Gene MER (Human)

MER

Species: Human
Alias: C-MER, MER, MGC133349, MERTK, mer, c-mer
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 2q12,

Classification

Group: TK
Family: Axl

Sequence

Name Sequence Type Origin Length Description Download
MER.NA RNA Sugen Kinome 3638 None Fasta, JSON
MER.AA Protein Sugen Kinome 999 None Fasta, JSON
MER.kin_dom Protein Kinase Domain Sugen Kinome 266 None Fasta, JSON

Protein domain

Protein domains of MER.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG MER.AA IG 100-194 16 2e-06 28.58 SMART 1-58 (58) Show / Hide 
Range on Protein: 100-194
Range on HMM: 1-58/58
Sequence Identity: 16% (16 aa)

VGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDN---GSYICKMKINNEEIVS-DPIYIEVQ
 . .  .|   |...| .|        .|.|.                            . | .||..|    | | |  .  . .. | ......||
PP-VTVKEGETVTLTC-VS--------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set MER.AA I-set 127-176 28 0.100043 8.37 Pfam 31-76 (92) Show / Hide 
Range on Protein: 127-176
Range on HMM: 31-76/92
Sequence Identity: 28% (15 aa)

TISWWKDGKELL--GAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICK
..|| |||..|   . .| .|.          .... |. ||..| |.| |.
QVSWFKDGQPLRPDSDRHQMTYDG------DGTYTLTISNVQPDDEGKYTCV
IG MER.AA IG 203-281 16 8e-07 29.92 SMART 1-58 (58) Show / Hide 
Range on Protein: 203-281
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

PESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEM-----AVFSCEAHNDKGLTVS-KGVQINIK
|. . | .    .||| .       .|.|                 ||. ....      ... |.|.  .| . | .|... ..
PP-VTVKEGETVTLTC-VS------QIWWY----------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set MER.AA I-set 197-227 32 0.000156 17.9 Pfam 1-31 (92) Show / Hide 
Range on Protein: 197-227
Range on HMM: 1-31/92
Sequence Identity: 32% (10 aa)

PHFTKQPESMNVTRNTAFNLTCQAVGPPEPV
|.||..| .. |.   . ...||. | |.|.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQ
FN3 MER.AA FN3 284-368 15 9.3e-09 36.34 SMART 1-69 (69) Show / Hide 
Range on Protein: 284-368
Range on HMM: 1-69/69
Sequence Identity: 15% (16 aa)

PSPPTE---VSIRNSTAH------SILISWV-PGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQAL----ANYSIGVSCMNE--IGW
|.||.    ..... |..      |. .||  |   ||.                               | .. |..      .|.. |.. |.   |.
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-IVGYR-------------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

S
.
G
FN3 MER.AA FN3 384-470 15 8.2e-05 23.23 SMART 1-69 (69) Show / Hide 
Range on Protein: 384-470
Range on HMM: 1-69/69
Sequence Identity: 15% (16 aa)

SVAPLN---VTVFLNESS-----DNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHN----ATCTVRIAAVTR--GGV
  .| |   ..|    |.     . | ..| .|         ||||                        ....  . .     . ..|..||..  .| 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGE

G
|
G
Kinase MER.AA Axl 587-852 82 8.10000000001e-213 713.3 In-house 1-267 (267) Show / Hide 
Range on Protein: 587-852
Range on HMM: 1-267/267
Sequence Identity: 82% (219 aa)

LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSS-QGIPKPMVILPFMKYGDLHTYLLY
..|||.||||||||||||.||||||...|||||.||.|...|.|||||||||||||.|.||||.||.||||.||. |.||||||||||||.|||||.|||
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

SRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWA
|||...|...|||.|.|||||||.||||||||||.||||||||||||.||||||||||||||||||||||||.|||||||||||||||||||||||||||
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVWA

FGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRL
||||||||.|||.||||||.||||||||.|||||||||||.||||..||.||..||.|||.|||||.
FGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase MER.AA Pkinase_Tyr 587-854 42 5.5e-140 474.73 Pfam 1-270 (270) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-270/270
Sequence Identity: 42% (118 aa)

LILGKILGEGEFGSVMEGNLK-QEDGTSLKVAVKTMKLDNSSQRE--IEEFLSEAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHT
...|| ||||.||.|..| .| ..|.| ..||||..  .......  .|.|..||. || . .|||..||.|||. .  ..   ........|..|||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

YLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYY-RQGRIAKMPVKWIAIESLADRVYTSK
||   |  ..........||.. ..|| |||||...|. |||||||||.. ....| ..||||.. ||. ||| |..  .|.|.|| | |.......|.|
YLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

SDVWAFGVTMWEIATRGMTP-YPGVQNHEMYDYL-LHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQL
||||.|||.|||| |.|..| |||. |.|.|.|.  .|.|...||.| ||.|..| .||. || |||||| .. ||
SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MER.AA TyrKc 587-854 40 7.50000000001e-132 445.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-280/280
Sequence Identity: 40% (119 aa)

LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDF--SHPNVIRLLGVCIEMSSQGI---PKPMVILPFMKYGDLHT
. |||.||||.|| |..| .|      ..||||..| |      .|.|..||  |. .  .|||..||.|||.. . .     . .|... .|..|||. 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKD

YLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG-------DYYRQGR--IAK--MPVKWIAIE
|| ..| .     .....||.|...|| |||||. .|. |||||||||.. .. || ..|||||..||..       ||||.     .|  .|..| |.|
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

SLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG-----VQNHEMYDYLLHGHRLKQPED--------CLDELYEIMYSCWRTDPLDRPTFSVLRLQL
.. ....|.|||||.|||.|||| |.|..||||     . | |.. |. .|.|..||..        | ||.|.|| .||. || |||||| .. ..
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MER.AA TK 587-854 25 1.2e-114 385.91 In-house 1-486 (486) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

LILGKILGEGEFG---SVMEGNLKQED----------------------GTSLKVAVKTMKLD-NSSQREIEE-----------FLSEAACMKDFS----
..||| ||||.||    |..| .....                      |.  .||||..|.. ..||.| ..           ||.||. || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVIRLLGVCIEMSSQ-------GIPKPMVILPFMKYGD----LHTYLLYSRLETGP-----------------------------------------
 |||..||.||| .  ..       . . .|... .|..||    |..||  .| .. .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------KHIPLQTLLKFMVDIALGMEYLSNR------NFLHRDLAARNCMLRDDMT-----------VCVADFG---
                              ......|| ....|| |||||. .      || |||||||||.. ....           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKKIYS------------------------GDYYRQGRIAKMPVKWIAIESLADRV---------YTSKSDVWAFGVTMWEIATRG-MTPYPGV
     |...|||                         |||||   .|.|..| | |.|.|||         .|.|||||.|||.|||| |.| ...|.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

QN---------HEMYDYLLHG--------------HRLKQPEDCL--------------DELYEIMYSCWRTDPLDRPTFSVLRLQL
 |         .|...||  |              .|..||..|               .|.|..| .||. || |||||| |. ||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MER.AA Met 588-848 39 8.99999999999e-106 347.82 In-house 1-271 (271) Show / Hide 
Range on Protein: 588-848
Range on HMM: 1-271/271
Sequence Identity: 39% (110 aa)

ILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMK-LDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYS
 .....| | || |  | . ..||   ..|.|. .        .|..|| |.  ||.|.||||  |.|.|.. ..     |.|.||.|| ||| |.    
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGH---MPWVVLPYMKHGDLKTF----

RLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKI-YSGDYY--RQGRI-AKMPVKWIAIESLA--------D
  .   . .    |. |  ..| ||.|.  . | |||||.|||||  ..|| ||||||. .. |   ||  .. .  |. |||| | |.|         .
-IRNPQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPT

RV-YTSKSDVWAFGVTMWEIATRGMTPYPGVQN-HEMYDYLLHG--HRLKQPEDCLDELY-EIMYSCWRTDPLDRPTFS
.  .|.||||| ||| |||  ||| .||| | |      .|  |   || ||| | | || ..| .||. .| |||.||
YRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase MER.AA UTK 587-854 35 2.9e-97 329.42 In-house 1-296 (296) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-296/296
Sequence Identity: 35% (106 aa)

LILGKILGEGEFGSVMEGNLKQED--GTSLKVAVKTMKLDNSSQREIE---EFLSEAA---CMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYG
..||. ||.|.|| | .. ..|..  .. ..||||. . . ..|.| |   .|. ||.    || |. ||||.||.|||   .      .|... .|. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-----WMIVTEYMENG

DLHTYLLYSRLETG-PKHIPLQT-LLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDD-------MTVCVADFG---LSKKIY---------SGDYYRQ
|| .|| ..| ... . |.   . .|....||| ||.||....| ||||||||| . ..       |.. .||||   .|. ..         . .||..
DLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

GRIAKMPVKWIAIESLADR-VYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHG--HRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQ
    ..|..| | |.|...  .|.|||||.|||..||| |.| .||||  |..    .. |  .|...|.|| ...|..| .||..|| .||.|  |. |
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

L
.
M
Kinase MER.AA InsR 587-856 40 9e-91 305.11 In-house 1-278 (278) Show / Hide 
Range on Protein: 587-856
Range on HMM: 1-278/278
Sequence Identity: 40% (115 aa)

LILGKILGEGEFGSVMEGNLKQ--EDGTSL--KVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTY
..|.. .|.| || | ||..|   .|. .   ..|.|| . .| | ||  |||.||  || | . .|.||||||    |.| |  .|.  .|.|||| .|
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVN-ENASMRERIEFLNEASVMKEFNCHHVVRLLGVC----SRGQPM-YVVMEMMTYGDLKSY

LLYSRLETG------P---KHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLA
|.  | | .      .   . ..|. ..    .|. || ||  ..| |||||.||||  .| || ..|||.   ||  |||| |.  ..|| | | ||| 
LRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLK

DRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYL-LHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
| |.|..|||| ||| .||..| |  || |  | .  .|    |  |..|| | . ..|.|  ||.  | .||||  .   |  
DGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase MER.AA TK-Unique 587-854 34 4.4e-90 305.59 In-house 1-294 (294) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

LILGKILGEGEFGSVMEGNLKQ---EDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTY
| .|...|||.|| |  | ...   ...   .||||. | ||... .  .||.|.. ||    |||....||.|.. .      .| |.... .|.| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK-DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD----EPWMIIMEYCPCGNLQHY

LLYSRLE-------------------TGPKH-IPLQTLLKFMVDIALGMEYLSN--RNFLHRDLAARNCMLRDDMTVCVADFGLSKKIY-SGDYYRQGRI
| ..| .                   . ..  | ...|. |...|| |||||.   ... ||||.|||..| .| .. ..|||.....|  |.| .... 
LRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQ

AKMPVKWIAIESLA--DRVY-TSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC-LDELYEIMYSCWRTDPLDRPTFSVLRLQL
 ..|..| | |||   ...| |.|||||.|||.||||.| | .||||. . .. . .  |.|..||| |  .|.|..|.|||. .| .||.|. .. .|
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MER.AA Abl 587-854 44 8.1e-83 276.06 In-house 1-252 (252) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-252/252
Sequence Identity: 44% (120 aa)

LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYS
... . || | .| | ||  |. | |   |||||.| |.    |..||| ||| ||.  |||...|||||        |   .|  || || |  ||   
IMMKHKLGGGQYGEVYEGVWKRHDCT---VAVKTLKEDT---MEVHEFLKEAAIMKEMKHPNLVQLLGVCTRE-----PPFYIITEFMCYGNLLDYL---

RLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAF
  |.. ...|  .||     || ||.|| .|.|.|||||||||.. ..  | ||||||. ..  .| |     || |.|| | ||||   . ||||||||
-RECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLA-RMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAF

GVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQL
|| .||||| ||.||||..  ..|. | .|.|. .|| | .. ||.|  ||. .. |||.|  .  ..
GVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase MER.AA HMTK 587-853 34 2e-79 270.21 In-house 1-291 (291) Show / Hide 
Range on Protein: 587-853
Range on HMM: 1-291/291
Sequence Identity: 34% (104 aa)

LILGKILGEGEFG-----------------SVMEGNLK------QEDGTSLK-VAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQ
|. .|..| | ||                  |  . ..      ..|. . . .|||... |.|..  .||||.||  |  ..|||...| ||| .    
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHE-DREEFLREAEVMCQLRHPNLVQLVGVCMQQ---

GIPKP-MVILPFMKYGDLHTYLLYSRLETGPKHIPLQTL--LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIY-SGDYYRQGR
   .| .. | .|.||||   .| .  |   | |.|...  |.|.| .| ||.|..   ..|.|||||||.. .   | .|||||. ..    ||...  
---RPWLCVLEYMQYGDLRN-VLKTCRE---KNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRK

IA-KMPVKWIAIESLA--DRVYTSKSDVWAFGVTMWEIATRGMTPYP--GVQNHEMYDYLLHGHRLKQPED--CLDELYEIMYSCWRTDPLDRPTFSVLR
 . |.|.|| |.| ..  ...   ||||||||||||||.. |..||.  .. | |. ...  | || ||..  | |.... |..||. ||  ||||. |.
HMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQ

LQ
  
KM
Kinase MER.AA Src 587-854 39 2.9e-79 268.93 In-house 1-255 (255) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-255/255
Sequence Identity: 39% (106 aa)

LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILP-FMKYGDLHTYLLY
. | . ||.| || | .|  ..    . ||||||.| ..    . | || ||  || ..|.....|. || .        |  |   .|. | | .||  
IKLCRKLGQGQFGEVWMGYWNG----NTKVAVKTLKPGT---MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE------PIYIVTEYMSHGSLLDYLKK

SRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG-DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVW
   ..  .|..|..|. .   .| ||.||. .|. ||||||||    ..  . |||||| . |  . | |     ||.|.|| | | .  ...| |||||
---DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVW

AFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYE-IMYSCWRTDPLDRPTFSVLRLQL
 ||. ..|| |.| .|||| .|||  . . .| |. .|. | ||||| ||  ||. || .||||  |.  |
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase MER.AA Fer 684-855 32 4.8e-56 189.36 In-house 96-283 (283) Show / Hide 
Range on Protein: 684-855
Range on HMM: 96-283/283
Sequence Identity: 32% (62 aa)

LYSRLETGPKH-IPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVC---VADFGLSKK--IYSGDYYRQGRIAKMPVKWIAIESLADRVY
| |.| . ..  ... .....  ..| |||||  .| .|||.||||| . .| ...   ..|||.|..   |  ||.      |.|..| | |.. ...|
LDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIY

TSKSDVWAFGVTMWEIATRGMTPYPG----VQNHEM-----YDYLLHGHRLKQPEDCLDELYEIMY-SCWRTDPLDRPTFSVLRLQLE
..|.|||.|||..||| |.| .||||    ... ..       .   |.... |. . .|...||  .||  || ||||.. .. .|.
SPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase MER.AA S_TKc 587-861 21 1.7e-43 151.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 587-861
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKY--GDLHTYLL
  .....|.| ||.|. .  |    |  .||.| .|         | ...| ...|   |||...|..|. .       .  ... ..    |||..|. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIK

YSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTS-KSDV
  . . ... .|  .  ..|  |....||. .....||||   | .| .  .. ..||||....         .       ..| | |    |.  |.|.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRL--QLEKLLESL
|..|....| .. | .|.|  | ..|.. ..            .|. ...  |.. || .|||   .    .. |. . .
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MER.AA Pkinase 587-854 20 4.9e-39 139.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 587-854
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLS--EAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYG----DLH
. .|...|.| ||.|    . .. ||. .||||..|... .  . .. .   |.. || ..|||..||.... .      ... ......  |    ||.
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLF

TYLLYSRLETGPKHIPL----QTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTV----CVADFGLSKKIYSGDYYRQGRIAKMPV---KWIAI
.|.         .| ..    ... ..|  |. |.||. .....||||   |... .....    ...||||.|...    |  .. .. ..    ..| 
DYIST------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAP

ESLA-DRVYTSKSDVWAFGVTMWEIATRGMTPYPGV------QNHEMYDYLLH-GHRLKQPEDCL-------------------DELYEIMYSCWRTDPL
| .  .. |..|.|.|..|....| .. | .|.||          .|..  ..   .   |..|                    .|. .....|.. || 
EVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

DRPTFSVLRLQ--L
.|||.  .     .
KRPTAEQILQHPWF
Kinase MER.AA Fer 587-656 42 1.6e-21 70.19 In-house 1-78 (283) Show / Hide 
Range on Protein: 587-656
Range on HMM: 1-78/283
Sequence Identity: 42% (33 aa)

LILGKILGEGEFGSVMEG--NLKQEDGTSLKV---AVKTMKL-DNSSQRE-IEEFLSEAACMKD-FSHPNVIRLLGVC
 .|||.|||| || |  |   ||  .|... |   |||..|.  .....| |.||. ||  |.  ..||||... |||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVC