Gene MLK2 (Human)

MLK2

Species: Human
Alias: MLK2, MAP3K10, MST
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 19q13.1,

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK2.NA RNA Sugen Kinome 3453 None Fasta, JSON
MLK2.AA Protein Sugen Kinome 954 None Fasta, JSON
MLK2.kin_dom Protein Kinase Domain Sugen Kinome 263 None Fasta, JSON

Protein domain

Protein domains of MLK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK2.AA SH3 19-80 39 1.9e-21 78.47 SMART 1-58 (58) Show / Hide 
Range on Protein: 19-80
Range on HMM: 1-58/58
Sequence Identity: 39% (25 aa)

PVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLP-SGRVGVFPSNYVAPGA
|.  |..||.| ...||....|| ..||..|     |.||| |..  .|..| ||||||..  
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 MLK2.AA SH3_1 22-73 33 5.6e-14 50.15 Pfam 1-49 (49) Show / Hide 
Range on Protein: 22-73
Range on HMM: 1-49/49
Sequence Identity: 33% (18 aa)

TAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDE-GWWTGQLPS-GRVGVFPS
.| .||.| ...||....|| ..|....     |. .||.|.. . |..| |||
VALYDYQAQQPDELSFKKGDIIHVIEKS-----DDWDWWKGRCNNTGQEGWFPS
SH3_2 MLK2.AA SH3_2 20-79 22 1.4e-11 43.42 Pfam 1-68 (68) Show / Hide 
Range on Protein: 20-79
Range on HMM: 1-68/68
Sequence Identity: 22% (16 aa)

VWTAVFDYEA-AGDEE-----LTLRRGDRVQVLSQDCAVS--GDEGWWTG-QL-PSGRV--GVFPSNYVAPG
.  ...||.. .. .|     |....|| . |..    ..   ...|| .      ||.  |.|||..|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVID----NGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase MLK2.AA MLK 98-357 71 7.29999999999e-199 663.22 In-house 1-280 (280) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-280/280
Sequence Identity: 71% (201 aa)

LQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVT---AEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPH
|...||||.||||||||| |.||||||||.| |||.|...|   ||||.||||||..|.|||||||||.||..|||||||||.|||.|.||.||.|.|||
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGKRIPPH

VLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIE-----------------NHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRL
||||||||.|||||||||.||||||||||||.||||||.|.                 .|......||||||||||||||||.|||||||||||||||. 
VLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKE

SLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRL
|..||.|||||.|||||||||||||||.||.|||||||||||||||||||||||.|.|...||..||| ||.|..||..|
STWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase MLK2.AA MLK 98-357 46 7.1e-159 534.11 In-house 1-291 (291) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-291/291
Sequence Identity: 46% (138 aa)

LQLEEIIGVGGFGKVYRALWRGEE-----VAVKAARLDPEKDPAVT---AEQVCQEARLFGALQHPN----IIALRGACLNPPH-LCLVMEYARGGALSR
.|..|.||.|.||||... ||...     ||||..| ... | ..|   .... .|.|..  |.|||    ||...|.||.||. .|.||||..|| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLAGRR---------------VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT-T-KMSAAGTY
||.|.|               .......|||.|.||||.|||..||.||||||||| ||||.| |.. ......|||.|||..|.||.. | .||.||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AWMAPEVI---RLSLFSKSSDVWSFGVLLWELLTGEVPYR-EIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRL
||||||||   | . .|...||||.||.|||.||.||||. ..|..|.|..||.|.|..||||||||....|...||..||| ||.| .|.. |
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK2.AA TKL 104-357 30 9.60000000001e-106 357.61 In-house 1-364 (364) Show / Hide 
Range on Protein: 104-357
Range on HMM: 1-364/364
Sequence Identity: 30% (114 aa)

IGVGGFGKVYRALWRG----------EEVAVKAARLDP-----------------------EKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPH-
|| ||||.||.. |||          ..||||  . .                        ....    ..  .|...   |.||||. . |.|..||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVMEYARGGA-LSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAP-----VPIIHRDLKSINILILEAIENHN------LADTVLK
            ||.||||. ||  |....      .|....|| ..||||||||.. |      ||||||||| |||. |  .|..       || ..|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ITDFGLAREWHKT---------------------TKMSAAGTYAWMAPEVIRLS----------------LFSKSSDVWSFGVLLWELLTGEVPYREIDA
|.||||.|.....                     |.|.  ||..||||||.| .                 .|...||.|||..|||.||...||.... 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

LAVA---------YGVAMNKLTLPIP------------STCPEPFARLLEECWDPDPHGRPDFGSILKRL
  .          ..|. ..| .|||            ..||.....|...|||.||. || |  |||||
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK2.AA TyrKc 98-357 30 7.2e-82 279.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-280/280
Sequence Identity: 30% (90 aa)

LQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGAL--QHPNIIALRGACLNP-------PHLCLVMEYARGGALSRVLAG
..|....| | ||.||.. |. ..||||  . |         |  ..|||.   |  .||||..| |.|. .       . |..||||. .|.|   |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RR--VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT--------TKM-----SAA--GTYAWMA
.|  ...  |.....|.|.||.|||     ..|||||   |.|. |          . ||.||||.|...          ...     ..     . |||
HRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREI----DALAVAYGVAMNKLTLPIPST--------CPEPFARLLEECWDPDPHGRPDFGSILKRL
||.|. . |.  ||||||||..||..| |. || ..       . ..   ..   .|.|          ||.   .. ..||. ||. || |  | ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK2.AA LZK 152-357 48 1.1e-80 271.73 In-house 44-241 (241) Show / Hide 
Range on Protein: 152-357
Range on HMM: 44-241/241
Sequence Identity: 48% (101 aa)

LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFG
|.|||||...| |   |  | .|||   | |  || ..| ..|. .|.|  |.| ||.|||      |||||||| ||||         .. |.|| |||
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNILI--------SHNDVVKICDFG

LAREWHKT--TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRP
  ..| .   |||| .|| |||||||||    |   |.||||| |||.||.|.||...|  |. .||  | | ||.|||||| |  |.  ||   |  ||
TSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRP

DFGSILKRL
 |  ||  .
SFRQILMHW
Kinase MLK2.AA Pkinase 98-357 26 5.9e-76 263.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

LQLEEIIGVGGFGKVYRALWRGEE--VAVKAARLDPEKDPAVTAEQVC-QEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG----ALSRVLA---
......|| |.||.||.. ..|..  ||||  ... .... .  . .  .|...   |.||||. |.... ...|...||||..||     |....    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GRRV--PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWHKTTKMSAAGTYAWMAPEVIR-LSLFS
....  ..... ... |..||..|.|.     |||||||. |||| .  ..       .||.|||||.   . ...  .. .||. .|||||||  .  .
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KSSDVWSFGVLLWELLTGEVPYREI------DALAVAYGVAMNKLTLPIPSTCP-------------------EPFARLLEECWDPDPHGRPDFGSILKR
...|.||.|..|.|.|.|. |...       | ... . . . .|  ..| .|.                   |..  ... |...||. || .  ||. 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase MLK2.AA Dicty4 98-359 35 4e-75 250.01 In-house 1-277 (277) Show / Hide 
Range on Protein: 98-359
Range on HMM: 1-277/277
Sequence Identity: 35% (101 aa)

LQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACL----NPPHLCLVMEYARGGALSRVLAG-----
.. |..|| |.||.||.. ||| ||||| . .. ... . . .   .|. . . ..||||. . |||.    .|. .| |.||   | | ..|       
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-RRVPPH-VLVNW----AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR----EWHKTT-KMSAAGTYAWMAPEVIRL
  ....   |.      |  .|||||.||.  || |||||||| |.|. .        . . |..||||..    .  ...  |.|.|| .|||||| . 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH

SLFSKSSDVWSFGVLLWELLTGEVPYR--EIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKR--LEV
  .  ..|| ||| .|||.||.. ||    ..   .. .|.  || .|||. || ....|...|||.||  || |  |..|  || 
QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK2.AA TKL-Unique 100-357 35 1.2e-71 244.39 In-house 1-290 (290) Show / Hide 
Range on Protein: 100-357
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

LEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQ-VCQEARLFGALQ-HPNIIALRGACL----NPPHLCLVMEYARGGALSRVLA------
  . || ||.|.||.. |||..||.|   .  . |.  . .|    | ..   |. ||||  . |.|      ||..|.||||  || |  ||.      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----GRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAA-----------GTYAWMA
         .. . |. | ..|.||.|||.  |  |||||||| |.|. ..    | |    || ||||..   | .||..            |.. |||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNS---NIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEVIRL--SLFSKSSDVWSFGVLLWELLTGEV------PYREIDALAVAYGVAM--NKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRL
|||.|   ...|..|||.|||. |||..|...      ||...|  ...  |.    .. .|||. ||. .  |...||..||  || | .|..||
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK2.AA LRRK 98-359 30 4.7e-70 239.04 In-house 1-351 (351) Show / Hide 
Range on Protein: 98-359
Range on HMM: 1-351/351
Sequence Identity: 30% (111 aa)

LQLEEIIGVGGFG-KVYRALWRG----------------------------EEVAVKAARLDP------------------------EKDPAVTAEQVC-
|  || ||.|||| .|||| |||                            ..||.|   .||                        |  . . .|  | 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

------QEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR---------V-PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSIN
      .|. .   |.||||. | | |..|  ||.|||||. |.|...|  ..         . .....   |.|.|.||.|||.  | ||||||||| |
AFREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPN

ILILEAIENH----NLADTVLKITDFGLAR--EWHKTT-KMSAAGTYAWMAPEVIR---LSLFSKSSDVWSFGVLLWELLTGE-VPYREIDALAVAYGVA
||. .  .||      |... || |||. |     ...  .   |.  |||||..|    . ..  .|. |||..||||||..  |..|.|     ... 
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHD----FFDHM

--MNKLTL--------PIPST-CPE-----PFARLLEECWDPDPHGRPDFGSILKRLEV
  |... .        .||.. ||.      .  |...||. ||  || | .|.|||. 
QWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK2.AA Pkinase_Tyr 98-357 32 2e-68 232.37 Pfam 1-270 (270) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-270/270
Sequence Identity: 32% (93 aa)

LQLEEIIGVGGFGKVYRALWR------GEEVAVKAARLDPEKDPAVT--AEQVCQEARLFGAL-QHPNIIALRGACL--NPP-HLCLVMEYARGGALSRV
... . .| | ||.||.. |.      . .||||  .   |.        |   .||..   | .||||. | |.|.    | ....||||. .| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LAGR-----RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHK-----TTKMSAAGTYAWMAPEVI
|  .     ..... |.....|.|.||.||..    ..|||||   |.|. |        . | ||.||||||  ..     ... ..     |||||.|
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECI

RLSLFSKSSDVWSFGVLLWELLT-GEVP-YREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRL
. . |.  |||||||||.||..| || | | ...   |   .. .   .|.|  ||..  .|. .||..||  || |  |. .|
NYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK2.AA ZAK 98-356 37 1.7e-67 230.53 In-house 1-257 (257) Show / Hide 
Range on Protein: 98-356
Range on HMM: 1-257/257
Sequence Identity: 37% (106 aa)

LQLEEIIGVGGFGKVYRALWRGEE-----VAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPH-LCLVMEYARGGAL--------S
.|. . .||| || |||| |         .|||   .  ||           ||     . | |||   | |. ||     | |||  | |        |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKV-FKIEK-----------EAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRS

RVLA----GRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR-EWHKTTKMSAAGTYAWMAPEVIRLS
  ..    |      . . || |.|.|| ||| |||. |||||||| |. |         .. |.|| |||  |   | .| ||  || .|||||.|  |
QEMDSSSGGNSM--DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVI--------DKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQS

L-FSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKR
.  .   ||||.|| |||.|| ||||.. . . ..  .     .| ||. || ||. |. .||  ||  || .  |   
EPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase MLK2.AA TK 98-357 18 1.2e-65 218.81 In-house 1-486 (486) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)

LQLEEIIGVGGFG---KVYRALWRG---------------------------EEVAVKAARLDPEKDPAVTAE-------------QVCQEARLFG--AL
..|.. .| | ||   .||...|||                           ..||||  ... . ...   .             . ..|. ..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNIIALRGACLNP------------PHLCLVMEYARGGA----LSRVLAGRR----------------------------------------------
.||||. | |.|. .            .....||||. .|     |   |  .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPPHVLVNWAVQVARGMNYLHND--APV--PIIHRDLKSINILILEAIENH---NLADTVLKITDFG--
                               ...| |. ...|.|.|| |||          ..||||   |.|. |   ..        | ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAREWHKTTKMSAAGTYA----------------------------WMAPEVIRLSL---------FSKSSDVWSFGVLLWELLT-G-EVPYRE
      |||. .. .   ....|                             |||||...            |.  |||||||||.||..| | | .| .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IDA---------LAVAYGVAMN-------------KLTLPIPSTCP--------------EPFARLLEECWDPDPHGRPDFGSILKRL
..            |   . .              .. .| |  ||              | ...|. .||..||  ||.|  ....|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK2.AA S_TKc 98-366 27 2.3e-65 224.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 98-366
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LQLEEIIGVGGFGKVYRALWRG--EEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARG--GALSRVLAGRR---
 .. ..|| |.|||||.. ...  ..||.|  .           |....| ..    .||||. | ... .  ||..||||. |  | | ...  |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSK-SSD
     |. .   .. |......|.|.     |||||||  |||. |          ..||.||||||.      ..  ||  .|||||.    ..| ..|
LRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALF
.||.|..|.|.|.|. |..    ... . . .           ....  ... |.. ||  ||    .|.. ..| .   |
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK2.AA DRK 98-359 34 1.2e-64 217.84 In-house 1-258 (258) Show / Hide 
Range on Protein: 98-359
Range on HMM: 1-258/258
Sequence Identity: 34% (93 aa)

LQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPH--V
      || |..| |.|  ||| .|||| . .. . |     |   .|. |   | ||||.   |.|.|||  | .|||   | | ..|    .      
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNE-FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL

LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR----EWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGV
.   .  .|.||.|||.  |. |||||||| | |. |            |. ||||.        ... | . ||  | |||| |   .    ||.||..
MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVDEHWQ--------VKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAI

LLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEV
 |||..| . ||  .  . |   |   .. .|.|  || ....|. .||. ||  || .  .|.||| 
VLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA