Gene MAP3K5 (Human)

MAP3K5

Species: Human
Alias: ASK1, MAPKKK5, MEKK5, NAP160, MAP3K5
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6q23.3-q24,

Classification

Group: STE
Family: STE11
Subfamily: ASK

Sequence

Name Sequence Type Origin Length Description Download
MAP3K5.NA RNA Sugen Kinome 5215 None Fasta, JSON
MAP3K5.AA Protein Sugen Kinome 1374 None Fasta, JSON
MAP3K5.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of MAP3K5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ASK_nterm_v5 MAP3K5.AA ASK_nterm_v5 131-185 65 7.8e-34 118.72 In-house 1-55 (55) Show / Hide 
Range on Protein: 131-185
Range on HMM: 1-55/55
Sequence Identity: 65% (36 aa)

HFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYC
 |..|||||| ..|.|||||...|.||....||.||||||||.|| |.|||||||
EFMRLDFGETDMFDEFYNADVVIVDMSIDHQQPNLFYHLGVRHSFKMRNNIILYC
TPR_ASK_1 MAP3K5.AA TPR_ASK_1 311-344 50 2.3e-20 67.19 In-house 1-38 (38) Show / Hide 
Range on Protein: 311-344
Range on HMM: 1-38/38
Sequence Identity: 50% (19 aa)

ADIVINLLLSYRDIQDYDSIVKLVETLE---KLPTF-D
.|||.|...||||||||||...|||.|.   ..|.. .
GDIVHNFMHSYRDIQDYDSMIELVEDLKEGEHIPNCCK
TPR_ASK_2 MAP3K5.AA TPR_ASK_2 387-429 52 4.1e-27 85.56 In-house 1-46 (46) Show / Hide 
Range on Protein: 387-429
Range on HMM: 1-46/46
Sequence Identity: 52% (24 aa)

SDMYCLVGRIYKDMFLDSNFTD---TESRDHGASWFKKAFESEPTL
.||.|..|||||||||.|..||   .||||..  |..|.||..|..
PDMWCMCGRIYKDMFLESQYTDEAARESRDQAIHWYRKGFEIQPNH
TPR_ASK_3 MAP3K5.AA TPR_ASK_3 475-508 47 1.2e-14 54.08 In-house 1-34 (34) Show / Hide 
Range on Protein: 475-508
Range on HMM: 1-34/34
Sequence Identity: 47% (16 aa)

YWEVGFFLGASVLANDHMRVIQASEKLFKLKTPA
|| |..|...|.||.|  ...||.|..|||| | 
YWDVATFFEISILACDYHKCMQACECMFKLKPPN
Kinase MAP3K5.AA ASK 685-938 84 6.5e-197 660.47 In-house 1-254 (254) Show / Hide 
Range on Protein: 685-938
Range on HMM: 1-254/254
Sequence Identity: 84% (215 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYT
|||||||||||||||...||||||||||||||||.|||||||||||.|.|.|||||||..||||..||||||||||||||||||||||.||||.|. |||
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT

KQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL
|||||||||||.||||||||||||||.||||||.|||||||.|||||||||||||||||||||||.||.|.|||||.|||||.|||..|||||||||.||
KQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHEL

GEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL
||||||||||||.|.||||||..|||.|.|||.||||||.|||.|.||| |.||
GEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K5.AA STE11 680-938 44 2.6e-164 552.18 In-house 1-303 (303) Show / Hide 
Range on Protein: 680-938
Range on HMM: 1-303/303
Sequence Identity: 44% (135 aa)

NGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSR--------YSQP------LHEEIALHKHLKHKNIVQYLGS---FSENGFIKIFMEQVPGGSL
   . ..|||..| ||...........|.|.|......        . |.      ..|||.|.|||.|||||.|.|.    ..|....||||..|||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTET----------FTGTLQ--------
|..||.||||.|..|..| .|||||||||.|||...|.||||||.|.|......|.|..|||..||||.|..||..          .|||..        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEIIDKGPRG-YGKAADIWSLGCTIIEMATGKPPFYELGE-PQAAMFKVGMF-KVHPEIPESMS------AEAKAFILKCFEPDPDKRACANDLLVD
.||||.|....|. ||..|||||||||.|||||||||...... ..|||||.||. | ||.|||.||      .|...|...|||.|| ||. ||.|| .
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

EFL
 |.
PFI
Kinase MAP3K5.AA STE 681-938 27 3.6e-107 362.36 In-house 1-359 (359) Show / Hide 
Range on Protein: 681-938
Range on HMM: 1-359/359
Sequence Identity: 27% (101 aa)

GDR-VVLGKGTYGIVYAGRDLS---------------NQVRIAIKEIPERDS-----------------RYSQPLHEEIALHKHLK--HKNIVQYLGSFS
 ..  ..|||..| || ...                 .....|||... ...                    | . .|| ..|...  |.|||.|.|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ENG-------FIKIFMEQVPGGSLSALLRSKWGPLKDN-----------EQTIGFYTKQILEG-LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTS
 .|        . |.|| ..||||. ....|.|..|..           |. |.....|||.| |.|||...|.|||||..|.|.       |..|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KRLAGINP----------------CTETFTGTLQYMAPEIIDKGPRG----YGKAADIWSLGCTIIEMATGKPPF---YELGEPQAAMFKVGMF------
..|. ...                 . ||.||  .||||.|... .|    |.  .||||||||||||||||||.   . .    ...|. .|.      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KVHPEIPE-------------------SMSAEAKAFILKCFEPDPDKRACANDLLV--DEFL
    . .| .|.                   ..| | | || ||.. ||.||. |..||    .|.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K5.AA S_TKc 680-938 31 1.9e-94 321.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 680-938
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

NGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPG--GSLSALLRSKWGPLK---
     ..|||..| || .|. . . . |||.|.       . .  ||...|. .|.|||.....| . ... ..|| ..|  |.|  ..... .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

DNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGK-AADIWSLGCTIIE
 .| .. ||..||...|.|.|...|.|||.| .|.|...   ..||.||| ...|        || ||. |||||..     |||| ..|.||.||...|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

MATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLV-------DEFL
|..|.|||.     ...|||. .           | ||| || ||.. ||.||  | ..|        ....
MLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K5.AA STE11-Unclassified 683-938 35 2e-94 320.04 In-house 4-308 (308) Show / Hide 
Range on Protein: 683-938
Range on HMM: 4-308/308
Sequence Identity: 35% (111 aa)

RVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSR-----YSQP----LHEEIALHKHLKHKNIVQYLGSF--SENGFIKIFMEQVPGGSLSALLRSKWG
. ..|||..| || . ....   .|.|.| . |.        .     . .|... |.| |||||||.|     ....| ||||..||||....|. | |
GEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLN-KYG

PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLA------------------GIN-PCTE------TFTGTLQ--
..  .|..|  |||||||||.||| . |.||||||.|.|| .  |. |..|||..|  .                   |  .  .      .  ||..  
CF--DEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDF-DGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-YMAPEIIDKGPR-GYGKAADIWSLGCTIIEMATGKPPFYELGE--PQAAMFKVGMFKVHPEIPESMS-----------AEAKAFILKCFEPDPDKRACA
 .||||.|.     |.. ..||||||||.|||||||.|.. . .  ...|..|..| .  |.||| .|           .|.|.|. |||. || ||. |
FWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

NDLLVDEFL
| || . |.
NQLLQHPFI
Kinase MAP3K5.AA Pkinase 685-938 30 7.3e-79 273.1 Pfam 6-293 (293) Show / Hide 
Range on Protein: 685-938
Range on HMM: 6-293/293
Sequence Identity: 30% (89 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHE----EIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGG----SLSALLR-SKWGPLKD
..|.|..| || ... ... . |.|.|. |. . ... .     ||...|.|.|.|||.....| ... | . || ..||    .|..... .. |..  
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

NEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVL----KISDFGTSKRL-AGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
 |... || .|||.||.|.|.. |.|||.| .|.||.   |..    ||.||| .| .    |. . ||.||. |||||.|  | ..||...|.||.||.
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCI

IIEMATGKPPFYEL-----GEPQAAMFKVGMFKVHPEIPES-------------------MSAEAKAFILKCFEPDPDKRACANDLLVDEFL
..||..|.|||..       .... ...... ..| ..|..                   .| |.| || .|...|| ||  | ..| ....
LYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K5.AA MEKK15 679-938 42 1.9e-71 243.64 In-house 2-264 (264) Show / Hide 
Range on Protein: 679-938
Range on HMM: 2-264/264
Sequence Identity: 42% (116 aa)

ENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP------ERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGP
. |.  .|||| || || |     |. ||.| .       |.  .  . | ||. | | ||||||| |||   |.  . |||. |||||.|...  ..||
KKGN--ILGKGAYGTVYCGLTNTGQL-IAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSII-NRFGP

LKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLA--GINPCT----ETFTGTLQYMAPEIIDKGPRGYGKAADIWS
|  .|     ||||||.| .|||.| .||||||| ||..    |..|. |||  |||.  |||           ||  .||||.|     |||. .||||
L--DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIME--TGYGRKSDIWS

LGCTIIEMATGKPPFYELGEPQAAMFKVGMF-KVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL
.|||. ||||.|||. .. .. |||| .|    . |..|.  | .|. |.  |   | . |. | .||   |.
IGCTVFEMATRKPPWADM-DRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K5.AA CAMK 685-938 17 4.1e-65 208.49 In-house 1-425 (425) Show / Hide 
Range on Protein: 685-938
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

VLGKGTYGIVYAGRDLSNQ------------VRIAIKEIP-----------------ERDSRYS-----------QPLHEEIALHKH-------LKHKNI
.||.|..|.|. ... ...            .. ||| |.                  ..|. .           . .  ||...|.       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYLGSFSENGF-------------------IKIFM---EQVPGG----SLSALLRSK--------------WGPLKDNEQTIGFYTKQILEGLKYLHDN
.. .  .  . .                   . ..|   | ..||     |   ....              .| .  .|.   .| .||.....|.|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRF--TEREARRYFRQICSAVHYCHSH

QIVHRDIKGDNVLINTYS----------------GVLKISDFGTSKRLAGI-----------------------NPCTETFTGTLQYMA-PEIIDKGP--
 |||||.| .|.|... .                . .||.||| .... .                        ..  .|| ||. ||| ||.. . .  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAA--------------MFKVGMFK-VHPEIPE-------------------SMSAEA
          ..||...|.||.|.    | .|.||||.  . .                . . | .   .|....                     |.|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KAFILKCFEPDPDKRACANDLLVDEFL
| .| |. ..||.||. . . | ....
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K5.AA MEKK2 685-938 40 1.8e-63 217.16 In-house 6-262 (262) Show / Hide 
Range on Protein: 685-938
Range on HMM: 6-262/262
Sequence Identity: 40% (107 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERD-----SRYSQPLHEEIALHKHLKHKNIVQYLGSFSENG--FIKIFMEQVPGGSLSALLRSKWGPLKDNE
.||.| .| ||   |      .|.| ..  .     ..  | |. || | | |.|. |||| |   .|.   . |||| .||||.   |.  .|.| .. 
LLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKA-YGALTET-

QTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCT---ETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEM
     ||.|||||..||||. |||||||| |.| .  || .|..||| ||||  |        . |||  .|.||.|.    |||. ||.||.|||..||
-VTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDS-SGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVING--EGYGRKADVWSIGCTVVEM

ATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL
 | |||. |  |  ||.||.   .  |..|...| .|. |. .||      |  |..||  .| 
LTEKPPWAEY-EAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K5.AA Ciliate-E2 685-938 21 1.8e-60 206.27 In-house 6-365 (365) Show / Hide 
Range on Protein: 685-938
Range on HMM: 6-365/365
Sequence Identity: 21% (81 aa)

VLGKGTYGIVYAGRDLSNQVR-----------------------IAIKEIPERDSRYSQP-LHEEIALH------------KHLKHKNIVQYLGSFS--E
..|.|..|.|| ... ..| .                       .|.| . ... ..    .|.   ..            ..|.|.||...  .|    
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

NGFIKIFMEQVPGGSLSALLRSKWGPLKDN--------EQTIGFYTKQILE---------------GLKYLHDNQ-IVHRDIKGDNVLINTYSGVLKISD
.  | . || . ||.|  ......   . .        |. |....||||.               .|.||| .  |.||||| .|.|.      .||.|
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIID

FGTSKRLAGINP-------------------------------CTETFTGTLQYMAPEIIDKGP-------RGYGKAADIWSLGCTIIEMATGKPPFYEL
||.||..   |                                 . |. ||. ||||||. ...        ||....||||||... || .|||||   
FGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---

GEPQAAMFKVGMFKVHPE--------------IPESMSAEAKAFILK----CFEPDPDKRAC-ANDLLVDEFL
        | . ..  ..              .... | |.| .| |    ... ||.||   ....|  ...
----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MAP3K5.AA STE20 682-938 34 9.1e-59 201.56 In-house 3-288 (288) Show / Hide 
Range on Protein: 682-938
Range on HMM: 3-288/288
Sequence Identity: 34% (99 aa)

DRVVLGKGTYGIVYAGRDLSNQVR----IAIKEIPERDS----RYSQPLHEEIALHKHLKHKNIVQYLGSFSEN----GFIKIFMEQVPGGSLSALLRS-
.  ..|.|.|| || ... ...      .||| .. ..        . .  ||   | .||.|||.|.||.  .      . | ||   ||||. ...  
LLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHC

-KWG------PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG-----INPCTETFTGTLQYMAPEIIDKGP-
 |.|      |.  ||. | . ....|.||.||| |.|.|||||.||.|... .|  |..||| .  |       ...   || ||  .||||.| .   
MKCGKNHKGHPM--NEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--RGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHP---EI--PESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL
   ||.  .|||||| |.||||.|.||....  |  |||..   .  |   .   |.. | | . |. || . ||.||. | .||  .|.
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K5.AA Ciliate-E2-Unclassified 685-938 23 4.3e-53 182.51 In-house 6-352 (352) Show / Hide 
Range on Protein: 685-938
Range on HMM: 6-352/352
Sequence Identity: 23% (82 aa)

VLGKGTYGIVYAGRDLSNQVRI-----AI-------KEIPERDSRYSQPLHEEIALH---------------KHLKHKNIVQYLGSFSENGFIKIFMEQV
..|.| .|.||  .. ...  .     ..       | | . | .... ..|.  .                ....| .|| ..  |     | | ||..
QIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYC

PGGSLSALLRSKWG---------------PLKDNEQTIG----FYTKQILEGLKYLHDNQ-IVHRDIKGDNVLINTYSG--VLKISDFGTSKRLAGINPC
.||.|.  ......                  . .|...    ||..|||.||.||| .. |.||||| .|.|..   .   .||.||| ||..   | |
EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNC

---------------TETFTGTLQYM----APEIIDKGPRGYG--KAADIWSLGCTIIEMATGKPPFY-ELGEP----------------QAAMFKVGMF
               . ||.||..||    |||....   .    ...||||||. . || .|..||| .  |                 .   .| . .
DTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNI

KVHPEIP----ESMSAEAKAFIL----KCFEPDPDKRACANDLLVDEFL
.. .. .       | ||| ||     |... .|.||  ....|   ..
QFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MAP3K5.AA Pkinase_Tyr 685-824 27 2.2e-18 62.86 Pfam 6-156 (270) Show / Hide 
Range on Protein: 685-824
Range on HMM: 6-156/270
Sequence Identity: 27% (42 aa)

VLGKGTYGIVYAGRDL----SNQVRIAIKEI-PERDSRY--SQPLHEEIALHKHL-KHKNIVQYLGSFS-ENGF--IKIFMEQVPGGSLSALLRSK--WG
.||.| .| || |.      ....  |.| . .  ...   .. . .|... |.| .|.|||...|  . . .   | | || .|.|.|   ||..  ..
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
.  . .. ...   || .|. ||......|||.   |.|..  ..| ||.|||
QPLTMKDLLQM-CWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFG
Kinase MAP3K5.AA TyrKc 685-937 22 5.5e-17 51.94 SMART 6-280 (280) Show / Hide 
Range on Protein: 685-937
Range on HMM: 6-280/280
Sequence Identity: 22% (66 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHL--KHKNIVQYLGSFSEN-------GFIKIFMEQVPGGSLSALLRSKWGPLKD
.|| | .|.|| |.     .  |.| . |      . ...|. . ..|  .|.|||. .|  ..        . . | || .|.|.|   ||.. .    
KLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--L

NEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI---------NPC----TETFTGTLQYMAPEIIDKGPRGYGKAA
. ..   .  || .|  |||.....|||.   |.|..    . |||||| |. .                    . .   .  |||| |..|   .  . 
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG--KFTTKS

DIWSLGCTIIEMAT-GKPPFYEL----GEPQAAMFKVGMFKVHPEIPES--------MSAEAKAFILKCFEPDPDKRACANDLLVDEF
|.|| | .. |. | |..| ..      ..| .. .|   .  ...|..        ...|    ...| . ||..| . ... ...|
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR-MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MAP3K5.AA Pkinase_Tyr 846-937 22 0.000151 16.02 Pfam 181-270 (270) Show / Hide 
Range on Protein: 846-937
Range on HMM: 181-270/270
Sequence Identity: 22% (21 aa)

MAPEIIDKGPRGYGKAADIWSLGCTIIEMAT-GKPP-FYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEF
|||| |  |   .  . |.|| | .. |. | |. | ....  ..  . ...      ..||  ..|    ...| ..||..|    .. . ..
MAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI-HEQL
Sam7 MAP3K5.AA sam7 1308-1370 21 6.6e-12 40.23 In-house 1-70 (70) Show / Hide 
Range on Protein: 1308-1370
Range on HMM: 1-70/70
Sequence Identity: 21% (15 aa)

TEDSELTDWLRVNGA--DEDTISRFLAEDY----TLLDVLYYVTRDDLKCLRL-RGGMLCTLWKAIIDFR
. ......||.  |   ... ...|.....    | .|.| ..|..||. .   |.|  . .|..| ..|
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR