Gene MYO3A (Human)

MYO3A

Species: Human
Alias: MYO3A, DFNB30
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 10p12.1,

Classification

Group: STE
Family: STE20
Subfamily: NinaC

Sequence

Name Sequence Type Origin Length Description Download
MYO3A.NA RNA Sugen Kinome 5798 None Fasta, JSON
MYO3A.AA Protein Sugen Kinome 1616 None Fasta, JSON
MYO3A.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of MYO3A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MYO3A.AA NinaC 21-287 78 4.1e-229 767.43 In-house 1-267 (267) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-267/267
Sequence Identity: 78% (209 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGE
|||.||||||||||||||.||.|||.|||||...|||.|||||||||||....||||||||||.|.||||.|||.||.|.|.|.||||||.|||.||.|.
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQHYIHDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNGDQLWFVMEYCNGGSVTDMVKGLLKCGR

RMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITA
||.|..||||||||.|||||||.|..||||||||||||||||||||.||||||||.||||||||.||||.|||||||||.||.|..||||||.|||||||
RMREEHIAYILHEACMGLQHLHCNHVIHRDVKGNNILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITA

IELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
|||||||||.||.|||||.|||||||||.|..||.|..|||||||.||.|||||||.....|.|.||
IELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPENWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase MYO3A.AA STE20 21-287 51 4.5e-160 538.09 In-house 1-288 (288) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-288/288
Sequence Identity: 51% (148 aa)

WEITETIGKGTYGKVFKVLNKKNGQK----AAVKILDPIH-----DIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDL
.|..| ||.|.||||.|. .|..|..    .|.|...  .     |  |.|. |..|.| .  |||.|..|| |.|.|.  .|.||.| |.|.|||.||.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTC-DDELWIVMEYCGGGSLTDI

VKGFLKRGE-----RMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTS----TRH-RRNTSVGTPFWMAPEVIACEQ
.|...|.|      .|.|. ||||..|.| ||..||.|. ||||.|..|||||..| |||.||||.||||.    |.. .||| ||||.|||||||.|..
MKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

QLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIP--RNPPPKLRQ--PELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
. |  || .|| |||||||||. .| ||..|.|||||.|.||  .||||.|..  |. || ||.||..|||.||.|||||.|.||.|.||
GPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MYO3A.AA STE 21-287 37 5.4e-132 444.8 In-house 1-359 (359) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-359/359
Sequence Identity: 37% (137 aa)

WEITETIGKGTYGKVFKVLNK------KNGQK---------AAVKILDPIH------------------DIDEEIEAEYNILKALSD-HPNVVRFYGIYF
||. | ||||..|.|.| .|.      |.|..          |.|...  .                  .. ..|. | .|.| ... |||.|..|| ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KKDKV--NGDKLWLVLELCSGGSVTDLVKGFLKRGE----------RMSEPLIAYILHEALMG-LQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSA
|...   |.|.||...|...|||..|..|   ..|.          |..|..||||... | | |..||... ||||.|. ||||     |||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLTS---------------TRH-RRNTSVGTPFWMAPEVIACEQQL-DTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN-----------
|||.               |.  .||| |||| ||||||| ...|  |  ||..|| ||||.|.||. .| ||..|.|||||.| ||.|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----PPPKLRQ-----------------PELWSAEFNDFISKCLTKDYEKRPTVSELLQ--HKFI
    |||.| .                 |. || ||.|||.|||.||..||||.|.||.  |.||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MYO3A.AA MSN 21-287 54 4.7e-122 404.93 In-house 1-265 (265) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-265/265
Sequence Identity: 54% (147 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRG
.|. |..|.||||.|.| . .| || ||.|..|  .| .|||  | |.||  | | |.. .|| ..||    . ..||.|.|.|. ||||||||    .|
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVK--MTKG

ERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGIT
. . |  ||||  | | ||.||| .| ||||.|| |.||| .  ||||||||||||  |  |||| .|||.|||||||||. . |.||| | | ||.|||
QSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGIT

AIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
|||. .|.||| |.||||||| |||||||||.  . ||  |..|. ||| |.|..||.  ..|.| ||
AIEMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase MYO3A.AA MST 21-287 48 4.8e-117 373.61 In-house 1-254 (254) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-254/254
Sequence Identity: 48% (130 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDID-EEIEAEYNILKALSDHPNVVRFYGIYF-KKDKVNGDKLWLVLELCSGGSVTDLVKGFLKR
 .| | .| | ||.|.| ..|..|.  |.|.. |. . | .||. | .|..   . ...|..|| ||  |..     .|.| | | .||| |..|    .
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMV-PV-NEDLQEIIKEISIMQQC-KSKYIVKYYGSYFDAKNN----HCWIVMEYCGMGSVCDIMK---IT

GERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGI
.   .|  || ||  .| ||| ||.|| |||| |  |||| .||  || |||||.||| |   ||| .|||.|||||||         ||   | |||||
QRTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ-----EIKYDCKADIWSLGI

TAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
||||.  | ||..|.|||||.|.|| .|||... || || |||||..|||.|. |.|.|  .|||| ||
TAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase MYO3A.AA YSK 21-287 45 3.3e-113 342.29 In-house 1-257 (257) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-257/257
Sequence Identity: 45% (123 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDID--EEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKG-FLK
. ..| ||.| .| |.|  ... ..  |.||.|  |. |  | |  | ..|  . | |.. ..|| | |     . ||| . | | |||. || |  .. 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQC-DSPYITKYYGSYLK-----DTKLWIIMEYCGGGSCLDLMKPKYV-

RGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLG
    . |. || ||.| | ||  || .. ||||.|  |.||. .| ||| ||||..|.| |  .||| ||||.||||||| .|    . ||.  | ||||
--GQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV---SYYDFKADIWSLG

ITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
|||.|.  | ||..|.||||..| || |.||||   . .|  | .|.  || || |.||. .||| ||||
ITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MYO3A.AA S_TKc 21-287 34 9.4e-93 315.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-231/231
Sequence Identity: 34% (97 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSG--GSVTDLVKGFLKR
.|| ..||||..|||.|. .|| |.. |.||..      | |. | .|||   .|||.|..|...        |.|..|.|.|.|  |.. |. |   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRH

GER--MSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDA-RCDTWS
| |  ..|  ....... . .|...|... ||||.|  ||||..   .|. |||...||       .| .|||..|||||.         |.  .|| ||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--------GYGKCKCDWWS

LGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQ-------HKFI
.|.. .|.  | ||      | ..||. .            | |. |||.|||.|| |||||. |.||       | ..
CGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MYO3A.AA SLK 21-287 41 4.6e-91 307.46 In-house 1-259 (259) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-259/259
Sequence Identity: 41% (112 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDID-EEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRG
|||   .| | .||| |  .| ... || |...  .. . |.   | .||  .  |||.|. |. |.       .|||...| | || |  ..   .  .
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYYYD-----NKLWMMIEFCDGGAVDNIM---VELE

ERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGIT
. . |. |.|. .. . .|..||.|| ||||.|  |||.| .|.|.| ||||||....|...| | .|||.||||||..||   |. || . | ||||||
HPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGIT

AIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
 ||. ...||  .. ||| |.|| .  ||.| ||  || ||.||. ||| || ..|.| ..|.||...
LIEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase MYO3A.AA KHS 21-287 44 3.4e-89 300.16 In-house 1-258 (258) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-258/258
Sequence Identity: 44% (121 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKR
.|.   .| |||| |.|  ... .. ||||.  ..|  |. . |  |  ..|  . |||.| ..| |...     ||||...| | |||. |.     . 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDF-AVIQQEIMMMKDCR-HPNIVAYFGSYLRR-----DKLWICMEYCGGGSLQDI----YHV

GERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGI
   .||  |||. .|.| ||..||... .|||.|| ||||| .| ||| |||||||.| |  .|   .|||.|||||| | |..    |.  || |..||
TGPLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERK--GGYNQLCDIWAVGI

TAIELGDGDPPLADLHPMRALFKIPRNP--PPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
|||||..  ||. ||||||||| . .    ||||.. . ||. | .|.  .|||.  |||| . ||||.|.
TAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase MYO3A.AA PAKA 21-287 40 3.9e-85 289.16 In-house 1-260 (260) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-260/260
Sequence Identity: 40% (110 aa)

WEITETIGKGTYGKVFKVLNKKNGQK--AAVKILD-PIHDIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLK
 . .| ||.|  |.|... |.|..|.   |.| ..    .  | |  |  ..|  . |.|.|...  |    .|  |.||.|.|  .||. ||... . .
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKE-CKHKNIVNYIDSY----LV-DDELWVVMEYMEGGCLTDVITQCCN

RGER-MSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSL
     |.|  |||.. | | ||. .|... ||||.|  |||| ..| ||. |||  ||||  . .||| |||| |||||||   |     ||   | |||
IQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQ-----YDEKVDIWSL

GITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
|| |||. .| ||  .  | ||.. |  |  |....|. || ||.|| .||| .| ..|....|||.| |.
GIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase MYO3A.AA PAKL 21-287 40 1.4e-83 283.93 In-house 1-256 (256) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-256/256
Sequence Identity: 40% (111 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDI-D-EEIEAEYNILKALSDHPNVVRFYGIYFKK-DKVNGDKLWLVLELCSGGSVTDLVKGFLK
 |. |  | | || |.|.. |  .   |.| . .|    . ..|| | .|||     ||.|  .|    | .     ..|  .. || ||. |. .   |
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVI-EIKESNEIKDIEKEIQILKK-CKCPNIVSYFGSIQQKLN-----HYWILMDYCSLGSINDMMESCCK

RGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRH-RRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSL
    . |  |. ||  .| ||  ||    ||||.|  ||||.  . ||. ||||| || ..     |  .|||.|||||.|     . . |.  || |||
---TLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEII-----NKQNYNNKCDIWSL

GITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
||||||. || ||. |. ||||.  ||. |||..  |  || .||||. .|..|| |||. ...|| | ||
GITAIEMADGFPPHYDMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase MYO3A.AA Pkinase 21-287 29 9e-78 269.48 Pfam 1-293 (293) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEA-----EYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGG----SVTDL
..| ..||.|..|.|.|  .|..|.. ||||..  |. ... ..     |  |.| | .|||.||.|...       .|....|.|.| ||    .  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDY

VKGFLKRGERM--SEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGV----KLVDFGVSAQL-TSTRHRRNTSVGTPFWMAPEVIACEQQLD
...  .|. ..  ||  .  .. . | ||...|... ||||.|  |||.  .| .    |. |||...|. .   .  .| .|||..||||||      .
IST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GG

TTYDARCDTWSLGITAIELGDGDPPLADL----HPMRALFKIPRNPPPKLRQPELWS---------------------AEFNDFISKCLTKDYEKRPTVS
. |. ..| ||.|.. .|.  | ||  .     . .. ...| |. .|.|. .. |.                      |. |||..||.|| .||||  
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELLQHKFI
..|||...
QILQHPWF
Kinase MYO3A.AA Pkinase_Tyr 21-286 24 2.9e-28 96.34 Pfam 1-270 (270) Show / Hide 
Range on Protein: 21-286
Range on HMM: 1-270/270
Sequence Identity: 24% (70 aa)

WEITETIGKGTYGKVFKVLNK----KNGQKAAVKILDPIHDID----EEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLV
 .. ...|.| .|.|.|   |    ..... |||.| . .. .    |.  .| .|.| | .|||.||.||.  .... |  ....|.|.. .|   || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHG---DLL

KGFLKR----GERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQL--TSTR-HRRNTSVGTPFWMAPEVIACEQQLDT
. .|..    ... . . .  . ..  .|...|.... ||||.   |.|.| .. ||  ||| .  .  ...  . |  .    .|||||.|.       
D-YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----

TYDARCDTWSLGITAIELGD-GDPP-LADLHPMRALFKI-PRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKF
 .    | || |..  |.   |. |  ... . . . .|  ..    . .||. ..|  | . .|  .| |.||| ||. ....
-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI-HEQL
Kinase MYO3A.AA TyrKc 21-287 23 7.4e-17 49.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKAL-SDHPNVVRFYGIYFKKDKVNG---DKLWLVLELCSGGSVTDLVKGFL
 .  ...| | .|.|.|   |   .. ||| | . .   |..  | .|.. |  .|||.||.||.  ..        . |..|.|....|.     | .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGD----LKDYL

KRGER-MSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTST--------RHRRNTSVGTP-----FWMAPEVIACEQQ
.. ..  . .   .. . .  | ..|| .. ||||    |.|.. .. ||  ||| |  ...           |  .. |.       |||||.|     
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----

LDTTYDARCDTWSLGITAIEL-GDGDPPLAD-----LHPMRALFKIPRNPPPKLRQPEL--------WSAEFNDFISKCLTKDYEKRPTVSELLQHKFI
 . ..    | || |..  |.  .|..|  .     . . ... .. .     ..||.          ..|  . ...|   | |.||| ||.  |...
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG--YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
MYSc MYO3A.AA MYSc 332-1054 33 6.8e-256 857.3 SMART 1-771 (771) Show / Hide 
Range on Protein: 332-1054
Range on HMM: 1-771/771
Sequence Identity: 33% (272 aa)

PLISNLKDVDDLATLEILDENTVSEQLEKCYSRDQIYVYVGDILIALNPFQSL-GLYSTKHSKLYI------GSKRTASPPHIFAMADLGYQSMITYNSD
     ...|||...|. | | .| . |.| | .|||| | |...||.||.. | ..|.  . |.|       | .|   |||||| ||  |..| ... .
MNPPKFEGVDDMCMLTYLNEPAVLHNLKKRYMNDQIYTYIGPVCIAVNPYKQLPPIYTPDVIKQYRNRKFDDGKHRYEMPPHIFAIADNAYRNMLNDKEN

QCIVISGESGAGKTENAHLLVQQLTVLGKANNRTLQEKILQVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAIGEK
|||.||||||||||||.... | |. ..  . ......||| | . |||||| |. |.|||||||| |. |  .| ..|| |. ||||||||..|. || 
QCIIISGESGAGKTENTKKIMQYLAAVSG-QVERVEQQILQSNPILEAFGNAKTVRNNNSSRFGKYMEIHFDEKGKICGAKIENYLLEKSRVVYQNKGER

NFHIFYYIYAG--LAEKKKLAHYK----------LPENK-PPRYLQNDHLRTVQDIMNNSFYKSQYEL----IEQCFKVIGFTMEQLGSIYSILAAILNV
|.||||...||   ..|...   .          |  .. ....   .|.   ...      .  ..     ... ..|.||. |.  .|..|.||||  
NYHIFYQLCAGASEEQKQEFHLKPFSHNPEDYHYLNQGGHYWNN-K-RHQSQCFTVD-GIDDAEEFKETCEQTCNAMRVMGFSEEEQEWIFRIVAAILHL

GNIEFSSVAT--EHQIDKS-HISNHTALENCASLLCIRADELQEALTSHCVVTRGE---TIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCINSLLKHD
|||||.. .   . |   | .......|.|...|| . ...|...||.  ..|..|   .|..|..|| |.. |||.||..|.|||.|||. ||. .   
GNIEFEQGRNQYDNQAVCSEKVKDEEELQNACELLGVDPEDLEKWLTHRKMKTGHEGGTWITKPLNVEQAIYARDALAKAIYSRLFDWIVKRINQSM---

SSPSGNGDELSIGILDIFGFENFKKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNEDVDARVIEYE--DNWPLLDMFLQK---PMGLLSLLDEESRF
       . ..||.|||.|||.|..|||||.||| .||. |...|.|.|  || || .| .. . |..   || | .|   .|   |||..||||||..|
-------HNYFIGVLDIYGFEIFEHNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYQREGIEWTFIDFFMYDNQPCCDLIEKKGKRPMGIFSLLDEECMF

---PKATDQTLVEKFEGN-----LKSQYFWRP------------KRMELSFGIHHYAGKVLYNASGFLAKNRDTLPTDIVLLLRSSDNSVIRQLVNHPLT
   ||.||||..||  ..     .|.  ....            .... .|.|.||||.| ||. |.| ||.|||. |.. |..||.|..|.|| ..  .
HAQPKGTDQTFLEKLNKQDYHQHHKNHPHFSKPHKSHRCCKPKKRMGRTHFIIKHYAGDVTYNVEGWLEKNKDTLFDDLIQLMQSSKNPFIKQLFPEYED

KT-------------------------GNLPHSKTKNVINYQMRTSEKLINLAKGDTGEATRHARETTNMKTQTVASYFRYSLMDLLSKMVVGQPHFVRC
.|                         .                                   .  .   . .||.. |. .| .|....   .||..||
QTSQTPQEKSSQGKNKSRRKKRMMQMKK-----------------------------------TC-MQKKRFPTVGFQFK-QLNELMETLNSCHPHYIRC

IKPNSERQARKYDKEKVLLQLRYTGILETARIRRLGFSHRILFANFIKRYYLLCYKSSEEPR---------MSPDTCATILEKAG---------LDNWAL
||||.|......| ..|| |||. |.||. |||| ||..|. .. | .||..|| .  . ..         .  . | .||.. |          | ...
IKPNEEKKPWDFDDDLVLHQLRCCGVLENIRIRRAGFPYRWPYQEFYQRYKMLCPPTWPNWGNPWKNQLFGDPKKACEAILQQLGEYIQHQNWDPDMYQF

GKTKVFLK-YYHVEQLNLMRKE
||||||.. ..... |  ||..
GKTKVFFRNPGQLFHLEEMRER
Myosin_head MYO3A.AA Myosin_head 340-1041 33 5.6e-225 758.5 Pfam 1-765 (765) Show / Hide 
Range on Protein: 340-1041
Range on HMM: 1-765/765
Sequence Identity: 33% (266 aa)

VDDLATLEILDENTVSEQLEKCYS-RDQIYVYVGDILIALNPFQSLGLYSTKHSKLYIGSKRTASPPHIFAMADLGYQSMITYNSDQCIVISGESGAGKT
|.|.. |. | |..| . |.| |   |.|| |.|...|..||.. | .|. .. . | | .|.  |||||| ||  |..| ..  .|||.|.||||||||
VEDMVMLTYLNEPSVLHNLKKRYMTGDLIYTYSGHFCISVNPYKQLPIYTQDMIQEYRGKHRYEMPPHIFAIADEAYRHMRHDRENQCIIICGESGAGKT

ENAHLLVQQLTVLGKANN----RTLQEKILQVNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAV----VGAQISEYLLEKSRVIHQAIGEKNFHIFY
||. .. | .. ..  |.    ... ..||| | . |||||| |. |.||||||||.|. |. .| .    ||. |. ||||||||..|. || ||||||
ENTKYVMQYFASVSGSNPGVNMGRVEQQILQSNPILEAFGNAKTTRNNNSSRFGKYMEIHFDKTGKINPTAVGGNIENYLLEKSRVVYQTPGERNFHIFY

YIYAGLAEKKKLAHYKLP--ENKPPRYLQNDH---LRTVQDIMNNSFYKSQYELIEQCFKVIGFTMEQLGSIYSILAAILNVGNIE-FSSVATEHQIDKS
...||... . .....|     |  .|| ..      || | ....     .. ... ...|||| |.  ||..|.||||. ||.. | . . | |    
QLLAGASQQEEKKELHLTSADPKDYHYLNQSGTNPCYTVDDGIDDA---EEFQHTRNAMDIIGFTHEEQRSIFRIVAAILHLGNMKGFKQDQNEEQA---

HISNHTA-LENCASLLCIRADELQEALTSHCVVTR----GETIIRPNTVEKATDVRDAMAKTLYGRLFSWIVNCINSLLKHDS-----------------
 ...... .|. ..|... . |.. .|..  ..|.     |.. .| ..|.|.. |||.||..|.|.| |||| ||  ..|                   
VVDDTEEICEIICELMGVDPEEFEKWLCYRRIKTGGGKRREWVTKPQNCEQAMYARDALAKAIYSRMFDWIVNRINQAICHKTQNTDDSDGQAAQWDDTV

--------SPSGNGDELSIGILDIFGFENF-KKNSFEQLCINIANEQIQYYYNQHVFAWEQNEYLNEDVDARVIEY-EDNWPLLDMFLQK--PMGLLSLL
         | ..   . ||.|||.||| | .||||||.||| .||. |...|.|.|  || || .|... . |.|  || |  |  . |  |||.||||
SITVVDVPDPAFDKRNYFIGVLDIYGFEIFCEKNSFEQFCINYCNEKLQQFFNHHMFKLEQEEYVREGIQWTFIDYGFDNQPCCD-LIEKKKPMGILSLL

DEESRFPKATDQTLVEKFEGNL--KSQ--YF-WRP-K------RMELSFGIHHYAGKVLYNASGFLAKNRDTLPTDIVLLLRSSDN-SVIRQLVNHPLTK
|||..||||||||...|  ..   |.    |  .| .      ... .| |.||||.| ||..|.| ||.|.|. | . |...|.. . ...| . . . 
DEECWFPKATDQTFLQKLYQTHSSKHPRLHFAQKPGRFYKRHRQGNTHFIIKHYAGDVWYNCEGWLEKNKDPLFDDLIELMWCSWDNPFMQELFPDWEWA

TGNLPHSKTKNVINYQMRTSEKLINLAKGDTGEAT---------RHARETTNMKTQTVASYFRYSLMDLLSKMVVG---QPHFVRCIKPNSERQARKYDK
.  ..                 .   |. .. |..         .  .  .... |||.. |. ..  |.  .       ||.|||||||...|... | 
EWAHMQ----------------IDFEADFHEEEFKRRYNRNGCQKGKQGKKKWFMQTVWFQFKEQCNHLMKWLYQCAWWHPHYVRCIKPNENKQPWQFDN

EKVLLQLRYTGILE-TARIRRLGFSHRILFANFIKRYYLLCYKSS-----EEPRMSP-DTCATILEKA---GL--DNWALGKTKVFLK
. || |||. |.|| . ||.| ||..|.... | .||..|| |.      .|. ... . | .||..    ..  . ...||||.|..
SMVLHQLRCNGVLEINIRICRAGFPYRWTYDEFFQRYRILCPKTWWSWIWPEWNGDTKQGCEKILQHLSWGNMDKEEYQFGKTKIFFR
IQ MYO3A.AA IQ 1056-1076 33 0.00106 15.86 Pfam 1-21 (21) Show / Hide 
Range on Protein: 1056-1076
Range on HMM: 1-21/21
Sequence Identity: 33% (7 aa)

IDKLILIQACVRAFLCSRRYQ
 .  |.|||..|..|. ..|.
HRAAIKIQAWWRGYLARKHYR
IQ MYO3A.AA IQ 1054-1076 34 0.039894 11.73 SMART 1-23 (23) Show / Hide 
Range on Protein: 1054-1076
Range on HMM: 1-23/23
Sequence Identity: 34% (8 aa)

EAIDKLILIQACVRAFLCSRRYQ
.     |.|||..| .|. .||.
RMHRAAIIIQAWWRGYLARKRYK
IQ MYO3A.AA IQ 1081-1103 47 8e-06 26.68 SMART 1-23 (23) Show / Hide 
Range on Protein: 1081-1103
Range on HMM: 1-23/23
Sequence Identity: 47% (11 aa)

KRKESAIIIQSAARGHLVRKQRK
.....|||||...||.|.||. |
RMHRAAIIIQAWWRGYLARKRYK
IQ MYO3A.AA IQ 1083-1101 47 1e-05 22.49 Pfam 1-19 (21) Show / Hide 
Range on Protein: 1083-1101
Range on HMM: 1-19/21
Sequence Identity: 47% (9 aa)

KESAIIIQSAARGHLVRKQ
...||.||.. ||.|.||.
HRAAIKIQAWWRGYLARKH
IQ MYO3A.AA IQ 1347-1367 42 0.000132 18.79 Pfam 1-21 (21) Show / Hide 
Range on Protein: 1347-1367
Range on HMM: 1-21/21
Sequence Identity: 42% (9 aa)

DKAAVFIQSKYRGYKRRQQLR
 .||. ||. .|||. |...|
HRAAIKIQAWWRGYLARKHYR
IQ MYO3A.AA IQ 1345-1367 34 0.000593 20.38 SMART 1-23 (23) Show / Hide 
Range on Protein: 1345-1367
Range on HMM: 1-23/23
Sequence Identity: 34% (8 aa)

EEDKAAVFIQSKYRGYKRRQQLR
.. .||..||. .|||. |.. .
RMHRAAIIIQAWWRGYLARKRYK