Gene MAP3K1 (Human)

MAP3K1

Species: Human
Alias: MEKK1, MEKK, MAP3K1, MAPKKK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 5q11.2-q13,

Classification

Group: STE
Family: STE11
Subfamily: MEKK1

Sequence

Name Sequence Type Origin Length Description Download
MAP3K1.NA RNA Sugen Kinome 7522 None Fasta, JSON
MAP3K1.AA Protein Sugen Kinome 1512 None Fasta, JSON
MAP3K1.kin_dom Protein Kinase Domain Sugen Kinome 266 None Fasta, JSON

Protein domain

Protein domains of MAP3K1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SWIM_MAP3K1 MAP3K1.AA SWIM_MAP3K1 327-397 40 2.1e-38 133.66 In-house 1-77 (77) Show / Hide 
Range on Protein: 327-397
Range on HMM: 1-77/77
Sequence Identity: 40% (31 aa)

FLIGGDSPDNKYRVFIG-PQNCSCA-----RGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRS
|...|....|.|.|.|| |..|.|.     ||..|.|...||.||||.....|..|.|.|...|||.|||..|....
FHVKGHTSGNVYTVHIGDPHTCTCPDCQKHRGNHCKHICWVMMRVFQVPRDHPWWWQKGLTQTEVEWLFQHKHMAKR
SWIM MAP3K1.AA SWIM 338-366 29 9.3e-08 26.26 Pfam 1-37 (37) Show / Hide 
Range on Protein: 338-366
Range on HMM: 1-37/37
Sequence Identity: 29% (11 aa)

YRVFIG----PQNCSCA----RGTFCIHLLFVMLRVF
|||...    . .|||     .|  | |.| |.... 
YRVQLDDDIVKCTCSCPMWQYYGYPCKHILAVLYHCN
RING_MAP3K1 MAP3K1.AA RING_MAP3K1 438-495 36 8.8e-33 108.25 In-house 1-80 (80) Show / Hide 
Range on Protein: 438-495
Range on HMM: 1-80/80
Sequence Identity: 36% (29 aa)

EEEQMCPICLLGMLDEE-------------SLTVCEDGCRNKLHHHCMSIWAEECRRN------REP---LICPLCRSKW
.||.|||||. .|.|..             ....|..||.|.||||||..|...||..      |.|   ..||.||..|
DEEDMCPICYEPMCDDDDVNPNNPDGKEKEPIWWCCCGCGNNLHHHCMRMWIKHCRQTAEFLNYRDPRHSVTCPWCRCDW
Kinase MAP3K1.AA MEKK1 1243-1508 78 3.4e-252 844.1 In-house 1-266 (266) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-266/266
Sequence Identity: 78% (208 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFK
|.||||||.|||||||.||||.|||||||||.||.||.||.||.|.|..|.|||||.|.|||.||||.||||..|.||.|||||.||||||||..|||||
WTKGQQIGTGAFSSCYMAQDVKTGTLMAVKQITYCRNNSSDQEDVMEEIRKEIRMMAHFNHPHIIRMMGATCHDSHYNVFIEWMPGGSVAHLLKDYGAFK

ESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEM
.||||||..|..|||||||.||||||||||||||.||||..|||||||.|||..|..|...|||||.||||||||||||||||||||||.|||||.||||
NSVVINYIHQVCRGLSYLHDNQIIHRDVKGANLLMDSTGHHLRIADFGTAARMNSDITRTDEFQGQFLGTIAFMAPEVLRGQQYGRSCDIWSVGCCIIEM

ACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF
.|.|||||.||||||..||||||||.|.|.||.||||||||..|||||.|||||||..||||||||
CCTKPPWNNEKHSNHYQLIFKIASANTPPPIPEHLSPGLRDITLRCLEAQPQDRPPVMELLKHPVF
Kinase MAP3K1.AA STE11 1243-1508 40 3e-150 505.47 In-house 1-303 (303) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-303/303
Sequence Identity: 40% (122 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTS--SEQEEVVEA------LREEIRMMSHLNHPNIIRMLGATC---EKSNYNLFIEWMAGGSV
| ||. || |||...|.. .| ||.||||||. ...|..  ..||. ...      ..|||..|.||||.||.|..|...   .....| | |...|||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

AHLLS-KYGA--FKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQG------QLLGTIA--------
...|. |.|.  | |.|. .|| |.|.||.|||...|||||.||||.|.||.|.....||||.| |||. .| . ....      .. ||.         
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

FMAPEVLRGQQ---YGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASA-TTAPSIPSHLS------PGLRDVALRCLELQPQDRPPSRELLK
.|||||.....   |||..|.||.|| .||||..||||.  .| || | .|||... ...| ||.|.|      . .||  ..|.| .|..|| ...||.
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDH-NHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQ

HPVF
|| .
HPFI
Kinase MAP3K1.AA STE 1244-1508 25 3.8e-93 315.75 In-house 1-359 (359) Show / Hide 
Range on Protein: 1244-1508
Range on HMM: 1-359/359
Sequence Identity: 25% (95 aa)

LKG-QQIGLGAFSSCYQAQDVG---------------TGTLMAVKQVTYVRNTSSEQE------------EVVEALREEIRMMSHLN--HPNIIRMLGAT
..| ..|| ||| . |.| ..                ||..||.||. . ...... |            | .. . .||..|...|  ||||.. .|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

CEK-------SNYNLFIEWMAGGSVAHLLS-KYGAFK-------------ESVVINYTEQLLRG-LSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA
  .       .. ... |.|.|||.  ..  ||| .|             ||... .. |.|.| |.|||...|||||.|.|| |.        ..||| 
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGV

AARLASKGTGA------------GEFQGQLLGTIAFMAPEVLRG------QQYGRSCDVWSVGCAIIEMACAKPPWNA-EKHSNHLALIFKIASAT----
...|......             ..    . ||  .|||||...      ..|...||.||.|| |||||. ||||     ... .. .|.....     
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

------TAPSIPS-------------------HLSPGLRDVALRCLELQPQDRPPSRELLK--HPVF
      . |..|.                   ..|| ..|   .||.  |..|| . .|||  || .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K1.AA STE11-Unclassified 1243-1508 33 1.7e-91 310.26 In-house 1-308 (308) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-308/308
Sequence Identity: 33% (103 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTS--SEQEEV-VEALREEIRMMSHLNHPNIIRMLGAT--CEKSNYNLFIEWMAGGSVAHLLSK
| ||. || |.| . |.. .. || .|||||.  . ..|   . ... ......|.. . .|||.||.. .|.    .....|.| | |.|||.. .| |
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

YGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAA---------------------RLASKGTGAGEFQGQLLGTIA--
||.| |.|  .|| |.| ||.|||.. |||||.||||.|||. | .  ..|||.|                       . ..     ..   . ||.   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDG-ICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-FMAPEVLRG--QQ-YGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLS-----------PGLRDVALRCLELQPQDRPPS
  |||||...  |. ..|. |.||.|| .|||| .|.||   .  |  ..|.||... ..| ||.|||           . ..|   .|... |..|| .
FWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

RELLKHPVF
..||.||  
NQLLQHPFI
Kinase MAP3K1.AA S_TKc 1243-1508 28 5.4e-88 299.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-231/231
Sequence Identity: 28% (81 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAG--GSVAHLLSKYGA
. ....|| |||...|......|| ..|.|..              | .| ||..... .||||......  . ... .. | . |  |.. ... |.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGR-SCDVW
      | | ..  |. |....| |.|...|||||.| .|.|.|.   .. |.||| |..|             . ||  .||||||   .||. .||.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWW

SVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLK-------HPVF
|.|| ..||.| .||.       .....||.             || ..|   .||.  |..||   |.|.       || |
SCGCILYEMLCGYPPFP------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K1.AA Pkinase 1243-1508 30 2.2e-87 301.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGG----SVAHLLS--
. .|..|| |.|...|.....||| . |||.. .... |..... . .   ||..| .||||||.|....  .|... .  |.. ||    . ....|  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KYGAF--KESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQR---LRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLR-GQQYGRSC
..|.|   | ....|  |.|||| |.|.. |||||.| .|.|||..|.    ..|.||| |. .    .  ..    . ||. .|||||.| || ||...
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSVGCAIIEMACAKPPWNAE----KHSNHLALIFKIASATTAPSIPSHLS-------------------PGLRDVALRCLELQPQDRPPSRELLKHPV
|.||.|| ..||.| .||.  .    .  .....|..| .. .  ..|   |                   . ..|.  .||.. |..||  ...|.|| 
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase MAP3K1.AA MEKK2 1243-1508 41 2.8e-74 253.06 In-house 1-262 (262) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-262/262
Sequence Identity: 41% (112 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS--NYNLFIEWMAGGSVAHLLSKYGA
| .|. .| |||   |   || ||  .|||||  . . ..|    |.||. ||...  | |. |.   |   ..      .|.|.|.||||   |  |||
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQ-FDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGA

FKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII
  |.|   || |.| |..|||.. |.|||.||||.| ||.|  ....||||. ||          .    ||  .|.|||. |  |||  ||||.|| ..
LTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGN-VKLGDFGASKRLQTICMHITGMK-SVTGTPYWMSPEVINGEGYGRKADVWSIGCTVV

EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF
||   |||| ||     .| |||||   | | .|.|.|   ||   ||     ||||   |||.|   
EMLTEKPPW-AEYEA--MAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K1.AA MEKK15 1243-1508 35 1.1e-65 224.57 In-house 1-264 (264) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-264/264
Sequence Identity: 35% (96 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFK
| ||. .| ||.   |      || |.|||||        . ..    | ||. ..  | | ||.  || . |    |.|.... |||.. .. ..|.  
WKKGNILGKGAYGTVYCGL-TNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLD

ESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGE--FQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII
| |   || |.|.|  ||||| ..|||.||.|... .||  ... ||| | ||. .|    .      . ||  .|||||.    |||  |.||.|| . 
EMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGI-IKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVF

EMACAKPPWNAEKHSNHLALIFKIASA-TTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF
|||  ||||      . .| .| | .     | .| . |   |.    ||    ..||   .|||||  
EMATRKPPWAD---MDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K1.AA ASK 1249-1508 37 1.3e-62 207.0 In-house 2-254 (254) Show / Hide 
Range on Protein: 1249-1508
Range on HMM: 2-254/254
Sequence Identity: 37% (99 aa)

IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLL-SKYGAFK--ESV
.| |..   | . |  |   .|.| .    .        |  | ||| . ..| | ||.. ||.. | .   .|.| . |||.. || ||.| .|  |. 
LGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR------YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENT

VINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQQ-YGRSCDVWSVGCAIIEMA
.  || |.| ||.|||||||.|||.|| | |.      ..|.||| . |||     .  |.    ||. .|||||. .||  ||.. |.||.|| ..|||
MNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFT----GTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMA

CAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF
 .|||.  |  . . |. ||.    . | ||. ||   ..  ||| | .|..|. ...||. |  
TGKPPF-HELGEPQAAM-FKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K1.AA CAMK 1248-1508 17 1e-54 174.4 In-house 1-425 (425) Show / Hide 
Range on Protein: 1248-1508
Range on HMM: 1-425/425
Sequence Identity: 17% (74 aa)

QIGLGAFSSCYQAQDVGTG------------TLMAVKQVTYVRNTSSE----------------------QEEVVEALREEIRMMSH-------LNHPNI
..| |.|.  . ...  |.            .  |.| .   . ....                      ...  . .| ||..|..       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRMLGATCE-------------------KSNYNLFI---EWMAGG----SVAHLLSKY---------------GAFKESVVINYTEQLLRGLSYLHENQI
|... .                      .... ..    | . ||     .   . .                | |.|. .  |  |.. .. |.|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDVKGANLLIDSTG----------------QRLRIADFGAAARLASKGTGA-------------------GEFQGQLLGTIAFMA-PEVLRGQQ----
.||| |  |.|.|. .                  . |.||| |... ..                       |.      || ..|| ||||.|..    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGRSCDVWSVGCAIIEMACAKPPWNAEKHS----------NHLALIFKIASAT-T-APSIPSH--------------------LSPGLRD
          ||..||.||.|.    | | .||.......          |   |  || ..  .  |.  |.                    .|.  .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VALRCLELQPQDRPPSRELLKHPVF
   ..|.  |..|.   . |.|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K1.AA TKL 1249-1506 21 2e-52 180.47 In-house 1-364 (364) Show / Hide 
Range on Protein: 1249-1506
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

IGLGAFSSCYQAQDVG--------TGTLMAVKQVTYVRNT---------------------SSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSN-
|| |.|.  |...  |        ||. .|||.     .                      . |..   . ..|||.||| |.||||....|. |. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQ--------IIHRDVKGANLLIDSTGQ-------------RLR
            . .  |.. |||  |.|        .. ..   .  ||..||| ..        ||||| | .|.|.|. ..             .. 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADFGAAARL----ASKGTGAGEF-----------QGQLLGTIAFMAPEVLRGQ----------------QYGRSCDVWSVGCAIIEMACAKPPWNAEKH
|.||| . ..     .. |. ..             .   ||...|||||||||                .|  .|||.| |  . |... ..|.  ...
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

SNHL------ALIFKIASATTAPSIP------------SHLSPGLRDVALRCLELQPQDRPPSRELLKHP
. ..      . . ....    | ||            ..  |.... . .| .  |..||   |.||. 
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MAP3K1.AA STE-Unique 1320-1508 24 5.1e-40 139.28 In-house 370-616 (616) Show / Hide 
Range on Protein: 1320-1508
Range on HMM: 370-616/616
Sequence Identity: 24% (62 aa)

NLFIEWMAGGSVAHLLSKYGA---------FKESVVINYTEQLLRGLSYLHENQ--IIHRDVKGANLLIDSTG----QRLRIADFGAAARLASKGTGA--
..| |   .|..  ..   |.         | |. || || |.| || |||  .  |||||.| .| .... |     . .|.||| | ...  . .   
WIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDN

--------------------------------GEFQGQLLGTIAFMAPEVLRGQ-----QYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIA
                                  .   . ||   |.|||....      |..  |.|| || ...|.|  |||.  . .. .|.|  . 
NSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWH--QRYHMQAYIEMCI

SATTAPS------IPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF
  .. |       ||. ..|....    |||. | .||.  .||.|.  
HIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase MAP3K1.AA TyrKc 1243-1508 20 3.1e-17 55.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 1243-1508
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL--NHPNIIRMLGATCEK-------SNYNLFIEWMAGGSVAH
  .|...| |||   |...     .  ||| .             .|....|.|.|..|  .||||.|..|.  ..         . .  | |..|.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLSKYGA-FKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASK-------GTGAGEF--QGQLLGTIAFMAPEVLRG
 | |..  .. .  ...  |  .| .|||....||||    | |... . . .|.||| .  . ..        .       .|  .  |  ||||... 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

QQYGRSCDVWSVGCAIIEMA--CAKPPWN-AEKHSNHLALIFKIASATTAPSIPSH--------LSPGLRDVALRCLELQPQDRPPSRELLKHPVF
  .    |||| |  . |.   ...|... ...     . ...   .   . .| .         .. . .. ..| . .| |||  .|.  |  |
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAP3K1.AA Pkinase_Tyr 1245-1390 24 1.4e-15 53.37 Pfam 3-156 (270) Show / Hide 
Range on Protein: 1245-1390
Range on HMM: 3-156/270
Sequence Identity: 24% (39 aa)

KGQQIGLGAFSSCYQAQDV----GTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL-NHPNIIRMLGATC-EKSN--YNLFIEWMAGGSVAHLLS
.|...| ||| . |..       .|..  ||| .   ........   |.. .|...|..| .||||.|..|.   ..    . .  | |..|.  . | 
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KY----GAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFG
|     .... .  ...  |  .|..||.....||||.   | |.....   .|.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFG
Kinase MAP3K1.AA STE-Unique 1244-1317 25 1.7e-10 32.93 In-house 1-74 (616) Show / Hide 
Range on Protein: 1244-1317
Range on HMM: 1-74/616
Sequence Identity: 25% (19 aa)

LKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKS
.  | || |.|   . .|.  ..  .|.| .     . . ||  |. . .||  |. |.|.||.. .|.  ...
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGG
Kinase MAP3K1.AA Pkinase_Tyr 1416-1434 42 2.047032 2.03 Pfam 181-199 (270) Show / Hide 
Range on Protein: 1416-1434
Range on HMM: 181-199/270
Sequence Identity: 42% (8 aa)

MAPEVLRGQQYGRSCDVWS
||||...   .    ||||
MAPECINYGKFTTKSDVWS