Gene NDR2 (Human)

NDR2

Species: Human
Alias: KIAA0965, STK38L, NDR2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards ,
Annotation: Consensus chromosomal location: 12p11,

Classification

Group: AGC
Family: NDR
Subfamily: NDR

Sequence

Name Sequence Type Origin Length Description Download
NDR2.NA RNA Sugen Kinome 5110 None Fasta, JSON
NDR2.AA Protein Sugen Kinome 464 None Fasta, JSON
NDR2.kin_dom Protein Kinase Domain Sugen Kinome 294 None Fasta, JSON

Protein domain

Protein domains of NDR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NDR2.AA NDR 90-383 54 2.8e-238 743.62 In-house 1-350 (350) Show / Hide 
Range on Protein: 90-383
Range on HMM: 1-350/350
Sequence Identity: 54% (192 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD--GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMT---LLMKKDT
||..|.||.||||||.||.||||||||||||.|||.|..|.||||.||||||..|||    ||||..|||||| .|||.||..|||||||   ||||.|.
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTG---------------------LKKAHRTEFYRNLTHNPPSDFS----
.||....|||.|.|.||...|..|.|||||||||.|.|..||.||.|||||||                     ... |....|.|. .  |.||.    
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

FQNMNSKR-----------------KAETWKKNRRQLAYSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKET
 ..||.|.                 ....||.|||.|||||||||||.|||||.| ||||..|||||||.||||||.|||||||.|||||..|.||||.|
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----VFPPEVPISEKAKDLILRFCI-DSENRIG-NS-GVEEIKGHPFF
.      ||||...|..|.||| |.|  | ..|.| .  ||.||| ||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase NDR2.AA AGC 90-383 33 2.4e-190 497.63 In-house 1-395 (395) Show / Hide 
Range on Protein: 90-383
Range on HMM: 1-395/395
Sequence Identity: 33% (136 aa)

FESLKVIGRGAFGEVRLVQKK------DTGHIYAMKILRKSD--------MLEKEQVAH-------IRAERDILVEADG----------AWVVK-MFYSF
|| |||||.|.||.|.||.||      |||..||||.|.|..        |.|. ...|       ...||.||.....           ..|| ..|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKRN--LYLIMEFLP---------GG-DMMTLLM---KKDTLTEEETQFYISE-------TVLAIDAIHQ-LGFIHRD-IKPDNLLLDAKGHVKLSDFG
|||..  ||..||..|         || .... |.   |. ...||...||..|       .|||.. .|. .|.|||| .||.|.|||..||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------LKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNR-----------RQLAYSTVG--TPDYIAPEVFMQTGYNKLC
||.                 ... |.... . ..     ...  . |. .....|..|.           |..... .|  ||.|.|||..    |.| |
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS-----NMD--T-NK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKAC

DWWS--LGVIMYEMLIGYPPFCSETPQ----------ETYRKVM------NWKETL------VFPPEVPISEKAKDLILRFCI-DSENRIGNS-------
||||  ||..|||||.|||||....||          |.. |.|      |||...       ||... .|. ||||| ...  | |.|.|.        
DWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDK

GVEEIKGHPFF
|.|||| ||.|
GAEEIKNHPWF
Kinase NDR2.AA DMPK 90-235 51 1.6e-112 279.33 In-house 1-147 (270) Show / Hide 
Range on Protein: 90-235
Range on HMM: 1-147/270
Sequence Identity: 51% (75 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKD-TLTEE
|| |||||||.|||| .|. | |. .||||.. | .|| ....|  . ||||.| ..  |... .| |||...||..||. ||||. ||. . .  . |.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

ETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLC
 ..||. | ||||..|||.|..|||||||| |||  ||.|| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase NDR2.AA RSK 93-383 36 6.30000000001e-104 351.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 93-383
Range on HMM: 1-278/278
Sequence Identity: 36% (113 aa)

LKVIGRGAFGEVRLVQKK---DTGHIYAMKILRKSDMLEKEQ-VAHIRAERDILVEAD-GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDT---
||| |.|..|.| |..|.   |||.|||||.|.|. .  ..  ..| ..||.|| .      .|. .|.||..  ||||||...||.. | | |. .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDA---KGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNR-RQLA
..|.| .||..| |||.. .||.|.||||.||.| |.|     ||.||.|||.|  .                                   ...  |..
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----------------------------------RCDHNQWT

YSTVGTPDYIAPEVFM----QTGYNKLCDWWSLGVIMYEMLIGYPPFCS---ETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR-FCIDSENRIG--
.. ..| .|.|||. .    | |..| ||||||||.||||| |.||| .   ....|. ..... | .| .|    .|. ||||| . .. | ..|.|  
MTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCG

NSGVEEIKGHPFF
 ...|||| ||.|
PQDAEEIKQHPWF
Kinase NDR2.AA S_TKc 90-383 32 6.6e-103 349.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 90-383
Range on HMM: 1-231/231
Sequence Identity: 32% (100 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPG--GDMMTLLMKKDT---
.| |..||.||||.|.....|.||.|.|.||..           ||| |..|| . .  ..||....|||  .||..||...|  ||..... |. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAY
   ..| ...||. ....|.. .|..|.||||.||.|.|||   |.|..||||.. |                                          .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------T

STVGTPDYIAPEVFMQTGYNK-LCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCI-DSENRIGNSGVEE---
. .|||.|.||||.   ||.|  |||||.|.|.|||| |||||.  ..|....|..              |. |||.| . .  | |.|..   . .   
TFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

-IKGHPFF
 || ||.|
DIKCHPWF
Kinase NDR2.AA AktR 90-383 36 1.4e-97 330.45 In-house 1-268 (268) Show / Hide 
Range on Protein: 90-383
Range on HMM: 1-268/268
Sequence Identity: 36% (110 aa)

FESLKVIGRGAFGEVRLVQKK-DTGHIYAMKILRKSDMLEKEQVAHIRAERDILV-EADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTE
|. .|..|.||||.| ||||| |.. .||||...|... |..|  |.. ||.|.  ...    ||..|.||.|..|..|||. |||.. . | || ...|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EETQFYISETVLAIDAIHQL-GFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKN-RRQLAYSTVG
|...||... .||..  ||    | ||.||.|.|||  ||||..||||                                      ... ....||| .|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK----------------------------------LQFMMHYDEKAYSFCG

TPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR--FCIDSENRIG--NSGVEEIKGH
|| |.|||. ..  |.|| .|||..|.  |||..|.||| ..  .. . |  .    . ||. ...|...|||| |  .| . ..|.|  ..| |||| |
TPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSH

PFF
|.|
PWF
Kinase NDR2.AA Pkinase 90-383 26 1.1e-81 282.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 90-383
Range on HMM: 1-293/293
Sequence Identity: 26% (88 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIR-AERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGG----DMMTLLM--KK
.. ...||.|.||.|.. ..|.||.|.|.||..|..  ......|.| .|  |. . .   .|.....|.||...|..||...||    | .....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DTL--TEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHV----KLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNR
 ..  .|.| .||. ... ... .|. |.||||.||.|.|.| .||.    |..||||.  ..                                    .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------------------------------Y-N

RQLAYSTVGTPDYIAPEVFM-QTGYNKLCDWWSLGVIMYEMLIGYPPFCSE------TPQETYRKVMNWKETLVFPPEVPIS-----------------E
 . ... .|||.|.|||| . ...| . .|.||.|.|.|||| |.|||...      .... ....|  .    .| . .||                 |
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE

KAKDLILR-FCIDSENRIGNSGVEEIKGHPFF
 .||.| . .| | . |..    |.|. ||.|
ECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase NDR2.AA MAST 90-234 45 1e-79 243.06 In-house 1-148 (337) Show / Hide 
Range on Protein: 90-234
Range on HMM: 1-148/337
Sequence Identity: 45% (67 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQD--KRNLYLIMEFLPGGDMMTLLMKKD-TLT
|| .|.|..||.| | ||..|.|. ..|||.....|.. | || ....||.||..... .|||||||||   |. |...||.. |||  .||     .. 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGL
|.....|| ||||... .|  | .|||.||||.|.|..||.|| ||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase NDR2.AA MAST 90-234 47 7.7e-78 250.44 In-house 1-145 (334) Show / Hide 
Range on Protein: 90-234
Range on HMM: 1-145/334
Sequence Identity: 47% (69 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEE
||  |.|..||.| | || .|.|. ..|||...||||. | .| . ..||.|| .... .||||||||| |..|...||.. |||  .||    .. |. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

TQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGL
...||.||||... .|. | .|||.||||.|.|..||.|| ||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase NDR2.AA Akt 90-235 43 1.5e-71 228.01 In-house 1-148 (264) Show / Hide 
Range on Protein: 90-235
Range on HMM: 1-148/264
Sequence Identity: 43% (65 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIY-AMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEE
|. |||.|.|.|| | ||.||||. .| |||.|.|.  ..| ||.|. .|| ||.  .   .|.. ||||.. .||..|.. .||.  ..| .| . .|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

ETQFYISETVLAIDAIHQLGFIHRD-IKPDNLLLDAKGHVKLSDFGLC
.. ||..| .|||.. |. . | ||  || |.|.|..||..| |||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase NDR2.AA GEK 90-240 54 7.4e-70 233.59 In-house 1-152 (269) Show / Hide 
Range on Protein: 90-240
Range on HMM: 1-152/269
Sequence Identity: 54% (83 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEE
|| ||||||||||||  |. |.|...|||||| | .|| .  .|  | |||.||. |  |. .. | ||| ..|||.|..  |||..||| | .| | |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

ETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK
  .|||.| |.|||..|||...||||||||.||| .||..| ||| |  ..|
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNK
Kinase NDR2.AA ROCK 90-235 52 8.5e-65 219.58 In-house 1-145 (263) Show / Hide 
Range on Protein: 90-235
Range on HMM: 1-145/263
Sequence Identity: 52% (76 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEE
|. .|||||||||||.|| .| . ..||||.| | .|. .   |    ||||.  |   |.|...| |||.| ||..|...||||.. |. . | . |  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD-VPEKW

TQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLC
..||  | |||.|||| .||||||.||||.||| .||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase NDR2.AA DMPK 284-383 50 3.2e-64 157.18 In-house 162-270 (270) Show / Hide 
Range on Protein: 284-383
Range on HMM: 162-270/270
Sequence Identity: 50% (55 aa)

VGTPDYIAPEVF--MQTG----YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNW-KETLVFPPEVP--ISEKAKDLILRFCIDSENRIGNSGV
|||||||.|||   | ..    | . |||||.||.||||| |  ||  ..  ||| | ||  |. | ||....  .||.||||| ..  |.|.|.|  |.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

EEIKGHPFF
|..| ||||
EDFKCHPFF
Kinase NDR2.AA MAST 284-383 44 1.3e-46 140.03 In-house 229-337 (337) Show / Hide 
Range on Protein: 284-383
Range on HMM: 229-337/337
Sequence Identity: 44% (48 aa)

VGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYPPFCSETPQE-TYRKVMNWKETLVFPPE------VPISEKAKDLILRF-CIDSENRIGNSGV
.||||||||||   .| |.|  ||||.|.|||| |.|.|||  .||.| .  .. | .. . .|.|       ..|. |.||| ..   .   |.|  |.
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

EEIKGHPFF
.||| ||||
DEIKQHPFF
Kinase NDR2.AA MAST 284-383 41 8.1e-42 132.38 In-house 225-334 (334) Show / Hide 
Range on Protein: 284-383
Range on HMM: 225-334/334
Sequence Identity: 41% (46 aa)

VGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWK-ETLVFPPE------VPISEKAKDLILRF-CIDSENRIGNS-G
.||||||||||  ..| ..|  ||||.|.|||| |.|.|||. .||.|.. .. | .     .|..        .|. |.||| ..   | . |.| . |
CGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNG

VEEIKGHPFF
..|.| ||||
ADEVKQHPFF
Kinase NDR2.AA ROCK 284-383 51 3.9e-40 134.21 In-house 160-263 (263) Show / Hide 
Range on Protein: 284-383
Range on HMM: 160-263/263
Sequence Identity: 51% (54 aa)

VGTPDYIAPEVFMQTG----YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKG
|||||||.|||    |    | . ||||| || .||||.|  ||  ..   || |.|. |. | ||..| ||..||||| .|  | |.|.|  ||..|| 
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase NDR2.AA GEK 284-383 50 3.4e-38 125.54 In-house 162-269 (269) Show / Hide 
Range on Protein: 284-383
Range on HMM: 162-269/269
Sequence Identity: 50% (54 aa)

VGTPDYIAPEVF--MQTG---YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVP---ISEKAKDLILRFCIDSENRIGNSGVE
|||||||.||.   |. |   | . ||||||||.||||| |  || .|   ||| |.||.|. . ||...    .||.||||| .    .|.|.|  |..
VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQ

EIKGHPFF
. | ||||
DFKKHPFF
Kinase NDR2.AA Akt 278-383 37 1.4e-33 104.65 In-house 157-264 (264) Show / Hide 
Range on Protein: 278-383
Range on HMM: 157-264/264
Sequence Identity: 37% (41 aa)

QLAYSTVGTPDYIAPEVFMQTGYNKLCDWWS-LGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFC-IDSENRIG--NSG
. ...  ||| |.|||.  ..|. | .|||. ||..||||. | ||| ..  .. . | .|  . . ||.   || ..|||| . .  | ..| |  ...
DKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKN--QPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPND

VEEIKGHPFF
..||| ||.|
AQEIKRHPWF
Kinase NDR2.AA Pkinase_C 401-447 25 3.5e-11 42.62 Pfam 1-46 (46) Show / Hide 
Range on Protein: 401-447
Range on HMM: 1-46/46
Sequence Identity: 25% (12 aa)

EIKSIDDTSNFD-DFPESDILQPVPNTTEPDYKSKDWVFLNYTYKRFE
..||..|||||| .| . .    . ....   ..... | ..||....
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase NDR2.AA TyrKc 90-377 19 9.3e-11 -48.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 90-377
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEA--DGAWVVKMFYSFQDK-------RNLYLIMEFLPGGDMMTLLM
 . .|..|.||||||.. . |      | | |...       .. .. |  |. .   .   .|...    ..         |...||. |.||    | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KKDT-LTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKA-HRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQ
|.   |. ..   .        . .|. ..||||.   | |......|| |||||.  ..   ..                    ... .  . .|... 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------------------ESKDYYRKKEHKGGKT

-LAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEML-IGYPPFCS-----ETPQETYRKVMNWKETLVFPPE------VPISEKAKDLILRFCID-
 | .         |||...   ..   | || || |.|..  | .|         ..|| ...|..  . .  ||.      |  ...  ..... .   
MLPIR------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

SENR-----IGNSGVEEI
 |.|     |    .|..
PEDRPTFSEI----HECF
Kinase NDR2.AA S_TK_X 384-445 25 2.2e-05 23.03 SMART 1-79 (79) Show / Hide 
Range on Protein: 384-445
Range on HMM: 1-79/79
Sequence Identity: 25% (20 aa)

EGVDWEHIRE--RPAAIPI--EIK----SIDDTSNFD-DFPE-SDILQPVPNTTEPDYKSKDWV--------FLNYTYKR
 |.||....   .    |.  .||    |  |||||| .|.| .. |.|.. .  .    .. .        |...||..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase NDR2.AA Pkinase_Tyr 205-235 38 0.001205 12.97 Pfam 128-158 (270) Show / Hide 
Range on Protein: 205-235
Range on HMM: 128-158/270
Sequence Identity: 38% (12 aa)

HQLGFIHRDIKPDNLLLDAKGHVKLSDFGLC
.. ..||||.   | |.. ...|| .||||.
ESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase NDR2.AA Pkinase_Tyr 90-106 47 0.022417 8.67 Pfam 1-17 (270) Show / Hide 
Range on Protein: 90-106
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FESLKVIGRGAFGEVRL
 . .|..|.||||||..
ITFGKKLGEGAFGEVYK
Kinase NDR2.AA Pkinase_Tyr 291-337 28 0.152489 5.85 Pfam 182-231 (270) Show / Hide 
Range on Protein: 291-337
Range on HMM: 182-231/270
Sequence Identity: 28% (14 aa)

APEVFMQTGYNKLCDWWSLGVIMYEMLI-GYPP-FCSETPQETYRKV-MN
|||...   ..   | || || |.|..  |  | .   ...| |...  .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase NDR2.AA Pkinase_Tyr 162-189 34 3.362372 1.3 Pfam 81-112 (270) Show / Hide 
Range on Protein: 162-189
Range on HMM: 81-112/270
Sequence Identity: 34% (11 aa)

NLYLIMEFLPGGDMMTLLMK----KDTLTEEE
..|..||. |.||. . | |    |. || ..
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD