Gene MUSK (Human)

MUSK

Species: Human
Alias: MUSK, MGC126323, MGC126324
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9q32-q33,

Classification

Group: TK
Family: Musk

Sequence

Name Sequence Type Origin Length Description Download
MUSK.NA RNA Sugen Kinome 2781 None Fasta, JSON
MUSK.AA Protein Sugen Kinome 878 None Fasta, JSON
MUSK.kin_dom Protein Kinase Domain Sugen Kinome 281 None Fasta, JSON

Protein domain

Protein domains of MUSK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
I-set MUSK.AA I-set 28-117 30 6.4e-17 59.93 Pfam 1-92 (92) Show / Hide 
Range on Protein: 28-117
Range on HMM: 1-92/92
Sequence Identity: 30% (28 aa)

PVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENG---QLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQV
|..|...  | . . | |.| | |. .|.|..||...   ..  . |......|   . |||. |. .| |.| |.| |  .| .|.   |.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS-FGEAECTAELTV
IGc2 MUSK.AA IGc2 40-106 25 4.2e-11 44.12 SMART 1-56 (56) Show / Hide 
Range on Protein: 40-106
Range on HMM: 1-56/56
Sequence Identity: 25% (17 aa)

LVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVG
.  . .|. | .. .| |.|.|..    .           ... ||| .|. .|.|.| |.| | .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG MUSK.AA IG 34-118 22 4.6e-09 37.35 SMART 1-58 (58) Show / Hide 
Range on Protein: 34-118
Range on HMM: 1-58/58
Sequence Identity: 22% (20 aa)

LETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDD---GIYCCTANNGVGGAVES--CGALQVK
 . | . . | .|. | |.     .|.|.                     ||| .|. .|    |.| |.|.   .| ..|     |.|.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
V-set MUSK.AA V-set 27-104 19 6.198157 1.6 Pfam 1-115 (128) Show / Hide 
Range on Protein: 27-104
Range on HMM: 1-115/128
Sequence Identity: 19% (22 aa)

APVITT-PLE----TVDALVEEVATFMCAVE-SY----PQPEISWTR-NKI-----LIK-----------------LFDTRYSIRENGQ----LLTILSV
. ..|. | .     | . . . .|. | .  .|    .   |.| |  .      .|                   |  |...  |..     ||| ..
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

EDSDDGIYCCTANNG
. || |.| | . |.
QPSDSGTYYCAVWNC
I-set MUSK.AA I-set 121-208 40 5.7e-35 121.19 Pfam 1-92 (92) Show / Hide 
Range on Protein: 121-208
Range on HMM: 1-92/92
Sequence Identity: 40% (38 aa)

PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRE-NSRIAVLESG----SLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEV
||.|..| .|.. ||  | . |.  |.|.|.||| |...|||. ..|. . ..|    .|.| |||..|.|.|.|||.||.|.| .. ..|.|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEA-ECTAELTV
IGc2 MUSK.AA IGc2 133-197 36 1.1e-17 65.95 SMART 1-56 (56) Show / Hide 
Range on Protein: 133-197
Range on HMM: 1-56/56
Sequence Identity: 36% (24 aa)

IEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLG
.||  ..|.|   ||| |...|.| ..||          ...|.| ||..||.| |.|.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG MUSK.AA IG 127-209 25 1.1e-14 56.03 SMART 1-58 (58) Show / Hide 
Range on Protein: 127-209
Range on HMM: 1-58/58
Sequence Identity: 25% (22 aa)

PINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDA---GQYRCVAKNSLGTAYS-KVVKLEVE
|  |   ||  ..|.|        ...|                    |.| |||.||.   | |.|.|.   |...| . ..|.|.
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set MUSK.AA V-set 134-208 18 1e-07 28.43 Pfam 20-128 (128) Show / Hide 
Range on Protein: 134-208
Range on HMM: 20-128/128
Sequence Identity: 18% (20 aa)

EGLKAVLPCTTMGNP----KP-SVSWIK-GDS-----------------------PLRENSRIAVLESGS-----LRIHNVQKEDAGQYRCVAKNSLGTA
|| .. |||. . ..     . ...|.. ...                       . | . |. .  ..|     |.|.|.| .| | | |...|.    
EGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDY

YSKVVKLEV
. . ..| |
FGHGTRLTV
IGv MUSK.AA IGv 137-192 16 0.000601 10.49 SMART 1-76 (76) Show / Hide 
Range on Protein: 137-192
Range on HMM: 1-76/76
Sequence Identity: 16% (13 aa)

KAVLPCTTMGNPKPSVSWIKG-------DSPLR-----ENSRIAVLESG---------SLRIHNVQKEDAGQYRCVA
 . |.|.. |.    ..|..        ...|        .|. .  .          .|...|.. || | | |  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
IGc2 MUSK.AA IGc2 233-298 31 8.5e-07 29.82 SMART 1-56 (56) Show / Hide 
Range on Protein: 233-298
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

TFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHG
  |  ||| | ||| |.|.|.|.  |  ..             ...|..   .|   |.|||.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG MUSK.AA IG 227-309 20 4.2e-05 24.2 SMART 1-58 (58) Show / Hide 
Range on Protein: 227-309
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

PESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP--------GLYTCIATNKHGEKFS--TAKAAAT
|. . |  |. |||.| ..     .|.|                          | | .         | |.| ||  ||...|  ...   .
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set MUSK.AA I-set 221-265 21 7e-05 19.07 Pfam 1-46 (92) Show / Hide 
Range on Protein: 221-265
Range on HMM: 1-46/92
Sequence Identity: 21% (10 aa)

ARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSS-GS
 .... | .  |. |. ... |..|| | |...|  .|  ... ..
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSD
I-set MUSK.AA I-set 287-305 57 0.005633 12.61 Pfam 71-89 (92) Show / Hide 
Range on Protein: 287-305
Range on HMM: 71-89/92
Sequence Identity: 57% (11 aa)

GLYTCIATNKHGEKFSTAK
| |||.|||. ||  .||.
GKYTCVATNSFGEAECTAE
Fz MUSK.AA Fz 326-457 27 3.2e-48 148.91 Pfam 1-143 (143) Show / Hide 
Range on Protein: 326-457
Range on HMM: 1-143/143
Sequence Identity: 27% (40 aa)

CAQYR--GEVCNAVLAKDALVFLNTS-----YADPEEAQELLVHTAWNELKVV----SPVCRPAAEALLCNHIFQECSPGVVPTP-IPICREYCLAVKEL
|...|  ...|. .. . .... . .     ... |...|.. ...|..|. .    || |.|... .||.. |..| .|....| || ||..|.||||.
CQPIRNDIPMCHGMPYNMTWMPNLLHHETGTQKEAELQWEMM-IHQWWPLVHTSTHLSPKCHPHIQFFLCSMYFPMCTDGFHHPPPIPPCRSMCEAVKEQ

FCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACA
.|....  ||.| ||..|.  .| . ...|.|.|..| |...| 
GCEPVMQMMEDKKHRRMYPFGFHWPEMLNCNKFPHHHDDRHMCM
Kinase MUSK.AA Musk 584-865 76 1.4e-241 806.52 In-house 1-282 (282) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-282/282
Sequence Identity: 76% (217 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|.|||||||||||||||||||||.|||..|||||||||..||..||.||||||..|||||.||||||||||.||.||||||||||||||||||.|.|||.
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

VCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESI
.||..|.|..|||||||||||.|.|..|||.|.|.|.|||||||..||||||||||||..|.|.||||||||||.||..||||..|||.|||||||||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

FYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL
.||..|.|||||||||.|||||||.|||||||.|||||||.|.|||||||||||...|.|||.||.|.|||||.|..||...
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase MUSK.AA Pkinase_Tyr 584-865 45 1.4e-149 507.17 Pfam 1-270 (270) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-270/270
Sequence Identity: 45% (131 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADM--QADFQREAALMAEF-DNPNIVKLLGVCA-VGKP--MCLLFEYMAYGDLNEFLR
|.  . .||||||.|..... | .| .. . |||||||| |. .   ..|| |||..| .. ..||||.|.|||   |.|  ... .|||..||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYY-KANENDAIPIR
. .                    ....||.  . |....|.|.||.||......|||||.|||||.||.||||.||||.| ||. ||| .. ..  .||.
KHR--------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK

WMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQP-YYGMAHEEVIYYV-RDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL
||.||.|.|...||.||||..||..||||.|| || |.||  |||. |. .||. . |||||| |.|.||..|| . |.|||.|. ||..|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MUSK.AA TyrKc 584-865 40 7e-145 488.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-280/280
Sequence Identity: 40% (126 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF--DNPNIVKLLGVCAVG-------KPMCLLFEYMAYGDLNE
|.  . .||||||.|.....         ..||||||||.|    ..|| ||| .| ..  ..||||.|.|||  .       .|.....|||..|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA-------DYYKA
.||.  |.                       |. .. | .. |.|.||.||......|||||.|||||||| .|||.||||||.||.        |||..
YLRKHRPK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

----NENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG-----MAHEEVIYYVRDGNILSCPEN--------CPVELYNLMRLCWSK
    .... .|||||.||.|.|...||.||||..||..||||.|| |||.|     |  .||| ||..|. . .|.|        || |.|..|. ||  
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

LPADRPSFTSIHRIL
 |.|||.|. ||...
DPEDRPTFSEIHECF
Kinase MUSK.AA TK 584-865 26 7.6e-126 424.14 In-house 1-486 (486) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-486/486
Sequence Identity: 26% (131 aa)

IEYVRDIGEGAFG---RVFQARAPGLLPYEPF--------------------TMVAVKMLKEEASADMQADFQ-------------REAALMAEFD----
|.... .|||.||   .|..... |. |...                     | ||||||||........ |.             .||. |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-NPNIVKLLGVCAVG------------KPMCLLFEYMAYGD----LNEFLRSMSPHTVCSLSHSDLSMRAQVSS--------------------------
  ||||.|.|||  |            .|.... |||..||    | ..||. .|.. ......| . . ...|                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------PGPPPLSCAEQLC-------------------IARQVAAGMAYLSER------KFVHRDLATRNCLVGENMV-----------VKIADFG----
      . ||||. ...|.                   ...|.|.||.||...      .|||||||.||||||||.|           .||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSRNIYSADYYKANE------------------------NDAIPIRWMPPESIF---------YNRYTTESDVWAYGVVLWEIFSYGLQPYYG-MA
    |.| ||| |.| . .                        .. .|||||.||...         |...||.||||..||..||||.|| .|||| | 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

H---------EEVIYYVRDG--------------NILSCPENCP--------------VELYNLMRLCWSKLPADRPSFTSIHRIL
.         .||. |.|.|              . . .|..||               |.| ||. ||.. |.|||.|. .|. |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MUSK.AA Ror 584-862 48 2.4e-124 419.39 In-house 1-272 (308) Show / Hide 
Range on Protein: 584-862
Range on HMM: 1-272/308
Sequence Identity: 48% (135 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
..    .||..|| |.     |... .. . ||.| .|..||   ..||..|. |||... ||||.|||||   .|.| |||||. ||| ||| . ||| 
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

VCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESI
    | ||     . |      |. .. | || |.|||| ||| . |||||||.|||||||  .|||.||||.| |||.|||.   .   |||||.||.|
DHGCS-SDDDRMVKSS------LDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAI

FYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIH
 | . ...||.| .|||||||.|||.|||||    |||  .|   .|.||.|||   | ||  ||.  |. || |. ||
MYGKFSEDSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIH
Kinase MUSK.AA Trk 584-865 45 1.1e-123 417.25 In-house 1-275 (275) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-275/275
Sequence Identity: 45% (130 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|   ...||||||.|| |    |.| .  .||||| || .|| .   |||||| |. . . ..|||. |||  ..|. . ||||  ||||..||.  |  
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLK-DASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

VCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYS-ADYYKANENDAIPIRWMPPES
.| .   .   .         ||   . | ||.|.|.|| |. .  |||||.||||||||.| .|||.|||.|| .||  |||.     . |||||||||
MCYAQYQPRQAPG--------PLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPES

IFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNI-LSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRIL
| | ..|.||||| .|||.||.|.|| ||.|..   ||| ..  |   | .|. || |.|..|. || . |  | .  .|| |.
IMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase MUSK.AA UTK 584-868 36 9.69999999999e-104 350.95 In-house 1-296 (296) Show / Hide 
Range on Protein: 584-868
Range on HMM: 1-296/296
Sequence Identity: 36% (114 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD----FQREAA---LMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEF
..  |..|.|||| |. ||.    . ..   |||| ....|.|  . .    | .||.   .|. |.  ||...|.|||  ..|.... |||. |||  .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN-------MVVKIADFG---LSRNIY-----
||. .| .                 . |  |.  ..|| |...|.||.||....||||||| |||||...       ||.||||||   .||...     
LRRHRPTPP----------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFS

----SADYYKANENDAIPIRWMPPESIFYN-RYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDG--NILSCPENCPVELYNLMRLCWSKLPA
    ...||.|...|..||||| ||.. .. |.|| ||||..|||.|||...| .|| ||....|.  |..|    . ||. || ..|.||. || . |.
NRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQ

DRPSFTSIHRILERM
.||.|   ......|
ERPDF---EDLVQQM
Kinase MUSK.AA InsR 584-867 40 9.3e-99 332.35 In-house 1-278 (278) Show / Hide 
Range on Protein: 584-867
Range on HMM: 1-278/278
Sequence Identity: 40% (119 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFT--MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSP
|.  |  |.|.|| |    | |..| |. .   .|.| ..|.||.    .|  ||  | ||.  ..|.|||||  | ||    | |.||||  .|||  |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

HTVCSLSHSDLSMRAQVSSPGPP----PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRW
  .                || .    . .  . .  | ... |||||  .|||||||| |||.| .   |||.|||. | ||  |||.       |.||
EEEF-------------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRW

MPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV-RDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILER
|.|||.    .|| |||| .||||||. . | ||| |   |.|  |. .|||.|  |||||  .. ||. ||   | .||.|. |  .|  
MAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase MUSK.AA DDR 584-865 38 1.9e-91 310.14 In-house 1-306 (306) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-306/306
Sequence Identity: 38% (119 aa)

IEYVRDIGEGAFGRVFQARAPGLL-------PYE----PFTMVAVKMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAY-G
   |  |||| || |    . |..       . .      |.||||||...|.    .|| .|.. |.     ||||.|.||| . .|.|.. ||| . |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG--LSRNIYSADYYKAN
||| |.    . ....   .     .| ..     .| .  . |. |.|.||.||.   ||||||||||||||..  .||.|||  .||| || |||.  
DLNQFWMEHEAENSGLMNCKADTQNCQKPT-----ISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVE

E-----NDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYG-LQPYYGMAHEEVI-----YYVRDGN--ILSCPENCPVELY-NLMRLCWSKLPAD
          ||||| .|||  .  || ||||| || .||.|.    |||  .  | ||      .  .|.  .|. | .|| |.| .||  ||.  .  
GFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQ

RPSFTSIHRIL
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RPSFEEIHKFL
Kinase MUSK.AA TK-Unique 584-865 36 2.1e-89 303.3 In-house 1-294 (294) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-294/294
Sequence Identity: 36% (114 aa)

IEYVRDIGEGAFGRVFQARAPGLL-PYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGK-PMCLLFEYMAYGDLNEFLRSMS
.|  . ||||||| |. . . |.  . . .. |||||||..|.   ..|| .|...| | .  ||||..||.|     |.....||...|.|  .||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PHTVCS---------------------LSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSE--RKFVHRDLATRNCLVGENMVVKIADFGLSR
| .. .                     .|  ||                     .| |.| ||.||..  .|.|||||..||.|..|. |.||.|||..|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH-------------------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMAR

NIY-SADYYKANENDAIPIRWMPPESIF--YNRY-TTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENC-PVELYNLMRLCWSKLP
 .|   .| .  .   ||||||.|||.   .. | ||.||||..||..||||..| .||.||  ....  .||| ..  ||.| . |.||||. ||.. |
DVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEP

ADRPSFTSIHRIL
 .||||..|  .|
EERPSFRQIKHRL
Kinase MUSK.AA Src 584-865 37 3.5e-89 302.57 In-house 1-255 (255) Show / Hide 
Range on Protein: 584-865
Range on HMM: 1-255/255
Sequence Identity: 37% (107 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHT
|  .| .|.| || |...       .   | |||| ||.      ...|..|| .| ... ...|.|. ||  ..|     |||. | | ..|.      
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

VCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA-DYYKANENDAIPIRWMPPES
                ..    |.  ... .| |||.|||||......||||| || ||||| |.|.||||| | |    | | | .   .||.|. || 
----------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEA

IFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYN-LMRLCWSKLPADRPSFTSIHRIL
| |.|.|. |||| .|. |.||..||  || ||  .||.  |  |  . ||.||| |||. .|. || | | .|| |  ..  |
INYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase MUSK.AA ALK 584-867 39 2.9e-86 292.91 In-house 1-273 (273) Show / Hide 
Range on Protein: 584-867
Range on HMM: 1-273/273
Sequence Identity: 39% (113 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTM-VAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPH
|. ||  | |||| |. .   . .|  .  | ||.| |.| .| . . ||  ||. |. |. .|.|...|.|   .|   . |||. ||.  |||   ||
ITLVRALGHGAFGEVYMGQYSH-MPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPH

TVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLV---GENMVVKIADFGLSRNI-YSADYYKANENDAIPIRWM
 . ||  | | |.                | ... ||.|  || |..|.||| | ||||    |   |.|||||| .| | | ||||  .    .|. ||
PE-SLQPSQLTMK--------------DLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWM

PPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILER
|||      .|. .|||..|| .||||| |  || |.  .||.  |  |. .  | |||.  |..|. ||   |.|||.|..|  ... 
PPEAFMDGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase MUSK.AA S_TKc 584-868 21 3.7e-42 147.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 584-868
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY--GDLNEFLRSMSP
 | .| ||.||||.|...|  .         ||.|..|         ...|| ... . . ||||||..|.   . ... .||.    ||| ...... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

HTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPE
|  ..                  |..  .  ....|.. ...|. .....||||   | |. |  ..||.||||.| .                 .|.||
HGLRF------------------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPE

SIFYNRYTT-ESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHR------ILERM
 .    |.. ..|.|. |..|.| .. |  |..   ...... .            . |. ...| |. | |..||.   . .      . . .
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MUSK.AA Pkinase 584-868 20 1.9e-39 140.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 584-868
Range on HMM: 1-293/293
Sequence Identity: 20% (69 aa)

IEYVRDIGEGAFGRVFQARAPGL-LPYEPFTMVAVKMLKEEASADMQAD--FQR--EAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYG----DLNE
.. .| ||.|.||.|....  |         .|||| .| . ..... |    |  |...|.... ||||.|....  .. ... .||.  |    || .
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPL--SCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVV----KIADFGLSRNIYSADYYKAN
...                           ..  |  |  ....|.. |..|. .....||||   |.|. .|...    ||.||||.. ..    .  .
YIST----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-M

ENDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGM------AHEEVIYYVRD-GNILSCPENCP-------------------VELY
   .  ...|.|| |  .. |....|.|..|..|.| .. |  |..|        . ..|. ...  .  ..|. |.                    |. 
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

NLMRLCWSKLPADRPSFTSIHRILER--M
 ... |. | |..||.   .. ||.   .
DFIKWCLCKDPKKRPT---AEQILQHPWF