|.|. |||| ..| .||||.||.||||     .||||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GRLVDSKA----------------KT-RSAGCAAYMAPERIDPPDPT-KPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKNCKTD------------
|.|.|| |                |.   .|.  .||||.|.. . . ...||...|.||||. .       .|.|||. |. . .              
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI-------IEMATGKPPWHDMHPMRAMFMIPFNYHM

---FEVLTKVLQEEPPLLPGH-----------------MGFSGDFQSFVKDCLTKDHRKRPKYNKLLE--HSFI
   ||.| ......|| || |                   .| .|. |.. ||.|| .|||....||.  |.||
QQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K7.AA STE7-Unclassified 136-403 33 1.6e-85 290.4 In-house 1-301 (301) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-301/301
Sequence Identity: 33% (103 aa)

LENLGEMGSGTCGQVWKMRFRK------TGHVIAVKQMRRSGN-KEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTD---VFIAMELMGTCAEK----
|| |.. |.|  | | | .  .      .| ..| |. .   |  |  | ||. | .. |   .||||...| ...      ..|.||.|.  .      
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

-LKKRMQ------GPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSK--AKTRSAGCAAYMAPERIDPPDPTK
 .|| ..      |.|||..|||.. .. ..| ||.||| .||||.||.|||....||.|.||||..|.|...   |||  .||  ||.||||    | .
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

PDYDIRADVWSLGISLPCPSPSQVELATGQFPY--------KNCKTD------FEVLTKVLQEEPPLLPGHM---GFSGDFQSFVKDCLTKDHRKRPKYN
|.| .. |.||||...        |.||| .||        .| . .      .|.|....... | ||.      .| .|..|.. |. |. | || . 
PSYSVKSDIWSLGLTI-------WECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIH

KLLE-HSFI
 ||. | .|
QLLNEHPWI
Kinase MAP2K7.AA S_TKc 136-403 27 5.6e-68 233.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGT----CAEKLKKRMQGP--
 | | . |.|. |.|.| | .|||.. |.|...        ..|.  ...  |  ..|.||.....| . ..... ||....      . .|||  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDI-RADVWSLGI
  .||    ...  |..|| |. .. |.||||.||.||||||  .||.||||.. .|      |   |   ||||| .         |.  ..|.||.|.
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGC

SLPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE-------HSFI
 |        |...|. |.     . ... |..             | .. .|.. ||.|| .|||   ..|.       | ..
IL-------YEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP2K7.AA MEK5 136-403 39 7e-60 205.26 In-house 1-254 (254) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-254/254
Sequence Identity: 39% (107 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERIL
.     .| |  | |.|     .|...||| .      |  |.|. .|... |  | |||.  .| | .   . |  | |   .  . ..    ||| ||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC----IPEHIL

GKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQ
|.||||||| | || .   ..||||||||.|   .|||||||||.|  ||.| ..|   |  ||||||||        .| | .|||||||..       
GRMTVAIVKGLNYLWNLK-IMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI-----SGDQYGIHSDVWSLGIFF-------

VELATGQFPYKNCKTDF------EVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
.|.|||.||| . . |       ..|  . .|.|| ||    ||  |  |.  |. |  . ||| . |..| ||
MEMATGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDK-FSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K7.AA MEK1 136-344 41 3.5e-56 190.34 In-house 1-195 (297) Show / Hide 
Range on Protein: 136-344
Range on HMM: 1-195/297
Sequence Identity: 41% (88 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM-GTCAEKLKKRMQGPIPERI
.|..||.|.|  | | |.| |.|| ..| | ..        . |. .|  ||     ||||  .| |. . .. | || | |   . . |.  | |||.|
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQ-VLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-GRIPEKI

LGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPS
|||..||... | ||..|| ..||||||||||   || |||||||.||.|.|| |     |  .||.|||.     .   | ...|.||.|.||      
LGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERL-----QGTHYTVQSDIWSMGLSL------

QVELATGQFP
 ||.| |..|
-VEMAIGRYP
Kinase MAP2K7.AA Pkinase 136-403 23 2.6e-54 191.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL---MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM--G----TCAEKLKKRM
.. ..  |||. |.|.| . ..||.. |||.......|.. ....   . . . ..  ..|.||.....| ..... . ||..  |      .. .. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QGPI--PERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI----KLCDFGISGR--LVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIR
.|..  .|. . ..   |...|.|. . .|.||||.||.|||.|..|.|    |.||||..    .  .   |  .|   ||||| |     . ..|. .
HGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPK

ADVWSLGISLPCPSPSQVELATGQFPYKNC-----KTDFEVLTKVLQEEPPLLPGHM------------------GFSGDFQSFVKDCLTKDHRKRPKYN
.|.||.|. |        |...|..|....      .. ... .... ...                          | ....|.|.||.||  |||   
VDMWSCGCIL-------YEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

KLLEHSFI
 .|.| ..
QILQHPWF
Kinase MAP2K7.AA STE20 136-403 28 8.2e-49 168.49 In-house 1-288 (288) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-288/288
Sequence Identity: 28% (86 aa)

LENLGEMGSGTCGQVWKMRFRKTGHV----IAVKQMRRSGNK---EENKRILMDLDVVLKSHDCPYIVQCFGTFITN----TDVFIAMELMGT-CAEKLK
 |.| . |.|. |.| | . ..|| .    .|.|.|  .  .   .| . |.   ..  ... .|.||. .|... .    .. .|.||..|  ..  . 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

KR--MQG------PIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVD----SKA-K-TRSAGCAAYMAPERIDPPD
|.  . |      |. |     ..  ....| ||  ....||||.|  ||||.|.|..||.||| .. | .    ... |     |   .|||| |   .
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYL-HSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

PTKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKNCKTDFEVLTKVL--QEEPPLLPG--HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
  . .|| ..|.||||| .        |.|.|. || ..   . .. ...  |..|| | .  .  .| .|. ||. ||.||  |||   .||.|.||
GPDKGYDYKCDIWSLGITA-------IEMAEGEPPYFDMHP-MRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K7.AA TKL 142-401 18 5.9e-39 135.75 In-house 1-364 (364) Show / Hide 
Range on Protein: 142-401
Range on HMM: 1-364/364
Sequence Identity: 18% (70 aa)

MGSGTCGQVWKMRFRK--------TGHVIAVKQMRRSG----------------------NKEENKRILMDLDVVLKS---HDCPYIVQCFGTFITNTD-
 |||. |.|.| ..|         || ..|||....                        | .|....   . .....    ..| |||. |  . ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VFIAMELM-GTC-AEKLKKRMQGPIPERILGKMTVAIVKALYYLKE-------KHGVIHRDVKPSNILLDERGQ--------------
             .| ||.. | .  . |            . ..   | ....||         | ..|||| |..|||.|| ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

IKLCDFGISGRL--------------------VDSKAKTRSAGCAAYMAPERIDPPDPTKP-----------DYDIRADVWSLGISLPCPSPSQVELATG
.|.||||.| ..                    . .|.. .  |  ..|||| ..  ....            .|. ..||.| || |        |..|.
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL-------WEILTR

QFPYKNCKTDFEV---------LTKVLQEEPPLLPGH----------MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHS
. ||.. . . ..            ..  ..|..| .            .  .. .  .||   | .|||  ...|.. 
CRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MAP2K7.AA TyrKc 136-403 21 1.1e-11 -33.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKS-HDCPYIVQCFGTFITN-------TDVFIAMELMGTCAEKLKKRM-
.. . . |.|  |.|.| . .      ||| .. .      . ..  . .  |   . | ||...|  ..          ..| ||.|  .   ||..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM--PHGDLKDYLR

--QGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDS-------KAKTRSA--GCA-----AYMAPERIDPPDP
  .. .. . | .. . | .   || .| ..||||    |.|..|....| .||| |  . |        . .. .   |.        |||| |     
KHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----

TKPDYDIRADVWSLGISLPCPSPSQVELAT-GQFPYKNC----KTDFEVLTKVLQEEPPLLPGH------MGFSGDFQSFVKDCLTKDHRKRPKYNKLLE
 .  . .  |||| |. .        |. | || || .     ....||. .| | . .  | .       . . .  .  |.|   |  .||  . .  
NYGKFTTKSDVWSFGVCM-------WEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--

HSFI
|...
HECF
Kinase MAP2K7.AA MEK1 352-403 42 1.2e-10 32.08 In-house 247-297 (297) Show / Hide 
Range on Protein: 352-403
Range on HMM: 247-297/297
Sequence Identity: 42% (22 aa)

FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
||.|  . .| || || .. || .|| ||. || |    |    .|. | ||
FEMLDYIVNEPPPKLPHRV-FSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K7.AA Pkinase_Tyr 251-358 25 0.000167 15.88 Pfam 128-228 (270) Show / Hide 
Range on Protein: 251-358
Range on HMM: 128-228/270
Sequence Identity: 25% (30 aa)

EKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLV----DS-KAKTRSAGCAAYMAPE----RIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELAT-
| .. ||||.   |.|..| ...| |||| . |..       .... .      ||||    ..         . .  |||| |. .        |. | 
ESKNCIHRDLAARNCLVTENNVVKICDFGLA-RDIYNDDYYYRKRGGGKLPIKWMAPECINYGK---------FTTKSDVWSFGVLM-------WEIFTY

GQFP-YKNCKTDFEVLTKV
|. | |... ...||. ..
GEQPTYPGM-SNEEVYEYI