Gene MAP3K6 (Human)

MAP3K6

Species: Human
Alias: MGC20114, MGC125653, MAP3K6, MAPKKK6, ASK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p36.1,

Classification

Group: STE
Family: STE11
Subfamily: ASK

Sequence

Name Sequence Type Origin Length Description Download
MAP3K6.NA RNA Sugen Kinome 4333 None Fasta, JSON
MAP3K6.AA Protein Sugen Kinome 1288 None Fasta, JSON
MAP3K6.kin_dom Protein Kinase Domain Sugen Kinome 262 None Fasta, JSON

Protein domain

Protein domains of MAP3K6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ASK_nterm_v5 MAP3K6.AA ASK_nterm_v5 95-149 52 3.1e-28 100.15 In-house 1-55 (55) Show / Hide 
Range on Protein: 95-149
Range on HMM: 1-55/55
Sequence Identity: 52% (29 aa)

PFGTLELGDTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCS
.|..|. |.|. .| |||||||. ..|    ||.||||||||.|| |.||..|. 
EFMRLDFGETDMFDEFYNADVVIVDMSIDHQQPNLFYHLGVRHSFKMRNNIILYC
TPR_ASK_1 MAP3K6.AA TPR_ASK_1 274-307 47 5.4e-20 65.95 In-house 1-38 (38) Show / Hide 
Range on Protein: 274-307
Range on HMM: 1-38/38
Sequence Identity: 47% (18 aa)

PDIIMNLLLSYRDVQDYSAIIELVETLQ---ALPTC-D
.||..|...||||.|||...|||||.|.   ..|.| .
GDIVHNFMHSYRDIQDYDSMIELVEDLKEGEHIPNCCK
TPR_ASK_2 MAP3K6.AA TPR_ASK_2 350-392 54 2.5e-32 102.39 In-house 1-46 (46) Show / Hide 
Range on Protein: 350-392
Range on HMM: 1-46/46
Sequence Identity: 54% (25 aa)

PDLYCMCGRIYKDMFFSSGFQD---AGHREQAYHWYRKAFDVEPSL
||..|||||||||||..|...|   ...|.||.|||||.|...|..
PDMWCMCGRIYKDMFLESQYTDEAARESRDQAIHWYRKGFEIQPNH
TPR_ASK_3 MAP3K6.AA TPR_ASK_3 438-471 38 2.9e-18 67.02 In-house 1-34 (34) Show / Hide 
Range on Protein: 438-471
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

YWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPI
||||.......|||.|......|.|...||..|.
YWDVATFFEISILACDYHKCMQACECMFKLKPPN
Kinase MAP3K6.AA ASK 653-906 78 2.4e-189 635.18 In-house 1-254 (254) Show / Hide 
Range on Protein: 653-906
Range on HMM: 1-254/254
Sequence Identity: 78% (199 aa)

VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYT
||||||||.||||||.||.||||||||||||||..||||||||||..|||.|||.|||..|..||.|||||.|||||||.||||.|||.||||.|..|||
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT

RQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHEL
.|||.|| |||.|.||||||||||||.||.||..|||||||.||||||.||||||||||||||||.||||.|||||.|||||.|||..|||||.||||||
KQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHEL

GSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL
|.||||||.|||||.||..|..||||...|.||.|||||. |||||.|| ||||
GEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K6.AA STE11 648-906 42 5.3e-157 527.87 In-house 1-303 (303) Show / Hide 
Range on Protein: 648-906
Range on HMM: 1-303/303
Sequence Identity: 42% (130 aa)

TGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSR--------FSQP------LHEEIALHRRLRHKNIVRYLGS---ASQGGYLKIFMEEVPGGSL
  .. ..|||..|.||.... .| ...|.|.|......        . |.      ..|||.|.. |.|||||||.|.    .| ....|||| .|||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTET----------FTGTLQ--------
||.||. |||.|..|..|..||.|||.|| |||...|.||||||.|.|... ....|..|||..||||.|..||..          .|||..        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEIIDQGPRG-YGKAADIWSLGCTVIEMATGRPPFHELGS-PQAAMFQVGMY-KVHPPMPSSLS------AEAQAFLLRTFEPDPRLRASAQTLLGD
.||||.|.|..|. ||..||||||||||||||||.||.|.... ..|||| .||. | ||| |...|      .|...||...||.||  |..|. || .
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase MAP3K6.AA STE 649-906 27 8.49999999999e-103 347.82 In-house 1-359 (359) Show / Hide 
Range on Protein: 649-906
Range on HMM: 1-359/359
Sequence Identity: 27% (102 aa)

GER-LVLGKGTYGVVYAGRDRH---------------TRVRIAIKEIPERDS-----------------RFSQPLHEEIALHRRLR--HKNIVRYLGSAS
 |.  ..|||..|.|| .....               | ...|||... ...                    | . .|| ......  |.|||.|.|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QGG-------YLKIFMEEVPGGSLSSLLRSVWGPLKDN-----------ESTISFYTRQILQG-LGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTS
..|       .| |.|| ..||||........|..|..           || |....||||.| | |||..||.|||||..|.|.       |..|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KRLAGITP----------------CTETFTGTLQYMAPEIIDQGPRG----YGKAADIWSLGCTVIEMATGRPPF---HELGSPQAAMFQVGMY------
..|. . .                 . ||.||  .||||.|.|. .|    |.  .||||||||.||||||.||.   | .    ...|  .|.      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KVHPPMPS-------------------SLSAEAQAFLLRTFEPDPRLRASAQTLLG--DPFL
    . .|| |.                   ..| | . |. . .. ||. |..|. ||    ||.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K6.AA S_TKc 648-906 29 3e-88 300.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 648-906
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

TGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPG--GSLSSLLRSVWGPLK---
     ..|||..|.|| .|...|  . |||.|.       . .  ||..... .|.|||.....    ..| ..|| ..|  |.| .....  .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

DNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGK-AADIWSLGCTVIE
 .| .. ||..||...| |.|...|.|||.| .|.|...    .||.||| ...|        || ||. |||||..     |||| ..|.||.||...|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

MATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLG-------DPFL
|..|.|||.     ...||.. .           | ||  |. . .. ||. | .|  .|        .|..
MLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K6.AA STE11-Unclassified 651-906 33 4.3e-87 295.66 In-house 4-308 (308) Show / Hide 
Range on Protein: 651-906
Range on HMM: 4-308/308
Sequence Identity: 33% (104 aa)

RLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSR-----FSQP----LHEEIALHRRLRHKNIVRYLGSA--SQGGYLKIFMEEVPGGSLSSLLRSVWG
. ..|||..| || . . .|   .|.|.| . |.      . .     . .|... . |.|||||.|.|     ... . |||| .||||..|.|.   |
GEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK-YG

PLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLA------------------GIT-PCTE------TFTGTLQ--
..  .|..|. ||.|||.|| ||| ..|.||||||.|.||  | |  |..|||..|  .                   |. .  .      .  ||..  
CF--DEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILID-FDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-YMAPEIID---QGPRGYGKAADIWSLGCTVIEMATGRPPFHELGS--PQAAMFQVGMYKVHPPMPSSLS-----------AEAQAFLLRTFEPDPRLRA
 .||||.|.   |.  |.. ..|||||||||||||||..|.  .    ...|.. ..| .  |. |. ||           .|...|| ..|. ||  |.
FWMAPEVIKNSTQT--GHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRP

SAQTLLGDPFL
.|. || .||.
TANQLLQHPFI
Kinase MAP3K6.AA Pkinase 653-906 29 1.4e-72 252.24 Pfam 6-293 (293) Show / Hide 
Range on Protein: 653-906
Range on HMM: 6-293/293
Sequence Identity: 29% (85 aa)

VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHE----EIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGG----SLSSLLR-SVWGPLKD
..|.|..|.|| .... |. . |.|.|. |. . ... .     ||....||.|.||||....   .... . || ..||    .|..... .  |..  
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

NESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGL---LKISDFGTSKRL-AGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTV
 | .. || .|||.|| |.|.. |.|||.| .|.||.    .   .||.||| .| .     . . ||.||. |||||.|  | ..||...|.||.||..
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCIL

IEMATGRPPFHEL-----GSPQAAMFQVGMYKVHPPMPSSLS-------------------AEAQAFLLRTFEPDPRLRASAQTLLGDPFL
.||..||||| .       .... ...... ..| . | . |                    |.. |. . ...||  | .|. .| .|..
YEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K6.AA MEKK15 647-906 41 8.1e-66 224.98 In-house 2-264 (264) Show / Hide 
Range on Protein: 647-906
Range on HMM: 2-264/264
Sequence Identity: 41% (112 aa)

ETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP------ERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGP
. |.  .|||| || || |      . ||.| .       |.  .  . | ||. | . |.||||| ||| . .   . |||. |||||.||..   .||
KKGN--ILGKGAYGTVYCGLTNTGQL-IAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSII-NRFGP

LKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLA--GITPCT----ETFTGTLQYMAPEIIDQGPRGYGKAADIWS
|  .|     ||.|||||  |||.| .||||||| ||..    |..|. |||  |||.  ||            ||  .||||.|     |||. .||||
L--DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIME--TGYGRKSDIWS

LGCTVIEMATGRPPFHELGSPQAAMFQVGMY-KVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL
.|||| ||||..||. ..  . |||| .|    . |..|   | .|. |       |   |..|  ||  ||.
IGCTVFEMATRKPPWADM-DRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K6.AA STE20 653-906 34 6.7e-61 208.64 In-house 6-288 (288) Show / Hide 
Range on Protein: 653-906
Range on HMM: 6-288/288
Sequence Identity: 34% (100 aa)

VLGKGTYGVVYAGRDRHTRVR----IAIKEIPERDS----RFSQPLHEEIALHRRLRHKNIVRYLGSASQG----GYLKIFMEEVPGGSLSSLLRS--VW
..|.|.||.|| .....|       .||| .. ..        . .  ||   ....|.|||.|.||   .      | | ||   ||||. ...   ..
KIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKC

G------PLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAG-----ITPCTETFTGTLQYMAPEIIDQGP---R
|      |.  ||. |.. .|..|||| ||| |||.|||||.||.|... .|  |..||| .  |       . .   || ||  .||||.| .      
GKNHKGHPM--NEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDK

GYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP--M---PSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL
||.  .|||||| | ||||.|.||.... .|  |||..   .  ||  .   |.. | | . |. .  . ||  |..|. ||  ||.
GYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K6.AA MEKK2 653-906 40 1.7e-60 207.26 In-house 6-262 (262) Show / Hide 
Range on Protein: 653-906
Range on HMM: 6-262/262
Sequence Identity: 40% (106 aa)

VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFS-----QPLHEEIALHRRLRHKNIVRYLGSASQGG--YLKIFMEEVPGGSLSSLLRSVWGPLKDNE
.||.| .|.||   |  |   .|.| ..  ..        | |. || | . |.|. || | |   . .   | |||| .||||.   |. ..|.| .. 
LLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLK-AYGALTET-

STISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCT---ETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEM
     |||||| |. ||||..|||||||| |.| .  || .|..||| ||||  |        . |||  .|.||.|.    |||. ||.||.||||.||
-VTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDS-SGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVING--EGYGRKADVWSIGCTVVEM

ATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL
 | .||. |     ||.|..   .  | .|...| .|  || | |      | ||. ||   | 
LTEKPPWAEYEA-MAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K6.AA CAMK 653-906 17 3.9e-59 188.89 In-house 1-425 (425) Show / Hide 
Range on Protein: 653-906
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

VLGKGTYGVVYAGRDRHTR------------VRIAIKEIP-----------------ERDSRFS-----------QPLHEEIALHRR-------LRHKNI
.||.|..|.|. .....|             .. ||| |.                  ..|. .           . .  ||.....       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYLGSASQGGY-------------------LKIFM---EEVPGG----SLSSLLRSV--------------WGPLKDNESTISFYTRQILQGLGYLHDN
.. .     . |                   . ..|   | ..||     | . ...               .| .  .|.  ..| |||.... |.|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRF--TEREARRYFRQICSAVHYCHSH

HIVHRDIKGDNVLINTFS----------------GLLKISDFGTSKRLAGI-----------------------TPCTETFTGTLQYMA-PEIIDQGP--
.|||||.| .|.|... .                . .||.||| .... .                        ..  .|| ||. ||| ||.. . .  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGYGKAADIWSLGCTVIEMATGRPPFHE-----------LGSPQAAMFQ---VGMYK-VHPPMPS-------------------SLSAEA
          ..||...|.||.|.    | .|.||| .           .|  .  .|.    | |   .|...                     .|.|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QAFLLRTFEPDPRLRASAQTLLGDPFL
. .. .  ..||  |....  | .|..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K6.AA Ciliate-E2 653-906 19 4.2e-53 180.61 In-house 6-365 (365) Show / Hide 
Range on Protein: 653-906
Range on HMM: 6-365/365
Sequence Identity: 19% (73 aa)

VLGKGTYGVVYAGRDRHTRVR-----------------------IAIKEIPERD-SRFSQPLHEEIALH------------RRLRHKNIVRYLGSAS--Q
..|.|..|.|| .... .. .                       .|.| . ...   ..| .|.   ..            ..| |.||...  .    .
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

GGYLKIFMEEVPGGSLSSLLRSVWGPLKDN--------ESTISFYTRQILQ---------------GLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISD
  .. . || . ||.| ..... .   . .        |  |.....||||               .| ||| .. |.||||| .|.|.      .||.|
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIID

FGTSKRLAGI----------TPCTETF----------------------TGTLQYMAPEIIDQGP-------RGYGKAADIWSLGCTVIEMATGRPPFHE
||.||..               ... .                       ||. ||||||.  ..        ||....||||||..  || .|.|||  
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--

LGSPQAAMFQVGMYKVHPP--------------MPSSLSAEAQAFLLR----TFEPDPRLRAS-AQTLLGDPFL
         . . ..  .|               . ..| |.. .. .     .. ||  | . .. .|  |..
-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MAP3K6.AA Dicty2 653-906 37 1.6e-51 177.47 In-house 7-264 (264) Show / Hide 
Range on Protein: 653-906
Range on HMM: 7-264/264
Sequence Identity: 37% (98 aa)

VLGKGTYGVVYAGRDRHTRVRIAIKEIP----ERDSRFSQP--LHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNES
..|||  |.|| | .  |    ||| |           .|   .  || | ..|.| |||.|...     .| |..| . .||||  .    |..   ||
KIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKK-FGCFP--ES

TISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTF--SGLLKISDFGTSKRLA--GITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEM
 .. | .|.|.|| ||| . ..|||||..| ||..   ||  | .|||.   ..   ... . |. ||   ||||.|         | ||||||||.||.
LCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRY-TVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCTIIEL

ATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL
 || ||   |. | .|||       |||.|   |.|   ||.. |  || .|..|. ||  | .
LTGNPPYWDLN-PMHAMFRM-VQDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase MAP3K6.AA Pkinase_Tyr 653-849 26 5.6e-21 71.67 Pfam 6-216 (270) Show / Hide 
Range on Protein: 653-849
Range on HMM: 6-216/270
Sequence Identity: 26% (58 aa)

VLGKGTYGVVYAGRDR----HTRVRIAIKEIPERDSRF---SQPLHEEIALHRRL-RHKNIVRYLGSAS-QGGY--LKIFMEEVPGGSLSSLLRSV--WG
.||.| .|.|| |. .     |..  |.| ..|  .     .. . .|... . | .|.||||..|  . ||.   . | || .|.|.| . ||.   ..
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

PLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRL-----AGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWS
.  . .  ...  .|| .|. ||......|||.   |.|..  ..  ||.||| .. .       ..  ...       |||| |  |   .  . |.||
QPLTMKDLLQM-CWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPECINYGK--FTTKSDVWS

LGCTVIEMAT-GRPP-F
 | .  |. | |. | .
FGVLMWEIFTYGEQPTY
Kinase MAP3K6.AA TyrKc 648-904 23 1.5e-16 44.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 648-904
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

TGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRL--RHKNIVRYLGSASQG-------GYLKIFMEEVPGGSLSSLLRSVW
     .|| | .|.|| |. .   .  |.| . |      . ...|. . ..|  .|.|||| .| ..|.       . | | || .|.|.| . ||.  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGI---------TPC----TETFTGTLQYMAPEIIDQGPRG
.    . ..   .  || .|  |||.....|||.   |.|..      |||||| |. .                    . .   .  |||| |     |
PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYG

-YGKAADIWSLGCTVIEMAT-GRPPFHEL----GSPQAAMFQVGMYKVHPPMPS-------SLSAEAQAFLLRTFEPDPRLRASAQTLLGDP
 .  . |.|| | .  |. | | .|  .      |.| .. .|   .  |..|.         ..|     ..  . ||  | . ...  . 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Sam7 MAP3K6.AA sam7 1216-1278 21 3.9e-09 30.4 In-house 1-70 (70) Show / Hide 
Range on Protein: 1216-1278
Range on HMM: 1-70/70
Sequence Identity: 21% (15 aa)

STDQGLVQWLQELNV--DSGTIQMLLNHSF-----TLHTLLTYATRDDLIYTRI-RGGMVCRIWRAILAQR
 |.. ...||...    ..  ......| .     .. .|. . |..||    | |.|  ..||..|   |
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLC-HMTEEDLMEMGITRPGHRKKIWNHIQQMR