Gene MARK1 (Human)

MARK1

Species: Human
Alias: MGC126513, MGC126512, KIAA1477, MARK1, MARK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q41-q42,

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MARK1.NA RNA Sugen Kinome 5293 None Fasta, JSON
MARK1.AA Protein Sugen Kinome 795 None Fasta, JSON
MARK1.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of MARK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MARK1.AA MARK 60-311 57 7.6e-180 592.33 In-house 1-262 (262) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-262/262
Sequence Identity: 57% (151 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNP-TSLQKLFREVRIMKILNHPNIVKLFEVIE--TEKT-LYLVMEYASGGEVFDYLVAH--GR
|.. ||||.|..||||||.|..|||.||.||..|..||.  ......||..||| |.||||.|||.|||  ||.. .||.||||||||..||..||  ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

MKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDM--NIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV
..|.|||. ||||||||.|||.| |||||.|.||.|.| ..  ||||.|||||.... |.||.||||.|||.|||.|..|.||||.||.|||||.||..|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

SGSLPFDGQN--LKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
.|..||||..  .|||....|||||.||...|..|.||...||..|| .| ..|.|||..||
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MARK1.AA CAMKL 60-311 49 2.3e-171 551.28 In-house 1-297 (297) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-297/297
Sequence Identity: 49% (149 aa)

YRLQKTIGKGNFAKVKLARH-VLTGREVAVKIID--KTQLNPTSLQK-----------LFREVRIMKILN---HPNIVKLFEVIETEKT------LYLVM
||. ||.|||.|.|||||.|  .||..||.||||  |....| ....           ..||..||| ||   ||||.||.|||||...      .||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASGGE--VFDYLVAH----GRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDM--NIKIADFGFSNEFT-V----GNKLDTFCGSPPYA
||.||||   |||.|.|    |||.|.|||  ||||||||.|||.. |||||.|.||.||| ..  ||||.||||||... .    |.||.||||||||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELFQG--KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK---------ELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
|||.|||  |.||||.||.||.|||||..| | ||||.....         ....... ....|....| ||..|..|.|. || || ...|||...||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MARK1.AA QIK 60-311 58 3.9e-167 561.55 In-house 1-272 (272) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-272/272
Sequence Identity: 58% (160 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR------
| . .|||||||| ||||||  |  .||.|||||.||. . |||..||| ||| |.||.|.||..|.||.. .|.|.||.|.|| ||||..|||      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------MKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD
              |.|.||| .| ||.|||.|||.. ||||||||||.||| .|||||||||||| |. |  | |.||||||||||.|.||.||||.||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
.||.||.|| ||.|.|||||..|..||.||| ||.||||.||.||| | .. ||..| .| . .||.. |||
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MARK1.AA AMPK 60-311 50 1.1e-146 438.47 In-house 1-254 (254) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-254/254
Sequence Identity: 50% (127 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRIMKILNHPNIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
| ..||||.| | |||.. | ||| .||.||..|. .   . . .. ||..|.|...||.|..|.||| ||.. ...||||.|||| ||| | |||..|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF
||.  | ||.|.| |||.  ||||||| |||||| ..||||.||| ||  . |..| | |||| |||||. .||.| |||||.|| ||||| .. | |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
| .|  .|  ... |.| || ..|.....|.|..|  .|.|| . ..|... | 
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MARK1.AA CAMK 65-311 31 1.7e-145 472.19 In-house 1-425 (425) Show / Hide 
Range on Protein: 65-311
Range on HMM: 1-425/425
Sequence Identity: 31% (135 aa)

TIGKGNFAKVKLARHVLTG------------REVAVKIIDKTQLN--------------------------PTSLQKLFREVRIMKI-------LNHPNI
|.|.|.|.||||..| .|.            ..||.|||||..|                           | ......||..|||        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFEVIE------------TEKT--------LYLVM---EYASGG----EVFDYLVAH---------------GRMKEKEARAKFRQIVSAVQYCHQKY
.||.||.|            | ..        .|.||   ||.|||    ..|||.|.|               ||..|.|||  ||||.|||.|||.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKAENLLLDGDM-----------------NIKIADFGFSNEFTV------------------------GNKLDTFCGSPPYAA-PELFQG-----
||||||| ||.||| ..                 ||||.||||.|.|.                         | |. ||||.|.|.| ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KKYDGPEVDVWSLGVILYTLVSGSLPFDGQ-------------NLKELRERVLRGKYR-IPFYMST-----------------------DCE
        |.|.||..|.||.|||||....| .||.|              |..|| |....|||. .|.|.|.                       .| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLLKKLLVLNPIKRGSLEQIMKDRWM
.|..|.|. .| || ..||.... ||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MARK1.AA NuaK 60-311 49 3.2e-142 376.95 In-house 1-252 (252) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-252/252
Sequence Identity: 49% (125 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKE
|..||| ||| . |||||.   ||||||.| | |     .  . .  ||..||  ||||.|.. .|| |    . .||||||||| .||.   ... |.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD
||  |||||||| |||.  |.||||| || ||| . |.|||||| || .  .. | |||||| || ||   |. | ||||| |||||.|||.| |..|||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
|.. |.|   . .|.|. |   |. |. |  ..|  || .| ....| .  |.
GHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase MARK1.AA NIM1 60-311 44 1.9e-120 355.51 In-house 1-258 (258) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-258/258
Sequence Identity: 44% (114 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIID--KTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
||. . || ||| ||||. | ||   ||.||.|  || .    .  | ||.  |  ..|||||.|.||.||   ..||||||.||| . .    | . | 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

EARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTV----GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSG
..   | ||||||.  | . |||||.|||| ..     .|..|||||         . .|.|||||||||||||||   | |. |||| ||..||  . |
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTG

SLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
  ||      ..   .| |.| || | |  |  | .  |   |  |   .|.|.. ||
VMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase MARK1.AA BRSK 60-311 51 3.3e-113 382.38 In-house 1-254 (254) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-254/254
Sequence Identity: 51% (131 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN--PTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK
||| || |||   .|||  |  ||. ||.||| |  |   .  |.|  ||. |||  .||.. |...| |. | |||..|. |||| |||||  ||.. |
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF
|||  ||||.||. .|| . | ||||| ||||||.. ||||||||       .  |.| |||| || ||  .| ||||   |||| ||||| |  | |||
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF

DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
|  || .| |.| || . .| .   || .||....  .| || ||..| |  | 
DDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase MARK1.AA S_TKc 60-311 35 3.5e-110 373.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASG--GEVFDYLVAHGR----
|.. ..|||| |.||...||. |||.||.|||.         ... ||..|.|  .|||||||..|... . ||.||||..|  |..|||.. .||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV
  . | .||  ..||..|..|||.. |.||||| ||.|||   .|||.|||.. ..      .||||.| | |||..   .|.....|.||.|.||| ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMK-------DRWM
.|  ||.  ..... ....          | .. ....|.|. .| || .  ....       . |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MARK1.AA TSSK 60-311 37 8.99999999999e-110 361.45 In-house 1-289 (289) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-289/289
Sequence Identity: 37% (107 aa)

YRLQKTIGKGNFAKVKLARHVLTGRE----------------VAVKIIDKTQLNPTSLQK-LFREVRIMKI-LNHPNIVKLFEVIETEK-TLYLVMEYAS
| ..|.||.|..|||..|..  . ..                ||.||||..   .  |.| | ||  ||.. |.||||....| .||.    |.|||||.
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

GGEVFDYLVAH------GRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGN------KLDTFCGSPPYAAPELF
.| ...|  ..      |...|..||. |||.||||.||| . .|||||| ||.||| . |||..||||..... .       .. |||||  ||||| .
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEIL

QGKKYDGPEVDVWSLGVILYTLVSGSLPFDG--QNLKELRERVL-RG-KYRI--PFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
.|..||.  .||||.|||||..| |..|||   .|.. . ...  .. ....      |..| .|....| ..| .| ....|... ||
RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase MARK1.AA SNRK 60-311 49 1.9e-107 352.92 In-house 1-254 (254) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-254/254
Sequence Identity: 49% (126 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKE
| |.||.|.| || ||||||| ||  ||||.||||..   |  .||.||| ||.  |||||.|.|||.|   |||..|   |....||.. | . ..|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF
||  |.||. |..||||. .|||||| || .    .  .|. ||||||.|  |.||.|.|||  |.|||.  | .|| | ||.|||||||| || | .||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
.  |  |   ...  || .|  .|..| .|....|| .| || |||.|    |.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MARK1.AA Pkinase 60-311 34 1.5e-103 355.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 60-311
Range on HMM: 1-293/293
Sequence Identity: 34% (103 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFR--EVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGG----EVFDYLV--AH
|.. ..||.|.|..|....|. ||..||||||.|   ..  .| ..|  |..||| |||||||.|... |... .|.||||. ||    . |||.   .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRM--KEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNI----KIADFGFSNE--FTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL
|..   |.|..  ..||.....|||.. |.||||| ||.|.| ...|    ||.|||..       .  ..||||.|.|.|||. .| .|.||.||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYTLVSGSLPFDGQ------NLKELRERVLRGKYRIPFY---------------------MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM
|.||| ...| .||.|.      . ... .|....... ...                     .| .|  ..|..| ..| || . |||... |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MARK1.AA Pkinase_Tyr 60-202 32 1.9e-26 90.16 Pfam 1-156 (270) Show / Hide 
Range on Protein: 60-202
Range on HMM: 1-156/270
Sequence Identity: 32% (51 aa)

YRLQKTIGKGNFAKVKLARHV----LTGREVAVKIIDKTQLNPTS--LQKLFREVRIMKIL-NHPNIVKLFEVIE-TEKT--LYLVMEYASGGEVFDYLV
 .. |..|.|.| .|....       |. .||||.. | .  .    .....||..||| | .|||||.|  |.   ..   .|.||||. .|   ||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AH----GRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFG
.|    .. . |.     .|| .. .| ..| ..|||| | | |.. .. .||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MARK1.AA TyrKc 60-310 26 1.6e-25 92.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 60-310
Range on HMM: 1-280/280
Sequence Identity: 26% (76 aa)

YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL--NHPNIVKLFEVIETE-------KTLYLVMEYASGGEVFDYLVA
 .| |..| |.| .| ...     ..|||| . .       .. . || |||. |  .|||||.|. |. ..       . |..||||...|   ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HGR-MKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG------NKLDTF----CGS--PPYA--APELFQGKKYDG
|..  . |.      || .  .| |.| ..|||| | | |.. .  .||.||| | . . .       .  .     .|    |.   ||| .. .|.  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-

PEVDVWSLGVILYTLVS-GSLPFDG-----QNLKELRERVLRG-KYRIPFY--------MSTDCENLLKKLLVLNPIKRGSLEQIMKDRW
.. |||| || .. . . |  |  |      . .|..|.| .|   ..| .        ....  .. |.    .| .| . ..| ....
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MARK1.AA Pkinase_Tyr 239-277 34 0.032582 8.12 Pfam 196-236 (270) Show / Hide 
Range on Protein: 239-277
Range on HMM: 196-236/270
Sequence Identity: 34% (14 aa)

DVWSLGVILYTLVS-GSLP-FDGQNLKELRERVLRGKYRIP
|||| || .. ... |  | . |    |. |.. .  || |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMP
UBA_CAMKL MARK1.AA UBA_CAMKL 332-369 43 1.8e-15 53.51 In-house 1-41 (41) Show / Hide 
Range on Protein: 332-369
Range on HMM: 1-41/41
Sequence Identity: 43% (18 aa)

DTKRIDIMVTM--GFARDEINDALINQKY-DEVMATYILLG
| ..|..|..|  || |.|| ..| |.|| ....||| ||.
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
UBA MARK1.AA UBA 332-369 31 1.3e-10 42.5 SMART 1-38 (38) Show / Hide 
Range on Protein: 332-369
Range on HMM: 1-38/38
Sequence Identity: 31% (12 aa)

DTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLG
. ..|| .. ||| |.|. .|| ...... ||...|. 
YEEKIDQLMEMGFDREECVQALRACNWNVEMAMNWLFS
UBA MARK1.AA UBA 331-367 21 1e-06 27.43 Pfam 1-38 (38) Show / Hide 
Range on Protein: 331-367
Range on HMM: 1-38/38
Sequence Identity: 21% (8 aa)

NDTKRIDIMVTM-GFARDEINDALINQKYDEVMATYIL
 | . .. .. | || ...  .|| . .... .|...|
IDEEMVKQLMEMTGFSMMQCKKALRACNNNVERAVEWL
KA1 MARK1.AA KA1 749-795 43 1.7e-23 81.97 Pfam 1-48 (48) Show / Hide 
Range on Protein: 749-795
Range on HMM: 1-48/48
Sequence Identity: 43% (21 aa)

QDSLVQWEMEVCKLP-RLSLNGVRFKRISGTSIAFKNIASKIANELKL
 .. |..|..|||.| ||.|.||.|||.|| . ..|....|| .|..|
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL